17 results on '"Neunlist M"'
Search Results
2. Perinatal exposure to GOS/inulin prebiotics prevent food allergy by promoting tolerance and protecting intestine
- Author
-
Bouchaud, Grégory, Castan, Laure, Chesne, J., Braza, F., Aubert, P., Neunlist, M., Magnan, A., and Bodinier, Marie
- Abstract
Food allergies (FA) are increasing and prevention strategies are nonexistent. They are linked to imbalance of microbiota and immune system. Fibers as prebiotics have been proposed to restore this balance and seem to be one alternative to prevent or reduce allergies, particularly during infancy. In this context, we evaluated early nutritional intervention with prebiotics, via the mother during pregnancy and lactation (perinatal), to prevent food allergic risk in mice... more...
- Published
- 2016
Catalog
3. Impaired intestinal barrier permeability in irritable bowel syndrome:role of soluble factors
- Author
-
Piche T, Auber P, Galmiche J, Neunlist M., BARBARA, GIOVANNI, STANGHELLINI, VINCENZO, DE GIORGIO, ROBERTO, BRITISH SOCIETY OF GASTROENTEROLOGY, Piche T, Barbara G, Auber P, Stanghellini V, De Giorgio R, Galmiche J, and Neunlist M. more...
- Published
- 2007
4. Study of immuno-physiological mechanism implicated in atopic march using an original mouse model of food and respiratory combined allergy
- Author
-
Bouchaud, Gregory, Gourbeyre, Pascal, Bihouée-Roussey, T., Aubert, P., Lair, D., Denery-Papini, Sandra, Neunlist, M., Magnan, A., Bodinier, Marie, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Cardiopathies et mort subite [ERL 3147], Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN), U913 neuropathies du système nerveux entérique et pathologies digestives, Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre hospitalier universitaire de Nantes (CHU Nantes) more...
- Subjects
[SDV.IDA]Life Sciences [q-bio]/Food engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2013
5. A first sensitisation to food allergen induces an aggravation of asthmatic phenotype in a house dust mite asthmatic model
- Author
-
Lair, D., Roussey-Bihouée, T., Rolland-Debord, C., Aubert, P., Gourbeyre, Pascal, Cheminant, M.-A., Sagan, C., Neunlist, M., Bodinier, Marie, Magnan, A., ProdInra, Migration, Institut National de la Santé et de la Recherche Médicale (INSERM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), U913 neuropathies du système nerveux entérique et pathologies digestives, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), and Institut National de la Recherche Agronomique (INRA) more...
- Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,[SDV.IDA] Life Sciences [q-bio]/Food engineering ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2013
6. N-3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets
- Author
-
De Quelen, Francine, Chevalier, Jérome, Rolli-Derkinderen, M., Mourot, Jacques, Neunlist, M., Boudry, Gaëlle, Systèmes d'élevage, nutrition animale et humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Valorex SAS, U913, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des maladies de l'appareil digestif, Centre hospitalier universitaire de Nantes (CHU Nantes), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA) more...
- Subjects
[SDV]Life Sciences [q-bio] - Abstract
The intestinal epithelial barrier (IEB) plays a key role in the maintenance of gut homeostasis and the development of the immune system in newborns. The enteric nervous system (ENS), a key regulator of gastrointestinal functions, has been shown to be modulated by nutritional factors. However, it remains currently unknown whether maternal diet, in particular n-3 polyunsaturated fatty acids (n-3PUFA), can impact upon IEB in newborn piglets and whether the ENS is involved in this effect. Sows received either a control diet (lard-based) or an n-3PUFA diet (linseed oil-based) during gestation and lactation. Intestinal paracellular permeability was assessed in Ussing chamber on piglets at birth, 3, 7, 14, 21 and 28 post-natal days (PND). Basal jejunal permeability increased significantly and similarly in both groups until PND14 and decreased thereafter. However, at PND28, permeability was higher in n-3PUFA animals as compared to controls. In addition, VIP receptor antagonist increased paracellular permeability in controls but not in n-3PUFA piglets. Conversely, atropine and hexamethonium decreased paracellular permeability in the n-3PUFA group but not in the control group. Moreover, the n-3PUFA diet increased the proportion of ChAT-immunoreactive (IR) neurons and decreased the proportion of VIP-IR neurons in the submucosal plexus of piglet jejunum compared to controls. In addition, in primary culture of rat ENS, we showed that 20:5n-3 but not 18:3n-3 increased the proportion of ChAT-IR neurons and decreased the proportion of VIP-IR neurons. In conclusion, supplementation of the maternal diet with n-3PUFA modified intestinal permeability probably via diet-induced neuroplastic changes in the ENS of newborn piglets. more...
