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The aim of this study is to provide an overview of the geographical distribution of Ascariasis, Amebiasis and Giardiasis, and to identify specific geographical, socioeconomic and environmental factors that are associated with the incidence of these infections in Mexican children. We made use of publicly available data that was reported by federal organizations in Mexico for the year 2010. The contribution of geographical, socioeconomic and environmental factors to the incidence of infections was assessed by a multivariable regression model using a backwards selection procedure. A. lumbricoides incidence was associated with mean minimum temperature of the state, the state-wide rate of households without access to piped water and toilet, explaining 77% of the incidence of A. lumbricoides infections. Mean minimum precipitation in the state, the rate of households without access to a toilet, piped water and sewage system best explained (73%) the incidence of E. histolytica infections. G. lamblia infections were only explained by the latitude of the state (11%). In addition to the well-known socioeconomic factors contributing to the incidence of A. lumbricoides and E. histolytica we found that temperature and precipitation were associated with higher risk of infection.

The nutrient adequacy of a diet is typically assessed by comparing estimated nutrient intakes with established average nutrient requirements, this approach does not consider total energy consumed. In this multinational survey investigation in Indonesia, Mexico, and South Africa, we explore the applications of the “critical nutrient-density approach”—which brings energy requirements into the equation—in the context of public health epidemiology. We conducted 24 h dietary recalls in convenience samples of normal-weight (BMI 18.5–25 kg/m2) or obese (BMI &gt, 30 kg/m2), low-income women in three settings (n = 290). Dietary adequacy was assessed both in absolute terms and using the nutrient density approach. No significant differences in energy and nutrient intakes were observed between normal-weight and obese women within any of the three samples (p &gt, 0.05). Both the cut-point method (% of EAR) and critical nutrient density approach revealed a high probability of inadequate intakes for several micronutrients but with poor concordance between the two methods. We conclude that it may often require some approximate estimate of the habitual energy intake from an empirical source to apply a true critical nutrient density reference for a population or subgroup. This will logically signify that there would be more “problem nutrients” in the diets examined with this nutrient density approach, and efforts toward improved food selection or food- or biofortification will frequently be indicated.

OBJECTIVES: To evaluate the relationship between food insecurity, food environment and obesity in school-aged children in Queretaro. METHODS: In this cross-sectional study, weight, height and body fat % (BF%) were measured in 122 school-aged children (8.1 ± 1.5 y) from an urban area in Queretaro, Mexico. Additionally, household food insecurity was assessed using the Latin American and Caribbean Food Security Scale (ELCSA). Geolocation data of both food establishments (FE) and participants’ households (HH) were collected and uploaded into a GIS database. The distance to the closest FE within a 300 m radius from each participant's household was calculated using GIS. FE were categorized as follows: (1) FEPF, which mainly sold processed foods (e.g., convenient stores); and (2) FEnPF, which mainly sold non-processed foods (e.g., fruterías – only fruits and vegetables). Univariate analysis was used to assess the interaction of BF%, food insecurity and FE categories using SPSS v23.0. RESULTS: Almost half of the children showed high BF% (48%), while 43% lived in HH with some degree of food insecurity. Children in moderately/severely food insecure HH and who lived close to FEnPF had significantly lower BF% (18.9 ± 4.7%), compared to children in food secure HH (24.4 ± 2.5%) or HH experiencing mild food insecurity (25.0 ± 2.6%) (P

In Mexico, data from the last National Health and Nutrition Survey (2016) described the increase in the prevalence of overweight and obesity in school-aged children (33.2%). Obesity prevention strategies have not been effective, and currently, Mexico has one of the highest prevalence of childhood obesity. Thus, there is an urgent need to develop strategies that can prevent childhood obesity and also to avoid these children to remain overweight/obese through adulthood. The objective of this study was to provide a step-by-step description of the design, implementation and evaluation of an intervention plan for Mexican mothers of school aged children to promote healthy eating and to prevent childhood obesity. The program Niño Sano Adulto Sano was developed using the Intervention Mapping Approach and the Social Cognitive Theory frameworks to provide Mexican mothers with knowledge and skills to positively modify their children's food behavior, thus preventing future weight gain. The program was developed, piloted and delivered to the target population with positive results on the mothers' nutrition knowledge and children's BMI. Intervention Mapping and Social Cognitive Theory are useful models to design and deliver an intervention that provides a holistic approach to promote healthy eating.

Supplemental Material, sj-pdf-1-fnb-10.1177_03795721211033146 for Proximity and High Density of Convenience Stores Was Associated With Obesity in Children of a Rural Community of Mexico: Using a Geographic Information System Approach by Zavala Gerardo Antonio, Tenorio-Palos Yessica, Campos-Ponce Maiza, Elton-Puente Juana Elizabeth, López-González Carlos Alberto, Doak Colleen M, Rosado Jorge L and García Olga P in Food and Nutrition Bulletin

Background: Differences in gut microbiota composition have been associated with obesity and metabolic alterations in children. The aim of this study was to analyze the abundance of the main bacterial families of the gut among children according to their body composition and metabolic markers. Methods: A cross-sectional study was conducted with 93 school-aged children (8.4 ± 1.6 years old). Anthropometric and body composition variables were measured and a blood sample was collected to determine glucose, insulin, lipid profile, C-reactive protein, leptin, and cytokines [interleukin 6, interleukin 10 (IL-10), tumor necrosis factor α (TNFα)]. DNA was extracted from stool samples and the abundance of bacterial families (Bacteroidaceae-Porphyromonadaceae-Prevotellaceae, Lactobacillaceae, Enterococcaceae, and Lachnospiraceae-Ruminococcaceae) was determined by qPCR assays. Results: Children with obesity and high waist/height ratio had lower Bacteroidaceae-Porphyromonadaceae-Prevotellaceae and higher abundance of Lactobacillaceae when compared with normal-weight children. TNFα was negatively associated and IL-10 was positively associated with Bacteroidaceae-Porphyromonadaceae-Prevotellaceae. Triglycerides showed a positive relationship with Lachnospiraceae-Ruminococcaceae whereas high-density lipoprotein-cholesterol was negatively associated with Lactobacillaceae. Conclusion: In rural Mexican school-aged children, a low abundance of Bacteroidaceae-Porphyromonadaceae-Prevotellaceae and a high abundance of Lactobacillaceae are associated with obesity and metabolic disturbances.

