6 results on '"Nuño,L"'
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2. Methamphetamine use in chemsex and its consequences on mental health: a descriptive study,Uso de metanfetamina en el contexto chemsex y sus consecuencias en la salud mental: un estudio descriptivo
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Gavín, P., Arbelo, N., Monràs, M., Nuño, L., Bruguera, P., La Mora, L., Martínez-Rebollar, M., Laguno, M., Blanch, J., and Miquel, L.
3. [Detection and registration of alcohol use in the emergency department]
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Bruguera P, Barrio P, Oliveras C, Vázquez M, Soler V, Nuño L, Eduard Vieta, and Gual A
4. Maternal Satisfaction with Healthcare after Perinatal Loss in Monochorionic Twin Pregnancy
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Druguet, Mònica, Nuño Gómez, Laura, Rodó, Carlota, Arévalo, Silvia, Carreras Moratonas, Elena, Gómez-Benito, Juana, Universitat Autònoma de Barcelona, [Druguet M] Quantitative Psychology Unit, Faculty of Psychology, University of Barcelona, Barcelona, Spain. [Nuño L] Quantitative Psychology Unit, Faculty of Psychology, University of Barcelona, Barcelona, Spain. Clinical Institute of Neuroscience (ICN), Hospital Clinic, Barcelona, Spain. [Rodó C, Arévalo S, Carreras E] Medicina Maternal I Fetal, Servei d’ Obstetrícia, Hospital Universitari Vall d’Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Gómez-Benito J] Quantitative Psychology Unit, Faculty of Psychology, University of Barcelona, Barcelona, Spain. Group on Measurement Invariance and Analysis of Change (GEIMAC), Institute of Neurosciences, University of Barcelona, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Fetus - Mort ,Embaràs ,lcsh:Medicine ,0302 clinical medicine ,Pregnancy ,Assistència sanitària ,Health care ,grief ,030212 general & internal medicine ,Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, Diseases::Anemia, Neonatal::Fetofetal Transfusion [DISEASES] ,Depression (differential diagnoses) ,monochorionic pregnancy ,media_common ,Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Perinatal Death [DISEASES] ,Fetal surgery ,education.field_of_study ,fetal surgery ,Health Care Quality, Access, and Evaluation::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Patient Satisfaction [HEALTH CARE] ,030219 obstetrics & reproductive medicine ,Medical care ,psychological difficulties ,Monochorionic pregnancy ,General Medicine ,Psychological difficulties ,Test (assessment) ,Perinatal loss ,Maternal satisfaction ,professional care ,Anxiety ,medicine.symptom ,medicine.medical_specialty ,Pacients - Satisfacció ,media_common.quotation_subject ,Population ,Affect (psychology) ,Article ,03 medical and health sciences ,medicine ,enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacido::anemia neonatal::transfusión fetofetal [ENFERMEDADES] ,perinatal loss ,education ,Professional care ,enfermedades de los genitales femeninos y complicaciones del embarazo::complicaciones del embarazo::muerte perinatal [ENFERMEDADES] ,business.industry ,lcsh:R ,Beck Depression Inventory ,Family medicine ,maternal satisfaction ,Fetus - Nutrició ,Grief ,calidad, acceso y evaluación de la atención sanitaria::calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::mecanismos de evaluación de la atención sanitaria::satisfacción del paciente [ATENCIÓN DE SALUD] ,business - Abstract
Introduction: The analysis of patients&rsquo, satisfaction with healthcare is recognised as being useful in the evaluation of health outcomes and perceived quality of care. Little is known, however, about how the psychological status of women who experience perinatal complications may affect their perceived satisfaction with care. Methods: We assessed healthcare satisfaction in 52 women who had undergone intrauterine surgery during a complicated monochorionic twin pregnancy and examined the influence that fetal loss and sociodemographic, clinical, and psychological factors had on the degree of satisfaction. Data were gathered in an individual interview and through the administration of the Medical Patient Satisfaction Questionnaire, Beck Depression Inventory, and State&ndash, Trait Anxiety Inventory. Relationships between variables were analysed using a chi-square test, Spearman&rsquo, s rho, Student&rsquo, s t test, and the Mann&ndash, Whitney U test, in accordance with the metric nature of the variables and the assumptions fulfilled. Results: Age and level of education were not associated with the degree of healthcare satisfaction. Negative but non-significant correlations were observed between the level of satisfaction and symptoms of anxiety and depression. Satisfaction with healthcare was high in the sample as a whole, although it was significantly higher among women who had not experienced fetal loss. There were no differences in satisfaction with services involving direct contact with medical staff, whereas satisfaction with indirect services was lower among women who had experienced perinatal loss. Conclusions: Due to the unique characteristics of this population, specialised care teams of both professional healthcare and indirect services are needed. Although administrative aspects of healthcare are regarded as being of secondary importance, this may not be the case with more vulnerable populations.
