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41 results on '"Pallotta, S"'

1. X-ray qualification of hydrogenated amorphous silicon sensors on flexible substrate

Author

Menichelli, M., Antognini, L., Bashiri, A., Bizzarri, M., Calcagnile, L., Caprai, M., Caricato, A. P., Catalano, R., Cirrone, G. A. P., Croci, T., Cuttone, G., Dunand, S., Fabi, M., Frontini, L., Grimani, C., Ionica, M., Kanxheri, K., Large, M., Liberali, V., Martino, M., Maruccio, G., Mazza, G., Monteduro, A. G., Morozzi, A., Moscatelli, F., Pallotta, S., Papi, A., Passeri, D., Pedio, M., Petasecca, M., Petringa, G., Peverini, F., Piccolo, L., Placidi, P., Quarta, G., Rizzato, S., Rossi, G., Sabbatini, F., Stabile, A., Servoli, L., Talamonti, C., Tosti, L., Villani, M., Wheadon, R. J., Wyrsch, N., and Zema, N. more...

Subjects
Neutrons, Flexible detectors, Sensitivity, Polyethylene, Particle measurements, Sensitivity, Polyethylene, PIN photodiodes, Detectors, Polyimides, Neutrons, Particle measurements, Hydrogenated Silicon detectors, Radiation Hardness, Flexible detectors, Polyimides, Detectors, PIN photodiodes, Hydrogenated Silicon detectors, Radiation Hardness
Published
2023

2. Development of thin hydrogenated amorphous silicon detectors on a flexible substrate

Author

Menichelli, M., Bizzarri, M., Calcagnile, L., Caprai, M., Caricato, A. P., Catalano, R., Cirrone, G. A. P., Croci, T., Cuttone, G., Dunand, S., Fabi, M., Frontini, L., Gianfelici, B., Grimani, C., Ionica, M., Kanxheri, K., Large, M., Liberali, V., Martino, M., Maruccio, G., Mazza, G., Monteduro, A. G., Morozzi, A., Moscatelli, F., Pallotta, S., Papi, A., Passeri, D., Pedio, M., Petasecca, M., Petringa, G., Peverini, F., Piccolo, L., Placidi, P., Quarta, G., Rizzato, S., Rossi, G., Sabbatini, F., Stabile, A., Servoli, L., Talamonti, C., Villani, M., Wheadon, R. J., and Wyrsch, N. more...

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), High Energy Physics - Experiment
Abstract

The HASPIDE (Hydrogenated Amorphous Silicon PIxels DEtectors) project aims at the development of thin hydrogenated amorphous silicon (a-Si:H) detectors on flexible substrates (mostly Polyimide) for beam monitoring, neutron detection and space applications. Since a-Si:H is a material with superior radiation hardness, the benefit for the above-mentioned applications can be appreciated mostly in radiation harsh environments. Furthermore, the possibility to deposit this material on flexible substrates like Polyimide (PI), polyethylene naphthalate (PEN) or polyethylene terephthalate (PET) facilitates the usage of these detectors in medical dosimetry, beam flux and beam profile measurements. Particularly interesting is its use when positioned directly on the flange of the vacuum-to-air separation interface in a beam line, as well as other applications where a thin self-standing radiation flux detector is envisaged. In this paper, the HASPIDE project will be described and some preliminary results on PI and glass substrates will be reported. more...

Published
2022
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Books, media, physical & digital resources
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5. PALLIATIVE CARE FOR THE HOMELESS: A SCOPING REVIEW

Author

Coatsworth A, Keri J. West, Pallotta S, and Wrobel B

Subjects
Abstracts, Health (social science), Palliative care, Nursing, business.industry, mental disorders, Medicine, Life-span and Life-course Studies, business, Health Professions (miscellaneous)
Abstract

