1. Preparation and Chiral HPLC Separation of the Enantiomeric Forms of Natural Prostaglandins
- Author
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Mihály Kádár, Zita Róka, Zsuzsanna Kardos, Enikő Tormási, Laszlo Takacs, Adrienn Tóthné Rácz, and Márton Enesei
- Subjects
Synthetic Prostaglandins ,Prostaglandin ,ent-PGE1 ,01 natural sciences ,lcsh:Chemistry ,ent-PGE2 ,chemistry.chemical_compound ,mirror images ,otorhinolaryngologic diseases ,heterocyclic compounds ,0101 mathematics ,chiral HPLC ,preparation ,Chromatography ,010405 organic chemistry ,organic chemicals ,enantiomeric separation ,General Medicine ,ent-PGF2α ,ent-PGF1α ,enantiopurity ,0104 chemical sciences ,010101 applied mathematics ,Chiral column chromatography ,lcsh:QD1-999 ,chemistry ,lipids (amino acids, peptides, and proteins) ,Enantiomer ,circulatory and respiratory physiology - Abstract
Four enantiomeric forms of natural prostaglandins, ent-PGF2&alpha, ((&minus, )-1), ent-PGE2 ((+)-2) ent-PGF1&alpha, )-3), and ent-PGE1 ((+)-4) have been synthetized in gram scale by Corey synthesis used in the prostaglandin plants of CHINOIN, Budapest. Chiral HPLC methods have been developed to separate the enantiomeric pairs. Enantiomers of natural prostaglandins can be used as analytical standards to verify the enantiopurity of synthetic prostaglandins, or as biomarkers to study oxidation processes in vivo.
- Published
- 2020
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