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Costus speciosus (J. Koenig) Sm., commonly known as crepe ginger, is primarily used as an ornamental plant worldwide. The aim of this research was to study the phytoconstituents of locally collected C. speciosus plant samples and test their antimicrobial effect against selected bacterial strains. Phytochemical analysis showed the presence of alkaloids, flavonoids, steroids, phenolic compounds, tannins, glycosides, and cardiac glycosides in the extracts. The extracts displayed variable degrees of antibacterial activity against the microorganisms in a bioautography experiment based on thin-layer chromatography. All the extracts showed activity against S. aureus, and none showed any activity against P. aeuroginosa. The ethanol and ethyl acetate extracts from the plant leaf and stem showed efficacy against S. typhi and B. subtilis, while the ethyl acetate extracts prevented the growth of S. pneumoniae. Only the ethanol extract from plant leaves had a negligible effect on K. pneumoniae. Bangladesh J Microbiol, Volume 39, Number 2, December 2022, pp 46-52

Developing high-yielding hybrid rice varieties is much needed to ensure food security to meet the requirement of the increasing population across the world. Cytoplasmic male genetic sterility system is a valuable technology for the exploitation of heterosis and production of high-yielding hybrid rice with better grain quality. Large-scale commercial exploitation of hybrid vigor in rice largely depends on the availability of good CMS (Cytoplasmic Male Sterile) lines. A total of eighteen traits of five CMS lines of rice were evaluated to study the variability and correlation between floral and other yield-contributing traits with outcrossing rate using Randomized Complete Block Design with three replications. High significant variation was observed among the genotypes for all the studied traits. High GCV (Genotypic Coefficient of Variance) and PCV (phenotypic Coefficient of Variance) coupled with high heritability and high genetic advance in percent of mean were observed for number of panicles per plant, filled grain, flag leaf breadth, stigma length and breadth, filament length and outcrossing rate which indicated the broad genetic base, less environmental influence, and these traits are under the control of additive gene action. character association and path analysis indicated that number of grains per panicle, filled grains per panicle, stigma length, and breadth possessed both positive significant correlation and positive direct effects on outcrossing rate therefore, selection for the traits mentioned above will certainly bring in the improvement of the outcrossing percentage of the lines, which in turn enhances the seed quantity of the hybrid.

Cross sections of the 86Sr(p,3n)84mY, 86Sr(p,αn)82mRb, and 86Sr(p,x)85gSr reactions were measured from their respective thresholds up to 16.2 MeV and from 23.0 to 44.1 MeV at FZJ, and from 14.3 to 24.5 MeV at LBNL, using 96.4% enriched 86SrCO3 as target material. Thin targets prepared by sedimentation were irradiated with protons in a stacked-form, and the induced radioactivity was measured by high-resolution γ-ray spectrometry. Nuclear model calculations based on the code TALYS reproduced our experimental cross section data well. From the excitation functions, the integral yields of the above three radionuclides were calculated. The yield of 85gSr via the natSr(n,γ) process was also measured using the TRIGA Mark-II reactor at AERE, Savar. A comparison of the reactor and cyclotron production of carrier-added 85gSr is given. The production possibilities of the three investigated radionuclides in no-carrier-added forms at a 30 MeV cyclotron via new routes are discussed.

In the western mountainous region of Khyber Pakhtunkhwa Pakistan at the Shangla district, we found Physalis ixocarpa for the first time, not yet reported from Pakistan. Physalis ixocarpa was unidentified and has no ethnobotanical record in the flora of Pakistan. It is a member of family Solanaceae and having a close relation with Solanum tuberosum and Lycopersicon esculentum. The stem is prostrate with a dichotomous pattern of branches having leaves flower and fruits. Leaves are smooth, ovate and the margins of leaf blade dentation are poorly developed. The average length and width of the leaves are 6.50 and 3.61 cm respectively. P. ixocarpa grows to the length of 4-5 feet and an annual herb. The flowers of the plants are yellow in color and having purple color spots on the petals which are star-shaped. The round berry fruits are surrounded by persistent calyx and purple in color. The fruits are the 3-6cm in diameter. The plants are found in the different localities of district Shangla especially in Bar and Koz Kana. The life cycle of reporting plant is started in May and completed in November. Resumo Na região montanhosa ocidental de Khyber Pakhtunkhwa, Paquistão, no distrito de Shangla, encontramos Physalis ixocarpa pela primeira vez, ainda não relatada nesse país. A P. ixocarpa não foi identificada e não possui registro etnobotânico na flora do Paquistão. É membro da família Solanaceae e tem estreita relação com Solanum tuberosum e Lycopersicon esculentum. O caule é rastejante com um padrão dicotômico de ramos com folhas, flores e frutos. As folhas são lisas e ovais e as margens da dentição da lâmina foliar são pouco desenvolvidas. O comprimento e a largura médios das folhas são de 6,50 e 3,61 cm, respectivamente. A P. ixocarpa cresce aproximadamente 120-150 cm de comprimento e é uma planta anual. As flores das plantas são de cor amarela com manchas roxas nas pétalas em forma de estrela. Os frutos redondos da baga são rodeados por cálice persistente e de cor roxa. Os frutos têm 3-6 cm de diâmetro. As plantas são encontradas em diferentes localidades do distrito de Shangla, especialmente em Bar e Koz Kana. O ciclo de vida da planta reportado é iniciado em maio e concluído em novembro.