Homeless persons have higher burden of disease and mortality rates than the housed population; however, traditional models of palliative care are inaccessible to many dying homeless persons. There is a dearth of literature on the palliative needs and preferences of homeless persons and effective palliative care interventions for this population. A scoping review was undertaken to examine the literature regarding the deployment of palliative care services for homeless persons. Five medical databases, seven social science databases, and four grey literature databases were searched under the guidance of two University of Toronto librarians to identify literature on palliative care for homeless persons. The search resulted in 68 relevant titles. Six main themes emerged from the review: 1) characteristics of homeless persons who required end-of-life care; 2) preferences and concerns of homeless persons approaching end-of-life; 3) the role of spirituality for homeless persons at end-of-life; 4) barriers to care at the patient, provider and institutional/structural levels; 5) inclusive models of palliative care; and 6) implications for policy and practice at end-of-life. Homeless persons face considerable barriers to accessing appropriate end-of-life care. Several areas of improvement were identified for care providers and policymakers. Future research should focus on evaluating the effectiveness and financial viability of models of care, the perspectives of homeless persons regarding palliative care, and the unique needs and preferences of cultural and ethnic minority homeless populations. more...

Published
2018
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6. The PRIMA (Proton Imaging) collaboration: Status of the development of a proton Computed Tomography Scanner

Author

Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, and Zani, M more...

Subjects
Spatial resolution, Silicon detector, Proton computed tomography (pCT), Network security, Proton computed tomography, Computerized tomography, Proton beam, Radiography, Silicon micro-strip detector, Experiment, Nuclear physic, Residual energy, Medical imaging, Proton, Proton imaging, Stringent requirement, Data privacy, Beam test
Abstract

The PRIMA (Proton IMAging) experiment is aimed at developing a proton Computed Tomography (pCT) prototype based on tracking single protons. Approaches to the pCT consist in the use of silicon microstrip detectors to measure the position and direction of individual protons before and after they traverse the phantom, in view to reconstruct the trajectory of each proton, and a calorimeter for measuring particle residual energy. A small prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography, were carried out during these beam tests. Radiographies have been reconstructed with different methods: results show the good performances of the device, with spatial resolution fulfilling the stringent requirements of a pCT device. more...

Published
2012

7. PRIMA Proton Imaging for Clinical Application

Author

Talamonti C, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Vanzi E, Zani M., Talamonti, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Vanzi, E, and Zani, M more...

Subjects
Spatial resolution, Silicon microstrip tracker, Radiographic image, Proton computed tomography (pCT), Radiography image, Network security, Computerized tomography, Optical microscopy, Clinical application, Proton beam, Radiography, Image resolution, Polymethyl methacrylate, Nuclear physic, Quantitative result, Medical imaging, Proton, Energy resolution, Data privacy
Abstract

PRIMA project is an Italian project funded by INFN and MIUR (PRIN 2006), which developed a proton Computed Tomography (pCT) prototype based on tracking the single proton. PRIMA approaches to the pCT consist in the use of silicon detectors, which measure the energy and position of individual protons before and after they traverse the object. The device consists of a silicon microstrip tracker, used to reconstruct the trajectory of each proton, and a calorimeter that measure the particle residual energy. It is characterized by an active area of 5 × 5 cm2 and by an acquisition rate of 10kHz. PRIMA prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography images, were carried out during these beam tests. In particular in this paper will be reported the PRIMA experience on the data acquired using special phantoms. The performed tests aimed to evaluate the clinical applicability of proton radiography in terms of image quality. In order to test spatial resolution, electron density resolution and energy resolution of the system, PRIMA group has developed suitable phantoms for radiography. The phantoms are custom-made and suitable for high-contrast spatial resolution. They are PolyMetilMetacrilate (PMMA) cylinders with holes of different size and depth. In particular, the phantom diameter was chosen accordingly with the tracker field of view while the phantom length depends on the beam quality: it was 20mm and 150mm for 60MeV and 180MeV proton beam respectively. In this paper the experimental setup will be described, radiographic images will be shown and quantitative results on spatial resolution will be reported. more...

