978 results on '"Nam H"'
Search Results
2. Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population
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Heejin Jin, Soo Heon Kwak, Ji Won Yoon, Sanghun Lee, Kyong Soo Park, Sungho Won, and Nam H. Cho
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Endocrinology, Diabetes and Metabolism - Abstract
Background: Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date. However, genetic risk factors for the longitudinal deterioration of FPG have not been thoroughly evaluated. We aimed to identify genetic variants associated with longitudinal change of FPG over time.Methods: We used two prospective cohorts in Korean population, which included a total of 10,528 individuals without T2DM. GWAS of repeated measure of FPG using linear mixed model was performed to investigate the interaction of genetic variants and time, and meta-analysis was conducted. Genome-wide complex trait analysis was used for heritability calculation. In addition, expression quantitative trait loci (eQTL) analysis was performed using the Genotype-Tissue Expression project.Results: A small portion (4%) of the genome-wide single nucleotide polymorphism (SNP) interaction with time explained the total phenotypic variance of longitudinal change in FPG. A total of four known genetic variants of FPG were associated with repeated measure of FPG levels. One SNP (rs11187850) showed a genome-wide significant association for genetic interaction with time. The variant is an eQTL for NOC3 like DNA replication regulator (NOC3L) gene in pancreas and adipose tissue. Furthermore, NOC3L is also differentially expressed in pancreatic β-cells between subjects with or without T2DM. However, this variant was not associated with increased risk of T2DM nor elevated FPG level.Conclusion: We identified rs11187850, which is an eQTL of NOC3L, to be associated with longitudinal change of FPG in Korean population.
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- 2023
3. Abstract OT2-12-01: Clinical Application of LFSPRO: A Prospective Study
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Jacynda Woodman-Ross, Elissa Dodd-Eaton, Jessica Corredor, Sierra O. Green, Nam H. Nguyen, Nathaniel Hernandez, Courtney D. DiNardo, Wenyi Wang, and Banu K. Arun
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Cancer Research ,Oncology - Abstract
Background: Individuals with Li-Fraumeni Syndrome (LFS) have increased risk of developing cancers of several types, such as early-onset breast cancer, soft-tissue/bone sarcoma, leukemia, brain tumors, and more, throughout their lifetime. LFS is primarily caused by autosomal dominant germline mutations in the TP53 tumor suppressor gene. It is difficult to identify TP53 mutation carriers because of the overlap in the occurrence of multiple cancer types in LFS with other inherited cancer syndromes. In order to improve the accuracy of risk assessment for these families, the LFSPRO risk model was created to predict the likelihood of a proband having LFS based off detailed patient and family history information, as well as predict cancer-specific risks for patients who have already been identified as having LFS. Specific Aims: The primary aim of this study is to evaluate the concordance of LFSPRO and clinical criteria in predicting TP53 mutation status in patients undergoing germline TP53 testing. Trial Design: After receiving standard genetic counseling, patients identified as concerning for a potential TP53 mutation by a MD Anderson genetic counselor (GC) are run through LFSPRO. LFSPRO TP53 mutation carrier risk, whether the patient meets Chompret and/or Classic criteria, decision to test, and genetic test results are collected. Select GCs are then asked to complete a survey regarding their experience with LFSPRO. Eligibility Criteria: Through standard genetic counseling practice, MD Anderson GCs identify patients with a clinical suspicion for a TP53 germline mutation. All patients identified are run through LFSPRO. Out of these identified patients, select GCs that participated in the initial genetic counseling session are asked to complete a survey over their experience using the LFSPRO. Statistical methods: We will evaluate the concordance in the prediction of TP53 mutation carrier status between LFSPRO and current clinical criteria as compared to the outcome of genetic testing results. We will cross-tabulate the predicted TP53-mutation status (positive vs. negative) with the carrier status in a 2 × 2 table and calculate the sensitivity and specificity of each prediction tool separately (LFSPRO, clinical criteria), with 95% confidence interval. Accrual: Currently, 72 patients have been run through LFSPRO. Select GCs have completed the survey regarding their experience with LFSPRO on 20 of these patients. Data collection began in December 2021 and is currently ongoing. Funding: This research is supported by the Cancer Research and Prevention Institute of Texas. Contact: Jacynda Woodman-Ross, MS, CGC, The University of Texas MD Anderson Cancer Center, jawoodman@mdanderson.org Citation Format: Jacynda Woodman-Ross, Elissa Dodd-Eaton, Jessica Corredor, Sierra O. Green, Nam H. Nguyen, Nathaniel Hernandez, Courtney D. DiNardo, Wenyi Wang, Banu K. Arun. Clinical Application of LFSPRO: A Prospective Study [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr OT2-12-01.
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- 2023
4. Influence of spherical triggers on axial collapse of tapered tubes
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Na Qiu, Depei Wang, Yajie Li, Mingwei Xiao, Qiang Gao, and Nam H. Kim
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Mechanical Engineering ,Transportation ,Industrial and Manufacturing Engineering - Published
- 2023
5. Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease
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Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao, Norihiro Harada, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Taketo Yamada, Chikao Morimoto, and Kei Ohnuma
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Transplantation ,Hematopoietic Stem Cell Transplantation ,Graft vs Host Disease ,Mice, Transgenic ,CD8-Positive T-Lymphocytes ,Antibodies, Monoclonal, Humanized ,Mice, Inbred C57BL ,Mice ,Humans ,Animals ,Cytokines ,Immunology and Allergy ,Pharmacology (medical) ,Bone Marrow Transplantation - Abstract
IL-26 is a Th17 cytokine, with its gene being absent in rodents. To characterize the in vivo immunological effects of IL-26 in chronic systemic inflammation, we used human IL26 transgenic (hIL-26Tg) mice and human umbilical cord blood mononuclear cells (hCBMC) in mouse allogeneic-graft-versus-host disease (GVHD) and chronic xenogeneic-GVHD model, respectively. Transfer of bone marrow and spleen T cells from hIL-26Tg mice into B10.BR mice resulted in GVHD progression, with clinical signs of tissue damage in multiple organs. IL-26 markedly increased neutrophil levels both in the GVHD-target tissues and peripheral blood. Expression levels of Th17 cytokines in hIL-26Tg mice-derived donor CD4 T cells were significantly increased, whereas IL-26 did not affect cytotoxic function of donor CD8 T cells. In addition, granulocyte-colony stimulating factor, IL-1β, and IL-6 levels were particularly enhanced in hIL-26Tg mice. We also developed a humanized neutralizing anti-IL-26 monoclonal antibody (mAb) for therapeutic use, and its administration after onset of chronic xenogeneic-GVHD mitigated weight loss and prolonged survival, with preservation of graft-versus-leukemia effect. Taken together, our data elucidate the in vivo immunological effects of IL-26 in chronic GVHD models and suggest that a humanized anti-IL-26 mAb may be a potential therapeutic agent for the treatment of chronic GVHD.
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- 2022
6. Uncertainty quantification in elastic constants of SiCf/SiCm tubular composites using global sensitivity analysis
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Hemanth Thandaga Nagaraju, James Nance, Nam H Kim, Bhavani Sankar, and Ghatu Subhash
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Mechanics of Materials ,Mechanical Engineering ,Materials Chemistry ,Ceramics and Composites - Abstract
Silicon carbide fiber and silicon carbide matrix (SiCf/SiCm) tubes produced through the chemical vapor infiltration process have become a candidate cladding material in nuclear applications. The performance of this composite is influenced by many variables such as braiding angle, porosity, material properties, etc., which vary over a range of values due to the inherent fluctuations in the manufacturing process. In this study, the variability in elastic constants of SiCf/SiCm composite has been quantified through multiscale finite element (FE) simulations, variable screening, and high-fidelity surrogate modeling. The key variables dominantly affecting the elastic constants of SiCf/SiCm tubes were identified using global sensitivity analysis. A surrogate to the high-fidelity FE-based model was used in Monte Carlo simulations to generate a hundred thousand samples from which the uncertainty in elastic constants was assessed. It turned out that the coefficient of variation was less than 10%.