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- 2019
5. Clinical spectrum time course in anti jo-1 positive antisynthetase syndrome: Results from an international retrospective multicenter study
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Cavagna L., Nuno L., Scire C. A., Govoni M., Longo F. J. L., Franceschini F., Neri R., Castaneda S., Giraldo W. A. S., Caporali R., Iannone F., Fusaro E., Paolazzi G., Pellerito R., Schwarting A., Saketkoo L. A., Ortego-Centeno N., Quartuccio L., Bartoloni E., Specker C., Murcia T. P., La Corte R., Furini F., Foschi V., Corral J. B., Airo P., Cavazzana I., Martinez-Barrio J., Hinojosa M., Giannini M., Barsotti S., Menke J., Triantafyllias K., Vitetta R., Russo A., Bajocchi G., Bravi E., Barausse G., Bortolotti R., Selmi C., Parisi S., Montecucco C., Gonzalez-Gay M. A., Rosenthal K., Cavagna, L, Nuno, L, Scire, C, Govoni, M, Longo, F, Franceschini, F, Neri, R, Castaneda, S, Giraldo, W, Caporali, R, Iannone, F, Fusaro, E, Paolazzi, G, Pellerito, R, Schwarting, A, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Bartoloni, E, Specker, C, Murcia, T, La Corte, R, Furini, F, Foschi, V, Corral, J, Airo, P, Cavazzana, I, Martinez-Barrio, J, Hinojosa, M, Giannini, M, Barsotti, S, Menke, J, Triantafyllias, K, Vitetta, R, Russo, A, Bajocchi, G, Bravi, E, Barausse, G, Bortolotti, R, Selmi, C, Parisi, S, Montecucco, C, Gonzalez-Gay, M, Rosenthal, K, AENEAS (American, European NEtwork of Antisynthetase Syndrome) collaborative group, [Cavagna,L, Caporali,L, Montecucco,C] Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy. [Nuño,L] Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain. [Scire,CA] Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy. [Govoni ,M, Furini,F, La Corte,R, Foschi,V] UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy. [Lopez Longo.FJ, Martínez-Barrio,J, Hinojosa,M] Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Franceschini,F, Airó,P, Cavazzana,I] Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy. [Neri,R, Barsotti,S] Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. [Castañeda,S] Department of Rheumatology, Hospital Universitario de la Princesa, IIS Princesa, Madrid, Spain.[Sifuentes Giraldo,WA, Bachiller Corral,AJ] Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain. [Iannone,F] Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy. [Fusaro,E, Parisi,S] Department of Rheumatology, Città Della Salute e della Scienza, Torino, Italy. [Paolazzi,G, Barausse,G, Bortolotti,R] Rheumatology Unit, Santa Chiara Hospital, Trento, Italy. [Pellerito,R, Vitetta,R, Russo,A] Division of Rheumatology, Mauriziano Hospital, Turin, Italy. [Schwarting,A, Menke,J] Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany. [Saketkoo,LA] Tulane University Lung Center Tulane/UMC Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, USA. [Ortego-Centeno,N] Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain. [Quartuccio,L] Santa Maria della Misericordia Hospital, Udine, Italy. [Bartoloni,E] Clinic of Rheumatology, Department of Medical and Biological Sciences. Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy. [Specker,C] Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany. [Pina Murcia,T, and González-Gay,MA] Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain. [Triantafyllias,K] ACURA Rheumatology Center, Bad Kreuznach, Germany. [Bajocchi,G] Rheumatology Unit, Department of Internal Medicine, S. Maria Hospital—IRCCS, Reggio Emilia, Italy. [Bravi,E] Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy. [Selmi,C] Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milano, Italy.