Published
2012

8. Unusual skin toxicity after a chemotherapic combination

Author

Bangrazi C, Pallotta S, Paola Corsetti, Roberto Lisi, Stefano Calvieri, Emanuele Cigna, Carmen Cantisani, Passarelli F, Giovanni Paolino, and Rota L

Subjects
kaposi sarcoma, Skin toxicity, Computer science, calciphylaxis, diagnosis, General Medicine, Omics, Bioinformatics, chemotherapic
Published
2015

9. Definizioni di malattia,endpoint e risposta terapeutica nel pemfigo;International consensus.Statment e raccomandazioni GIDI e GIPMO

Author

Cianchini, G, Veller Fornaia, C, Lupi, F, Amato, S, Bellosta, M, Bergamo, F, Bettoli, V, Bruni, P, Cardinali, C, Carducci, M, Colonna, L, Congedo, M, Corona, D, Deledda, S, De Giorgi, V, De Pità, O, Di Carlo, A, Di Giuseppe, D, Filosa, G, Galluccio, A, Griseta, V, Kokelj, F, Lo Scocco, G, Mazzanti, C, Milioto, M, Mussi, A, Pallotta, S, Pellicano, R, Pigatto, P, Provenzano, E, Puddu, P, Pugliesi Guerra, A, Ricciuti, F, Pedona, P, Simonacci, M, Valenti, G, Valenzano, L, Valenzano, MC, CAMPISI, Giuseppina, Cianchini, G, Veller Fornaia, C, Lupi, F, Amato, S, Bellosta, M, Bergamo, F, Bettoli, V, Bruni, P, Campisi, G, Cardinali, C, Carducci, M, Colonna, L, Congedo, M, Corona, D, Deledda, S, De Giorgi, V, De Pità, O, Di Carlo, A, Di Giuseppe, D, Filosa, G, Galluccio, A, Griseta, V, Kokelj, F, Lo Scocco, G, Mazzanti, C, Milioto, M, Mussi, A, Pallotta, S, Pellicano, R, Pigatto, P, Provenzano, E, Puddu, P, Pugliesi Guerra, A, Ricciuti, F, Pedona, P, Simonacci, M, Valenti, G, Valenzano, L, and Valenzano, MC more...

Subjects
Pemfigo/International consensus
Published
2009

11. PRIMA+: A proton Computed Tomography apparatus

Author

Civinini, C., Bruzzi, M., Bucciolini, M., Cirrone, G. A. P., Cuttone, G., Lo Presti, D., Pallotta, S., Randazzo, N., Scaringella, M., Sipala, V., Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., and Zani, M. more...