Numerical predictions of blood flow and hemodynamic properties through stenosis and aneurysm artery have been studied in the presence of blood clots at the constricted area. The finite element method has been used to solve the partial differential equations of continuity, momentum, Oldroyd-B, and bioheat transport in cartesian coordinates systems. The present investigation carries the potential to compute blood velocity, pressure, and drag coefficients with significance at the throat of stenosis and aneurysm. The models have also been employed to study simulation, blood clots, and hemodynamic characteristics for all modifications. The impact of shearthinning on blood flow is intensified compared to the viscoelastic properties. It is found that the maximum effect of the drag coefficient is visible at the hub of stenotic for nonclotting models. The highest pressure and the lowest velocity are gained for the presence of blood clots at the constraint area. The impact of stenosis and aneurysm artery, drag coefficient, and blood clots on blood flow is the main physical outcome that may be reported in medical science to identify atherosclerosis diseases. The quantitative analysis has been completed numerically with the physiological significance of hemodynamic factors of blood flow which shows the validity of the present model.

The hilly and rural areas’ people of Bangladesh have a great history of putting into use numerous traditional medicinal plants to cure diseases. Therefore, with ethanol extract of Molineria capitulata (EEMC), methanol extract of Trichosanthes tricuspidata (METT), and methanol extract of Amorphophallus campanulatus (MEAC), we mandate evaluation of in vitro α-amylase inhibition, antioxidants, and molecular docking, and ADMET/T analysis. According to iodine starch methods, α-amylase inhibition was performed, and quantitative total phenolic and flavonoid content was determined by established methods, whereas DPPH free radical scavenging and reducing power assays were performed in previously established protocols, respectively. A comparative study among three plants (EEMC, METT, and MEAC) possessed a significant ( p < 0.01 ) effect but EEMC showed the highest impact on enzyme inhibition. Plants in the measuring phenolic content METT and flavonoid measurement MEAC displayed most potent in the same way in the DPPH test was METT, and in reducing power capability MEAC has showed the highest effect between three extracts. Docking’s study also reveals the compounds of METT (Cyclotricuspidoside A and Cyclotricuspidoside C) exhibit the superior score among all the compounds. This finding indicates that EEMC, METT, and MEAC substantially impact α-amylase inhibition along with antioxidants. In silico study also reveals the potency of these plants, but further in-depth, precise molecular studies are needed.

Objectives: The purpose of this study is to evaluate the endoscopic approach for sinonasal inverted papilloma and outcome of the surgical management. Study design: Retrospective. Place and duration of study: Dhaka Medical college Hospital and Bangladesh ENT Hospital Ltd. of Bangladesh, from January 2006 to December2020. Materials and methods: 189 cases of Inverted papillomas (confirmed by histopathology) presented in last 15 years were managed by Endoscopic Sinus Surgery and the outcome evaluated. Results: The age of the patients ranged from 41 to 80 years. The mean age was 60 years with Male Female ratio 2.04:1.165 patients had unilateral disease and 24 patients had bilateral. Hundred & seventy two patients with inverted papilloma resected by the endoscopic approach,09 patients by nasoendoscopy in combination with modified Caldwell-Luc approach and 8 patients by combined external and nasoendoscopic approach. Follow up revealed recurrence in nine patients. Conclusion: Findings suggest that endoscopic approach is a safe and effective way of treating sinonsal inverted papilloma. Most lesions were entirely resected through endoscopic approach. Importantly surgical strategies need to be thoughtfully chosen based on tumor stage to achieve maximum removal of the lesion and prevent recurrence. J Shaheed Suhrawardy Med Coll 2021; 13(2): 126-129

