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1. Discovery and Neurobiological Modeling of Rare Genetic Variant Risk for Mental Illness

Author

De Jong, Job, Kushner, Steven, Markx, Sander, and Psychiatry

Subjects
SDG 3 - Good Health and Well-being
Abstract

The subject of this thesis is the role of rare genetic variation in the etiology of psychiatric disorders. The studies included in this work include a human genetics study on depression, a disease-modeling study for autism spectrum disorder using brain organoids, and the generation of an in vitro cellular drug-screening platform for schizophrenia. The research participants in these studies come from the genetically isolated Amish and Mennonite populations.

Published
2021

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