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111 results on '"O-Desmethyltramadol"'

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1. Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6‐Mediated Drug‐Drug Interactions on Tramadol and O‐Desmethyltramadol Exposures via Allosteric and Competitive Inhibition

2. Automated high‐throughput analysis of tramadol and O‐desmethyltramadol in dried blood spots

3. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1–3 and Human Plasma Membrane Monoamine Transporter

4. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter

5. Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR

6. Intrinsic clearance rate of O-desmethyltramadol (M1) by glucuronide conjugation and phase I metabolism by feline, canine and common brush-tailed possum microsomes

7. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

8. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

9. Simultaneous electrochemical detection of tramadol and O-desmethyltramadol with Nafion-coated tetrahedral amorphous carbon electrode

10. HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study

11. Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling

12. Pharmacokinetic properties of tramadol and M1 metabolite in Northeast Brazilian donkeys (Equus asinus)

13. Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies

14. Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

15. Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs

16. On the sulfation of O -desmethyltramadol by human cytosolic sulfotransferases

17. Intracerebral microdialysis coupled to LC-MS/MS for the determination tramadol and its major pharmacologically active metaboliteO-desmethyltramadol in rat brain microdialysates

18. Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and O-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling

19. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

20. Quantitation of the enantiomers of tramadol and its three main metabolites in human whole blood using LC–MS/MS

21. Non-Medical Use of Novel Synthetic Opioids: A New Challenge to Public Health

22. Tramadol in the elderly : pharmacokinetic and pharmacodynamic modelling in healthy young and elderly subjects

23. First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose

24. Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects

25. PHARMACOKINETICS OF TRAMADOL HYDROCHLORIDE AND ITS METABOLITE O-DESMETHYLTRAMADOL FOLLOWING A SINGLE, ORALLY ADMINISTERED DOSE IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS)

26. Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

27. OCT1 pharmacogenetics in pain management: is a clinical application within reach?

28. Enantiomeric separation of tramadol and Its metabolites: method validation and application to environmental samples

29. Effects of age on the pharmacokinetics of tramadol and its active metabolite,O-desmethyltramadol following intravenous administration to foals

30. µ-Opioid receptor activation by tramadol and O-desmethyltramadol (M1)

31. Analysis of tramadol and O -desmethyltramadol in decomposed skeletal tissues following acute and repeated tramadol exposure by gas chromatography mass spectrometry

33. PHARMACOKINETICS OF TRAMADOL AND ITS PRIMARY METABOLITE O-DESMETHYLTRAMADOL IN AFRICAN PENGUINS (SPHENISCUS DEMERSUS)

34. Comprehensive quantum chemical and spectroscopic (FTIR, FT-Raman, 1H, 13C NMR) investigations of O-desmethyltramadol hydrochloride an active metabolite in tramadol – An analgesic drug

35. Inhibition byO-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal substantia gelatinosa neurons

36. Simultaneous Determination of Tramadol and O-Desmethyltramadol in Human Plasma Using HPLC–DAD

37. Postmortem Redistribution of Tramadol and O-Desmethyltramadol

38. Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography–mass spectrometry

39. Simultaneous quantification of tramadol andO-desmethyltramadol in hair samples by gas chromatography-electron impact/mass spectrometry

40. SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

41. Application of Mass Spectrometry for Analysis of Biologically Active and Clinically Significant Compounds

42. Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC–MS/MS: Application to clinical pharmacokinetics

43. Pharmacokinetics of tramadol and metabolites O-desmethyltramadol and N-desmethyltramadol in adult horses

44. Oral co-administration of fluconazole with tramadol markedly increases plasma and urine concentrations of tramadol and the O-desmethyltramadol metabolite (M1) in healthy dogs

45. Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics

46. Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

47. LC Determination of Tramadol, M1, M2, M4, and M5 in Plasma

48. Evaluation of tramadol and its main metabolites in horse plasma by high-performance liquid chromatography/fluorescence and liquid chromatography/electrospray ionization tandem mass spectrometry techniques

49. Determination of tramadol and O-desmethyltramadol in human plasma by high-performance liquid chromatography with mass spectrometry detection

50. Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration

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