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- 2022
7. Negative Pressure Pulmonary Edema due to Upper Airway Obstruction in Two Dogs
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Choi, D, Yang, MP, Kang, BT, Choi, M, Nam, H, Chae, Y, Koo, Y, Yun, T, Lee, D, and Kim, H
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postobstructive pulmonary edema ,respiratory distress ,tracheal collapse ,canine - Abstract
Two dogs were referred because of chronic cough and respiratory distress. One dog (Case 1) showed severe respiratory distress and mild interstitial patterns on the thoracic radiographs after external ring prostheses were placed to support a collapsing cervical trachea. The dog had received 1 mg/kg of furosemide three times daily for 2 days to treat pulmonary edema. Although appropriate treatment was provided to resolve pulmonary edema, persistent pulmonary edema and respiratory distress had been shown. There was no evidence of cardiogenic pulmonary edema based on the physical, radiographic, and echocardiographic examinations. The other dog (Case 2) was diagnosed with tracheal collapse and bronchomalacia. In addition, mild interstitial patterns were detected on the thoracic radiographs. There was no evidence of cardiac disease based on the physical and radiographic examinations. Because these findings were suspected to indicate negative pressure pulmonary edema due to airway obstruction, Case 1 was immediately given dexamethasone for 2 days to relieve postoperative swelling. Case 2 received 0.05 mg/kg of acepromazine for sedation and endotracheal intubation with positive-pressure ventilation for 2 days. All abnormal signs, including pulmonary edema, disappeared in Case 1, but Case 2 was discharged with a mild cough. This report describes the clinical course of negative pressure pulmonary edema due to airway obstruction in two dogs. Clinicians should be aware that airway obstruction can cause fulminant non-cardiogenic pulmonary edema in dogs.
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- 2023
8. Transfer Learning for Wireless Networks: A Comprehensive Survey
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Cong T. Nguyen, Nguyen Van Huynh, Nam H. Chu, Yuris Mulya Saputra, Dinh Thai Hoang, Diep N. Nguyen, Quoc-Viet Pham, Dusit Niyato, Eryk Dutkiewicz, Won-Joo Hwang, and School of Computer Science and Engineering
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0801 Artificial Intelligence and Image Processing, 0903 Biomedical Engineering, 0906 Electrical and Electronic Engineering ,Computer science and engineering [Engineering] ,Caching ,Electrical and Electronic Engineering ,Cognitive Radios - Abstract
With outstanding features, machine learning (ML) has become the backbone of numerous applications in wireless networks. However, the conventional ML approaches face many challenges in practical implementation, such as the lack of labeled data, the constantly changing wireless environments, the long training process, and the limited capacity of wireless devices. These challenges, if not addressed, can impede the effectiveness and applicability of ML in wireless networks. To address these problems, transfer learning (TL) has recently emerged to be a promising solution. The core idea of TL is to leverage and synthesize distilled knowledge from similar tasks and valuable experiences accumulated from the past to facilitate the learning of new problems. By doing so, TL techniques can reduce the dependence on labeled data, improve the learning speed, and enhance the ML methods' robustness to different wireless environments. This article aims to provide a comprehensive survey on the applications of TL in wireless networks. Particularly, we first provide an overview of TL, including formal definitions, classification, and various types of TL techniques. We then discuss diverse TL approaches proposed to address emerging issues in wireless networks. The issues include spectrum management, signal recognition, security, caching, localization, and human activity recognition, which are all important to next-generation networks, such as 5G and beyond. Finally, we highlight important challenges, open issues, and future research directions of TL in future wireless networks. Ministry of Education (MOE) National Research Foundation (NRF) This work was supported in part by the Australian Government through the Australian Research Council's Discovery Projects Funding Scheme under Project DE210100651 (by Dr. Hoang Dinh); in part by the Joint Technology and Innovation Research Centre-a partnership between the University of Technology Sydney and the VNU Ho Chi Minh City University of Technology (VNU HCMUT); in part by the Programme DesCartes-the National Research Foundation, Prime Minister's Office, Singapore, through its Campus for Research Excellence and Technological Enterprise (CREATE) Programme and its Emerging Areas Research Projects (EARP) Funding Initiative; in part by the Alibaba Group through the Alibaba Innovative Research (AIR) Program and the Alibaba-NTU Singapore Joint Research Institute (JRI); in part by the National Research Foundation, Singapore, through the AI Singapore Programme (AISG) under Grant AISG2-RP-2020-019; and in part by the Singapore Ministry of Education (MOE) Tier 1 under Grant RG16/20. The work of Cong T. Nguyen was supported in part by Vingroup JSC and in part by the Master, PhD Scholarship Programme of the Vingroup Innovation Foundation (VINIF), Institute of Big Data, Code 2021.TS.006. The work of Quoc-Viet Pham and Won-Joo Hwang was supported in part by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIT) under Grant NRF-2019R1C1C1006143 and Grant NRF-2019R1I1A3A01060518, in part by the Institute of Information and Communications Technology Planning and Evaluation (IITP) Grant funded by the Korea Government (MSIT) under Grant 2020-0-01450 [Artificial Intelligence Convergence Research Center (Pusan National University)], and in part by the BK21 Four, Korean Southeast Center for the 4th Industrial Revolution Leader Education.
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- 2022
9. Stochastic models of stem cells and their descendants under different criticality assumptions
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Nam H. Nguyen and Marek Kimmel
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FOS: Computer and information sciences ,Statistics and Probability ,Applied Mathematics ,Modeling and Simulation ,Probability (math.PR) ,FOS: Mathematics ,Mathematics - Statistics Theory ,Statistics Theory (math.ST) ,Statistics - Computation ,Mathematics - Probability ,Computation (stat.CO) - Abstract
We study time continuous branching processes with exponentially distributed lifetimes, with two types of cells that proliferate according to binary fission. A range of possible system dynamics are considered, each of which is characterized by the mutation rate of the original cells and the survival probability of the altered cells' progeny. For each system, we derive a closed-form expression for the joint probability generating function of cell counts, and perform asymptotic analysis on the behaviors of the cell population with particular focus on probability of extinction. Part of our results confirms known properties of branching processes using a different approach while other are original. While the model is best suited for modeling the fate of differentiating stem cells, we discuss other scenarios in which these system dynamics may be applicable in real life. We also discuss the history of the subject., Comment: 23 pages including abstract, references, and supplement
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- 2022
10. Enhancing Covid-19 virus spread modeling using an activity travel model
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Tri K. Nguyen, Nam H. Hoang, Graham Currie, and Hai L. Vu
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Business, Management and Accounting (miscellaneous) ,Aerospace Engineering ,Transportation ,Management Science and Operations Research ,Civil and Structural Engineering - Abstract
Coronavirus 2019 (COVID-19) and its variants are still spreading rapidly with deadly consequences and profound impacts on the global health and world economy. Without a suitable vaccine, mobility restriction has been the most effective method so far to prevent its spreading and avoid overwhelming the heath system of the affected country. The compartmental model SIR (or Susceptible, Infected, and Recovered) is the most popular mathematical model used to predict the course of the COVID-19 pandemic in order to plan the control actions and mobility restrictions against its spreading. A major limitation of this model in relation to modeling the spreading of COVID-19, and the mobility limitation strategy, is that the SIR model does not include mobility or take into account changes in mobility within its structure. This paper develops and tests a new hybrid SIR model; SIR-M which is integrated with an urban activity travel model to explore how it might improve the prediction of pandemic course and the testing of mobility limitation strategies in managing virus spread. The paper describes the enhanced methodology and tests a range of mobility limitation strategies on virus spread outcomes. Implications for policy and research futures are suggested.