Published
2013

12. DUO Registry Group. Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry

Author

Guillevin, L, Hunsche, E, Denton, Cp, Krieg, T, Schwierin, B, Rosenberg, D, Matucci Cerinic, M, DUO Registry Group Collaborators Raffier, B, Hirschi, M, Trautinger, F, Schmidt, P, Stetter, M, Hundstorfer, M, Reinhart, V, Monshi, B, Pirkhammer, D, Richter, L, Hamberger, N, Metz, S, Feldmann, R, Semmelweis, K, Lackner, K, Tomi, N, Kolle, H, Hafner, F, Brodmann, M, Kuen Spiegel, M, Minmair, G, Heil, Pm, Broil, H, Holzer, G, Illmer, X, Rintelen, B, Sautner, J, Takacs, M, Thun, M, Zemanova, I, Soukup, T, Smrzova, A, Bohmova, J, Prochazkova, L, Nemec, P, Fojtik, Z, Suchy, D, Becvar, R, Olsen, Ab, Sondergaard, Kh, Luosu jarvi, R, Vidqvist, Kl, Madaule, S, Beneton, N, Maillard, H, Charlanne, H, Granelbrocard, F, Hachulla, E, Hatron, Py, Jourdain, N, Lambert, M, Launay, D, Morell, S, Woijtasik, G, Skowron, F, Zenone, T, Dadban, A, Lok, C, Ferrandiz, D, Magybertrand, N, Moiton, Mp, Taieb, A, Balquiere, S, Belin, E, Droitcourt, C, Julien, S, Prey, S, Boulon, C, Constans, J, Doutre, Ms, Kostrzwewa, E, Richez, C, Greco, M, Misery, L, Sassolas, B, Collet, E, Berthier, S, Leguy Seguin, V, Imbert, B, Carpentier, P, Blaise, S, Couraud, A, Doeffel Hantz, V, Spars, A, Bezanahary, H, Boussely, N, Dumonteil, S, Fauchais, Al, Goudran, G, Loustaud Ratti, V, Manea, P, Vidal, E, Coppere, B, Desmursclavel, H, Girard Madoux MH, Hot, A, Ninet, J, Granel, B, Cohen, Jd, Keynote, A, Khau van Kien, A, Le Quellec, A, Riviere, S, Rullier, P, Bessis, D, Farcas, C, Bravetti, V, Moline, T, Wahl, D, Zuily, S, Granel Brocard, F, Agard, C, Durant, C, Fuzibet, Jg, Queyrel, V, Berezne, A, Mouthon, L, Cabane, J, Tiev, K, Toledano, C, Lazareth, I, Michon Pasturel, U, Priollet, P, Reguiai, Z, Cazaletslacoste, C, Jego, P, Letremy, A, Perlat, A, Duval Modeste AB, Chatelus, E, Chiffot, H, Sibillia, J, Sordet, C, Adoue, D, Couret, B, Moulis, G, Pugnet, G, Sailler, L, Diot, E, Gaches, F, Farge, D, Keshtmand, H, Frances, C, von Elling, A, Bora, D, Ebel, J, Ahmadi Simab, K, Klein, E, Hahn, K, Schulze, K, Rasche, C, Riemekasten, G, Lee, Hh, Deuschle, K, Mattat, K, Becker, M, Worm, M, Mensing, C, Klings, D, Mensing, H, Messall, J, Zuper, R, Eilbacher, P, Saar, P, Kaufmann, P, Hallermann, C, Schmidt, K, Wahn, H, Schildt, K, Schuart, T, Kaczmarczyk, A, Kellner, C, von Oelhafen, J, Baron von Bildering, P, Kunze, S, Kleiner, Hj, Alsheimer, B, Schuetz, N, Miirker