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Table S1A. Top50 hypermethylated DMRs in CRC versus NAT comparison. Table S1B. Top50 hypomethylated DMRs in CRC versus NAT comparison. Table S1C. Top50 hypermethylated DMRs in adenoma tissue compared to NAT samples. Table S1D. Top50 hypomethylated DMRs in adenoma tissue compared to NAT samples. (DOC 253 kb)

Figure S1. Box plots of significant DMRs in TP53 pathway gene promoters between CRC and NAT samples. Figure S2. DNA methylation pattern of top50 hypermethylated DMRs on an independent set of samples. Figure S3. DNA methylation profiles of the overlapping regions on methyl capture sequencing and EpiTect array results. (DOC 902 kb)

Box plot representation of DNA methylation alterations of analysed genes in biopsies and macrodissected specimens of NAT (n = 10), AD (n = 10), and CRC (n = 10) and in LCM epithelial cells of NAT (n = 5), AD (n = 5) and CRC (n = 5). Red dots are individual DNA methylation percent values, box plots represent median and standard deviation of the data. Asterisk (*) represents significance (p

Box plot representation of DNA methylation alterations of analysed genes in biopsies and macrodissected specimens of NAT (n = 10), AD (n = 10), and CRC (n = 10) and in LCM epithelial cells of NAT (n = 5), AD (n = 5) and CRC (n = 5). Red dots are individual DNA methylation percent values, box plots represent median and standard deviation of the data. Asterisk (*) represents significance (p

Clinical data of the analysed gene expression datasets (GSE4183, GSE37364, GSE10714 and GSE15960). (DOC 249 kb)

Gene expression of the selected marker set in normal (n = 49), adenoma (n = 49), and tumour (n = 49) biopsy samples. Results are represented as pairwise box plots showing single gene expession in the biopsy and in the laser microdissected epithelial cells from normal (n = 6), adenoma (n = 6), and tumour (n = 6). Red dots are normalised gene expression values, box plots represent median and standard deviation of the data. Asterisk (*) represents significance (p

Clinical data of patients involved in the study. (DOCX 24 kb)

Gene expression of the selected marker set in normal (n = 49), adenoma (n = 49), and tumour (n = 49) biopsy samples. Results are represented as pairwise box plots showing single gene expession in the biopsy and in the laser microdissected epithelial cells from normal (n = 6), adenoma (n = 6), and tumour (n = 6). Red dots are normalised gene expression values, box plots represent median and standard deviation of the data. Asterisk (*) represents significance (p