OBJECTIVES: To evaluate the relationship between household food insecurity and food insecurity of the mothers during her childhood with cognitive function in school children in Querétaro. METHODS: A total of 153 children (6–10 y) of public elementary schools in the municipality of Querétaro participated in a cross-sectional study. Household food insecurity was measured using the ELCSA (Latin American and Caribbean Food Security Scale) and a validated questionnaire to measure food insecurity of the mother during her childhood. Anthropometric measurements (weight, height, waist circumference) were taken by standardized personnel and the WISC IV scale adapted to children for the determination of cognitive function was applied by trained psychologists. Statistical ANOVA tests were used to determine mean differences in cognitive function between children with and without food insecurity. A logistic regression was also calculated to determine the odds of having low cognitive function in the presence of food insecurity, both at the household level and of the mother during her childhood. All analyses were adjusted for maternal level of education as a confounder. RESULTS: The children had a combined prevalence of overweight and obesity of 39.9%. A total of 54.3% of the households had food insecurity and 80.4% of the mothers had food insecurity in their childhood. The prevalence of the average score of the Total Intelligence Quotient (TIQ) of the children was 52.3%, and 38.2% had TIQ below average. Children living in households with food insecurity and with mothers that had food insecurity in their past had lower TIQ (89.08 ± 8.23, and, 91.87 ± 11.18, respectively) compared with children in food secure households (95.39 ± 12.20) and with mothers that had food security in their childhood (96.87 ± 12.03). However, after adjusting for maternal level of education, no relationship was observed between food insecurity and TIQ. Similarly, the adjusted logistic regression model showed no relationship between food insecurity in the household and mother's food insecurity in the past with TIQ. CONCLUSIONS: In the present study, food insecurity was not related to cognitive function of school-aged children in Querétaro, Mexico. FUNDING SOURCES: Partially funded by CONACYT.

Hormony tarczycy (thyroid hormones, TH) są zaangazowane w wiele roznych procesow biologicznych, wliczając rozwoj ukladu nerwowego, regulacje metabolizmu pośredniego oraz zuzycie energii. Aktywnie uczestniczą w podstawowym zuzyciu energii i termogenezie adaptacyjnej i z tego wzgledu mogą miec wplyw na mase ciala w przebiegu chorob tarczycy. Otylośc to niezakaźna, przewlekla, zapalna choroba metaboliczna, ktora implikuje dodatni bilans energetyczny. Tkanka tluszczowa produkuje szereg hormonow i adipocytokin, takich jak leptyna, ktore mogą wplywac na stan tarczycy na roznych poziomach. Istnieją dowody na to, ze dysfunkcja tarczycy moze predysponowac do otylości i odwrotnie, istnieją dowody sugerujące, ze otylośc powoduje zmiany dotyczące tarczycy. Celem tej pracy bylo opisanie związku miedzy ukladem tarczycy a otylością. Ponadto w pracy zaprezentowano hipotetyczny model podkreślający znaczenie obwodowej dejodynacji hormonow tarczycy i jego role w ustanowieniu dodatniego bilansu energetycznego. Podsumowując, mozemy stwierdzic, ze relacja miedzy ukladem tarczycy a otylością i nadwagą jest zlozona i obejmuje wiele poziomow interakcji. Ponadto, poddając ocenie otylego pacjenta, powinno sie rozwazyc ocene funkcji tarczycy, aby uzyskac lepsze i spersonalizowane efekty leczenia.

Background: In developing countries, where energy-dense foods with low nutrient content are highly accessible, the fear of feeling hungry and the desire of prolonging satiation have been documented. Objective: To evaluate the role of valuation of eating and satiation in the relationship of food insecurity with diet, obesity, and cardiometabolic risk with structural equation modeling. Methods: A validated questionnaire that measures the value of eating and satiation (VES) as the basis of wealth was administered to 321 adult women from Queretaro, Mexico. Instruments for measurement of socioeconomic status, food insecurity, physical activity, and a semiquantitative food frequency questionnaire were also applied. Women were measured and weighed, and they provided a fasting blood sample to determine lipid profile, glucose, and insulin concentrations. Structural equation models were used for prediction of the homeostasis model assessment–insulin resistance (HOMA-IR) index and triglyceride/high-density lipoprotein (HDL) cholesterol index. Results: The models confirmed, with acceptable goodness-of-fit parameters, the mediation position of VES between past experiences of food insecurity and a greater intake of carbohydrates and its impact on obesity, and on the HOMA-IR and the triglyceride/HDL-cholesterol index. Conclusion: Experiences of food insecurity may increase VES in women and influence eating behavior, increasing intake of sugars and starches in their diet, thus increasing the risk of obesity and cardiometabolic diseases such as diabetes. The understanding of essential values that induce unfavorable eating behavior in a population that has experienced past food insecurity may help to develop public health strategies for prevention of cardiometabolic diseases.