Hermann, E, Gottl, Kh, Weiss, E, Reischel, N, Kern, S, Goettl, Kh, Goetheuniversitiitsklinikum, Jw, Himsel, A, Henkemeier, U, Schwarting, A, Hazenbiller, A, Nichelmann, V, Rumbaur, C, Boesenberg, I, Schmeiser, T, Mueller Ladner, U, Unholzer, A, Starz, H, Welzel, J, Plaumann, K, Stoeckl, F, Sperling, S, Podda, M, Wagner, N, Rapprich, H, Niedermeier, A, Messer, G, Sardy, M, Bekou, V, Dill MUller, D, Wlodarz, M, Belloni, B, Huettig, B, Ziai, M, Hein, R, Kneitz, C, Federow, I, Schneider, K, Semmler, M, Hapke, S, Metzler, C, Stein, T, Enderlein, M, Kayser, M, Werthmann, M, Guenther, Cu, Neul, S, Hellmich, B, Loeffler, C, Pflugfelder, J, Karaenke, P, Mueglich, C, Tony, Hp, Marina, P, Popp, M, Mittag, M, Baumann, C, Scheib, Eg, Brand, H, Wilhelm, Hu, Bohm, J, Dyballa, J, Boehm, J, Taggeselle, J, Luthke, K, Wuerzburg, I, Niefanger, K, Mayer, L, Drabek, J, Harmuth, W, Dietl, S, Moritz, D, Gause, A, Gaubitz, M, Hallecker, A, Krupp, E, Rumpel, H, Moosig, F, Frey, P, Kahl, S, Linke, M, Merk, B, Bloching, Hh, Ochs, W, Kurthen, R, Eiden, E, Guertler, I, Aries, Pm, Kirchberg, S, Jahnke, K, Mettler, S, Toeller, S, Zwenger, S, Langer, He, Deininger, F, Hartmann, F, Neeck, G, Neek, G, Wernitzsch, H, Meier, L, Herr, U, Meier, U, Aaig, W, Bruckner, L, Sheikh, N, Wollenhaupt, J, Krog, B, Wollersdorfer, E, Hall, R, Diehm, C, Tiggers, C, Peters, J, Kirschke, J, Schroeder, Jo, Zeuner, R, Uhlig, S, Barth, S, Huegel, R, Glaeser, R, Schaefer, C, Monshausen, M, Mengden, T, Funkert, A, Blank, N, Lupaschko, S, Voss, B, Megahed, M, Sadeghlar, F, Seidel, M, Wasmuth, Jc, Kreuter, A, Vosswinkel, J, Pfoehler, C, Gerber, A, Haust, M, Hoff, Np, Mota, R, Akanay Diesel, S, Homey, B, Katzemich, A, Erfurt Berge, C, Sticherling, M, Beyer, C, Distler, J, Mitchell, A, Freundlieb, C, Rushentsova, U, Hermanns, G, Blaschke, S, Fiene, M, Wessel, C, Norgauer, J, Rabe, B, Schuster, J, Scholz, J, Kremer, K, Robakidze Torbahn, M, Moinzadeh, P, Dohse, A, Muhlack, A, Schultz, L, Schult, S, Frambach, Y, Kruse, S, Kettenbach, A, Fell, I, Schweda, K, Steinbrink, K, Podobinska, M, Fieri beck, G, Schanz, S, Pfeiffer, C, Hassel, R, Herrgott, I, Sunderkoetter, C, Guenzel, J, Athanassiou, P, Dimitroulas, T, Settas, L, Kritikos, I, Tsifetaki, N, Garyfallos, A, Vasilopoulos, D, Boura, P, Kamali, S, Aslanidis, S, Vlachoyannopoulos, P, Galanopoulo, V, Sakkas, L, Koutroubas, A, Elezoglou, T, Galanopoulos, N, Grier, A, Murray, M, O'Rourke, M, Del Papa, N, Maglione, W, Zeni, S, Foti, R, Benenati, A, De Vita, S, Ferraccioli, G, Grassi, W, de