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- 2022
11. Timescales of Chaos in the Inner Solar System: Lyapunov Spectrum and Quasi-integrals of Motion
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Federico Mogavero, Nam H. Hoang, and Jacques Laskar
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Earth and Planetary Astrophysics (astro-ph.EP) ,General Physics and Astronomy ,Classical Physics (physics.class-ph) ,FOS: Physical sciences ,Physics - Classical Physics ,Chaotic Dynamics (nlin.CD) ,Computational Physics (physics.comp-ph) ,Nonlinear Sciences - Chaotic Dynamics ,Physics - Computational Physics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Numerical integrations of the Solar System reveal a remarkable stability of the orbits of the inner planets over billions of years, in spite of their chaotic variations characterized by a Lyapunov time of only 5 million years and the lack of integrals of motion able to constrain their dynamics. To open a window on such long-term behavior, we compute the entire Lyapunov spectrum of a forced secular model of the inner planets. We uncover a hierarchy of characteristic exponents that spans two orders of magnitude, manifesting a slow-fast dynamics with a broad separation of timescales. A systematic analysis of the Fourier harmonics of the Hamiltonian, based on computer algebra, reveals three symmetries that characterize the strongest resonances responsible for the orbital chaos. These symmetries are broken only by weak resonances, leading to the existence of quasi-integrals of motion that are shown to relate to the smallest Lyapunov exponents. A principal component analysis of the orbital solutions independently confirms that the quasi-integrals are among the slowest degrees of freedom of the dynamics. Strong evidence emerges that they effectively constrain the chaotic diffusion of the orbits, playing a crucial role in the statistical stability over the Solar System lifetime., 24 pages, 11 figures. Published in Physical Review X
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- 2023
12. DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies
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Shohei Kikuchi, Akinori Wada, Yusuke Kamihara, Kosuke Okazaki, Paras Jawaid, Mati Ur Rehman, Eiji Kobayashi, Takeshi Susukida, Tomoki Minemura, Yoshimi Nabe, Noriaki Iwao, Tatsuhiko Ozawa, Ryo Hatano, Mitsugu Yamada, Hiroyuki Kishi, Yuji Matsuya, Mineyuki Mizuguchi, Yoshihiro Hayakawa, Nam H. Dang, Yasumitsu Sakamoto, Chikao Morimoto, and Tsutomu Sato
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DPP8 ,inhibitor ,anticancer agent ,hematological ,malignancies ,General Medicine - Abstract
DPP8/9 inhibition induces either pyroptotic or apoptotic cell death in hematological malignancies. We previously reported that treatment with the DPP8/9 inhibitor 1G244 resulted in apoptotic cell death in myeloma, and our current study further evaluates the mechanism of action of 1G244 in different blood cancer cell lines. Specifically, 1G244 inhibited DPP9 to induce GSDMD-mediated-pyroptosis at low concentrations and inhibited DPP8 to cause caspase-3-mediated-apoptosis at high concentrations. HCK expression is necessary to induce susceptibility to pyroptosis but does not participate in the induction of apoptosis. To further characterize this DPP8-dependent broad-spectrum apoptosis induction effect, we evaluated the potential antineoplastic role for an analog of 1G244 with higher DPP8 selectivity, tominostat (also known as 12 m). In vitro studies demonstrated that the cytotoxic effect of 1G244 at high concentrations was enhanced in tominostat. Meanwhile, in vivo work showed tominostat exhibited antitumor activity that was more effective on a cell line sensitive to 1G244, and at higher doses, it was also effective on a cell line resistant to 1G244. Importantly, the weight loss morbidity associated with increasing doses of 1G244 was not observed with tominostat. These results suggest the possible development of novel drugs with antineoplastic activity against selected hematological malignancies by refining and increasing the DPP8 selectivity of tominostat.
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- 2023
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13. Supplementary Figure Legends 1-3 from Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma
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Kristen N. Ganjoo, James E. Wooldridge, Brian K. Link, Mitchell R. Smith, Christopher A. Slapak, James G. Nelson, Barrett W. Allan, Susan P. Carpenter, Nam H. Dang, Damien M. Cronier, Maksim Pashkevich, Brad L. Pohlman, Sven de Vos, and Andres Forero-Torres
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PDF file - 69K
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- 2023
14. Data from CD26 Overexpression Is Associated with Prolonged Survival and Enhanced Chemosensitivity in Malignant Pleural Mesothelioma
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Chikao Morimoto, Takumi Kishimoto, Kouki Inai, Yukio Takeshima, Nam H. Dang, Taketo Yamada, Masanori Fujii, Akio Hiraki, Osamu Hosono, Kei Ohnuma, Nobukazu Fujimoto, Vishwa Jeet Amatya, and Keisuke Aoe
- Abstract
Purpose: Malignant pleural mesothelioma (MPM) is an aggressive and therapy-resistant neoplasm arising from the pleural mesothelial cells, without established indicators to predict responsiveness to chemotherapy.Experimental Design: Our study involving 79 MPM patients showed that 73.4% of MPM expressed CD26 on cell membrane.Results: The majority of epithelioid and biphasic types of MPM expressed CD26 on the cell membrane, whereas the sarcomatoid type showed a lack of CD26 surface expression. Although the sarcomatoid type was associated with poor prognosis (P < 0.0001), no significant relationship between CD26 expression and survival was observed. On the contrary, there was a trend for an association between response rate to chemotherapy and CD26 expression (P = 0.053), with a higher level of CD26 expression more likely to be linked to better response to chemotherapy. Moreover, CD26 expression was a significant factor associated with improved survival in patients who received chemotherapy [median survival time (MST), 18.6 vs. 10.7 months, P = 0.0083]. Furthermore, CD26 expression was significantly associated with better prognosis in patients receiving non–pemetrexed-containing regimens (MST, 14.2 vs. 7.4 months, P = 0.0042), whereas there was no significant association between CD26 expression and survival time for patients receiving pemetrexed-containing regimens. Our in vitro and microarray studies showed that mesothelioma cells expressing high CD26 displayed high proliferative activity, and CD26 expression was closely linked to cell-cycle regulation, apoptosis, and chemotherapy resistance.Conclusions: Our results strongly suggest that CD26 is a clinically significant biomarker for predicting response to chemotherapy for MPM. Clin Cancer Res; 18(5); 1447–56. ©2012 AACR.
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- 2023
15. Supplementary Figure 2 from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
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PDF file - 110K, Gene transfer of NEDD9 renders NSCLC cells (PC-9 cells) chemoresistant
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- 2023
16. Supplementary Figure 4 from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
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PDF file - 78K, Survival curves in the various setting of cutoff value of NEDD9 positivity
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- 2023
17. Supplementary Table 2 from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
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XLSX file, 15K, Clinical Characteristics and NEDD9 scoring of 60 NSCLC patients
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- 2023
18. Supplementary Figure 1 from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
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PDF file - 85K, Evaluation and selection of siRNA for NEDD9
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- 2023
19. Supplementary Figures 1-3 from Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma
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Kristen N. Ganjoo, James E. Wooldridge, Brian K. Link, Mitchell R. Smith, Christopher A. Slapak, James G. Nelson, Barrett W. Allan, Susan P. Carpenter, Nam H. Dang, Damien M. Cronier, Maksim Pashkevich, Brad L. Pohlman, Sven de Vos, and Andres Forero-Torres
- Abstract
PDF file - 122K
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- 2023
20. Data from Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma
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Kristen N. Ganjoo, James E. Wooldridge, Brian K. Link, Mitchell R. Smith, Christopher A. Slapak, James G. Nelson, Barrett W. Allan, Susan P. Carpenter, Nam H. Dang, Damien M. Cronier, Maksim Pashkevich, Brad L. Pohlman, Sven de Vos, and Andres Forero-Torres
- Abstract
Purpose: AME-133v is a humanized monoclonal antibody engineered to have increased affinity to CD20 and mediate antibody-dependent cell-mediated cytotoxicity (ADCC) better than rituximab. Safety, pharmacokinetics, and efficacy were assessed in a phase 1/2 trial in patients with previously treated follicular lymphoma (FL).Patients and Methods: AME-133v was characterized in vitro by ADCC and cell binding assays. A phase 1 study was conducted in which 23 previously treated patients with FL were assigned sequentially to one of five dose-escalation cohorts of AME-133v at 2, 7.5, 30, 100, or 375 mg/m2 weekly × 4 doses.Results: AME-133v showed a 13- to 20-fold greater binding affinity for CD20 and was 5- to 7-fold more potent than rituximab in ADCC assays. Cell binding assays showed AME-133v and rituximab competed for an overlapping epitope on the CD20 antigen, and AME-133v inhibited binding of biotinylated rituximab to CD20 in a concentration-dependent manner. AME-133v was well tolerated by patients and common related adverse events included chills and fatigue. One patient experienced a dose-limiting toxicity of neutropenia. AME-133v showed nonlinear pharmocokinetics with properties similar to rituximab. Selective reduction of B cells during and after AME-133v treatment was shown by flow cytometry of peripheral blood. A partial or complete response was observed in 5 of 23 (22%) patients and the median progression-free survival was 25.4 weeks.Conclusions: AME-133v was safe and well tolerated at the doses tested. AME-133v showed encouraging results as an anti-CD20 therapy in heavily pretreated FL patients with the less favorable FcγRIIIa F-carrier genotype. Clin Cancer Res; 18(5); 1395–403. ©2012 AACR.