Background: There are various varieties of habitats that have specific characteristics of water for the breeding of mosquito. A house-to-house cross-sectional entomological survey used to be carried out at per domestic area to become aware of larval breeding sites. Aedes aeygypti used to be primary vector and Aedes albopictus used to be predominant species in container-breeding habitats. Most breeding habitats have been category into excessive stage of larval density. Turbidity, pH, TOC, magnesium, calcium and sodium is amongst the characteristics that indicates a significant difference with larval density and species composition respectively. This study personal based entomological research and funding carried out by corresponding author. Students of zoology department of Rajshahi university involved in this research. Students were working as a research assistant for this study. Aim of this study was to assess determination of prevalence, density and breeding place of Aedes mosquito in Rajshahi city corporation. Methods: This observational study carried out 30 wards in Rajshahi city corporation areas have been surveyed in department of communicable diseases control, director general of health services, Dhaka, Bangladesh. Duration of study 3 years. Total 3 surveys were conducted in each year; pre monsoon, monsoon and post monsoon total 9 surveys conducted by this 3 years survey period. Data entered in MS excel and statistical analysis done by SPSS trial version. Results: This study shows that according to breeding area of 2020-2022. Here, total surveyed household were 8100. Total positive Wet container were 474 and positive place were 473 in these three years survey. Conclusions: Aedes aegypti and Aedes albopictus are properly established inside urban places. Meteorological variables additionally affected mosquito populations. Characteristics of mosquito breeding area can affect larval density and give impact quality of life.

Background: Dengue fever is a viral infection transmitted by mosquitoes and is a significant public health problem in many tropical and subtropical countries, including Bangladesh. The clinical spectrum of dengue fever can vary widely, ranging from asymptomatic infection to severe and potentially life-threatening illness. In this study, we aimed to describe the clinical spectrum of dengue fever in patients admitted to a tertiary care hospital in Bangladesh. The aim of the study was to observe the clinical spectrum of dengue fever patients. Methods: This prospective observational study was conducted at the department of medicine, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. The study duration was 7 months, from June 2022 to December 2022. During this period, a total of 65 cases of dengue fever cases admitted to the hospital for treatment were included in the study, who had a hospital stay of at least 3 days. Results: The mean age of the participants was 30.78 years, and the male: female ratio was 1:1.95. 86.15% of the participants had no comorbidities, while diabetes and hypertension were observed in 6.15% of patients each. Patients' mean temperature had been high at the first check-up and dropped slowly to normal levels throughout the following check-ups, but the mean platelet count had significantly dropped from the first check-up throughout the following check-ups, improving only at the 6th check-up. ≤20,000 platelet count was observed in 6.15% at the first check-up, 9.23% at the 2nd check-up, 15.38% at the 3rd, 5.41% at the 4th, 15% at the 5th, and 0% at the 6th check-up. The most common warning signs were a positive tourniquet test (21.54%), vomiting (16.92%), and abdominal pain (15.38%). Hospital stay duration was

Eclipta alba L. (Family: Asteraceae) is an evergreen herb of ethnomedicinal significance in the Indian subcontinent. The present study was carried out to determine the in vitro antioxidant, anti-inflammatory, antimicrobial and thrombolytic activities of n-hexane, chloroform and aqueous soluble fractions of ethanol crude extract of E. alba whole plant. Preliminary phytochemical screening was performed by qualitative tests which revealed the presence of alkaloids, steroids, glycosides, tannins, flavonoids, saponins and amides in E. alba. During the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay, the aqueous soluble fraction of E. alba at a dose of 100 μg/ml showed maximum 87.5% inhibition in scavenging the DPPH radical with IC50 value of 7.86 μg/ml. Anti-inflammatory activity was evaluated by egg albumin denaturation technique and RBC membrane stabilizing method. In both experiments, all the test samples of E. alba showed a concentration-dependent anti-inflammatory potential while the aqueous soluble fraction at the dose of 500 μg/ml demonstrated the maximum 90.12% inhibition of egg albumin denaturation and 78.42% inhibition of RBC membrane hemolysis against hypotonic solution. Antimicrobial sensitivity was evaluated by disc diffusion assay against several bacterial and fungal species. All the test samples at a concentration of 500 μg/disc exhibited noticeable antibacterial (zone of inhibition = 11-23 mm) and antifungal (zone of inhibition = 10-21 mm) activities when compared to the respective standard drug. The aqueous soluble fraction showed maximum activity against Lactobacillus casai (zone of inhibition = 23 mm). During antifungal test, the maximum activity was exhibited by the n-hexane fraction against Pityrosporum ovale (zone of inhibition = 21 mm). During in vitro thrombolytic assay, the aqueous soluble fraction revealed 56.84% lysis of blood clot, as compared to the standard streptokinase (84.60%). The results of our study suggest that E. alba can be considered for further investigation in order to discover the pharmacologically active natural products. Bangladesh Pharmaceutical Journal 26(1): 20-27, 2023 (January)