Angeli, R, Pomponio, G, Mussi, A, Colonna, L, Airo, P, Zingarelli, S, Scorza, R, Serverino, A, Puppo, F, Negrini, S, Roma, I, Salsano, F, Triolo, G, Mazzuca, S, Carignola, R, Gatti, S, Lunardi, G, Riccieri, V, Salvarani, C, Bajocchi, G, Varcasia, G, Marasini, B, Belloll, L, de Luca, R, Stisi, S, Bellissimo, S, Fusaro, E, Pellerito, R, Cozzi, F, Rizzo, M, Bartoluzzi, A, Trotta, F, Cantatore, F, Corrado, A, Ferri, Claudio, Colaci, M, Malavolta, N, Mule, R, Galeazzi, M, Lapadula, G, Mathieu, A, Vacca, A, Giacomelli, Roberto, Cipriani, Paola, Montecucco, Cm, Codullo, V, Bucci, R, Battaglia, E, Valentini, G, Cuomo, G, Terlizzi, N, Serafino, L, Reumatologia, Uo, Bombardieri, S, Della Rossa, A, Doveri, M, Perricone, R, de Mattia, M, Pallotta, S, Groenendael, Jh, Seys, P, Goekoop, Rj, Han, Kh, Wlarvens, M, Bonte Mineur, F, de Bois MH, de Beus WM, van Zeben, D, Vonk, M, Knaapen, Hk, Smit, A, Bootsma, H, Ton, E, Voskuyl, A, Dutmer, Ea, Stalk, Jn, Madland, Tm, Seip, M, Hoffmann Vold AM, Bitter, H, Stocklund Thomsen, R, Resende, C, Ponte, C, Martinho, S, Silva, F, Ferreira, P, Grilo, A, Riso, N, Santos, C, Camara, I, Costa, J, Alves, J, Oliveira, S, Almeida, I, Silva, I, Cordeiro, A, Coelho, P, Lukac, J, Dolnicar, As, Espinosa, G, Mejia, Jc, Ramos, M, Plasin Rodriguez MA, Mera, A, Blanco, Js, Diaz, Jj, Losada, L, Perez, E, Maneiro, Jr, Caamano, M, Fermindez, S, Insua, Sa, Barbado, J, Fonseca, Em, Nufio, Fj, Castellvi, I, Garcia de Ia Pena, P, Bellido, D, Paulino, M, Garcia, Pv, Salas, V, Minguez, Md, Sanchez, Ma, Urrego, C, Martin, I, Rueda, A, Calvo, J, Ripoll, Mm, Torres, Mc, Corteguera, M, Maceiras, F, Cruz, J, Mosquera, Ja, Gomez, R, Area, B, Carrio, I, Rubio, M, Castellvi Barranco, I, Santos, P, Simeon, Cp, Fonollosa, V, Egurbide, Mv, Garcia de Vicuna, R, Vicente, E, Villaverde, V, Fernandez, C, Garcia, E, Uson, J, Miguelez, R, Callejas, Jl, Ortego, N, Roman, J, Alegre Sancho JJ, Robles, A, Rios, Jj, Bonilla, Mg, Sanchez Andrade, A, Vazquez, Tr, Miranda, Ja, Saez, L, Zea, A, De la Puente, C, Martinez, Fg, Aguirre, Ma, Collado, P, Cruz, A, Crespo, M, Sanchez Roman, J, Castillo, Mj, Garcia, Am, Muniz, G, Hedin, Pj, Stahl, C, Bracin, T, Nordin, A, Albertsson, K, Rydvald, Y, Thorsson, C, Hermansson, E, Maurer, B, Verner, D, Schmidt Bosshard, R, Hall, F, Murphy, K, Lamb, J, Anderson, M, Moots, R, Buch, M, Bissell, L, Madhok, R, Hampson, R, D'Cruz, D, Choong, Lm, Gordon, P, Dobson, J, Salerno, R, Nisar, M, Williams, C, Wilcox, L, Denton, C, Ochiel, R, Ngcozana, T, Parker, L, Vincent, R, Mchugh, N, Cole, S, Brown, S, James, J, Herrick, A, Manning, J, Moore, T, Faizal, A, Skyes, H, Smythe, A, and Hamilton, A. more...