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Male ,Pathology ,Neurology ,Anti Jo-1 ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings] ,Medizin ,Arthritis ,Antisynthetase syndrome ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Antinuclear ,Masculino ,Myositis ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,Medicine (all) ,Interstitial lung disease ,Femenino ,General Medicine ,Middle Aged ,Diseases::Musculoskeletal Diseases::Muscular Diseases::Myositis [Medical Subject Headings] ,Humanos ,Anticuerpos antinucleares ,Antibodies, Antinuclear ,Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis [Medical Subject Headings] ,Female ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Antibodies, Antinuclear [Medical Subject Headings] ,Adult ,medicine.medical_specialty ,Check Tags::Male [Medical Subject Headings] ,Antibodies ,NO ,Estudios retrospectivos ,Internal medicine ,medicine ,Humans ,Risk factor ,Aged ,Retrospective Studies ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Artritis ,business.industry ,Retrospective cohort study ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Anti Jo-1, Antisynthetase Syndrome ,medicine.disease ,Dermatology ,Rheumatology ,Check Tags::Female [Medical Subject Headings] ,Miositis ,antisynthetase syndrome ,business - Abstract
Anti Jo-1 antibodies are the main markers of the antisynthetase syndrome (ASSD), an autoimmune disease clinically characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). These manifestations usually co-occur (for practical purpose complete forms) in the same patient, but cases with only 1 or 2 of these findings (for practical purpose incomplete forms) have been described. In incomplete forms, the ex novo occurrence of further manifestations is possible, although with frequencies and timing not still defined. The aim of this international, multicenter, retrospective study was to characterize the clinical time course of anti Jo-1 positive ASSD in a large cohort of patients. Included patients should be anti Jo-1 positive and with at least 1 feature between arthritis, myositis, and ILD. We evaluated the differences between complete and incomplete forms, timing of clinical picture appearance and analyzed factors predicting the appearance of further manifestations in incomplete ASSD. Finally, we collected 225 patients (58 males and 167 females) with a median follow-up of 80 months. At the onset, complete ASSD were 44 and incomplete 181. Patients with incomplete ASSD had frequently only 1 of the classic triad findings (110 cases), in particular, isolated arthritis in 54 cases, isolated myositis in 28 cases, and isolated ILD in 28 cases. At the end of follow-up, complete ASSD were 113, incomplete 112. Only 5 patients had an isolated arthritis, only 5 an isolated myositis, and 15 an isolated ILD. During the follow-up, 108 patients with incomplete forms developed further manifestations. Single main feature onset was the main risk factor for the ex novo appearance of further manifestation. ILD was the prevalent ex novo manifestation (74 cases). In conclusion, ASSD is a condition that should be carefully considered in all patients presenting with arthritis, myositis, and ILD, even when isolated. The ex novo appearance of further manifestations in patients with incomplete forms is common, thus indicating the need for an adequate clinical and instrumental follow-up. Furthermore, the study clearly suggested that in ASSD multidisciplinary approach involving Rheumatology, Neurology, Pneumology, and Internal Medicine specialists is mandatory. CA extern
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- 2015
6. The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis
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Dora Pascual-Salcedo, Ana M. Ortiz, Miguel A. López-Nevot, María Francisca González-Escribano, Laura Nuño, Isidoro González-Álvaro, Javier Martin, Blanca Rueda, Amalia Lamana, Alejandro Balsa, María Eugenia Miranda-Carús, [Lamana,A, Ortiz,AM, González-Álvaro,I] Rheumatology Service, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain. [Balsa,A, Nuño,L, Miranda-Carus,ME] Rheumatology Service, Hospital Universitario La Paz, IdiPaz, Instituto de Investigación Sanitaria La Paz, Madrid, Spain. [Rueda,B] Departamento de Enfermería, Facultad de Ciencias de la Salud, Universidad de Granada, Granada, Spain. [Gonzalez-Escribano,MF] Immunology Service, Hospital Universitario Virgen del Rocio, Sevilla, Spain. [Lopez-Nevot,MA] Immunology Service, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Pascual-Salcedo,D] Immunology Service, Hospital Universitario La Paz, IdiPaz, Instituto de Investigación Sanitaria La Paz, Madrid, Spain. [Martin,J] Instituto de Parasitología y Biomedicina Lopez Neyra, CSIC, Granada, Spain, This work was partially supported by the RETICS (Redes Tematicas de Investigación Cooperativa, Cooperative Research Thematic Networks) Program, RD08/0075 (RIER) and FIS (Fondo de Investigación en Salud) Health Research Fund grant FIS 08/0754 to IG-A from Instituto de Salud Carlos III (ISCIII, and UAM. Departamento de Medicina