In the year 2020, a total of 342 000 women were estimated to die of cervical cancer, of which 90%) were expected amongst low- and middle-income countries (LMIC). Globally incidence of cervical cancer has reduced as a result of improved personal hygiene, better living conditions and higher application of opportunistic screening programs. Yet GLOBOCAN shows that absolute number of cases are still increasing.We therefore conducted a 21 question multiple choice questionnaire online survey in Jan 2023 amongst 9 SAARC countries. A total of 367 replies were received and the representative answers for each country are being reported in this manuscript.A good possibility of achieving World Health Assembly target (Nov 17, 2020) was felt only by Bhutan and Nepal. For screening, most countries (Bhutan, India, Myanmar, Nepal, Pakistan and Sri Lanka) recommend for all asymptomatic eligible patients. Public health experts have suggested VIA / VILI as the best solution for LMICs. However, a dual screening strategy (HPV DNA plus) cytology was preferred by doctors in Afghanistan, Bhutan, India, Myanmar, Pakistan and Sri Lanka.Screening, triage and then treatment was the preferred by Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, Sri Lanka.HPV vaccination was recommended in all girls between ages 10 to 26 years in Bangladesh, India, Myanmar, Nepal, Pakistan and Sri Lanka. All the 9 countries would use HPV vaccination to all eligible patients if the cost of the vaccine was reasonably low.Our survey clearly outlines challenges faced in tackling cervical cancer in SAARC countries. We also provide consensus regarding several potential solutions that can be used in both public and private cervical cancer control programs.

Octamethyl tetraazamacrocycle, Me8[14]diene·2HClO4 and its three isomeric ligands (LA, LB and LC) were synthesized and characterized using analytical and spectroscopic data, and the antibacterial activities were evaluated against selected bacteria and yeast. Interaction of LC with excess acrylonitrile resulted in an N-pendent derivative (LCX). Square planar nickel(II) diperchlorate complex of LC, [NiLCα](ClO4)2, underwent axial addition reactions with KI and NaNO2 to yield six coordinated octahedral species, [NiLCαI2]·2H2O and [NiLCα(NO2)(ClO4)]. Five coordinated square pyramidal Ni(II) complexes, [NiLCXCl](ClO4), [NiLCX(NCS)](NO3) and [NiLCXI](NO3), were synthesized from Ni(II) salts and tetraazamacrocyclic ligand LCX. Among the complexes, [NiLCXCl](ClO4) was synthesized through the direct interaction of NiCl2 with LCX, followed by the subsequent addition of NaClO4·6H2O. On the other hand, [NiLCX(NCS)](NO3) and [NiLCXI](NO3) as well as octahedral [NiLCXBr2] and [NiLCX(NO2)(NO3)] were synthesized by the interaction of LCX with different Ni(II) salts.

An experiment was conducted at the research farm of Patuakhali Science and Technology University (PSTU), Dumki, Patuakhali, during the period from January to April 2015 to evaluate the growth, development, and yield performance of seven mungbean varieties for obtaining the most productive variety suitable for Patuakhali region. The experiment was laid out in a Randomized Complete Block Design with three replicates. Among the varieties, BARI mung 4 showed better performance in respect of growth, development, and yield contributing characteristics compared to other varieties. The results showed better performance on growth characters namely, the number of leaves per plant (15.62), branches per plant (5.427), leaf area per plant (1079 cm2), and total dry matter weight per plant (9.64 g) were recorded in BARI mung 4. The highest seed yield recorded in BARI mung 4(1.69t ha-1) might be due to superior growth characteristics thereby seed yield. Besides, BARI mung 4 produced a pod number of 24.22 and the maximum number of seeds per pod (6.42). In contrast, the lowest seed yield was recorded in the local variety (0.81 t ha-1) for its inferior growth and yield contributing characters. Therefore, BARI mung 4 may be cultivated commercially in the southern region of Bangladesh.

The work explores the optical wave solutions along with their graphical representations by proposing the coupled spatial-temporal fractional cubic-quartic nonlinear Schrödinger equation with the sense of two fractal derivatives (beta and conformable derivative) and Kerr law nonlinearity for birefringent fibers. The new extended direct algebraic method for the first time is implemented to achieve this goal. Many optical solutions are listed along with their existence criteria. Based on the existence criteria, the cubic-quartic bright, and singular optical soliton, periodic pulse, and rouge wave profiles are supported in birefringent fibers with the influence of both beta and conformable derivative parameter.

For obtaining analytical solutions to the modified forced Van der Pol equation, the modified harmonic balance method has been developed. In classical harmonic balance method, the numerical procedure is used for solving a set of nonlinear algebraic equations. But it requires laborious computational attempt and accurate primary guesses values which makes it very hard-working to calculate. According to our method, a set of nonlinear algebraic equations has been converted to a set of linear algebraic equations by using a nonlinear one instead of a set. As a result, it reduces the massive computational work. This method provides not only better results than the existing harmonic balance method but also provides very close solutions to the corresponding numerical results. It is noticeable that there is substantial similarity between the approximate and the numerical results attained by the fourth order Runge-Kutta method. Moreover, the method is facile and straightforward. This technique may play great role to handle strongly nonlinear damped systems with external forces.