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- 2023
21. Supplementary Figure 3 from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
- Abstract
PDF file - 107K, Gene transfer of NEDD9 renders NSCLC cells (A549 cells) chemoresistant
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- 2023
22. Supplementary Tables 1-4 from Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma
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Kristen N. Ganjoo, James E. Wooldridge, Brian K. Link, Mitchell R. Smith, Christopher A. Slapak, James G. Nelson, Barrett W. Allan, Susan P. Carpenter, Nam H. Dang, Damien M. Cronier, Maksim Pashkevich, Brad L. Pohlman, Sven de Vos, and Andres Forero-Torres
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PDF file - 62K
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- 2023
23. Supplementary Figures 1-2, Tables 1-2 from CD26 Overexpression Is Associated with Prolonged Survival and Enhanced Chemosensitivity in Malignant Pleural Mesothelioma
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Chikao Morimoto, Takumi Kishimoto, Kouki Inai, Yukio Takeshima, Nam H. Dang, Taketo Yamada, Masanori Fujii, Akio Hiraki, Osamu Hosono, Kei Ohnuma, Nobukazu Fujimoto, Vishwa Jeet Amatya, and Keisuke Aoe
- Abstract
PDF file - 171K
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- 2023
24. Data from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
- Abstract
Purpose: In a substantial population of non–small cell lung cancer (NSCLC), expression and activation of EGF receptor (EGFR) have been reported and is regarded as a novel molecular target. A growing body of evidence has shown the signaling crosstalk between EGFR and integrins in cellular migration and invasion. NEDD9 is an integrin signaling adaptor protein composed of multiple domains serving as substrate for a variety of tyrosine kinases. In the present study, we aimed at elucidating a role of NEDD9 in the signaling crosstalk between EGFR and integrins.Experimental Design: Using NSCLC cell lines, we conducted immunoblotting and cellular migration/invasion assay in vitro. Next, we analyzed metastasis assays in vivo by the use of xenograft transplantation model. Finally, we retrospectively evaluated clinical samples and records of patients with NSCLCs.Results: We showed that tyrosine phosphorylation of NEDD9 was reduced by the inhibition of EGFR in NSCLC cell lines. Overexpression of constitutively active EGFR caused tyrosine phosphorylation of NEDD9 in the absence of integrin stimulation. By gene transfer and gene knockdown, we showed that NEDD9 plays a pivotal role in cell migration and invasion of those cells in vitro. Furthermore, overexpression of NEDD9 promoted lung metastasis of an NSCLC cell line in NOD/Shi-scid, IL-2Rγnull mice (NOG) mice. Finally, univariate and multivariate Cox model analysis of NSCLC clinical specimens revealed a strong correlation between NEDD9 expression and recurrence-free survival as well as overall survival.Conclusion: Our data thus suggest that NEDD9 is a promising biomarker for the prognosis of NSCLCs and its expression can promote NSCLC metastasis. Clin Cancer Res; 18(22); 6326–38. ©2012 AACR.
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- 2023
25. Supplementary Table 1 from Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
- Author
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Chikao Morimoto, Nam H. Dang, Kazunori Kamiya, Michiie Sakamoto, Yuichiro Hayashi, Hirotoshi Tanaka, Hiroshi Kawasaki, Osamu Hosono, Hiroto Yamazaki, Akiko Souta-Kuribara, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Yusuke Inoue, Taketo Yamada, Satoshi Iwata, and Shunsuke Kondo
- Abstract
XLS file, 27K, Clinical characteristics of evaluated NSCLC patients and classification according to NEDD9 expression in the primary tumors
- Published
- 2023
26. Data from Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition
- Author
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Long H. Dang, Nam H. Dang, Brad St. Croix, William D. Ensminger, Douglas W. Blayney, Marcia Cruz-Correa, Nicholas J. Vogelzang, Elisabeth I. Heath, Nicola J. Mabjeesh, Pamela Havre, Shaowei Chen, Masako Abe, Kyunghee Burkitt, Sang Y. Chun, and Duyen T. Dang
- Abstract
Antiangiogenic therapy improves survival in patients with advanced stage cancers. Currently, there are no reliable predictors or markers for tumor vessel response to antiangiogenic therapy. To model effective antiangiogenic therapy, we disrupted the VEGF gene in three representative cancer cell lines. HCT116 xenografts had low proportions of endothelial tubes covered by pericytes that stained with α-smooth muscle actin (SMA) antibody. Upon disruption of VEGF, HCT116VEGF−/− xenografts had significantly decreased tumor microvessel perfusion compared with their parental counterparts. Furthermore, HCT116VEGF−/− xenografts mounted a tumor-reactive response to hypoxia, characterized by the induction of hypoxia-inducible factor-1 (HIF-1) target genes. One highly induced protein was DPP4, a measurable serum protein that has well-described roles in cancer progression. In contrast, LS174T and MKN45 tumor xenografts had high proportion of endothelial tubes that were covered by SMA+ pericytes. Upon disruption of VEGF, LS174TVEGF−/− and MKN45VEGF−/− xenografts maintained tumor microvessel perfusion. As such, there were no changes in intratumoral hypoxia or HIF-1α induction. Together, these data show that the extent of tumor vessel response to angiogenic inhibition could be correlated with (a) the preexisting coverage of tumor endothelial tubes with SMA+ pericytes and (b) differential tumor induction of HIF-1 target genes. The data further show that DPP4 is a novel marker of HIF-1 induction. Altogether, these preclinical findings suggest novel clinical trials for predicting and monitoring tumor vessel responses to antiangiogenic therapy. [Cancer Res 2008;68(6):1872–80]
- Published
- 2023
27. Supplementary Figure 1 from Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition
- Author
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Long H. Dang, Nam H. Dang, Brad St. Croix, William D. Ensminger, Douglas W. Blayney, Marcia Cruz-Correa, Nicholas J. Vogelzang, Elisabeth I. Heath, Nicola J. Mabjeesh, Pamela Havre, Shaowei Chen, Masako Abe, Kyunghee Burkitt, Sang Y. Chun, and Duyen T. Dang
- Abstract
Supplementary Figure 1 from Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition
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- 2023
28. Well-Rounded ideal lattices of cyclic cubic and quartic fields
- Author
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Tran, Dat T., Le, Nam H., and Tran, Ha T. N.
