1. Erythropoietin levels in aqueous humor of patients with glaucoma
- Author
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Nassiri, Nader, Nassiri, Nariman, Majdi, Mercede, Mehrjardi, Hadi Z, Shakiba, Yadollah, Haghnegahdar, Maryam, Heidari, Amir Behzad, Djalilian, Ali R., and Mirahmadian, Mahroo
- Subjects
Male ,genetic structures ,Age Factors ,Middle Aged ,Exfoliation Syndrome ,Severity of Illness Index ,eye diseases ,Cataract ,Aqueous Humor ,Glaucoma, Neovascular ,Sex Factors ,Humans ,Regression Analysis ,Female ,sense organs ,Prospective Studies ,Erythropoietin ,Glaucoma, Open-Angle ,Intraocular Pressure ,Research Article ,Aged - Abstract
Purpose To compare the aqueous concentration of erythropoietin (EPO) in eyes with primary open-angle (POAG), pseudoexfoliative (PXFG), and neovascular (NVG) glaucoma with age-matched eyes with cataracts, and to correlate its concentration with other factors including age, gender, intraocular pressure (IOP), type of glaucoma, and severity of glaucoma. Methods In this prospective non-randomized comparative study, a total of 26 eyes with cataracts (control group) and 92 glaucomatous eyes (POAG, 40 eyes; PXFG, 26 eyes; NVG, 26 eyes) were enrolled. Aqueous samples (0.1 to 0.2 ml) were obtained during phacoemulsification, trabeculectomy, phacotrabeculectomy, or Ahmed valve glaucoma implants. The aqueous concentration of EPO was measured using an enzyme-linked immunosorbent assay. Results The mean±SEM aqueous level of EPO was statistically significantly higher in eyes with glaucoma (56.7±9.3 mIU/ml) compared to the control group (0.8±0.51 mIU/ml; p
- Published
- 2012