- Published
- 2011
- Full Text
- View/download PDF
7. Enteric glial cells produce 15-HETE to regulate intestinal epithelial properties: dysregulation in Crohn's disease
- Author
-
Pochard, C., Coquenlorge, S., Jaulin, J., Durand, T., nicolas Cenac, Vergnolle, N., Neunlist, M., and Rolli-Derkinderen, M.
8. L-PGDS lack in enteric glial cells from Crohn's disease patients restricts intestinal epithelial barrier healing
- Author
-
Rolli-Derkinderen, M., Coquenlorge, S., Landeghem, L., Jaulin, J., Cenac, N., Nathalie Vergnolle, and Neunlist, M.
9. Human enteric glial cells are defective for 15-HETE production and epithelial permeability control in Crohn's disease
- Author
-
Rolli-Derkinderen, M., Pochard, C., Coquenlorge, S., Jaulin, J., Durand, T., nicolas Cenac, Vergnolle, N., and Neunlist, M.
10. Enteric glial cells reaction to inflammation is lost in Crohn's disease
- Author
-
Pochard, C., Clairembault, T., nicolas Cenac, Vergnolle, N., Duchalais, E., Bourreille, A., Neunlist, M., and Rolli-Derkinderen, M.
11. Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1β-dependent pathway
- Author
-
Neunlist, M., Barouk, J., Michel, K., Just, I., Oreshkova, T., Michael Schemann, and Galmiche, J. P.
12. Enteric glial cells from Crohn's disease patients misproduce 15-deoxy-Delta 12,14-prostaglandin J2: defect in intestinal epithelial barrier resistance
- Author
-
Coquenlorge, S., nicolas Cenac, Biraud, M., Jaulin, J., Vergnolle, N., Neunlist, M., and Rolli-Derkinderen, M.
13. Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms
- Author
-
M. Péré, D. Drui, Bertrand Cariou, Emmanuel Coron, Maria Raffaella Barbaro, D. Masson, Michel Neunlist, Justine Blin, Giovanni Barbara, Kalyane Bach-Ngohou, L Quénéhervé, The Enteric Nervous System in gut and brain disorders [U1235] (TENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Hôtel-Dieu de Nantes, Centre hospitalier universitaire de Nantes (CHU Nantes), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), University of Bologna/Università di Bologna, NantesU M, Dépôt, Queneherve L., Drui D., Blin J., Pere M., Coron E., Barbara G., Barbaro M.R., Cariou B., Neunlist M., Masson D., and Bach-Ngohou K. more...
- Subjects
Adult ,Male ,Abdominal pain ,medicine.medical_specialty ,Secondary adrenal insufficiency ,[SDV]Life Sciences [q-bio] ,Science ,Functional gastrointestinal disorders ,Article ,Primary Adrenal Insufficiency ,Irritable Bowel Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,Surveys and Questionnaires ,Adrenal insufficiency ,medicine ,Humans ,In patient ,Congenital adrenal hyperplasia ,Irritable bowel syndrome ,Adrenal gland diseases ,Multidisciplinary ,business.industry ,Endocrine system and metabolic diseases ,chronic adrenal insufciency ,Middle Aged ,medicine.disease ,[SDV] Life Sciences [q-bio] ,030220 oncology & carcinogenesis ,Quality of Life ,Medicine ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Adrenal Insufficiency - Abstract
Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association “Adrenals” (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p p more...
- Published
- 2020
- Full Text
- View/download PDF
14. Glioplasticity in irritable bowel syndrome
- Author
-
Malvyne Rolli-Derkinderen, C Brochard, L Quénéhervé, Emmanuel Coron, Nicoletta Libera Lilli, Michel Neunlist, R. De Giorgio, Giovanni Barbara, Jean-Benoit Hardouin, Philippe Aubert, Tony Durand, S. Bruley des Varannes, Philippe Naveilhan, S. Haddara, Institut des maladies de l'appareil digestif [Nantes] (IMAD), Centre hospitalier universitaire de Nantes (CHU Nantes), The Enteric Nervous System in gut and brain disorders [U1235] (TENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Lilli, N.L., Quénéhervé, L., Haddara, S., Brochard, C., Aubert, P., Rolli-Derkinderen, M., Durand, T., Naveilhan, P., Hardouin, J.-B., De Giorgio, R., Barbara, G., Bruley des Varannes, S., Coron, E., Neunlist, M., Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, University of Bologna and S. Orsola Malpighi General Hospital, and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques more...