OBJECTIVES: Evaluate the effect of the nutrition program Niño Sano, Adulto Sano (Healthy Child, Healthy Adult) on mother's nutrition knowledge and food practices. Also, to determine its effect on Body Mass Index (BMI) of both mothers and their children. METHODS: A total of 43 mothers (35 ± 5 y) and their school-aged children (9 ± 3 y) participated in a 6-month longitudinal controlled study. Participants were residents of two low income communities in Queretaro, Mexico. The program Niño Sano, Adulto Sano was developed using the Intervention Mapping Approach and Social Cognitive Theory and consisted on six nutrition education sessions (1 per month) and six cooking workshops. The control group received three sessions (1 every 2 months) of nutrition education following the Mexican Official Guidelines. Height and weight of mothers and children were taken at baseline and after 6 months to determine mother's BMI and children's BMI-for-age z-score following WHO procedures. Mothers answered a validated questionnaire that consisted of eight Likert-type questions to evaluate nutrition knowledge and food practices at the beginning and end of the study. The data was analyzed by T-student of dependent variables using SPSSv19. RESULTS: The combined prevalence of overweight and obesity at baseline was 88.3% and 51.4% for the mothers and their children, respectively. 47% of the children were girls. Mothers that participated in the nutrition program improved their nutrition related knowledge and food practices by 2.99 points (3.14, 95%CI: 1.21, 4.76; P = 0.0001) compared to the control group (1.27, 95%CI: 0.15, 2.39; P = 0.028). Children of the mothers that participated in the program significantly reduce their BMI for age by −0.27 units (0.30, 95%CI: 0.22, 0.39; P = 0.0001) compared with the control group (0.02, 95%IC: −0.11, 0.17 P = 0.70). No differences were observed between groups in the mothers’ BMI at the end of the study. CONCLUSIONS: The nutrition intervention Niño Sano, Adulto Sano improved nutrition knowledge and food practices of participating mothers, it reduced BMI for age a of their children, but had no effect on mother's BMI. FUNDING SOURCES: Fondo de Proyectos Especiales de Rectoría (FOPER) of the Universidad Autónoma de Querétaro.

Purpose Obesity and depression are among the leading causes of disability in Mexico, but their association has not been explored yet. The aim of the current study was to investigate the association between obesity and depression in Mexican population. Methods We used data from the health and nutrition survey (ENSANUT 2012), which is representative of the Mexican population. Obesity was determined using the body mass index (BMI) and abdominal obesity by measuring waist circumference. Depressive symptoms were reported using the Center for Epidemiological Studies Depression Scale Short-Form (CES-D-SF, scale 0–21). Regression analyses were performed between obesity and depression, adjusting for gender, age, living with a partner, education, and diabetes history. Results Obese women had 1.28 (95% CI 1.07–1.53) times the odds of having depression in comparison with normal-weight women, whereas no association was found for men (OR 0.94; 95% CI 0.74–1.19). A significant association between BMI and depressive symptoms score (β = 0.05, 95% CI 0.02–0.07) was present in women, but no association was found for men (β = − 0.02, 95% CI − 0.05 to 0.00). There was a statistically significant association between waist circumference and depression scores again for women (β = 0.03, 95% CI 0.01–0.04) but not for men (β = 0.00, 95% CI − 0.01 to 0.01). No associations were found between abdominal obesity and depression for both genders. No association was found between different obesity severity levels and depression for both genders. Conclusion Obesity was associated with depression in Mexican women, whereas no association was found between obesity and depression in men.

Chrononutrition, or the circadian timing of food intake, proposes that nutrients, bioactive compounds, and foods modulate the peripheral clocks with implications on health. We evaluated the effects of biscuits supplemented with the antioxidant dietary fiber isolated from spent coffee grounds as a food ingredient (SCF-B) or a combination of spent coffee grounds and fructooligosaccharides (SC-FOS-B), and a traditional recipe (TB, without added fiber) on the modulation of circadian rhythm in young adults. The repeated intake (21 days/45 g portion) of SCF-B or SC-FOS-B decreased (p < 0.05) the evening chronotypes. SCF-B and SC-FOS-B consumption enhanced the chronodisruption associated with colonic short chain fatty acid production, thus improving the quality and length of sleep. This is the first study on the positive impact of antioxidant dietary fiber obtained from spent coffee grounds on circadian activity improvement in young adults. Further clinical trials and the role of other bioactive compounds as therapeutic candidates for health disturbances related to circadian dysfunction are necessary to confirm the results., Author Karla Y. Oseguera Castro was supported by a scholarship from the Consejo Nacional de Ciencia y Tecnología (CONACYT-Mexico) [grant number 581700]. This study was supported by the National Council of Science and Technology (CONACyT) Project No. 242282, Fondo Mixto CONACYT-Gobierno del Estado de Querétaro QRO-2016-02-279751 and MINECO, Spain, Project SUSCOFFEE (AGL2014-57239-R).

Childhood overweight and obesity are worldwide public health problems and risk factors for chronic diseases. The presence of SNP in several genes has been associated with the presence of obesity. A total of 580 children (8–13 years old) from Queretaro, Mexico, participated in this cross-sectional study, which evaluated the associations of rs9939609 (fat mass obesity-associated (FTO)), rs17782313 (melanocortin 4 receptor (MC4R)) and rs6548238 (transmembrane protein 18 (TMEM18)) SNP with obesity and metabolic risk factors. Overweight and obesity prevalence was 19·8 and 19·1 %, respectively. FTO, MC4R and TMEM18 risk allele frequency was 17, 9·8 and 89·5 %, respectively. A significant association between FTO homozygous and MC4R heterozygous risk alleles and obesity was found (OR 3·9; 95 % CI 1·46, 10·22, and OR 2·1; 95 % CI 1·22, 3·71; respectively). The FTO heterozygous subjects showed higher systolic and diastolic blood pressures, compared with the homozygous for the ancestral allele subjects. These results remain significant after considering adiposity as a covariate. The FTO and MC4R genotypes were not significantly associated with total cholesterol, HDL-cholesterol and insulin concentration. No association was found between TMEM18 risk allele and obesity and/or metabolic alterations. Our results show that, in addition to a higher BMI, there is also an association of the risk genotype with blood pressure in the presence of the FTO risk genotype. The possible presence of a risk genotype in obese children must be considered to offer a more comprehensive therapeutic approach in order to delay and/or prevent the development of chronic diseases.

