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74 results on '"Noventa, F"'

1. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

2. Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial

Author

Prandoni P, Noventa F, Quintavalla R, Bova C, Siragusa S, Bucherini E, Astorri F, Cuppini S, Dalla Valle F, Lensing AW, Prins MH, Villalta S, Canano Investigators Collaborators […, Vedovetto V, Barbar S, Campello E, Milan M, Filippi L, Rocci A, Chiappetta P, Pellegrini R, Fiaschi E, Vallone G, D'Amico E, Noto A, Pili C, Costantini E, Gasperon M, Palareti G, Malato A, Saccullo G, Brini C, Bitti G, Marzolo M, Ramazzina E, Zamboni S., COSMI, BENILDE, Epidemiologie, MUMC+: KIO Kemta (9), RS: CAPHRI School for Public Health and Primary Care, Prandoni P, Noventa F, Quintavalla R, Bova C, Cosmi B, Siragusa S, Bucherini E, Astorri F, Cuppini S, Dalla Valle F, Lensing AW, Prins MH, Villalta S, Canano Investigators Collaborators […, Vedovetto V, Barbar S, Campello E, Milan M, Filippi L, Rocci A, Chiappetta P, Pellegrini R, Fiaschi E, Vallone G, D'Amico E, Noto A, Pili C, Costantini E, Gasperon M, Palareti G, Malato A, Saccullo G, Brini C, Bitti G, Marzolo M, Ramazzina E, Zamboni S., …], Prandoni, P, Noventa, F, Quintavalla, R, Bova, C, Cosmi, B, Siragusa, S, Bucherini, E, Astorri, F, Cuppini, S, Dalla Valle, F, Lensing, A, Prins, M, and Villalta, S

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Time Factors, Immunology, Thigh, behavioral disciplines and activities, Biochemistry, Postthrombotic Syndrome, Settore MED/15 - Malattie Del Sangue, law.invention, POST-THROMBOTIC SYNDROME, Young Adult, Randomized controlled trial, law, medicine, Humans, Knee, Aged, Aged, 80 and over, Venous Thrombosis, First episode, VENOUS THROMBOEMBOLISM, business.industry, Pruritus, Hazard ratio, Cell Biology, Hematology, Middle Aged, musculoskeletal system, medicine.disease, Thrombosis, humanities, Confidence interval, Discontinuation, Surgery, Venous thrombosis, Treatment Outcome, medicine.anatomical_structure, Erythema, Patient Compliance, Female, venous thrombosis, business, Stockings, Compression, Follow-Up Studies
Abstract

Although below-knee compression elastic stockings (CES) are effective for the prevention of the postthrombotic syndrome (PTS), a substantial number of patients with deep venous thrombosis still develop PTS. In the present open-label, randomized clinical trial, we compared thigh-length with below-knee CES for the prevention of PTS. A total of 267 patients with the first episode of proximal deep venous thrombosis were randomized to wear either thigh-length or below-knee CES for 2 years. After 3, 6, 12, 18, 24, and 36 months, they were assessed for PTS manifestations according to the Villalta scale. PTS developed in 44 (32.6%) of the 135 patients randomized to thigh-length CES and in 47 (35.6%) of the 132 allocated to below-knee CES, for an adjusted hazard ratio of 0.93 (95% confidence interval, 0.62-1.41). Severe PTS developed in 3 patients in each group. CES-related side effects developed in 55 (40.7%) of the 135 patients allocated to thigh-length CES and in 36 (27.3%) of those randomized to the below-knee group (P = .017), and led to premature discontinuation of their use in 29 (21.5%) and 18 (13.6%) patients, respectively. We conclude that thigh-length CES do not offer a better protection against PTS than below-knee CES and are less well tolerated. This study is registered as Clinical Trial number NCT00426075.

Published
2012
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3. The heliosphere dimensions and cosmic rays modulation

Author

Bobik, P, Boschini, MJ, CONSOLANDI, CRISTINA, Della Torre, S, GERVASI, MASSIMO, Grandi, D, Kudela, K, Noventa, F, PENSOTTI, SIMONETTA, Rancoita, PG, ROZZA, DAVIDE, Giano, S, Leroy, C, Price, L, Rancoita, PG, Ruchti, R, Bobik, P, Boschini, M, Consolandi, C, Della Torre, S, Gervasi, M, Grandi, D, Kudela, K, Noventa, F, Pensotti, S, Rancoita, P, and Rozza, D

Subjects
FIS/05 - ASTRONOMIA E ASTROFISICA, Solar Modulation, Cosmic ray, Monte Carlo simulations
Abstract

Cosmic Ray differential intensity at Earth has been reproduced using a 2D stochastic Montecarlo diffusion code and compared with measured data. We evaluated the effect of a stretched and compressed heliosphere on the Cosmic Ray fluxes at the Earth. We introduced a dependence of the diffusion parameter on the heliospheric size. We then found, for our 2D model, in comparison with experimental data, the optimum value of the heliospheric radius, which changes with time and solar activity. Differences in the heliospheric radius are effective only at energy below a few hundred MeV. Our results are in agreement with Voyager measurements and with models of heliospheric size modulation.

