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1. Covalently trapping MutS on DNA to study DNA mismatch recognition and signaling

Author

Heinze, Roger J., Sekerina, Svetlana, Winkler, Ines, Biertuempfel, Christian, Oretskaya, Tatiana S., Kubareva, Elena, Friedhoff, Peter, and Justus Liebig University Giessen

Subjects
ddc:570
Abstract

The DNA repair protein MutS forms clamp-like structures on DNA that search for and recognize base mismatches leading to ATP-transformed signaling clamps. In this study, the mobile MutS clamps were trapped on DNA in a functional state using single-cysteine variants of MutS and thiol-modified homoduplex or heteroduplex DNA. This approach allows stabilization of various transient MutS-DNA complexes and will enable their structural and functional analysis.

Published
2012
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