Background Effective treatment and prevention of obesity and its co-morbidities requires the recognition and understanding of cultural and social aspects of eating practices. The objective of the present study was to identify social factors and beliefs that may explain undesirable eating practices among women with high body mass index (HBMI) compared with normal-weight (NW) women from rural and urban areas classified as middle-low socioeconomic status (SES) in the State of Querétaro, Mexico. Methods A qualitative technique with individual in-depth interviews was used. Fifty-five women with either NW or HBMI from rural and urban areas participated in the study. The responses were analyzed by coding and grouping text fragments into categories in a data matrix, in order to make comparisons between BMI groups and between rural and urban women. Results The habit of skipping breakfast prevailed among women with HBMI who also reported childhood food deprivation. Feelings related to eating seemed to be more important than losing weight among women with HBMI from urban and rural areas. Thus, overweight might be interpreted as a social symbol of the enjoyment of a good life, primarily in rural areas. Overweight was socially accepted when it occurred in children and in married woman, mainly because it is a symbol of the good life that the head of the household provides, and also because women may feel more relaxed about their weight when they already have a partner. The study also revealed that women with HBMI were not sufficiently motivated to lose weight unless they experience a physical indication of poor health. Conclusion The findings from this study are helpful in the understanding of the reasons why strategies for the prevention and treatment of obesity may not be as effective as expected. The belief system of particular social groups within different SESs should be considered in order to understand the etiology of obesity and develop effective strategies.

The aim of the present study was to evaluate the synergic effect of lycopene (LYC) treatment with a dietary control in a nonalcoholic fatty liver disease (NAFLD) model induced with a high-fat diet (HFD). Sprague-Dawley rats were fed during 4 weeks with a normal diet (ND·4w) or an HFD (HFD·4w) to produce an NAFLD model. Then, rats from the ND·4w group continued during 4 weeks with the same diet (ND·8w), and rats from HFD were fed during 4 weeks with an ND (HFD·4w+ND·4w) or an ND plus LYC (HFD·4w+ND+LYC·4w). LYC (20 mg/kg) was administered daily by gavage. ND and ND+LYC diets partially reverted the following alterations due to HFD: liver weight, serum low-density lipoproteins (LDL), hepatic total cholesterol (TC), and catalytic activity of hepatic superoxide dismutase, catalase, and glutathione peroxidase, as well as macroscopic and microscopic images of livers. A higher recuperation to reach normality was obtained with ND+LYC in: liver weight, hepatic TC, serum LDL, and, in some instances, macroscopic and microscopic images of livers. Failures to recovery with both NDs were observed for malondialdehyde level and serum aspartate aminotransferase activity. Taken together, the results from this study suggest the potentially protective role of LYC against NAFLD; however, more clinical trials are needed to support this idea.

BACKGROUND: Intestinal parasites, virus and bacterial infections are positively associated with obesity and adiposity in vitro and in animal models, but conclusive evidence of this relationship in humans is lacking. The aim of this cross-sectional study was to determine differences in adiposity between infected and non-infected children, with a high prevalence of intestinal parasitic infection and obesity. SUBJECTS: A total of 296 school-aged children (8.0 ± 1.5 years) from a rural area in Queretaro, Mexico, participated in this study. Anthropometry (weight, height and waist circumference) and body fat (DXA) were measured in all children. A fresh stool sample was collected from each child and analysed for parasites. Questionnaires related to socioeconomic status and clinical history were completed by caretakers. RESULTS: Approximately 11% of the children were obese, and 19% were overweight. The overall prevalence of infection was 61%. Ascaris lumbricoides was the most prevalent soil transmitted helminth (16%) followed by hookworm. Entamoeba coli was the predominant protozoa (20%) followed by Endolimax nana, Balantidium coli, Entamoeba histolytica/dispar, Iodamoeba butschlii and Giardia lamblia. Children with moderate-heavy infection of E. coli had significantly higher waist circumference, waist-to-height ratio, body and abdominal fat than children not infected or with light-intensity infection (p

Infant formulas have been conventionally prepared with an excess of total protein in order to provide sufficient amounts of essential amino acids to the rapidly growing infant. However, this practice leads to higher than necessary protein intake during early infant development, inducing accelerated growth patterns correlated with the development of chronic diseases later in life. This study was aimed at assessing the safety of an infant formula enriched with bovine alpha-lactalbumin containing a total protein concentration very close to that of human milk, and determining its efficacy in the support of healthy infant growth from the first month to the fourth month of age. Healthy full-term infants &le, 40 days of age were randomized in this controlled single blind trial to one of the following infant formulas: IF 1 (containing 1.0 g protein/dL, n = 30), IF 2 (containing 1.3 g protein/dL, n = 24), and IF 3 (containing 1.5 g protein/dL, n = 42). A control group consisting of exclusively breastfed infants (HM, n = 212) was included in the study. Anthropometric measurements and Z-scores were evaluated at baseline, at 1 month of age, and at 4 months of age. Weight gain (g/day) was similar in the IF 1 and the HM groups (p = 0.644), and it was significantly greater in the IF 2 and IF 3 groups than in the HM group. Growth patterns in both breastfed or IF-fed infants were in accordance with the World Health Organization (WHO) growth standards. At four months of age, the mean weight-for-age Z-score (WAZ) adjusted for initial value in the IF 1 group was similar to that of the HM group and significantly lower than that of the IF 2 and IF 3 groups (p = 0.031 and p = 0.014 for IF 2 and IF 3, respectively). Length-for-age (LAZ) adjusted for initial value was similar among all groups at four months of age. From 1 to 4 months of life, IF 1 containing 1.0 g protein/dL promotes growth and weight gain similar to those observed in exclusively breastfed infants. As this is a first approach to studying an IF containing total protein in a level below that recommended by international committees on nutrition, further investigations are needed to support these findings evaluating infant&rsquo, s metabolic profile and growth in the long term.