In this paper, we explore the Riccati-based boundary feedback stabilization of the incompressible Navier–Stokes flow via the Krylov subspace techniques. Since the volume of data derived from the original models is gigantic, the feedback stabilization process through the Riccati equation is always infeasible. We apply aℋ2optimal model-order reduction scheme for reduced-order modeling, preserving the sparsity of the system. An extended form of the Krylov subspace-based two-sided iterative algorithm (TSIA) is implemented, where the computation of an equivalent Sylvester equation is included for minimizing the computation time and enhancing the stability of the reduced-order models with satisfying the Wilson conditions. Inverse projection approaches are applied to get the optimal feedback matrix from the reduced-order models. To validate the efficiency of the proposed techniques, transient behaviors of the target systems are observed incorporating the tabular and figurative comparisons with MATLAB simulations. Finally, to reveal the advancement of the proposed techniques, we compare our work with some existing works.

Universal provision of iron supplements or iron-containing multiple micronutrient powders (MNPs) is widely used to prevent anemia in young children in low- and middle-income countries. The BRISC (Benefits and Risks of Iron Interventions in Children) trial compared iron supplements and MNPs with placebo in children2 y old in rural Bangladesh.We aimed to assess the cost-effectiveness of iron supplements or iron-containing MNPs among young children in rural Bangladesh.We did a cost-effectiveness analysis of MNPs and iron supplements using the BRISC trial outcomes and resource use data, and programmatic data from the literature. Health care costs were assessed from a health system perspective. We calculated incremental cost-effectiveness ratios (ICERs) in terms of US$ per disability-adjusted life-year (DALY) averted. To explore uncertainty, we constructed cost-effectiveness acceptability curves using bootstrapped data over a range of cost-effectiveness thresholds. One- and 2-way sensitivity analyses tested the impact of varying key parameter values on our results.Provision of MNPs was estimated to avert 0.0031 (95% CI: 0.0022, 0.0041) DALYs/child, whereas iron supplements averted 0.0039 (95% CI: 0.0030, 0.0048) DALYs/child, over 1 y compared with no intervention. Incremental mean costs were $0.75 (95% CI: 0.73, 0.77) for MNPs compared with no intervention and $0.64 ($0.62, $0.67) for iron supplements compared with no intervention. Iron supplementation dominated MNPs because it was cheaper and averted more DALYs. Iron supplementation had an ICER of $1645 ($1333, $2153) per DALY averted compared with no intervention, and had a 0% probability of being the optimal strategy at cost-effectiveness thresholds of $200 (reflecting health opportunity costs in Bangladesh) and $985 [half of gross domestic product (GDP) per capita] per DALY averted. Scenario and sensitivity analyses supported the base case findings.These findings do not support universal iron supplementation or micronutrient powders as a cost-effective intervention for young children in rural Bangladesh.This trial was registered at anzctr.org.au as ACTRN1261700066038 and trialsearch.who.int as U1111-1196-1125.

The term e-commerce is not confined to the purchase and sale of goods only. There are several occasions where students are not able to comprehend any idea on their own. With the availability of online learning platforms such as Massive Open Online Courses (MOOCs) and Virtual Learning Environments (VLEs), students may visit online Internet sites, where various articles are made available with a single click. With mobile devices in their hands, they can also listen to the presentations of different academics from anywhere and at any time. In an online learning environment, it is challenging to provide tailored learning content to students that fulfill their needs and requirement. Therefore, we in this research paper propose an adaptive smartphone learning framework. The framework first considers students’ academic performance, preferred learning content, and memory load i.e., cognitive characteristics. Based on students’ academic performance, preferred learning content, and memory load, appropriate adaptive and motivational triggers are sent on students’ smartphones to guide and motivate them in their learning process. We have introduced ten types of adaptive triggers that in different scenarios will be presented to students to help them in remembering important learning points. Furthermore, performance-based motivational triggers in connection with adaptive triggers are also introduced. These motivational triggers are sent on students’ smartphones for giving them a suggestion, hope, appreciation, and warnings during their studies. In this study, we also show how different students’ learning scenarios are created and how our framework deals with those scenarios in students’ learning process. &nbsp

A technique is developed for obtaining the solution of second order over-damped non-linear systems based on the Krylov-Bogoliubov-Mitropolskii (KBM) method for small ratio of the eigenvalues. The solution is also useful for large ratio of the eigenvalues. The method is illustrated by an example.

Background: Preoperative carcinoembryonic antigen (CEA) level is considered as a factor predictive of survival in colorectal cancer patients. Patients with normal (5 ng/ml. The median 5 years survival rate for patients with preoperative CEA 5 ng/ml patients respectively (p < 0.001). The tumour was primary located at the colon in 23(59%) while the rest was found at the rectum 16(41%). Tumour size was 2cm in 14(35.9%) patients. ...............