Published
2012

5. Serial 2-Point Ultrasonography Plus D-Dimer vs Whole-Leg Color-Coded Doppler Ultrasonography for Diagnosing Suspected Symptomatic Deep Vein Thrombosis

Author

Bernardi, E, Camporese, G, Büller, HR, SIRAGUSA, Sergio, Imberti, D, Berchio, A, Ghirarduzzi, A, Verlato, F, ANASTASIO, Raffaela, Prati, C, Piccioli, A, Pesavento, R, Bova, C, Maltempi, P, Zanatta, N, Cogo, A, Cappelli, R, Bucherini, E, Cuppini, S, Noventa, F, Prandoni, P, Zotta, L, Franz, F, Chiarion, C, Nardi, M, Andreozzi, GM, MALATO, Alessandra, LO COCO, Lucio, MILIO, Glauco, Cormaci, O, Cavallotti, P, Orlando, S, Rolfo, E, Valenzano, C, Iotti, M, Cattabiani, ML, Visonà, A, Salsa, F, Pagnan Ricchio, R, Noto, A, Settembrini, PG, Santonastaso, M, Mognol, D, Bicchi, M, Maggi, F, Zamboni, S, Baccaglini, U, Spreafico, G., ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, Bernardi, E, Camporese, G, Büller, HR, Siragusa, S, Imberti, D, Berchio, A, Ghirarduzzi, A, Verlato, F, Anastasio, R, Prati, C, Piccioli, A, Pesavento, R, Bova, C, Maltempi, P, Zanatta, N, Cogo, A, Cappelli, R, Bucherini, E, Cuppini, S, Noventa, F, Prandoni, P, (Erasmus Study Group) Zotta, L, Franz, F, Chiarion, C, Nardi, M, Andreozzi, GM, Malato, A, Lo Coco, L, Milio, G, Cormaci, O, Cavallotti, P, Orlando, S, Rolfo, E, Valenzano, C, Iotti, M, Cattabiani, ML, Visonà, A, Salsa, F, Pagnan Ricchio, R, Noto, A, Settembrini, PG, Santonastaso, M, Mognol, D, Bicchi, M, Maggi, F, Zamboni, S, Baccaglini, U, and Spreafico, G

Subjects
Male, medicine.medical_specialty, Deep vein, Context (language use), Veins, Settore MED/15 - Malattie Del Sangue, law.invention, Fibrin Fibrinogen Degradation Products, Randomized controlled trial, law, D-dimer, medicine, Humans, Prospective Studies, Ultrasonography, Doppler, Color, Prospective cohort study, Aged, Venous Thrombosis, First episode, Leg, business.industry, deep vein thrombosi, ultrasonography, General Medicine, Middle Aged, medicine.disease, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Thrombosis, Surgery, Venous thrombosis, medicine.anatomical_structure, Female, Radiology, business
Abstract

Context Patients with suspected deep vein thrombosis ( DVT) of the lower extremities are usually investigated with ultrasonography either by the proximal veins ( 2-point ultrasonography) or the entire deep vein system ( whole- leg ultrasonography). The latter approach is thought to be better based on its ability to detect isolated calf vein thrombosis; however, it requires skilled operators and is mainly available only during working hours. No randomized comparisons are yet available evaluating the relative values of these 2 strategies. Objective To assess if the 2 diagnostic strategies are equivalent for the management of symptomatic outpatients with suspected DVT of the lower extremities. Design, Setting, and Patients A prospective, randomized, multicenter study of consecutive symptomatic outpatients ( n= 2465) with a first episode of suspected DVT of the lower extremities who were randomized to undergo 2- point or whole- leg ultrasonography. Data were taken from ultrasound laboratories of 14 Italian universities or civic hospitals between January 1, 2003, and December 21, 2006. Patients with normal ultrasound findings were followed up for 3 months, with study completion on March 20, 2007. Main Outcome Measure Objectively confirmed 3- month incidence of symptomatic venous thromboembolism in patients with an initially normal diagnostic workup. Results Of 2465 eligible patients, 345 met 1 or more exclusion criteria and 22 refused to participate; therefore, 2098 patients were randomized to either 2- point ( n= 1045) or whole- leg ( n= 1053) ultrasonography. Symptomatic venous thromboembolism occurred in 7 of 801 patients ( incidence, 0.9%; 95% confidence interval [ CI], 0.3%1.8%) in the 2- point strategy group and in 9 of 763 patients ( incidence, 1.2%; 95% CI, 0.5%- 2.2%) in the whole- leg strategy group. This met the established equivalence criterion ( observed difference, 0.3%; 95% CI, - 1.4% to 0.8%). Conclusion The 2 diagnostic strategies are equivalent when used for the management of symptomatic outpatients with suspected DVT of the lower extremities. Trial Registration clinicaltrials. gov Identifier: NCT00353093