The amount of lipids in a diet and their source are determining factors of the lipid profile. The purpose of this study was to evaluate the addition of six types of different commercial vegetable oils (avocado, canola, high oleic safflower, soybean, grape seed and partially hydrogenated vegetable oil) to the diet of Wistar rats at two different concentrations (14.4% and 25.6% of energy intake from each added oil) and check rats' tolerance and lipid profile effect following consumption for 5 weeks. Rats fed with soybean and avocado oils had significantly lower LDL (29.27 ±8.85 and 26.51±10.85 mg/dL, respectively) and total cholesterol values (48.10±11.41 and 45.83±5.78 mg/dL, respectively) vs. treatment with hydrogenated oil (p

Hormony tarczycy (thyroid hormones, TH) są zaangażowane w wiele różnych procesów biologicznych, wliczając rozwój układu nerwowego, regulację metabolizmu pośredniego oraz zużycie energii. Aktywnie uczestniczą w podstawowym zużyciu energii i termogenezie adaptacyjnej i z tego względu mogą mieć wpływ na masę ciała w przebiegu chorób tarczycy. Otyłość to niezakaźna, przewlekła, zapalna choroba metaboliczna, która implikuje dodatni bilans energetyczny. Tkanka tłuszczowa produkuje szereg hormonów i adipocytokin, takich jak leptyna, które mogą wpływać na stan tarczycy na różnych poziomach. Istnieją dowody na to, że dysfunkcja tarczycy może predysponować do otyłości i odwrotnie, istnieją dowody sugerujące, że otyłość powoduje zmiany dotyczące tarczycy. Celem tej pracy było opisanie związku między układem tarczycy a otyłością. Ponadto w pracy zaprezentowano hipotetyczny model podkreślający znaczenie obwodowej dejodynacji hormonów tarczycy i jego rolę w ustanowieniu dodatniego bilansu energetycznego. Podsumowując, możemy stwierdzić, że relacja między układem tarczycy a otyłością i nadwagą jest złożona i obejmuje wiele poziomów interakcji. Ponadto, poddając ocenie otyłego pacjenta, powinno się rozważyć ocenę funkcji tarczycy, aby uzyskać lepsze i spersonalizowane efekty leczenia.

AIMS: Evaluate associations between intestinal parasitic infection with intestinal and systemic inflammatory markers in school-aged children with high rates of obesity.METHODS AND RESULTS: Plasma concentrations of CRP, leptin, TNF-α, IL-6 and IL-10 were measured as systemic inflammation markers and count of stool leukocytes as marker of intestinal inflammation in 291 children (6-10y). Intestinal parasitic infection was measured by stool examination. Logistic regression analyses were performed to determine the odds of having high inflammatory markers for each parasite or group of parasites as compared to parasite-free children while adjusting for sex, age, mother educational level and % of body fat. The prevalence of soil transmitted helminths and intestinal protozoa infections was 12% and 36%, respectively. Parasitic infection was not associated with CRP, IL-6, IL-10 or TNF-α. Children infected with Ascaris lumbricoides (aOR: 5.91, 95%CI: 1.97-17.70) and Entamoeba coli (aOR: 8.46, 95%CI: 2.85-25.14) were more likely to have higher stool leucocytes than parasite-free children. Children with multiple-infections (aOR: 10.60, 95%CI: 2.85-25.14) were more likely to have higher leptin concentrations than parasite-free children.CONCLUSION: Intestinal parasitic infection was not associated with systemic inflammation, but was associated with intestinal inflammation. Having multiple-infections were associated with higher leptin concentrations. This article is protected by copyright. All rights reserved.

Qualitative research using semi-structured interviews and key informant interviews were used to explore how women from low socioeconomic rural households in Queretaro State, Mexico perceived and reacted to their obesogenic environment. Reduced availability of healthy food options and household financial constraints along with reduced agency of women in this setting were factors that limited women's ability to access and consume diets consistent with the promotion of good health. The cultural values that emphasised obesity as a desirable state for women and the women's social networks that promoted these values were also identified as playing a role in reinforcing certain behaviours. Public health advocates wanting to design interventions in such settings need to be sensitive to the cultural as well as the environmental context described for rural Mexican women.

OBJECTIVES: Determine the association between mothers’ perceived self-efficacy and nutrition practices with children's food consumption. METHODS: A total of 45 mothers of school-aged children were randomly selected from a low-income community in Queretaro, Mexico, to participate in this cross-sectional study. Mothers answered a validated questionnaire, consisting on eight Likert-type questions that evaluated nutrition practices, and four questions with a 10 to 100-scale, to determine their perceived efficacy related to the confidence to accomplish certain dietary guidelines with their children. Guidelines included providing a varied diet, giving at least 5 portions of fruits and vegetables and to limit the consumption of food with added sugar. Dietary intake of their children was determined using a food frequency questionnaire that included 147 foods in the categories of fruits and vegetables, legumes, dairy, non-processed meat, cereals, and food and beverages with added sugar. Separate univariate regression analyses were done to examine predictors of children's intake of fruits and vegetables, food with added sugar and the variety of their diet. Significant univariate predictors were included in a multivariate regression model to determine the factors that influence children's food behavior. Data was analyzed using the software SPSS version 19. RESULTS: Participants were mostly housewives (90%) and 80% concluded junior high school. Mothers of children with the most varied diet had higher scores of nutrition knowledge and practices (B = 0.760, 95%CI: 0.096, 1.443; P = 0.027). On the other hand, mothers of children with a higher consumption of fruits and vegetables presented better self-efficacy (B = 0.029, 95%CI: 0.003, 0.059; P = 0.032). No associations were found between children's consumption of foods with added sugar and nutrition practices or self-efficacy. CONCLUSIONS: Mothers’ nutrition practices and self-efficacy influence children's fruit and vegetables intake and the variety of their diet, but did not predict intake of foods with added sugar. FUNDING SOURCES: Fondo de Proyectos Especiales de Rectoría (FOPER), Universidad Autónoma de Querétaro; Red de Prevención y Tratamiento de la Obesidad, CONACYT.