Accurate classification of brain tumors is vital for detecting brain cancer in the Medical Internet of Things. Detecting brain cancer at its early stages is a tremendous medical problem, and many researchers have proposed various diagnostic systems; however, these systems still do not effectively detect brain cancer. To address this issue, we proposed an automatic diagnosing framework that will assist medical experts in diagnosing brain cancer and ensuring proper treatment. In developing the proposed integrated framework, we first integrated a Convolutional Neural Networks model to extract deep features from Magnetic resonance imaging. The extracted features are forwarded to a Long Short Term Memory model, which performs the final classification. Augmentation techniques were applied to increase the data size, thereby boosting the performance of our model. We used the hold-out Cross-validation technique for training and validating our method. In addition, we used various metrics to evaluate the proposed model. The results obtained from the experiments show that our model achieved higher performance than previous models. The proposed model is strongly recommended to be used to diagnose brain cancer in Medical Internet of Things healthcare systems due to its higher predictive outcomes.

An investigation on variation (temporal and spatial) in the contents of some selected inorganic nutrients (nitrite, nitrate, ammonium, phosphate and silicate) was carried out in the lower Meghna river estuary, Bangladesh during September 2001 to May 2002 (covering an annual cycle). All the nutrients studied showed irregular pattern of temporal and spatial fluctuations where most of the nutrients showed peak values during premonsoon and trough values during monsoon. A decreasing trend in nutrient concentrations was observed towards the sea in all the seasons.

The classification of brain tumors is significantly important for diagnosing and treating brain tumors in IoT healthcare systems. In this work, we have proposed a robust classification model for brain tumors employing deep learning techniques. In the design of the proposed method, an improved Convolutional neural network is used to classify Meningioma, Glioma, and Pituitary types of brain tumors. To test the multi-level convolutional neural network model, brain magnetic resonance image data is utilized. The MCNN model classification results were improved using data augmentation and transfer learning methods. In addition, hold-out and performance evaluation metrics have been employed in the proposed MCNN model. The experimental results show that the proposed model obtained higher outcomes than the state-of-the-art techniques and achieved 99.89% classification accuracy. Due to the higher results of the proposed approach, we recommend it for the identification of brain cancer in IoT-healthcare systems.

This study aims to explore analgesic, antidiarrheal, neuropharmacological, and antibacterial activities of petroleum ether and water fractions of Justicia aurea (J. aurea). The results of analgesic activity showed that both nonpolar (petroleum ether) and polar (water) fractions of J. aurea extract at 250 and 500 mg/kg significantly suppressed the writhing reflex dose-dependently. Here, the potentiality of petroleum ether fraction was higher than that of water fraction. In the castor oil-induced diarrheal mice, both fractions of J. aurea extract, at 250 and 500 mg/kg, significantly delayed the onset of diarrhea and lessened the total number of feces in a dose-dependent manner. Of the two fractions, the nonpolar fraction was found to exhibit a better effect. Both fractions appreciably reduced the number of squares crossed by the mice at both 250 and 500 mg/kg. At 500 mg/kg, petroleum ether fraction reflected a slightly better effect than that of water fraction. In disc diffusion antibacterial assay, both fractions showed minor effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), however, only the water fraction exhibited low activity against Salmonella enterica (S. enterica). In conclusion, the nonpolar fraction of J. aurea. showed better analgesic, antidiarrheal, and CNS depression effects.

Now-a-days mobile phone has become an essential part of our life. However despite the convenience its use along with social media brings to affect our daily life in negative sense. The aim of the study is to explore the pattern of mobile phone and social media usage among the medical students of the Chittagong city, Bangladesh to observe the extent of addictive behavior towards the usage of mobile phone and social media. This will be an observational study. The study will be performed in different medical colleges of Chittagong for a period of 1 year. Responses on general and specific variables will be documented. Data will be collected with predesigned questionnaire. At the end of the study data will be analyzed by using windows based computer software devised with SPSS-23 using statistical method. Results will be published, presented and utilized for the quality usages of mobile phone and social media and betterment of our life.

The fundamental purpose of this study was to evaluate the technical feasibility of incorporating fly ash (FA) and dyeing sludge (DS) in the production of brick. An attempt was taken to replace 10% to 100% clay by DS and FA in brick-making by volume. A brick firing kiln was used to burn the uniform-shaped bricks after replacing clay with DS and FA. Size and shape, hardness, soundness, water absorption, efflorescence, dry density, loss of ignition, firing shrinkage, specific gravity, compressive strength, and leaching tests were carried out to study the properties of these bricks. The compressive strength of the brink ranged from 6.25 MPa to 0.33 MPa and indicates a decreasing pattern in strength with the increase in the volume of DS and FA. Only 18.8% water absorption capacity was found in control bricks without DS and FA, while a maximum absorption of 40.19% was found for a particular combination of DS and FA. Similarly, dry density decreased with the increase in the volume of DS and FA. Besides, efflorescence in bricks was found within the allowable limits for certain combinations of DS and FA, which exceeded the allowable limits for other combinations. The presence of heavy metals (Ni, Zn, Cr, Cu, and Pb) in the extraction solution was insignificant. Based on the results of this study, we recommend that up to 10% clay can be substituted with DS and FA without substantially affecting the quality of bricks.