- Subjects
Mathematics - Number Theory ,FOS: Mathematics ,Number Theory (math.NT) ,11R16, 06B10, 06B99, 11Y40 - Abstract
In this paper, we find criteria for when cyclic cubic and cyclic quartic fields have well-rounded ideal lattices. We show that every cyclic cubic field has at least one well-rounded ideal. We also prove that there exist families of cyclic quartic fields which have well-rounded ideals and explicitly construct their minimal bases. In addition, for a given prime number $p$, if a cyclic quartic field has a unique prime ideal above $p$, then we provide the necessary and sufficient conditions for that ideal to be well-rounded. Moreover, in cyclic quartic fields, we provide the prime decomposition of all odd prime numbers and construct an explicit integral basis for every prime ideal., 26 pages
- Published
- 2023
29. Defeating Eavesdroppers with Ambient Backscatter Communications
- Author
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Van Huynh, Nguyen, Hieu, Nguyen Quang, Chu, Nam H., Nguyen, Diep N., Hoang, Dinh Thai, and Dutkiewicz, Eryk
- Subjects
Signal Processing (eess.SP) ,FOS: Computer and information sciences ,Computer Science - Information Theory ,Information Theory (cs.IT) ,FOS: Electrical engineering, electronic engineering, information engineering ,Data_CODINGANDINFORMATIONTHEORY ,Electrical Engineering and Systems Science - Signal Processing ,Computer Science::Information Theory ,Computer Science::Cryptography and Security - Abstract
Unlike conventional anti-eavesdropping methods that always require additional energy or computing resources (e.g., in friendly jamming and cryptography-based solutions), this work proposes a novel anti-eavesdropping solution that comes with mostly no extra power nor computing resource requirement. This is achieved by leveraging the ambient backscatter communications in which secret information can be transmitted by backscattering it over ambient radio signals. Specifically, the original message at the transmitter is first encoded into two parts: (i) active transmit message and (ii) backscatter message. The active transmit message is then transmitted by using the conventional wireless transmission method while the backscatter message is transmitted by backscattering it on the active transmit signals via an ambient backscatter tag. As the backscatter tag does not generate any active RF signals, it is intractable for the eavesdropper to detect the backscatter message. Therefore, secret information, e.g., secret key for decryption, can be carried by the backscattered message, making the adversary unable to decode the original message. Simulation results demonstrate that our proposed solution can significantly enhance security protection for communication systems.
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- 2023
30. Personalized Risk Prediction for Cancer Survivors: A Bayesian Semi-parametric Recurrent Event Model with Competing Outcomes
- Author
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Nam H Nguyen, Seung Jun Shin, Elissa B Dodd-Eaton, Jing Ning, and Wenyi Wang
- Abstract
Multiple primary cancers are increasingly more frequent due to improved survival of cancer patients. Characteristics of the first primary cancer largely impact the risk of developing subsequent primary cancers. Hence, model-based risk characterization of cancer survivors that captures patient-specific variables is needed for healthcare policy making. We propose a Bayesian semi-parametric framework, where the occurrence processes of the competing cancer types follow independent non-homogeneous Poisson processes and adjust for covariates including the type and age at diagnosis of the first primary. Applying this framework to a historically collected cohort with families presenting a highly enriched history of multiple primary tumors and diverse cancer types, we have derived a suite of age-to-onset penetrance curves for cancer survivors. This includes penetrance estimates for second primary lung cancer, potentially impactful to ongoing cancer screening decisions. Using Receiver Operating Characteristic (ROC) curves, we have validated the good predictive performance of our models in predicting second primary lung cancer, sarcoma, breast cancer, and all other cancers combined, with areas under the curves (AUCs) at 0.89, 0.91, 0.76 and 0.68, respectively. In conclusion, our framework provides covariate-adjusted quantitative risk assessment for cancer survivors, hence moving a step closer to personalized health management for this unique population.
- Published
- 2023
31. Metabolic Dysfunction-Associated Fatty Liver Disease Predicts Long-term Mortality and Cardiovascular Disease
- Author
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Bo Kyung Koo, Nam H. Cho, Joon Ho Moon, and Won Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Overweight ,Gastroenterology ,Cohort Studies ,Non-alcoholic Fatty Liver Disease ,Internal medicine ,Nonalcoholic fatty liver disease ,medicine ,Humans ,Prospective Studies ,Aged ,Hepatology ,business.industry ,Fatty liver ,Hazard ratio ,Type 2 Diabetes Mellitus ,Middle Aged ,medicine.disease ,Obesity ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,medicine.symptom ,business ,Body mass index ,Cohort study - Abstract
Background/aims We investigated the effect of metabolic dysfunction-associated fatty liver disease (MAFLD) on future mortality and cardiovascular disease (CVD) using a prospective community-based cohort study. Methods Individuals from two community-based cohorts who were 40 to 70 years old were prospectively followed for 16 years. MAFLD was defined as a high fatty liver index (FLI ≥60) plus one of the following conditions: overweight/obesity (body mass index ≥23 kg/m2), type 2 diabetes mellitus, or ≥2 metabolic risk abnormalities. Nonalcoholic fatty liver disease (NAFLD) was defined as FLI ≥60 without any secondary cause of hepatic steatosis. Results Among 8,919 subjects (age 52.2±8.9 years, 47.7% of males), 1,509 (16.9%) had MAFLD. During the median follow-up of 15.7 years, MAFLD independently predicted overall mortality after adjustment for confounders (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.05 to 1.69) but NAFLD did not (HR, 1.20; 95% CI, 0.94 to 1.53). MAFLD also predicted CVD after adjustment for age, sex, and body mass index (HR, 1.35; 95% CI, 1.13 to 1.62), which lost its statistical significance by further adjustments. Stratified analysis indicated that metabolic dysfunction contributed to mortality (HR, 1.51; 95% CI, 1.21 to 1.89) and CVD (HR, 1.27; 95% CI, 1.02 to 1.59). Among metabolic dysfunctions used for defining MAFLD, type 2 diabetes mellitus in MAFLD increased the risk of both mortality (HR, 2.07; 95% CI, 1.52 to 2.81) and CVD (HR, 1.42; 95% CI, 1.09 to 1.85). Conclusions MAFLD independently increased overall mortality. Heterogeneity in mortality and CVD risk of subjects with MAFLD may be determined by the accompanying metabolic dysfunctions.
- Published
- 2022
32. Political Corruption and Corporate Risk-Taking
- Author
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Hinh Khieu, Nam H. Nguyen, Hieu V. Phan, and Jon A. Fulkerson
- Subjects
Economics and Econometrics ,Arts and Humanities (miscellaneous) ,Business and International Management ,Law ,General Business, Management and Accounting - Published
- 2022
33. Long-term instability of the inner Solar system: numerical experiments
- Author
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Nam H Hoang, Federico Mogavero, Jacques Laskar, Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and ANR-19-CE31-0002,AstroMeso,Solution astronomique pour le Mésozoïque(2019)
- Subjects
Earth and Planetary Astrophysics (astro-ph.EP) ,methods: statistical ,planets and satellites: dynamical evolution and stability ,chaos ,Classical Physics (physics.class-ph) ,FOS: Physical sciences ,Astronomy and Astrophysics ,celestial mechanics ,Physics - Classical Physics ,Computational Physics (physics.comp-ph) ,Nonlinear Sciences - Chaotic Dynamics ,methods: numerical ,instabilities ,[SDU]Sciences of the Universe [physics] ,Space and Planetary Science ,Astrophysics::Earth and Planetary Astrophysics ,Chaotic Dynamics (nlin.CD) ,Physics - Computational Physics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Apart from being chaotic, the inner planets in the Solar System constitute an open system, as they are forced by the regular long-term motion of the outer ones. No integrals of motion can bound a priori the stochastic wanderings in their high-dimensional phase space. Still, the probability of a dynamical instability is remarkably low over the next 5 billion years, a timescale thousand times longer than the Lyapunov time. The dynamical half-life of Mercury has indeed been estimated recently at 40 billion years. By means of the computer algebra system TRIP, we consider a set of dynamical models resulting from truncation of the forced secular dynamics recently proposed for the inner planets at different degrees in eccentricities and inclinations. Through ensembles of $10^3$ to $10^5$ numerical integrations spanning 5 to 100 Gyr, we find that the Hamiltonian truncated at degree 4 practically does not allow any instability over 5 Gyr. The destabilisation is mainly due to terms of degree 6. This surprising result suggests an analogy to the Fermi-Pasta-Ulam-Tsingou problem, in which tangency to Toda Hamiltonian explains the very long timescale of thermalisation, which Fermi unsuccessfully looked for., Accepted for publication in MNRAS. 9 pages, 7 figures
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- 2022
34. Shareholder Litigation and Corporate Social Responsibility
- Author
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Steven Freund, Nam H. Nguyen, and Hieu V. Phan
- Subjects
Economics and Econometrics ,Accounting ,Finance - Abstract
This research examines the relation between shareholder litigation and corporate social responsibility (CSR). Exploiting exogenous changes in shareholder litigation rights following the staggered adoption of universal demand laws by U.S. states and the Ninth Circuit Court of Appeals’ ruling on securities class action lawsuits, we show that weaker shareholder litigation rights lead to lower CSR scores. Moreover, the relation is stronger for firms facing higher litigation risk, and a decreased CSR score enhances firm value. Our evidence suggests that firms engage in CSR activities partly to reduce shareholder litigation risk ex ante and mitigate its consequences ex post.