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Physiology ,Colon ,Mrna expression ,S100 Calcium Binding Protein beta Subunit ,Endocrine and Autonomic System ,Enteric Nervous System ,Flow cytometry ,Irritable Bowel Syndrome ,03 medical and health sciences ,chemistry.chemical_compound ,Ca 2+ response ,0302 clinical medicine ,Bloating ,Adenosine Triphosphate ,Enteric glial cell ,Internal medicine ,medicine ,Animals ,Humans ,In patient ,Intestinal Mucosa ,Pyrilamine ,Irritable bowel syndrome ,Cells, Cultured ,medicine.diagnostic_test ,Endocrine and Autonomic Systems ,business.industry ,Gastroenterology ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Middle Aged ,medicine.disease ,histamine ,Pathophysiology ,Rats ,030104 developmental biology ,Endocrinology ,enteric glial cells ,chemistry ,030211 gastroenterology & hepatology ,Calcium ,Female ,business ,Neuroglia ,Histamine ,Ca2+ response - Abstract
International audience; Background: growing evidence indicates a wide array of cellular remodeling in the mucosal microenvironment during irritable bowel syndrome (IBS), which possibly contributes to pathophysiology and symptom generation. Here, we investigated whether enteric glial cells (EGC) may be altered, and which factors/mechanisms lead to these changes.Methods: Colonic mucosal biopsies of IBS patients (13 IBS‐Constipation [IBS‐C]; 10 IBS‐Diarrhea [IBS‐D]; 11 IBS‐Mixed [IBS‐M]) and 24 healthy controls (HC) were analyzed. Expression of S100β and GFAP was measured. Cultured rat EGC were incubated with supernatants from mucosal biopsies, then proliferation and Ca2+ response to ATP were analyzed using flow cytometry and Ca2+ imaging. Histamine and histamine 1‐receptor (H1R) involvement in the effects of supernatant upon EGC was analyzed.Key Results: Compared to HC, the mucosal area immunoreactive for S100β was significantly reduced in biopsies of IBS patients, independently of the IBS subtype. IBS‐C supernatants reduced EGC proliferation and IBS‐D and IBS‐M supernatants reduced Ca2+ response to ATP in EGC. EGC expressed H1R and the effects of supernatant upon Ca2+ response to ATP in EGC were blocked by pyrilamine and reproduced by histamine via H1R. IBS supernatants reduced mRNA expression of connexin‐43. The S100β‐stained area was negatively correlated with the frequency and intensity of pain and bloating.Conclusion and Inferences: Changes in EGC occur in IBS, involving mucosal soluble factors. Histamine, via activation of H1R‐dependent pathways, partly mediates altered Ca2+ response to ATP in EGC. These changes may contribute to the pathophysiology and the perception of pain and bloating in patients with IBS. more...
- Published
- 2018
- Full Text
- View/download PDF
15. Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome
- Author
-
D. Defilippis, Giovanni Barbara, Marc Pigrau, Maria Raffaella Barbaro, Teresa Iuvone, Beatriz Lobo, Cesare Cremon, Javier Santos, Fernando Azpiroz, Rosanna Cogliandro, Vincenzo Stanghellini, V. Di Marzo, Stefania Petrosino, María Vicario, C. Alonso Cotoner, Michel Neunlist, S. Bruley des Varannes, Lara Bellacosa, Cremon, C., Stanghellini, V., Barbaro, M.R., Cogliandro, R.F., Bellacosa, L., Santos, J., Vicario, M., Pigrau, M., Alonso Cotoner, C., Lobo, B., Azpiroz, F., Bruley des Varannes, S., Neunlist, M., Defilippis, D., Iuvone, T., Petrosino, S., Di Marzo, V., and Barbara, G more...
- Subjects
Adult ,Male ,0301 basic medicine ,Abdominal pain ,Analgesic ,Cell Count ,Palmitic Acids ,Pharmacology ,Placebo ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Oleoylethanolamide ,0302 clinical medicine ,Double-Blind Method ,Glucosides ,Stilbenes ,Humans ,Medicine ,Pharmacology (medical) ,Mast Cells ,palmitoylethanolamide ,Irritable bowel syndrome ,irritable bowel syndrome ,Analgesics ,Palmitoylethanolamide ,Hepatology ,business.industry ,digestive, oral, and skin physiology ,Gastroenterology ,endocannabinoid ,Middle Aged ,Mast cell ,medicine.disease ,Amides ,Pathophysiology ,Abdominal Pain ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Ethanolamines ,Dietary Supplements ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Background: Intestinal immune activation is involved in irritable bowel syndrome (IBS) pathophysiology. While most dietary approaches in IBS involve food avoidance, there are fewer indications on food supplementation. Palmithoylethanolamide, structurally related to the endocannabinoid anandamide, and polydatin are dietary compounds which act synergistically to reduce mast cell activation. Aim: To assess the effect on mast cell count and the efficacy of palmithoylethanolamide/polydatin in patients with IBS. Methods: We conducted a pilot, 12-week, randomised, double-blind, placebo-controlled, multicentre study assessing the effect of palmithoylethanolamide/polydatin 200mg/20mg or placebo b.d. on low-grade immune activation, endocannabinoid system and symptoms in IBS patients. Biopsy samples, obtained at screening visit and at the end of the study, were analysed by immunohistochemistry, enzyme-linked immunoassay, liquid chromatography and Western blot. Results: A total of 54 patients with IBS and 12 healthy controls were enrolled from five European centres. Compared with controls, IBS patients showed higher mucosal mast cell counts (3.2±1.3 vs. 5.3±2.7%, P=0.013), reduced fatty acid amide oleoylethanolamide (12.7±9.8 vs. 45.8±55.6 pmol/mg, P=0.002) and increased expression of cannabinoid receptor 2 (0.7±0.1 vs. 1.0±0.8, P=0.012). The treatment did not significantly modify IBS biological profile, including mast cell count. Compared with placebo, palmithoylethanolamide/polydatin markedly improved abdominal pain severity (P  more...