Plants are the major source of therapeutic compounds and have huge applications in Pharma Industry. To identify new sources of therapeutic compounds, we studied acute toxicity, antihyperglycemic, anti-inflammatory, and anticoagulant activities of the polar and nonpolar fractions of Justicia aurea (J. aurea). Our initial phytochemical screening of J. aurea exhibited the presence of numerous secondary metabolites such as reducing sugars, glycosides, tannins, gums, alkaloids, phenolic compounds, and carbohydrates which might be primarily responsible for its medicinal properties. In the acute toxicity test, the result showed no toxicity up to 2000 mg/kg. In the antihyperglycemic activity test, administration of petroleum ether fraction and water fraction of J. aurea extract to glucoseloaded mice at 250 and 500 mg/kg body weight (BW) reduced the blood glucose levels compared to control mice. Between two fractions, the water fraction was found to exhibit better potentiality at 500 mg/kg BW. In the anti-inflammatory assay, at 250 and 500 mg/kg water fraction exhibited anti-inflammation by 20.00% and 31.67%, respectively and petroleum ether fraction by 13.33% and 18.00%, respectively. In anticoagulant activity, the test indicated that water fraction has minor anticoagulant potentiality compared to control. In conclusion, the polar water fraction shows better medicinal properties than the nonpolar petroleum ether fraction of J. aurea.

The (2+1)-dimensional interaction of a Riemann wave propagating along the y-axis with a long wave along the x-axis is described by the space-time fractional Calogero-Degasperis (CD) and fractional potential Kadomstev-Petviashvili (PKP) equation. It can be modeled according to the Hamiltonian structure, the lax pair with the non-isospectral problem, and the pain level property. The proposed equations are widely used in beachfront ocean and coastal engineering to describe the propagation of shallow-water waves, demonstrate the propagation of waves in dissipative and nonlinear media, and reveal the propagation of waves in dissipative and nonlinear media. In this paper, we have established further exact solutions to the nonlinear fractional partial differential equation (NLFPDEs), namely the space-time fractional CD and fractional PKP equations using the modified Rieman-Liouville fractional derivative of Jumarie through the two variable ( G ′ / G , 1 / G )-expansion method. As far as trigonometric, hyperbolic, and rational function solutions containing parameters are concerned, solutions are acquired when unique characteristics are assigned to the parameters. Subsequently, the solitary wave solutions are generated from the solutions of the traveling wave. It is important to observe that this method is a realistic, convenient, well-organized, and ground-breaking strategy for solving various types of NLFPDEs.

This work aims to assess the effect of the operating parameters of the gasifying agent preheating temperature and equivalence ratio (ER) on the conversion of sewage sludge (SS) to syngas through gasification and combined heat and power (CHP) generation. A novel gasification model was simulated in Aspen Plus to represent a fixed-bed updraft gasifier to generate syngas from SS through an equilibrium approach restricted by temperature. The novelty of this work is that the model was developed by applying the gasifying agent preheating temperature as an operating variable instead of the gasification temperature. It was calibrated by using a set of experimental values and then validated by comparing the numerical results with the experimental outcomes related to nine different operating conditions of air preheating temperatures and ER. A good agreement between the simulation and experimental results was observed. The optimum gasification process parameters of the air preheating temperature and ER were predicted to be 150 °C and 0.2, respectively. The CHP generation potentiality of SS was assessed to be 2.54 kW/kg SS as dry solids (DS), of which 0.81 kW was electrical and the remainder was thermal power. The conversion of SS to CHP through the proposed treatment can reduce 0.59 kg CO₂/kg SS as DS emissions compared with that of natural gas combustion to generate a similar quantity of energy.

