1. Stratification of latent tuberculosis infection by cellular immune profiling
- Author
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Halliday, A, Whitworth, H, Hermagild Kottoor, S, Niazi, U, Menzies, S, Kunst, H, Bremang, S, Badhan, A, Beverley, P, Kon, OM, Lalvani, A, and National Institute for Health Research
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,Immunology ,BIOMARKERS ,diagnostic ,risk stratification ,DIAGNOSIS ,Microbiology ,Sensitivity and Specificity ,cellular immune signatures ,Interferon-gamma ,Young Adult ,latent M. tuberculosis infection ,Latent Tuberculosis ,Tuberculosis ,Humans ,ASSAY ,Prospective Studies ,Aged ,RISK ,Science & Technology ,Tumor Necrosis Factor-alpha ,Mycobacterium tuberculosis ,11 Medical And Health Sciences ,ACTIVE TUBERCULOSIS ,GAMMA ,Middle Aged ,06 Biological Sciences ,bacterial infections and mycoses ,Infectious Diseases ,T-CELLS ,Interleukin-2 ,Female ,Life Sciences & Biomedicine - Abstract
Background: Recently-acquired and remotely-acquired latent tuberculosis (TB) infection (LTBI) are clinically indistinguishable, yet recent acquisition of infection is the greatest risk factor for progression to active TB (ATB) in immunocompetent individuals. We aimed to evaluate the ability of cellular immune signatures which differ between ATB and LTBI, to distinguish recently from remotely acquired LTBI. Methods: Fifty-nine individuals were recruited: ATB (n=20); recent LTBI (n=19); remote LTBI (n=20). The proportion of mycobacteria-specific TNFα+IFNγ-IL-2-- secreting CD4+ T cells with a differentiated effector phenotype (TNFα-only TEFF), and the level of CD27 expression on IFNγ-producing CD4+ T cells, were detected by flow-cytometry. Results: The TNFα-only TEFF signature was significantly higher in recent compared to remote LTBI (p
- Published
- 2017