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Reactivation of Epstein-Barr virus (EBV) is associated with the etiopathogenesis of a broad spectrum of diseases. This study aimed to investigate the association between psychological distress and EBV serological reactivation among community-dwelling older people and assess the role of sex differences in this association. This population-based cross-sectional survey was conducted among individuals who underwent annual health checkups (N = 2,821; median age 72.4 years). EBV serological reactivation was defined as elevation of EBV early antigen immunoglobulin G titers, and psychological distress was defined as Kessler 6 scores ≥5. Multivariable logistic regression analysis was performed to calculate odds ratios (OR) and 95% confidence intervals (CI) for EBV serological reactivation and psychological distress. EBV serological reactivation and psychological distress were detected in 16.4% and 8.7% of participants, respectively. Women accounted for 71% (328/463) of those with EBV serological reactivation. Multivariable logistic regression analysis showed psychological distress was not significantly associated with EBV serological reactivation among all participants (OR 1.31, 95% CI: 0.95, 1.82; P = 0.102). A sex-stratified multivariable analysis showed a positive association among women (OR 1.45, 95% CI: 1.01, 2.08; P = 0.043), but no association among men. EBV serological reactivation was independently associated with psychological distress in community-dwelling older women. The sex difference in our results warrants further investigation to clarify the physiological mechanisms underlying the association., Aging, 14(20), pp.8258-8269; 2022

Additional file 2: Supplemental Table 2. Characteristics of study population by status of reduced handgrip strength.

Additional file 1: Supplemental Table 1. Characteristics of study population by status of atherosclerosis.

Additional file 2: Table S1. Baseline characteristics of the patients. Table S2. Causes of death.

Additional file 1: Suppl. Fig. S1. Distribution of K6.

Additional file 1: Figure S1. The attainment of a complete renal response (CR) after 6 and 12 months of induction therapy in the early- and late-onset LN groups. *p

HLA-DRB1 allele carrier frequency in the patients with AOSD and age-matched healthy controls (1:2). (PDF 57 kb)

Conditional logistic regression analysis between the protective HLA alleles in AOSD. (PDF 43 kb)

HLA-DRB1 allele carrier frequency in the patients with AOSD and age-matched healthy controls (1:2). (PDF 57 kb)

Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder in which inflammasome activation plays a pathophysiological role. In view of the inflammatory nature of AOSD, we investigated whether serum amyloid A (SAA) gene polymorphisms affect the susceptibility of patients with AOSD. Eighty-seven Japanese patients with AOSD and 200 healthy Japanese subjects were recruited in this study. The genotypes of the -13C/T SNP in the 5′-flanking region of the SAA1 gene (rs12218) and two SNPs within exon 3 of SAA1 (2995C/T and 3010C/T polymorphisms) were determined using polymerase chain reaction fragment length polymorphism (PCR-RFLP) assay in all subjects. In AOSD patients, exons 1, 2, 3, and 10 of the MEFV gene were also genotyped by direct sequencing. The frequency of the SAA1.3 allele was increased in AOSD patients compared with that in healthy subjects (43.1% versus 37.5%), but the difference was not significant. The −13T allele was more frequently observed in AOSD patients than in healthy subjects (50.6% versus 41.0%, P = .0336). AOSD patients with the −13T allele had been treated with immunosuppressants more frequently than those without this allele. MEFV mutations were detected in 49 patients with AOSD (49/87, 57.3%). AOSD patients with MEFV variants frequently exhibit macrophage activation syndrome, but the difference was not significant (34.7% versus 18.4%, P = .081). Also, there was no significant difference in SAA1 -13C/T allele frequency between AOSD patients with and without MEFV mutations. Our data shows a significant association between T allele of rs12218 and AOSD in Japanese population.

A 71-year-old man was noted to have a nodular opacity in S8 of the right lung. Thirteen months later, the chest CT showed a lesion "gloved finger shape " with focal calcification, and a small nodular opacity appeared in right S7. A right lower lobectomy was performed under video-assisted thoracic surgery. The tumor filled the S8 bronchus, with invasion into the pulmonary parenchyma and S7 metastasis. Mitotic figures were seen in 5 of 10 high power fields. Positive staining for chromogranin A and synaptophysin led to the diagnosis of atypical carcinoid. The patient has been disease-free without treatment for 9 months., Acta medica Nagasakiensia, 53(3), pp.69-72 ; 2009