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Male ,PTPN22 protein, human ,Arthritis ,lcsh:Medicine ,Genome-wide association study ,Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Gastroenterology ,Severity of Illness Index ,Genetics of the immune system ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Disability Evaluation ,Mediana Edad ,Human genetics ,Polymorphism (computer science) ,Genotype ,Genetics of the Immune System ,Longitudinal Studies ,lcsh:Science ,skin and connective tissue diseases ,Genetics of disease ,Multidisciplinary ,Adulto ,Confounding ,Middle Aged ,STAT4 Transcription Factor ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Disability Evaluation [Medical Subject Headings] ,Rheumatoid arthritis ,Observational Studies ,Medicine ,Evaluación de la Discapacidad ,Female ,Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 Chains [Medical Subject Headings] ,Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings] ,Alelos ,Research Article ,musculoskeletal diseases ,Adult ,medicine.medical_specialty ,Medicina ,Clinical Research Design ,Disabilities ,Anciano ,Índice de Severidad de la Enfermedad ,Predisposición Genética a la Enfermedad ,Check Tags::Male [Medical Subject Headings] ,Rheumatoid Arthritis ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::STAT Transcription Factors::STAT4 Transcription Factor [Medical Subject Headings] ,Factor de Transcripción STAT4 ,Polymorphism, Single Nucleotide ,Autoimmune Diseases ,PTPN22 ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings] ,Rheumatology ,Internal medicine ,medicine ,Genetics ,Named Groups::Persons::Age Groups::Adult [Medical Subject Headings] ,Humans ,Genetic Predisposition to Disease ,Allele ,Polymorphism ,Variant genotypes ,Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,Biology ,Alleles ,Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings] ,Aged ,Clinical Genetics ,Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings] ,Artritis ,business.industry ,lcsh:R ,Personalized Medicine ,Protein Tyrosine Phosphatase, Non-Receptor Type 22 ,medicine.disease ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Index [Medical Subject Headings] ,Check Tags::Female [Medical Subject Headings] ,Immunology ,Genetic Polymorphism ,lcsh:Q ,Clinical Immunology ,Polimorfismo de Nucleótido Simple ,business ,Genotipo ,Population Genetics ,HLA-DRB1 Chains ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Protein Tyrosine Phosphatases::Protein Tyrosine Phosphatases, Non-Receptor::Protein Tyrosine Phosphatase, Non-Receptor Type 22 [Medical Subject Headings] - Abstract
Background: The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the effects of these genetic variants on disease activity and disability in patients with early arthritis. Methodology and Results: We studied 640 patients with early arthritis (76% women; median age, 52 years), recording disease-related variables every 6 months during a 2-year follow-up. HLA-DRB1 alleles were determined by PCR-SSO, while rs7574865 and rs2476601 were genotyped with the Taqman 5′ allelic discrimination assay. Multivariate analysis was performed using generalized estimating equations for repeated measures. After adjusting for confounding variables such as gender, age and ACPA, the TT genotype of rs7574865 in STAT4 was associated with increased disease activity (DAS28) as compared with the GG genotype (β coefficient [95% confidence interval] = 0.42 [0.01-0.83], p = 0.044). Conversely, the presence of the T allele of rs2476601 in PTPN22 was associated with diminished disease activity during follow-up in a dose-dependent manner (CT genotype = -0.27 [-0.56- -0.01], p = 0.042; TT genotype = -0.68 [-1.64- -0.27], p = 0.162). After adjustment for gender, age and disease activity, homozygosity for the T allele of rs7574865 in STAT4 was associated with greater disability as compared with the GG genotype. Conclusions: Our data suggest that patients with early arthritis who are homozygous for the T allele of rs7574865 in STAT4 may develop a more severe form of the disease with increased disease activity and disability. © 2012 Lamana et al.
- Published
- 2012
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