OBJECTIVES: To determine the association between food environment and obesity in school-aged children using Geographic Information Database (GIS). METHODS: A total of 218 school-age children (8.4 ± 1.5 y) from a low-income setting in Mexico participated in this cross-sectional study. Weight and height were measured in all children to calculate BMI- for-age z-score (BMIz). Body composition (total body fat and abdominal fat) was measured using DXA. Geolocation of both convenience stores (CS) and participants’ households was collected and introduced into a GIS database. The shelf-space of processed foods and unprocessed foods available at each CS was measured. The distance to the closest CS, the number of CS, and the shelf-space of processed foods of CS within a 250 m radius from each participant's household was calculated using GIS. Multivariable model assessing the association between obesity and food environment were performed controlling for confounders, using SPSS v23.0. RESULTS: More than half of the children (55%) were girls, and 52% of the children had elevated body fat % (>30% for girls and >25% for boys). A total of 58 food venues were found in this community; from these venues, 40 were CS. 91% of the children had access to a CS within a 250 m radius. In average, 48% of the shelf-meters of the CS were of processed food. A positive association between BMIz (β = 0.028; IC 95%: 0.005,0.047; P

Childhood overweight and obesity are worldwide public health problems and risk factors for chronic diseases. The presence of SNP in several genes has been associated with the presence of obesity. A total of 580 children (8-13 years old) from Queretaro, Mexico, participated in this cross-sectional study, which evaluated the associations of rs9939609 (fat mass obesity-associated (

It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the concentrations of inflammatory cytokines. A cross-sectional study was carried out to evaluate the association of specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (sd7·5) years) from seven rural communities in Mexico. Measurements of weight, height and waist circumference were made on all women and body composition was determined by dual-energy X-ray absorptiometry. Concentrations of the cytokines IL-1, TNF-α, IL-6, IL-10 and IL-12, lipid profile, and the micronutrients Zn and vitamins A, C and E were determined in fasting blood samples. Ordered logistic regression models were used to determine associations between categorised cytokine levels and micronutrients. It was found that 80 % of women were overweight or obese, and had significantly higher concentrations of C-reactive protein than normal-weight women (P= 0·05). The risk of higher levels of TNF-α, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0·63, 95 % CI 0·42, 0·96,P= 0·03; OR 0·57, 95 % CI 0·39, 0·86,P= 0·025; OR 0·63, 95 % CI 0·41, 0·96,P= 0·04; OR 0·62, 95 % CI 0·41, 0·95,P= 0·03, respectively). Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0·97, 95 % CI 0·95, 0·99,P= 0·03; OR 0·97, 95 % CI 0·94, 0·99,P= 0·03, respectively); when adjusting for BMI, this association was lost. No associations were found between vitamin C or vitamin E:lipids concentrations and inflammatory cytokines. In conclusion, higher Zn concentrations are associated with reduced risks of higher concentration of inflammation markers in a population of women with a high prevalence of obesity.

Obesity has been associated with low-grade systemic inflammation and with micronutrient deficiencies. Obese individuals have been found to have lower vitamin A levels and lower vitamin A intake compared with normal-weight individuals. Vitamin A plays a major role in the immune function, including innate immunity, cell-mediated immunity and humoral antibody immunity. It has also been recognised recently that vitamin A has important regulatory functions. Vitamin A status has an important effect on the chronic inflammatory response. Vitamin A deficiency increases a T-helper type 1 (Th1) response, elevates levels of pro-inflammatory cytokines, increases the expression of leptin, resistin and uncoupling proteins (UCP) and promotes adipogenesis. The effect of vitamin A deficiency on obesity might be increasing the risk of fat deposition and also the risk of chronic inflammation associated with obesity. Supplementation with vitamin Ain vitroand in animal models has been found to reduce concentrations of adipocytokines, such as leptin and resistin. In conclusion, vitamin A deficiency increases a Th1 response in the presence of obesity and thus, increases the inflammatory process involved in chronic inflammation and fat deposition. The metabolism of leptin and other adipocytokines may play a critical role in the effect of vitamin A deficiency in the inflammatory response observed in obesity.

Objective: The purpose of this study was to identify the best predictors of dyslipidemias in Mexican obese children using different anthropometric and body composition measurements. Methods: In an observational, cross-sectional study, 905 children from 5 schools were measured for weight, height, waist and hip circumference, and triceps and subscapular skinfolds. A fasting blood sample was taken from a random sub-sample of 306 children to determine lipid profile. Abnormal total cholesterol, LDL, HDL, triglycerides, total cholesterol to HDL ratio, and LDL to HDL ratio, were determined. Logistic regressions and ROC analysis were carried out to determine the best anthropometric predictors of these risk factors. Results: Prevalence of elevated total cholesterol, triglycerides and LDL cholesterol was 14%, 56% and 58%, respectively. In logistic regressions, BMI and triceps skinfold had the highest odds ratios to predict elevated total cholesterol (1.05, 95% CI: 0.97 - 1.14; 1.07, 1.01 - 1.13, respectively), triglycerides (1.19, 1.11 - 1.27; 1.12, 1.08 - 1.17, respectively), LDL cholesterol (1.11, 1.04 - 1.18; 1.09, 1.05 - 1.14, respectively), total cholesterol to HDL ratio (1.06, 1.00-1.14; 1.07,1.03-1.12, respectively) and LDL to HDL ratio risk (1.08,1.01-1.15; 1.07, 1.03-1.12, respectively). After BMI and triceps skinfold, subscapular skinfold also predicted dyslipidemias, except for low HDL; both skinfolds had a narrower odds ratio confidence interval than BMI. In ROC analysis, subscapular skinfold was the best predictor of elevated triglycerides with an AUC ≥ 0.7. Conclusion: Anthropometric measurements are not strongly associated with dyslipidemias in Mexican children. However, since triceps and subscapular skinfolds were better predictors than other anthropometry measures, they may be a simple way to predict dyslipidemias in Mexican children.

The objective of the present study was to determine the effect of a whey-based nutritional supplement (WPS) on zinc and iron absorption from a plant-based diet (PBD) in Mexican children. Study 1 ev...

Dietary calcium plays an important role in the regulation of energy metabolism. The aim of this study was to examine the association between calcium from dairy and non-dairy products with obesity i...

Food insecurity has been found to be prevalent in obese individuals in different populations, but the information has been inconsistent. The aim of this cross-sectional study was to assess the asso...

The objective of this cross-sectional study was to evaluate the effect of Ascaris lumbricoides (A. lumbricoides) and Entamoeba coli (E. coli) on micronutrient status of school-aged children. A tota...

Ascaris lumbricoides (A. Lumbricoides) and Entamoeba coli (E. coli) are two of the most prevalent intestinal parasites in Mexican children. The objective of this study was to determine the associat...