Background and Objective: Globally, Colorectal Cancers are also third most common cancers and fourth leading cause of death due to carcinoma. Burden of Colorectal Cancers is also high in Pakistan. The main risk factor for Colorectal Cancer is age, however, other risk factors are e.g. family history, irritable bowel disease, sedentary life-style, high visceral adipose tissues, smoking and alcohol. Hence; the main objective of current study was to determine point prevalence of Colorectal Cancers in a mega city of Pakistan, Karachi; a representative population of Pakistan. It is hypothesized that incidences of Colorectal Cancers would be higher in Karachi than rest of the country. Materials and Methods: The retrospective cross-sectional study was conducted in Karachi. Duration of study was from January-2015 to October-2019. Data has been collected from two state-owned and four private hospitals of Karachi. Precision analysis technique was used to determine the sample size of study. Study is approved by Board of Advanced Studies & Research, University of Karachi (Reference Number: BASR/01046/Pharm.). Objective of study was explained to patients before initiation the study; informed consent was taken from each patient. S.P.S.S (Statistical-Package-for-Social-Sciences) software version 22 was used to analyze the data. Results: Among 1,617 patients: male 54.35% (N=879); female 45.64% (N=738). Mean age of diagnosis of colorectal cancer: male 49.51±14.72 years; female 45.28±13.52 years. Significantly higher point prevalence was found in ethnicity speaking Sindhi compared with ethnicity speaking Balochi (p=0.001), Pashto (p=0.0001), Punjabi (p=0.001) and Siraiki (p=0.0001); Urdu speaking compared with Balochi speaking (p=0.0001), Pashto speaking (p=0.0001), Punjabi speaking (p=0.0001) and Siraiki speaking (p=0.0001) in male. In female; Sindhi speaking point prevalence is significantly higher than Siraiki speaking (p=0.028); Urdu speaking point prevalence is significantly higher than patients speaking Balochi (p=0.012), Pashto (p=0.002), Punjabi (p=0.002) and Siraiki (p=0.0001). Conclusion: Allocation of resources are required at governmental and non-governmental level for early screening. National cancer registry program should also be initiated to support health policy makers for the development of counter strategies. Peer Review History: Received: 26 February 2023; Revised: 13 March; Accepted: 27 April 2023, Available online: 15 May 2023 Academic Editor: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com

Averrhoa carambola L. (A. carambola) is particularly well-known for its distinctive star-shaped fruit (Star fruit), cultivated in Southeast Asia, the Indian subcontinent, and northern and southern America. Historically, it has been used for a long time to cure many ailments, including vomiting, fever, arthralgia, cough, hypertension, hangovers, chronic paroxysmal headache, hyperglycemia, and diabetic nephropathy. This study aimed to examine its preliminary phytochemical and some biological properties. For this, fresh leaves of A. carambola were extracted (hot and cold) with ethanol, which was then fractionated with n-hexane and chloroform. Following a preliminary investigation of phytochemicals, radical scavenging, membrane stabilizing, alpha-glucosidase inhibitory, and clot lysis effects were evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, egg albumin model, alpha-amylase assay, and human blood clot lysis assay, respectively using suitable reference standards. The results suggest that A. carambola contains alkaloids, glycosides, steroids, tannins, flavonoids, saponins, and reducing sugars. All the organic fractions demonstrated significant (p

This letter reports a highly scaled 90 nm gate length beta-Ga2O3 T-gate MOSFET with no current collapse and record power gain cut off frequency (fMAX). The epitaxial stack of 60 nm thin channel MOSFET was grown by Molecular Beam Epitaxy (MBE) and highly doped (n++) contact regrowth was carried out by Metal Organic Chemical Vapour Deposition (MOCVD) in the source/drain region. Maximum on current (IDS, MAX) of 160 mA/mm and transconductance (gm) around 36 mS/mm was measured at VDS= 10 V for LSD= 1.5 micrometer channel length. Transconductance is limited by higher channel sheet resistance (Rsheet). We observed no current collapse for both drain and gate lag measurement even at higher VDG,Q quiescent bias points. This is the first report of Ga2O3 FET showing no current collapse without any external passivation. Breakdown voltage around 125 V was reported for LGD= 1.2 micrometer. We extracted 27 GHz current gain cut off frequency (fT) and 100 GHz fMAX for 20 V drain bias. fMAX value mentioned here is the highest for Ga2O3 and the first demonstration of 100 GHz operation. fT. VBR product of 3.375 THz.V has been calculated which is comparable with state-of-art GaN HEMT. This letter suggests that Ga2O3 can be a suitable candidate for X-band application.

This Letter reports a high performance β-Ga2O3 thin channel MOSFET with T gate and degenerately doped (n++) source/drain contacts regrown by metal organic chemical vapor deposition. Highly scaled T-gate with a gate length of 160–200 nm was fabricated to achieve enhanced RF performance and passivated with 200 nm silicon nitride. Peak drain current (ID,MAX) of 285 mA/mm and peak transconductance (gm) of 52 mS/mm were measured at 10 V drain bias with 23.5 Ω mm on resistance (RON). Metal/n++ contact resistance of 0.078 Ω mm was extracted from transfer length measurements. RON is possibly dominated by interface resistance between channel and highly doped n++ regrown layer. A gate-to-drain breakdown voltage of 192 V is measured for LGD = 355 nm resulting in average breakdown field (EAVG) of 5.4 MV/cm. This EAVG is the highest reported among all sub-micron gate length lateral FETs. Current gain cut off frequency (fT) of 11 GHz and record power gain cut off frequency (fMAX) of approximately 48 GHz were extracted from small signal measurements. fT is limited by DC-RF dispersion due to interface traps which needs further investigation. The fT·VBR product is 2.112 THz V for 192 V breakdown voltage. Device surpasses the switching figure of merit of Silicon and competitive with mature wide bandgap devices.