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Your search keyword '"Nowicka, Zuzanna"' showing total 4 results
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4 results on '"Nowicka, Zuzanna"'

1. Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy

Author

Widmer, Carmen A, Klebic, Ismar, Domanitskaya, Natalya, Decollogny, Morgane Francine, Howald, Denise, Siffert, Myriam, Essers, Paul, Nowicka, Zuzanna, Stokar-Regenscheit, Nadine, van de Ven, Marieke, de Korte-Grimmerink, Renske, Galván, José A, Pritchard, Colin E.J., Huijbers, Ivo J, Fendler, Wojciech, Vens, Conchita, and Rottenberg, Sven

Subjects
630 Agriculture
Published
2022
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2. Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining

Author

Francica, Paola, Mutlu, Merve, Blomen, Vincent A, Oliveira, Catarina, Nowicka, Zuzanna, Trenner, Anika, Gerhards, Nora M, Bouwman, Peter, Stickel, Elmer, Hekkelman, Maarten L, Lingg, Lea, Klebic, Ismar, van de Ven, Marieke, de Korte-Grimmerink, Renske, Howald, Denise, Jonkers, Jos, Sartori, Alessandro A, Fendler, Wojciech, Chapman, J Ross, Brummelkamp, Thijn, Rottenberg, Sven, University of Zurich, and Rottenberg, Sven

Subjects
Mice, DNA End-Joining Repair, lcsh:Biology (General), 630 Agriculture, 1300 General Biochemistry, Genetics and Molecular Biology, 10061 Institute of Molecular Cancer Research, DNA Helicases, Animals, Humans, 570 Life sciences, biology, 610 Medicine & health, lcsh:QH301-705.5
Abstract

Summary: Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage response genes and members of the recently identified shieldin and CTC1-STN1-TEN1 (CST) complexes. We show that ERCC6L2 contributes to non-homologous end joining (NHEJ), and it may exert this function through interactions with SFPQ. In addition to causing radiosensitivity, ERCC6L2 loss restores DNA end resection and partially rescues homologous recombination (HR) in BRCA1-deficient cells. As a consequence, ERCC6L2 deficiency confers resistance to poly (ADP-ribose) polymerase (PARP) inhibition in tumors deficient for both BRCA1 and p53. Moreover, we show that ERCC6L2 mutations are found in human tumors and correlate with a better overall survival in patients treated with radiotherapy (RT); this finding suggests that ERCC6L2 is a predictive biomarker of RT response.

Published
2020
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4. Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining

Author

Franica, Paola, Mutlu, Merve, Blomen, Vincent A., Oliveira, Catarina, Nowicka, Zuzanna, Trenner, Anika, Gerhards, Nora M., Bouwman, Peter, Stickel, Elmer, Hekkelman, Maarten L., Lingg, Lea, Klebic, Ismar, Van Den Ven, Marieke, De Korte-Grimmerink, Renske, Howald, Denise, Jonkers, Jos, Sartori, Alessandro A., Fendler, Wojciech, Chapman, J. Ross, Brummelkamp, Thijn, and Rottenberg, Sven

Subjects
630 Agriculture, 570 Life sciences, biology, 610 Medicine & health, 3. Good health

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