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- 2022
35. Volumetric Mix Design Adjustments for Improving Asphalt Mixture Durability
- Author
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Nam H. Tran, Fan Yin, Fabricio Leiva, Carolina Rodezno, Gerald Huber, and William Pine
- Subjects
Mechanical Engineering ,Civil and Structural Engineering - Abstract
State highway agencies (SHAs) are looking for guidance on how they can make changes to their Superpave volumetric mix design procedures to obtain higher design binder contents to improve the cracking resistance and durability of asphalt mixtures. To assist SHAs, this paper was prepared to: (a) synthesize most common adjustments made by SHAs to their Superpave volumetric mix design procedures to obtain higher design binder contents; and (b) verify the effectiveness of these adjustments through laboratory experiments. Based on a survey of SHAs, the three most common adjustments to the Superpave mix design system to obtain higher design binder contents include: lowered design gyrations (Ndesign), increased minimum requirements for voids in mineral aggregate (VMA), and lowered design air voids (including air voids regression). These adjustments were verified in a laboratory testing program which included a virgin fine-graded mixture and a 20% reclaimed asphalt pavement (RAP) coarse-graded mixture. The results suggest that lowering Ndesign may help increase the design binder content initially but mix designers can select design gradations to reduce VMA and binder content back to levels achieved with the higher Ndesign levels. The other common adjustments (i.e., increased minimum VMA and lowered design air voids) can yield higher design binder contents. However, these approaches may be ineffective if Gsb is not accurately measured during mix design or if VMA is not controlled during mix production.
- Published
- 2022
36. Adaptive control for manipulators with model uncertainty and input disturbance
- Author
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Phuoc D. Nguyen, Nam H. Nguyen, and Ha T. Nguyen
- Subjects
Control and Optimization ,Control and Systems Engineering ,Mechanical Engineering ,Modeling and Simulation ,Electrical and Electronic Engineering ,Civil and Structural Engineering - Published
- 2023
37. Multidrug resistance plasmids underlie clonal expansions and international spread ofSalmonella entericaserotype 4,[5],12,i:- ST34 in Southeast Asia
- Author
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Hao Chung The, Phuong Pham, Ha Thanh Tuyen, Linh Vo Kim Phuong, Nguyen Phuong Yen, Son-Nam H Le, Duong Vu Thuy, Tran Thi Hong Chau, Hoang Le Phuc, Nguyen Minh Ngoc, Lu Lan Vi, Alison E. Mather, Guy E. Thwaites, Nicholas R. Thomson, Stephen Baker, and Duy Thanh Pham
- Abstract
Salmonella entericaserotype 4,[5],12,i:- (Typhimurium monophasic variant) of sequence type (ST) 34 has emerged as the predominant pandemic genotype in recent decades. Despite increasing reports of resistance to antimicrobials in Southeast Asia,SalmonellaST34 population structure and evolution remained understudied in the region. Here we performed detailed genomic investigations on 454 ST34 genomes collected from Vietnam and diverse geographical sources to elucidate the pathogen’s epidemiology, evolution and antimicrobial resistance. We showed that ST34 has been introduced into Vietnam in at least nine occasions since 2000, forming five co-circulating major clones responsible for paediatric diarrhoea and bloodstream infection. Most expansion events were associated with acquisitions of large multidrug resistance plasmids of IncHI2 or IncA/C2. Particularly, the self-conjugative IncA/C2 pST34VN2 (co-transferringblaCTX-M-55,mcr-3.1, andqnrS1) underlies local expansion and intercontinental spread in two separate ST34 clones. At the global scale, Southeast Asia was identified as a hotspot for the emergence and dissemination of multidrug resistantSalmonellaST34, and mutation analysis suggests of selection in antimicrobial responses and key virulence factors. Our work enriches the understanding on epidemiology and evolution of this variant in Southeast Asia, and determines that multidrug resistance plasmids have driven its local and potentially global success.
- Published
- 2023
38. Involvement of activation induced cytidine deaminase in malignant B-cells expressing two distinct M-components as an etiology of biclonal gammopathy
- Author
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Shohei Kikuchi, Akinori Wada, Yusuke Kamihara, Yoshimi Nabe, Tomoki Minemura, Jun Murakami, Nam H. Dang, and Tsutomu Sato
- Subjects
B-Lymphocytes ,Cytidine Deaminase ,Humans ,General Medicine ,Multiple Myeloma - Abstract
Biclonal gammopathy (BG) is a rare phenomenon in which 2 M proteins are detected in the same patient, with 2 major hypotheses regarding its etiology. One potential explanation is that completely different malignant B-cell clones produce different M proteins, while the other is that there is a malignant clone that produces both M proteins simultaneously. In this study, we examined 2 cases of B-cell malignancy with BG and found that some cells were double positive for both M proteins by immunofluorescence and flow cytometry. However, most of the remaining cells were single positive cells that produced only one of the M proteins. We hypothesized that double positive cells were in the process of transitioning from 1 single positive cell to another single positive cell, and that class switch recombination (CSR) would be involved as a mechanism. We then examined the expression of activation induced cytidine deaminase (AICDA), which is responsible for CSR, and found that lymphoma/myeloma cells in 2 BG patients were positive for AICDA by immunostaining. Our study is the first report suggesting that AICDA may be involved in the pathogenesis of BG.
- Published
- 2023
39. Hydrodynamics in a bubble column – Part 1: Two-phase flow
- Author
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Sommer, A.-E., Draw, M., Wang, L., Schmidtpeter, J., Gatter, J., Nam, H., Eckert, K., and Rzehak, R.
- Subjects
Shadowgraphy ,Particle Image Velocimetry (PIV) ,Two-phase bubble column - Abstract
Multiphase computational fluid dynamics (CFD) simulation is a useful tool to study the hydrodynamics in a bubble column, if appropriate closure models are known. Systematic assessment of different models is an ongoing venture that benefits from improved validation data. The present study accumulates a database on two-phase flow experiments in a bubble column. This is achieved by using a combination of Particle Image Velocimetry and Shadowgraphy to measure the liquid velocity field and gas dispersion properties simultaneously. This methodology is applied for different needle diameters and gas flow rates. A detailed description of the experimental The experimental data (Table 1) described in this repository is structured into different folders and files as follows: Level 1: Folders classified by measurement configuration: TX_Jg_Y_Di_ZZZ as outlined in Table 1 TX = Identifier Jg_Y = Superficial gas velocity in mm/s Di_ZZZ = Inner diameter of the needle in µm Level 2: Folders classified by measurement height:Z_XXX Z_XXX = Measurement height in mm Level 3: csv files classified by their analysis parameter: Gas_Eg_ub_over_x.csv: Each csv file consists of five columns, namely the x-coordinate (in m), the gas holdup, the uncertainty of the gas holdup, the averaged bubble rising velocity (in m/s) and the corresponding uncertainty (in m/s). Liquid_v_z_over_x.csv: Each csv file consists of three columns, namely the x-coordinate (in m), the averaged liquid velocity (in m/s) and the corresponding uncertainty (in m/s). Table 1: Overview of the measurement cases in this repository. | ID | Diameter of needle orifice in µm | Superficial gas velocity in mm/s | |----|----------------------------------|----------------------------------| | T1 | 200 | 2 | | T2 | 200 | 4 | | T3 | 200 | 6 | | T4 | 600 | 2 | | T5 | 600 | 4 | | T6 | 600 | 6
- Published
- 2023
40. StarDist Models for 'Hydrodynamics in a bubble column – Part 1: Two-phase flow'
- Author
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Sommer, A.-E., Draw, M., Wang, L., Schmidtpeter, J., Hessenkemper, H., Gatter, J., Nam, H., Eckert, K., and Rzehak, R.
