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Purpose: Despite all the progress with genetic mapping and multimodal treatment, the prognosis of GBM remains poor, with median overall survival (OS) of only 12 to 15 months. Several studies showed correlations between clinical features and prognosis, however the same don`t occurs with radiological features. The purpose of this study is to determine possible correlations between the volumetric analysis of glioblastoma compartments and the proliferation index represented by Ki-67. Methods: We performed a retrospective analysis of MRI studies of 70 patients with glioblastoma multiforme acquired up to one week before surgery. The tumor compartments were divided in enhancing zone; edema zone and tumor total zone. Each compartment was submitted to volumetric analysis using Horos Project software. Linear regression model was used to assess correlations between ki-67 index and volume of each compartment with p value of 0,05. Results: Male/female ratio in our study was 1.7:1, at a mean age of 60.7 ± 14.6 years. Tumor predominant location was the temporal lobe with 25% of cases and cystic morphology was present in 17%. The median of Ki-67 was 40%. The average tumor compartment volume was 40.8 cm3 for contrast-enhancing zone, 62.7 cm3 for edema zone and 103.5 cm3 for total tumor volume. A significant association between Ki-67 index and edema zone volume (p=0.02). Conclusion: Volumetric analysis of the edema zone in ​​patients with MRI scans suggestive of glioblastoma could offer the possibility of predicting tumor aggressiveness through correlation with Ki-67 index.