Background : Banana is a staple food in many regions with high iron deficiency and may be a potential vehicle for iron fortification. However, iron absorption from bananas is not known. Objective : The objective of this study was to evaluate total iron absorption from raw and cooked bananas. Design : Thirty women (34.9±6.6 years) from rural Mexico were randomly assigned to one of two groups each consuming: 1) 480 g/day of raw banana for 6 days, or 2) 500 g/day of cooked banana for 4 days. Iron absorption was measured after extrinsically labeling with 2 mg of 58 Fe and a reference dose of 6 mg 57 Fe; analysis was done using ICP-MS. Results : Iron content in cooked bananas was significantly higher than raw bananas (0.53 mg/100 g bananas vs. 0.33 mg/100 mg bananas, respectively) ( p< 0.001). Percent iron absorption was significantly higher in raw bananas (49.3±21.3%) compared with cooked banana (33.9±16.2%) ( p= 0.035). Total amount of iron absorbed from raw and cooked bananas was similar (0.77±0.33 mg vs. 0.86±0.41 mg, respectively). Conclusion : Total amount of absorbed iron is similar between cooked and raw bananas. The banana matrix does not affect iron absorption and is therefore a potential effective target for genetic modification for iron biofortification. Keywords : iron absorption; bananas; iron deficiency (Published: 5 February 2015) Citation: Food & Nutrition Research 2015, 59 : 25976 - http://dx.doi.org/10.3402/fnr.v59.25976 Responsible Editor: Seppo Salminen, University of Turku, Finland.

The study investigated the dietary habits and foods that are associated with obesity in women from a rural area in Mexico. Anthropometry and body fat were measured in 580 women. Participants answered a socioeconomic and a food-frequency questionnaire; a subsample (n = 80) also answered three 24-hour-recall questionnaires. Results showed that obese women consumed more soft drinks and fat than did overweight and normal-weight women. Women who consumed more energy during a mid-morning meal had higher BMI. A strategy to decrease the prevalence of obesity in rural areas could be to encourage limiting the consumption of soft drinks and eliminating or reducing caloric intake at a mid-morning meal.

One potentially sustainable approach to improving iron status at the community level is to encourage the consumption of local ascorbic acid-rich foods, in conjunction with meals high in nonheme iron.The study, conducted in rural Mexico, measured stable isotopes of iron to evaluate the effect on iron absorption of the addition of 25 mg ascorbic acid as agua de limón (limeade) to 2 typical meals per day for 2 wk.Fifteen nonpregnant, nonlactating, iron-deficient (ferritin12 microg/L) women (x +/- SD age: 28.3 +/- 7.7 y) fasted overnight and were brought to a community clinic. After an initial blood sample, subjects consumed 0.25 mg (57)Fe with both breakfast and lunch for 14 d. On day 29, another blood sample was taken, and a reference dose of 2.7 mg (58)Fe with 25 mg ascorbic acid was given. For the following 15 d, participants consumed 0.25 mg (57)Fe added to both breakfast and lunch with 25 mg ascorbic acid added to each meal as limeade. A final blood sample was taken on day 59.Iron absorption was calculated from recovery of isotopes in blood obtained 14 d after administration of each isotope. When 25 mg ascorbic acid as limeade was added to test meals twice a day for 2 wk, iron absorption increased significantly (P0.001) in every subject: the mean absorption rose from 6.6 +/- 3.0% to 22.9 +/- 12.6%.The consumption of 25 mg ascorbic acid as limeade twice daily with meals substantially improved iron absorption and may improve the iron status of nonpregnant, nonlactating, iron-deficient women.

Background: Although ascorbic acid (AA) increases dietary iron bioavailability, there has been no food-based community trial of its efficacy in improving iron status. Objective: The objective was to assess the efficacy of 25 mg AA as agua de limon (limeade), consumed with each of 2 daily meals, in improving the iron status of iron-deficient women. Design: Two rural Mexican populations were randomly assigned to an AA or a placebo group, each with 18 iron-deficient women. The AA group was given 500 mL limeade containing 25 mg AA twice a day, 6 d/wk, for 8 mo. The placebo group was given a lime-flavored beverage free of AA or citric acid. Beverages were consumed within 30 min of 2 main daily meals. Data were collected on morbidity (3 times/wk), dietary intake (on 6 d), socioeconomic status, parasites (twice), medical history, and response to treatment. Blood samples at 0, 2, 4, 6, and 8 mo were analyzed for hemoglobin, plasma AA, plasma ferritin, transferrin receptors, and C-reactive protein. Results: AA intake was significantly (P < 0.0001) higher in the AA group, but nonheme iron, heme iron, and phytic acid intakes did not differ significantly. Plasma AA was significantly (P < 0.01) higher in the AA group at 2, 4, 6, and 8 mo. There were no final differences between groups in hemoglobin, plasma ferritin, or transferrin receptor concentrations or in the ratio of transferrin receptors to plasma ferritin after control for initial concentrations. Conclusion: Increasing dietary AA by 25 mg at each of 2 meals/d did not improve iron status in iron-deficient women consuming diets high in phytate and nonheme iron. Am J Clin Nutr 2003;78:267‐73.

Milk protects the health of newborns because it contains essential compounds that perform metabolic activities. Despite these benefits, the study of phenolic compounds in milk has been poorly explored. The objective of this study was to develop and validate a technique for extracting total phenolic compounds (TPCs) from a milk matrix and then analyzing them using the Folin-Ciocalteu method. The extraction technique was applied to goat milk and involved the addition of methanol, acetonitrile, and Carrez I and II reagents, after which protein was separated from fat through centrifugation. Subsequently, the technique was applied to goat (69.03±6.23mg GAE/L), cow (49.00±10.77mg GAE/L), sheep (167.6±58.77mg GAE/L) and human milk (82.45±12.3mg GAE/L). The technique showed an acceptable linearity (R(2)=0.9998), limit of detection (6.03mg GAE/L) and quantification (16.2mg GAE/L), repeatability (RSD=4%), reproducibility (RSD=6.8%) and recovery (>85.41%); it is thus effective and can be used in the routine analysis of milk. TPCs obtained from each type of milk indicate a high variability among species and among members of the same species.