- Subjects
Bubble detection ,StarDist ,Shadowgraphy - Abstract
This package contains the software and the trained models described in the publication "Hydrodynamics in a bubble column – Part 1: Two-phase flow". Please refer to the readme.md for installation instructions and to the Prediction_demo.ipynb for usage demonstration.
- Published
- 2023
41. Balanced Mix Design Benchmarking of Field-Produced Asphalt Mixtures in Maine, U.S
- Author
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Ram Kumar Veeraragavan, Derek Nener-Plante, Leslie Myers, Casey Nash, and Nam H. Tran
- Subjects
Mechanical Engineering ,Civil and Structural Engineering - Abstract
Performance testing has been recognized by state highway agencies (SHAs) in the U.S. and the asphalt paving industry as an important tool to complement volumetric properties for improving asphalt pavement performance. Thus, Maine Department of Transportation (MaineDOT) initiated a research effort in 2019 to evaluate the cracking and rutting resistance of asphalt mixtures using several performance tests, including the Hamburg wheel-tracking test (HWTT), indirect tensile cracking test (IDEAL-CT), cyclic fatigue test, and stress sweep rutting (SSR) test. These tests were conducted on reheated common plant-produced asphalt mixtures, and results were analyzed to: (1) develop baseline rutting and cracking performance; (2) evaluate the effects of mixture properties on the performance test results; and (3) verify the performance enhancement from the extended use of polymer-modified asphalt binders. Several mixture properties, such as nominal maximum aggregate size (NMAS), binder performance grade (PG), binder content (Pb), and reclaimed asphalt pavement (RAP) %, were found to have statistically significant effects on the mixture rutting and cracking resistance, especially the HWTT and IDEAL-CT results. Based on the proposed criteria for rutting strain index (RSI) and apparent damage capacity (Sapp), the asphalt mixtures tested would provide satisfactory rutting performance under heavy traffic, and satisfactory cracking performance under standard traffic. In addition, based on the IDEAL-CT benchmarking results, mixtures with polymer-modified binder and/or smaller NMAS were found to have higher cracking tolerance index (CTindex) results. The information from the research effort will help MaineDOT to achieve its goal to move beyond sole use of volumetric properties for asphalt mixture design and acceptance with the implementation of balanced mix design (BMD) for improving the field performance of asphalt pavements.
- Published
- 2021
42. Clinical characteristics and factors influencing waiting time to surgery and length of stay in elderly patients with hip fractures
- Author
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Nam H. Nguyen, Le H. Nguyen, Khoa V. Vu, Chinh D. Duong, Loi B. Cao, and Anh T. Le
- Subjects
Orthopedic surgery ,waiting time to surgery ,hip fracture ,length of hospital stay ,RD701-811 - Abstract
Introduction To investigate clinical, laboratory findings and identify pre-operative variables associated with increased waiting time to surgery (WTS) and length of hospital stay (LOS) among hip fracture patients. Material and methods This prospective study is conducted between April 2020 and April 2021. Patients’ information was collected from medical records and subjected to analysis using a univariate and multivariate model. Results The study included 118 patients in a mean age of 79.5 years, and the majority were female (68.6 %). Overall, 66.9 % of the patients had at least one comorbidity. Almost all (95.8 %) patients had fractures due to a low-impact fall and an intertrochanteric fracture was the predominant type (61.9 %). The most abnormal laboratory findings at admission were elevated C-reactive protein (CRP) levels (94.9 %) followed by decreased mineral density (85.1 %), anaemia (81.4 %), electrolyte abnormalities (69.4 %) and hypoalbuminemia (66.1 %). The mean of WTS among 115 patients undergoing surgical treatment was 52.1 ± 47 hours and no patient-related factors had a significant influence on WTS. The mean hospital LOS was 15.9 ± 4.7 days. Marked elevation of CRP level (OR = 3.317, p = 0.042), type of surgery (OR = 4.413, p = 0.005) and WTS (OR = 4.602, p = 0.001) were independent predictors of prolonged LOS. Conclusion Most patients with hip fractures are elderly and suffer from many comorbidities and laboratory abnormalities. No patient-related factors are predictors of WTS but the elevation of CRP, type of surgery and time of waiting to surgery influence the LOS.
- Published
- 2021
43. Optimal Privacy Preserving in Wireless Federated Learning System over Mobile Edge Computing
- Author
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Nguyen, Hai M., Chu, Nam H., Diep N. Nguyen, Dinh Thai Hoang, Minh Hoang Ha, and Eryk Dutkiewicz
- Published
- 2022
44. Well-Rounded Twists of Ideal Lattices from Imaginary Quadratic Fields
- Author
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Nam H. Le, Ha T. N. Tran, and Dat T. Tran
- Subjects
Algebra and Number Theory ,Mathematics - Number Theory ,Applied Mathematics ,Astrophysics::Instrumentation and Methods for Astrophysics ,Computer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing) ,11Y16, 11Y40, 11R11, 11H31 ,Theoretical physics ,Quadratic equation ,Lattice (order) ,FOS: Mathematics ,Computer Science::General Literature ,Ideal (order theory) ,Quadratic field ,Number Theory (math.NT) ,The Imaginary ,Mathematics - Abstract
In this paper, we investigate the properties of well-rounded twists of a given ideal lattice of an imaginary quadratic field $K$. We show that every ideal lattice $I$ of $K$ has at least one well-rounded twist lattice. Moreover, we provide an explicit algorithm to compute all well-rounded twists of $I$., 24 pages
- Published
- 2022
45. Evolution of physico-chemical properties of Dicranopteris linearis-derived activated carbon under various physical activation atmospheres
- Author
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Phuong Lan Tran Nguyen, Minh N. Nguyen, Nga T. Mai, Nam H. Nguyen, and Toshiki Tsubota
- Subjects
020209 energy ,Science ,02 engineering and technology ,complex mixtures ,Article ,Biomaterials ,Specific surface area ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Char ,Multidisciplinary ,Structural properties ,biology ,Chemistry ,food and beverages ,021001 nanoscience & nanotechnology ,biology.organism_classification ,Materials science ,Chemical engineering ,Dicranopteris linearis ,Medicine ,0210 nano-technology ,Mesoporous material ,Pyrolysis ,Activated carbon ,medicine.drug - Abstract
This work emphasizes the effect of the physical activation using CO2 and steam agents on the physicochemical properties of activated carbon produced from Dicranopteris linearis (D. linearis), a fern species widely distributed across tropic and subtropic ecoregions. The D. linearis-derived chars produced under pyrolysis at 400 °C for 1 h were activated in various CO2-steam proportions. As revealed by the IR and Raman spectra, the structure of the activated chars was heavily dependent on the relative proportion of CO2 and steam. The total specific surface area (SSA) of the activated chars proportionally increased with the increase in steam proportion and was comparable to the values of commercial activated char products. Specifically, the activation under CO2− and steam-saturated conditions has correspondingly resulted in SSA increasing from 89 to 653 m2g−1 and from 89 to 1015 m2g−1. Steam also enhanced the development of mesoporous structures of the D. linearis-derived char products, thereby extending their potential applications, particularly for industries that require high rigidity in the product such as pharmaceutical and cosmetic sectors.
- Published
- 2021
46. Optimizing fire allocation in a Network Centric Warfare-type model
- Author
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Manh D Hy, Dinh V Bui, Nam H Nguyen, Anh N Ta, and My A Vu
- Subjects
010104 statistics & probability ,021103 operations research ,Optimization problem ,Computer science ,Modeling and Simulation ,Distributed computing ,0211 other engineering and technologies ,Network-centric warfare ,02 engineering and technology ,0101 mathematics ,Type (model theory) ,01 natural sciences ,Engineering (miscellaneous) - Abstract
In this paper, we introduce a non-linear Lanchester’s model of Network Centric Warfare type and investigate an optimization problem for this model, where only the Red force is supplied by several supply agents. Optimal fire allocation of the Blue force is sought in the form of a piece-wise constant function of time. A “threatening rate” is computed for the Red force and each of its supply agents at the beginning of each stage of the combat. These rates can be used to derive the optimal decision for the Blue force to focus its firepower to the Red force itself or one of its supply agents. This optimal fire allocation is derived and proved by considering an optimization problem of the number of Blue force troops. Numerical experiments are included to demonstrate the theoretical results.