Published
2008
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11. Clustering of albumin excretion rate abnormalities in Caucasian patients with NIDDM. The Italian NIDDM Nephropathy Study Group

Author

Faronato, P. P., Maioli, M., Tonolo, G., Brocco, E., Noventa, F., Piarulli, F., Abaterusso, Cataldo, Modena, F., de Bigontina, G., Velussi, M., Inchiostro, S., Santeusanio, F., Bueti, A., and Nosadini, R.

Subjects
Blood Glucose, Glycated Hemoglobin, Male, Diabetic Retinopathy, Alcohol Drinking, Smoking, Myocardial Infarction, Middle Aged, White People, Nuclear Family, Cholesterol, Diabetes Mellitus, Type 2, Italy, Creatinine, Hypertension, Odds Ratio, Albuminuria, Cluster Analysis, Humans, Family, Female, Diabetic Angiopathies, Triglycerides
Abstract

Proteinuria and nephropathy have been found to cluster in families of non-insulin-dependent diabetic (NIDDM) Pima Indian, and in Caucasian insulin-dependent diabetic (IDDM) patients. No information is at present available for Caucasian NIDDM patients. The aim of the present study was to determine whether micro-macroalbuminuria (AER+) is associated with albumin excretion rate abnormalities in diabetic and non-diabetic siblings of probands with NIDDM and AER+. We identified 169 Caucasian families with one NIDDM proband (the patient with longest known NIDDM duration) (101 families with only NIDDM siblings, 33 families with both NIDDM and non-NIDDM siblings and 35 families with only non-NIDDM siblings). Of the probands 56 had AER+ [Prob-NIDDM-(AER+)], 78 had AER-[Prob-NIDDM-(AER-)], 74 siblings of Prob-NIDDM-(AER+), and 113 siblings of Prob-NIDDM-(AER-) also had NIDDM. Data on albuminuria and retinopathy from multiple sibling pairs when the size of the sibship was more than two was adjusted according to a weighting factor. The odds ratio for AER+, in siblings of Prob-NIDDM-(AER+) adjusted for age, hypertension, glycated haemoglobin A1c and other confounding variables was 3.94 (95% confidence intervals: 1.93-9.01) as compared to siblings of Prob-NIDDM-(AER-). The 74 siblings of Prob-NIDDM-(AER+) had higher prevalence of proliferative retinopathy than siblings of Prob-NIDDM-(AER-) (14 vs 2%; p0.01). We also identified 66 non-diabetic siblings of 41 NIDDM probands with AER+ and 36 non-diabetic siblings of 27 NIDDM probands with AER-. Albumin excretion was two times higher, although still within the normal range, in the non-diabetic siblings of Prob-NIDDM-(AER+) than in siblings of Prob-NIDDM-(AER-) [median = 13.5 (range 0.5-148) vs 6.6 (range 1-17) micrograms/min (p0.05)]. In conclusion higher rates of albumin excretion aggregate in Caucasian families with NIDDM. Proliferative retinopathy is more frequently observed in families showing a clustering of AER+ and NIDDM. These findings suggest that familial factors play a role in the pathogenesis of renal and retinal complications in NIDDM.

Published
1997

16. Prevalence and natural history of hepatitis C infection in patients cured of childhood leukemia

Author

Locasciulli, A., Testa, M., PATRIZIA PONTISSO, Benvegnù, L., Fraschini, D., Corbetta, A., Noventa, F., Masera, G., and Alberti, A.

