In this paper, some exciting results on the volatile organic compounds (VOCs) response characteristics of In-, Sn- and Cr-doped WO3 nanomaterials have been reported. WO3 nanomaterials were synthesized by chemical co-precipitation route. The as-synthesized samples were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) for their structural and morphological characterizations. The XRD results confirm that the samples are nanocrystalline WO3 materials possessing monoclinic structure. The 1.5 at% In-doped WO3 nanostructure shows maximum response (~ 93%) at the operating temperature of 250°C for 50 ppm concentration of acetone vapour in air. In the case of Sn doping, the 2 at% Sn-doped sample exhibits the maximum response 82% to propan-2-ol, followed by 62.2% to ethanol and 58.2% to methanol, respectively at the operating temperature of 225°C for a concentration of 50 ppm test alcohol in air. Selective high response (~ 82%) to formaldehyde over methanol, ethanol, propan-2-ol, and acetone at the operating temperature of 200°C for 50 ppm concentration in air has been observed for the 1.5 at% Cr-doped WO3 nanosheet. The sensing mechanism has been explained based on chemisorption of atmospheric oxygen on the WO3 surface, and the subsequent reaction between the adsorbed oxygen species and the test gas molecules.