- Published
- 2021
47. Genome-wide CRISPR/Cas9 Screen Identifies Etoposide Response Modulators Associated with Outcomes in Pediatric AML
- Author
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Nam H. K. Nguyen, Roya Rafiee, Abderrahmane Tagmount, Amin Sobh, Alex Loguinov, Angelica K. de Jesus Sosa, Abdelrahman H. Elsayed, Mohammed Gbadamosi, Nathan Seligson, Christopher R. Cogle, Jeffery Rubnitz, Raul Ribeiro, James Downing, Xueyuan Cao, Stanley B. Pounds, Christopher D. Vulpe, and Jatinder K. Lamba
- Subjects
Hematology - Abstract
Etoposide is used to treat a wide range of malignant cancers, including acute myeloid leukemia (AML) in children. Despite the use of intensive chemotherapeutic regimens containing etoposide, a significant proportion of pediatric patients with AML become resistant to treatment and relapse, leading to poor survival. This poses a pressing clinical challenge to identify mechanisms underlying drug resistance to enable effective pharmacologic targeting. We performed a genome-wide CRISPR/Cas9 synthetic-lethal screening to identify functional modulators of etoposide response in leukemic cell line and integrated results from CRISPR-screen with gene expression and clinical outcomes in pediatric patients with AML treated with etoposide-containing regimen. Our results confirmed the involvement of well-characterized genes, including TOP2A and ABCC1, as well as identified novel genes such as RAD54L2, PRKDC, and ZNF451 that have potential to be novel drug targets. This study demonstrates the ability for leveraging CRISPR/Cas9 screening in conjunction with clinically relevant endpoints to make meaningful discoveries for the identification of prognostic biomarkers and novel therapeutic targets to overcome treatment resistance.
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- 2022
48. Case Report: Successful Treatment of a Child With COVID-19 Reinfection-Induced Fulminant Myocarditis by Cytokine-Adsorbing oXiris® Hemofilter Continuous Veno-Venous Hemofiltration and Extracorporeal Membrane Oxygenation
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Phuc H. Phan, Dung T. Nguyen, Nam H. Dao, Ha T. T. Nguyen, An V. Vu, Son T. Hoang, Lam V. Nguyen, Tung V. Cao, and Dien M. Tran
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Pediatrics, Perinatology and Child Health - Abstract
BackgroundIndirect cardiomyocyte damage-related hyperinflammatory response is one of the key mechanisms in COVID-19-induced fulminant myocarditis. In addition to the clinical benefit of using cytokines absorption hemofiltration, the effectiveness of instituting veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support for cardiac compromise has been reported. However, current literature enunciates a paucity of available data on the effectiveness of these novel modalities.Case PresentationWe reported a 9-year-old boy with recurrent COVID-19 infection-causing fulminant myocarditis, who was treated successfully by using novel modalities of oXiris® hemofilter continuous venovenous hemofiltration (CVVH) and VA-ECMO. The patient made a full recovery without any sequelae.ConclusionWe conclude that the novel highly-absorptive hemofilter CVVH and VA-ECMO may be effective treatment modalities in managing SARS-CoV-2-induced fulminant myocarditis. Our report highlights the need for further well-designed investigations to confirm this extrapolation.
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- 2022
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49. A Ten-Gene DNA-Damage Response Pathway Gene Expression Signature Predicts Gemtuzumab Ozogamicin Response in Pediatric AML Patients Treated on COGAAML0531 and AAML03P1 Trials
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Mohammed O. Gbadamosi, Vivek M. Shastri, Abdelrahman H. Elsayed, Rhonda Ries, Oluwaseyi Olabige, Nam H. K. Nguyen, Angelica De Jesus, Yi-Cheng Wang, Alice Dang, Betsy A. Hirsch, Todd A. Alonzo, Alan Gamis, Soheil Meshinchi, and Jatinder K. Lamba
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Cancer Research ,Sialic Acid Binding Ig-like Lectin 3 ,Hematology ,DNA ,Antibodies, Monoclonal, Humanized ,Gemtuzumab ,Article ,Leukemia, Myeloid, Acute ,Aminoglycosides ,Antineoplastic Agents, Immunological ,Oncology ,Calicheamicins ,Humans ,Child ,Transcriptome ,DNA Damage - Abstract
Gemtuzumab ozogamicin (GO) is an anti-CD33 monoclonal antibody linked to calicheamicin, a DNA damaging agent, and is a well-established therapeutic for treating acute myeloid leukemia (AML). In this study, we used LASSO regression modeling to develop a 10-gene DNA damage response gene expression score (CalDDR-GEx10) predictive of clinical outcome in pediatric AML patients treated with treatment regimen containing GO from the AAML03P1 and AAML0531 trials (ADE+GO arm, N = 301). When treated with ADE+GO, patients with a high CalDDR-GEx10 score had lower complete remission rates (62.8% vs. 85.5%, P = 1.77*10(−5)) and worse event-free survival (28.7% vs. 56.5% P = 4.08*10(−8)) compared to those with a low CalDDR-GEx10 score. However, the CalDDR-GEx10 score was not associated with clinical outcome in patients treated with standard chemotherapy alone (ADE, N = 242), implying the specificity of the CalDDR-GEx10 score to calicheamicin-induced DNA damage response. In multivariable models adjusted for risk group, FLT3-status, white blood cell count, and age, the CalDDR-GEx10 score remained a significant predictor of outcome in patients treated with ADE+GO. Our findings present a potential tool that can specifically assess response to calicheamicin-induced DNA damage preemptively via assessing diagnostic leukemic cell gene expression and guide clinical decisions related to treatment using GO.
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- 2022
50. Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study
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Nicole D. Armstrong, Vinodh Srinivasasainagendra, Lakshmi Manasa S. Chekka, Nam H. K. Nguyen, Noor A. Nahid, Alana C. Jones, Rikki M. Tanner, Bertha A. Hidalgo, Nita A. Limdi, Steven A. Claas, Yan Gong, Caitrin W. McDonough, Rhonda M. Cooper-DeHoff, Julie A. Johnson, Hemant K. Tiwari, Donna K. Arnett, and Marguerite R. Irvin
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Black or African American ,Glucose ,Hypertension ,Genetics ,Chlorthalidone ,Humans ,pharmacogenomics ,antihypertensives ,drug response ,Genetics (clinical) ,United States ,Genome-Wide Association Study - Abstract
Hypertension is a leading risk factor for cardiovascular disease mortality. African Americans (AAs) have the highest prevalence of hypertension in the United States, and to alleviate the burden of hypertension in this population, better control of blood pressure (BP) is needed. Previous studies have shown considerable interpersonal differences in BP response to antihypertensive treatment, suggesting a genetic component. Utilizing data from 4297 AA participants randomized to chlorthalidone from the Genetics of Hypertension Associated Treatments (GenHAT) study, we aimed to identify variants associated with the efficacy of chlorthalidone. An additional aim was to find variants that contributed to changes in fasting glucose (FG) in these individuals. We performed genome-wide association analyses on the change of systolic and diastolic BP (SBP and DBP) over six months and FG levels over 24 months of treatment. We sought replication in the International Consortia of Pharmacogenomics Studies. We identified eight variants statistically associated with BP response and nine variants associated with FG response. One suggestive LINC02211-CDH9 intergenic variant was marginally replicated with the same direction of effect. Given the impact of hypertension in AAs, this study implies that understanding the genetic background for BP control and glucose changes during chlorthalidone treatment may help prevent adverse cardiovascular events in this population.
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- 2022
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