The presence of FTO (rs9939609) and MC4R (rs17782313) single-nucleotide polymorphisms (SNPs) has been associated with an increased risk of overweight and obesity and alterations in the lipids profile. The aim of this study was to investigate the relation between these FTO and MC4R SNPs with the presence of overweight/obesity and metabolic risk in children. A total of 167 school-aged children (8 ± 1.5 years) from a rural area of ​​Queretaro, Mexico, have been evaluated until now. Weight, height, waist circumference and body composition (DXA) were measured. A fasting blood sample was taken for the analysis of glucose and lipid profile. Genotypic frequency of the SNPs was determined using qPCR. Prevalence of obesity and overweight was 12% and 17%, respectively. FTO genotypic frequency for TT, TA and AA was77%, 22% and 1%; the frequency of T and A alleles was 87% and 13%, respectively. As for MC4R, genotypic frequency for TT, TC and CC was 86.3%, 13% and 0.7%; the frequency of T and C alleles was ...

In a longitudinal controlled and randomized study the effect of supplementing with milk proteins and multiple micronutrients on anthropometry, body composition, and metabolic syndrome indicators wa...

The objective of this cross-sectional study was to evaluate the nutritional status and dietary pattern (DP) used by the Special Programme for Food Security (PESA/FAO) in an indigenous population (C...

Intestinal parasites, virus and bacterial infections have shown to be positively associated with obesity and adiposity in vitro and in animal models, but conclusive evidence of this relationship in humans is lacking. The aim of this cross-sectional study was to determine if intestinal parasites influence adiposity and obesity in a population that have a high prevalence of both parasitic infection and obesity. Until now, a total of 101 school-age children (8 ± 1.5 years) of a total of 300 children from a rural area in Queretaro, Mexico, have been evaluated. Anthropometry (weight, height, waist circumference) and body composition by DXA were measured in all children. A stool sample was analyzed by kato katz. The prevalence of obesity and overweight was 17.5% and 11.7%, respectively. Protozoa infection was present in 45.7% of the children and 11.2% were infected with helminthes: 9.1% with Ascaris lumbricoides, 1.5% with Hookworm, 1.5% with Hymenolepis nana. Preliminary analysis show no relationship between i...

Beverages such as fruit drinks (natural and artificially flavored), soft drinks and 100% fruit juices are regularly consumed by children as part of their diet. 198 children (8 ± 1.5 years) participated in a crosssectional study to evaluate the association of beverage intake with obesity, lipid profile and glucose concentration. Body fat (DXA), height, weight and waist circumference were measured in all children. Diet was evaluated with a food frequency questionnaire and three 24hr recalls. A fasting blood sample was taken to analyze lipid profile and glucose. 17% of the daily energy intake of these children came from beverages. Linear regressions adjusted for socio-demographic variables showed some significant associations (p

The objective of this cross-sectional study was to evaluate the relationship between micronutrient status and obesity, lipids, insulin resistance and chronic inflammation in children. Weight, height, waist circumference and body composition (dual-energy X-ray absorptiometry (DEXA)) were determined in 197 school-aged children. Lipids, glucose, insulin, C-reactive protein (CRP), zinc, iron and vitamins A, C and E were analyzed in blood. Vitamin C and vitamin E:lipids were negatively associated with Body Mass Index (BMI), waist-to-height ratio (WHR) and body and abdominal fat (p < 0.05). Vitamin A was positively associated with BMI, BMI-for-age, WHR and abdominal fat (p < 0.05). Iron and vitamin E:lipids were negatively associated with insulin (p < 0.05). Vitamins A, C and E and iron were negatively associated with CRP (p < 0.05). Interaction analysis showed that children who were overweight and obese who also had low concentrations of vitamin A had higher CRP and lower triglycerides (p < 0.1), children with low vitamin E had significantly lower glucose and triglycerides (p < 0.1) and higher low-density lipoprotein (LDL) concentrations (p < 0.05), and children with low zinc concentrations had higher insulin resistance compared with children with adequate weight (p < 0.05). In conclusion, low vitamin C concentration and vitamin E:lipids were associated with obesity. Furthermore, low concentrations of zinc, vitamins A and E in children who were overweight and obese were associated with lipids, inflammation and insulin resistance.

In developing countries, incomplete resolution of anemia with iron supplementation is often attributed to poor compliance or inadequate duration of supplementation, but it could result from deficiencies of other micronutrients.Our objective was to assess children's hematologic response to supervised, long-term iron supplementation and the relation of this response to other micronutrient deficiencies, anthropometry, morbidity, and usual dietary intake.Rural Mexican children aged 18-36 mo (n = 219) were supplemented for 12 mo with either 20 mg Fe, 20 mg Zn, both iron and zinc, or placebo. Children were categorized as iron-unsupplemented (IUS; n = 109) or iron supplemented (IS; n = 108). Hemoglobin, hematocrit, mean corpuscular volume, mean cell hemoglobin, plasma concentrations of micronutrients that can affect hematopoiesis, anthropometry, and diet were assessed at 0, 6, and 12 mo; morbidity was assessed biweekly.At baseline, 70% of children had low hemoglobin (/=115 g/L), 60% had low hematocrit, 48% were ferritin deficient, 10% had deficient and 33% had low plasma vitamin B-12 concentrations, 29% had deficient vitamin A concentrations, and 70% had deficient vitamin E concentrations. Iron supplementation increased ferritin from 11 +/- 14 microg/L at baseline to 31 +/- 18 microg/L after 6 mo (P0.001) and 41 +/- 17 microg/L after 12 mo. However, anemia persisted in 30% and 31% of supplemented children at 6 and 12 mo, respectively, and was not significantly different between the IUS and IS groups at 12 mo. Initial plasma vitamin B-12, height-for-age, and dietary quality predicted the hematopoietic response to iron.Lack of hemoglobin response to iron was associated with indicators of chronic undernutrition and multiple micronutrient deficiencies.