Subjects
Adult, Male, Adolescent, Genotype, Immunology, virus diseases, Alanine Transaminase, Hepacivirus, Cell Biology, Hematology, Hepatitis C Antibodies, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Hepatitis C, Biochemistry, digestive system diseases, Italy, Child, Preschool, Prevalence, Humans, RNA, Viral, Female, Prospective Studies, Viremia, Biomarkers, Follow-Up Studies
Abstract

The aim of this study was to ascertain prevalence and natural history of hepatitis C virus (HCV) infection in a large cohort of patients cured of childhood leukemia who had been followed prospectively for liver disease for at least 10 years since chemotherapy withdrawal: 114 consecutive patients entered the study. Liver function tests and ultrasonography were used to assess presence of liver disease. Patients were tested for antibody to HCV and for serum HCV-RNA at the end of chemotherapy and at the end of follow-up. At chemotherapy withdrawal, 56 patients (49%) were HCV-RNA positive, often without detectable anti-HCV, and in these cases, transaminase levels were more elevated during (P = .08) and after (P = .04) chemotherapy compared with HCV-RNA negative cases. Patients were then followed-up 13 to 27 years (mean, 17) after chemotherapy withdrawal. During this period, 38 initially anti-HCV negative patients seroconverted to anti-HCV and 17 initially anti-HCV positive cases lost reactivity. Forty patients were persistently HCV-RNA positive in serum, while 16 initially viremic patients became HCV-RNA negative during follow-up. At the end of the observation period, a persistent transaminase elevation was detected only in four HCV-RNA positive and anti-HCV positive cases, while no patient developed signs or symptoms of decompensated liver disease. Thus, hepatitis C was a frequent finding in long-term survivors after chemotherapy. It was associated with an atypical serologic profile and did not cause severe liver impairment over a period of 13 to 27 years.

Published
1997

17. HCV GENOTYPES IN ITALIAN PATIENTS WITH CHRONIC HCV INFECTION: A PROSPECTIVE MULTICENTRE STUDY

Author

Noventa, F, Urso, M, Ascione, A, Cavinato, F, Bonino, F, Caporaso, N, Romeo, R, Fuschi, P, Donada, C, Francavilla, A, Urban, F, Tarsetti, F, Fopntana, L, Gentilini, P, Giusti, G, Empini, S, Laghi, V, Artini, M, Brillanti, S, Caredda, F, Maselli, R, De Mitri, S, Deriu, U, Romeo, F, Vandelli, C, Colombo, M, Miglioli, M, Loroni, M, Pontisso, Patrizia, and Alberti, A.

Published
1996

18. HEPATITIS C: DIAGNOSIS AND THERAPY

Author

Alberti, A, Chemello, L, Pontisso, Patrizia, Cavalletto, L, Benvegnu', Luisa, Bernardinello, E, DE SALVO GL, and Noventa, F.

Published
1996

25. Survival and prognostic indicators in cryptogenic compensated cirrhosis

Author

Fattovich, Giovanna, Giustina, G., Degos, F., Tremolada, F., Diodati, G., Almasio, P., Solinas, A., Thomas, H. C., Brouwer, J. T., Nevens, F., Njapoum, C., Bonetti, P., Casarin, C., Fuschi, P., Tocco, A., Noventa, F., and Realdi, G.

Subjects
cirrhosis, prognosis, survival
Published
1995

27. Mortality and morbidity in cryptogenic (type C) compensated cirrhosis: a multicenter study

Author

Fattovich, Giovanna, Giustina, G., Degos, F., Tremolada, F., Diodati, G., Almasio, P., Nevens, F., Solinas, A., Mura, D., Brouwer, J. T., Thomas, H. C., Njapoum, C., Bonetti, P., Casarin, C., Fuschi, P., Basho, J., Tocco, A., Bhalla, A., Galassini, R., Noventa, F., Schalm, S. W., and Realdi, G.

Subjects
cirrhosis, morbidity, mortality
Published
1995

46. Natural history of cirrhosis due to virus

Author

Realdi, G, Fattovich, Giovanna, Alberti, A, Bortolotti, F, Noventa, F, and Tremolada, F.

Subjects
Viral hepatitis, cirrhosis, clinical course
Published
1987

50. Determinants of disease activity and evolution of chronic hepatitis type B

Author

Realdi, G., Fattovich, G., Noventa, F., Boscaro, S., and ALFREDO ALBERTI

Subjects
Hepatitis B virus, Hepatitis B Surface Antigens, Cytopathogenic Effect, Viral, chronic hepatitis B, prognostic factors, clinical course, DNA, Viral, Humans, Alanine Transaminase, Hepatitis B, Virus Replication, Follow-Up Studies
Published
1987

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