- Published
- 2017
- Full Text
- View/download PDF
16. Parkinson disease: The enteric nervous system spills its guts
- Author
-
Tiphaine Rouaud, R. De Giorgio, Thibaud Lebouvier, S. Bruley des Varannes, Pascal Derkinderen, Michel Neunlist, Derkinderen P, Rouaud T, Lebouvier T, Bruley des Varannes S, Neunlist M, and De Giorgio R. more...
- Subjects
Pathology ,medicine.medical_specialty ,Neuropathology ,Disease ,Biology ,Enteric Nervous System ,NO ,enteric nervous system ,gut ,Parkinson disease ,mental disorders ,Biopsy ,Lewy pathology ,medicine ,Animals ,Humans ,Lewy body ,medicine.diagnostic_test ,business.industry ,Parkinson Disease ,medicine.disease ,Staining ,Gastrointestinal Tract ,nervous system ,Neuronal circuits ,Lewy Bodies ,Enteric nervous system ,Neurology (clinical) ,business ,Neuroscience - Abstract
Lewy pathology in Parkinson disease (PD) extends well beyond the CNS, also affecting peripheral autonomic neuronal circuits, especially the enteric nervous system (ENS). The ENS is an integrative neuronal network also referred to as "the brain in the gut" because of its similarities to the CNS. We have recently shown that the ENS can be readily analyzed using routine colonic biopsies. This led us to propose that the ENS could represent a unique window to assess the neuropathology in living patients with PD. In this perspective, we discuss current evidence which indicates that the presence of ENS pathology may by exploited to improve our understanding and management of PD and likely other neurodegenerative disorders. more...
- Published
- 2011
- Full Text
- View/download PDF
17. Enteric glia and neuroprotection: basic and clinical aspects
- Author
-
Roberto De Giorgio, Hind Abdo, Bernard Lardeux, Elisa Boschetti, Michel Neunlist, Fiorella Giancola, De Giorgio R, Giancola F, Boschetti E, Abdo H, Lardeux B, and Neunlist M
- Subjects
Cell signaling ,Pathology ,medicine.medical_specialty ,Enteric glia ,Physiology ,Cell Communication ,Biology ,Neuroprotection ,Enteric Nervous System ,NO ,Physiology (medical) ,medicine ,Animals ,Humans ,Neurons ,Neuroprotecion ,Hepatology ,Enteric neuropathy ,Neurodegeneration ,Gastroenterology ,NEURODEGENERATION ,medicine.disease ,Enteric neurons ,medicine.anatomical_structure ,Cytoprotection ,Enteric neuron ,Neuroglia ,Enteric nervous system ,Neuron ,Gastrointestinal function ,Neuroscience - Abstract
The enteric nervous system (ENS), a major regulatory system for gastrointestinal function, is composed of neurons and enteric glial cells (EGCs). Enteric glia have long been thought to provide only structural support to neurons. However, recent evidence indicates enteric glia-neuron cross talk significantly contributes to neuronal maintenance, survival, and function. Thus damage to EGCs may trigger neurodegenerative processes thought to play a role in gastrointestinal dysfunctions and symptoms. The purpose of this review is to provide an update on EGCs, particularly focusing on their possible neuroprotective features and the resultant enteric neuron abnormalities subsequent to EGC damage. These neuroprotective mechanisms may have pathogenetic relevance in a variety of functional and inflammatory gut diseases. Basic and clinical (translational) studies support a neuroprotective role mediated by EGCs. Different models have been developed to test whether selective EGC damage/ablation has an impact on gut functions and the ENS. Preclinical data indicated that selective EGC alterations were associated with changes in gut physiology related to enteric neuron abnormalities. In humans, a substantial loss of EGCs was described in patients with various functional and/or inflammatory gastrointestinal diseases. However, whether EGC changes precede or follow neuronal degeneration and loss and how this damage occurs is not defined. Additional studies on EGC neuroprotective capacity are expected to improve knowledge of gut diseases and pave the way for targeted therapeutic strategies of underlying neuropathies. more...
- Published
- 2012
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.