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3 results on '"MacKenzie, Marius A."'

1. Additional file 7: of Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies

Author

Arts, Peer, Simons, Annet, Mofareh AlZahrani, Elanur Yilmaz, AlIdrissi, Eman, Aerde, Koen, Njood Alenezi, AlGhamdi, Hamza, Hadeel AlJubab, Abdulrahman Al-Hussaini, AlManjomi, Fahad, Alsaad, Alaa, Alsaleem, Badr, Abdulrahman Andijani, Asery, Ali, Ballourah, Walid, Bleeker-Rovers, Chantal, Deuren, Marcel, Flier, Michiel, Gerkes, Erica, Gilissen, Christian, Habazi, Murad, Hehir-Kwa, Jayne, Henriet, Stefanie, Hoppenreijs, Esther, Hortillosa, Sarah, Kerkhofs, Chantal, Keski-Filppula, Riikka, Lelieveld, Stefan, Lone, Khurram, MacKenzie, Marius, Mensenkamp, Arjen, Moilanen, Jukka, Nelen, Marcel, Oever, Jaap, Potjewijd, Judith, Paassen, Pieter, Schuurs-Hoeijmakers, Janneke, Simon, Anna, Stokowy, Tomasz, Vorst, Maartje, Vreeburg, Maaike, Wagner, Anja, Well, Gijs, Zafeiropoulou, Dimitra, Zonneveld-Huijssoon, Evelien, Veltman, Joris, Zelst-Stams, Wendy, Faqeih, Eissa, Veerdonk, Frank, Netea, Mihai, and Hoischen, Alexander

Subjects
3. Good health
Abstract

Additional material and references. (DOCX 31 kb)

Published
2019
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2. Treatment of secondary central nervous system lymphoma with intrathecal rituximab, high-dose methotrexate, and R-DHAP followed by autologous stem cell transplantation: Results of the HOVON 80 phase 2 study

Author

Doorduijn, Jeanette K., van Imhoff, Gustaaf W., van der Holt, Bronno, Schouten, Harry C., Schaafsma, Martijn R., MacKenzie, Marius A., Baars, Joke W., Kersten, Marie José, Lugtenburg, Pieternella J., van den Bent, Martin J., Enting, Roelien H., Spoelstra, Fokje M., Poortmans, Philip, Bromberg, Jacoline E. C., Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Hematologie (9), Interne Geneeskunde, CCA - Cancer Treatment and Quality of Life, Clinical Haematology, and Cancer Center Amsterdam

Subjects
treatment, AGGRESSIVE LYMPHOMA, MABTHERA INTERNATIONAL TRIAL, clinical trial, methotrexate, STUDY-GROUP DSHNHL, INTRAOCULAR LYMPHOMA, rituximab, PRIMARY CNS LYMPHOMA, NON-HODGKINS-LYMPHOMA, CHEMOTHERAPY PLUS RITUXIMAB, MARROW-TRANSPLANTATION, ELDERLY-PATIENTS, secondary CNS lymphoma, transplantation, RESPONSE CRITERIA
Abstract

The prognosis of central nervous system (CNS) relapse of systemic non-Hodgkin lymphoma is poor with 1-year survival historically at 0% to 20%. Aiming to improve these results, we performed a multicenter phase 2 study in patients with a CNS relapse, with or without concurrent systemic relapse. Treatment consisted of 2 cycles of R-DHAP alternating with high-dose methotrexate (MTX) and was combined with intrathecal rituximab. Responding patients received a third R-DHAP-MTX cycle followed by busulfan and cyclophosphamide myeloablative therapy and autologous stem cell transplantation. In patients with persistent cerebrospinal fluid lymphoma after cycle 1, the intrathecal rituximab was replaced by intrathecal triple therapy, with MTX, cytarabine, and dexamethasone. Thirty-six patients were included. Eighteen had evidence of cerebrospinal fluid lymphoma, 24 had brain parenchymal disease, and 20 (56%) had concurrent systemic disease. The overall response rate after 2 R-DHAP-MTX was 53% (19/36), with 22% (8/36) complete remission. Fifteen patients (42%) underwent a transplant. One-year progression-free survival was 19% (95% confidence interval, 9-34): 25% in patients without and 15% in patients with systemic disease. One-year overall survival was 25% (95% confidence interval, 12-40). This treatment regimen did not result in a major improvement of outcome of secondary CNS lymphoma, especially when concurrent systemic disease was present. Registered in the Dutch trial register www. trialregister.nl, NTR1757; EudraCT number 2006-002141-37.

Published
2017

3. Additional file 7: of Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies

Author

Arts, Peer, Simons, Annet, Mofareh AlZahrani, Elanur Yilmaz, AlIdrissi, Eman, Aerde, Koen, Njood Alenezi, AlGhamdi, Hamza, Hadeel AlJubab, Abdulrahman Al-Hussaini, AlManjomi, Fahad, Alsaad, Alaa, Alsaleem, Badr, Abdulrahman Andijani, Asery, Ali, Ballourah, Walid, Bleeker-Rovers, Chantal, Deuren, Marcel, Flier, Michiel, Gerkes, Erica, Gilissen, Christian, Habazi, Murad, Hehir-Kwa, Jayne, Henriet, Stefanie, Hoppenreijs, Esther, Hortillosa, Sarah, Kerkhofs, Chantal, Keski-Filppula, Riikka, Lelieveld, Stefan, Lone, Khurram, MacKenzie, Marius, Mensenkamp, Arjen, Moilanen, Jukka, Nelen, Marcel, Oever, Jaap, Potjewijd, Judith, Paassen, Pieter, Schuurs-Hoeijmakers, Janneke, Simon, Anna, Stokowy, Tomasz, Vorst, Maartje, Vreeburg, Maaike, Wagner, Anja, Well, Gijs, Zafeiropoulou, Dimitra, Zonneveld-Huijssoon, Evelien, Veltman, Joris, Zelst-Stams, Wendy, Faqeih, Eissa, Veerdonk, Frank, Netea, Mihai, and Hoischen, Alexander

Subjects
3. Good health
Abstract

Additional material and references. (DOCX 31 kb)

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