Published
2013

16. A review of rabeprazole in the treatment of acid-related diseases

Author

Pace, F., Pallotta, S., Canalini, S., and Bianchi Porro, G.

Subjects
Acid-related disorders, Gastro-esophageal reflux disease, Helicobacter pylori infection, Pharmacodynamics, Pharmacokinetics, Rabeprazole, Therapeutic use, Settore MED/12 - Gastroenterologia
Published
2007

17. Sensor radiance physical model for rugged heterogeneous surfaces in the 3-14 µm region

Author

Pallotta, S., Briottet, X., Miesch, C., Kerr, Yann H., Centre d'études spatiales de la biosphère (CESBIO), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS) more...

Subjects
[SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

18. Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole

Author

Pace, F., Annese, V., Prada, A., Zambelli, A., Casalini, S., Nardini, P., Bianchi Porro, G., Rossi, Z., Fenderico, P., Molinari, F., Molinari, A., Poletti, M., Benedetti, A., Bolognini, L., Cercamondi, P., Piergallini, S., Pieroni, N., Ridolfi, F., Palazzi, A., Agnolucci, A., Ceccatelli, P., Laurenzi, F., Grassini, M., Iaquinto, G., D'Onofrio, V., Giardullo, N., Pasquale, L., Sedici, A., Moschetta, R., Maurogiovanni, G., Costan, F., Germana, B., Lecis, P., Negrini, F., Signorelli, S., Landi, P., Malaguti, P., Roda, E., De, E., Gandolfi, L., Torresan, F., Chilovi, F., Benvenuti, S., Grasso, T., Adamo, S., Azzurro, M., Carrara, M., Rubbiani, C., P. V., Di, Di, M., Belvedere, F., Di, A., Giglio, A., De Medici, A., Rodino, S., Sacca, N., Neri, M., Carbone, F., Laterza, F., Trimboli, V., Accattatis, G. C., Rizzuti, L. F., Sabatino, A., Lupinacci, G., Faleo, D., De Francesco, V., Lombardi, L. P, Minenna, M., Nocchiero, M. C., Tonti, P., Bocchini, R., D'Imperio, N., Giaccari, S., Tronci, S., Dall'Acqua, S., Berrini, E., Garatti, S., Putignano, R., Sferrazzo, A., Giacosa, A., Blanchi, S., Munizzi, F., Morlando, L., Bruno, G., Guardascione, F., Benedetti, E., Orzes, N., Pincione, F., Dell'Amico, I., Vannucci, P., Maurano, A., Calabrese, A., Napoli, G., Quagliariello, G., Sabarese, G., Pracanica, G., Gullotti, G., Princiotta, A., Rando, L., Anderloni, A., Pallotta, S., Fesce, E., Abbiati, D., Crippa, C., Ideo, G. M., Mannucci, P. M., Abbiati, C., De Franchis, R., Fazzini, L., Rossi, A., Bini, M., Chahin, N. J., Testoni, P. A., Fossati, D., Frego, R., Passaretti, S., Catanzano, C., Siciliano, S., Sivero, L., Cattaneo, D., Di Martino, V., Inzirillo, A., Lavelli, M., Del Genio, A., Maffettone, V., Napolitano, V., Del Piano, M., Ballare, M., Garello, E., Orsello, M., Capezzuto, E., Amuso, M., Marino, M., Reina, G., Craxi, A., Arini, A., Di Pisa, M., Peralta, S., Ficano, L., Miceli, D., Tarantello, M., Orlando, A., Perego, M., Alvisi, C., Pozzi, L., Torello Viera, F., Marchi, S., Arpe, P., Bellini, M., Costa, F., Da Massa Carrara, P., Manghetti, M., Meletis, P., Romano, A., Torelli, E., Garcea, M. R., Lombardi, M., Tristaino, B., Farroni, F., Di Cicco, M., Proietti, M., Tanzilli, A., Benedetti, G., Guido, E., Lacchin, T., Sablich, R., Vitalba, A., Casetti, T., Cantoni, F., Salzetta, A., Polimeni, F., Bortoli, A., Buono, M., Gozzini, C., Barberani, F., Boschetto, S., Giovannone, M., Casale, V., Assisi, D., Grassi, A., Lapenta, R., Stigliano, V., Fedeli, G., Pirozzi, G. A., Pippa, G., Bazuro, M. E., Romano, M., Borgheresi, P., Andriulli, A., Fiorella, S., De Rocco, R., Greco, G., Meloni, M., Fina, G., Frosini, G., Macchiarelli, R., Virgilio, C., Borina, E., Lauria, M., Cappelletti, F., Puglisi, F., Ravizza, M., Emanuelli, G., Battaglia, E., Dughera, L., Navino, M., Ferrari, A., Martinoglio, P., Turco, D., Pera, A., Daperno, M., Lombardo, L., Gusmaroli, R., Milesi, F., Zilli, M., Brosolo, P., De, G., Zoratti, L., Curzio, M., Amato, A., Bisso, G., Feliziani, M., Gianfrate, L., Natale, C., Petillo, A., Spadaccini, A., Meddi, P., Sciampa, G., and Ubalducci, G. M. more...

Subjects
Adult, Male, Gastrointestinal, Time Factors, Severity of Illness Index, 2-Pyridinylmethylsulfinylbenzimidazoles, Endoscopy, Gastrointestinal, Helicobacter Infections, Dose-Response Relationship, Gastro-oesophageal reflux disease, Double-Blind Method, Heartburn, Esophagitis, Humans, Esophagitis, Peptic, Curative/maintenance therapy, Peptic, Hepatology, Dose-Response Relationship, Drug, Helicobacter pylori, Rabeprazole, Antacids, Anti-Ulcer Agents, Benzimidazoles, Female, Gastroesophageal Reflux, Middle Aged, Omeprazole, Patient Satisfaction, Treatment Outcome, Gastroenterology, Endoscopy, Drug
Abstract

Previous studies have shown similar effects of rabeprazole and omeprazole, when used at the same dose in the treatment of reflux oesophagitis. However, such studies have been conducted as superiority studies but interpreted as equivalence ones.To properly assess the comparative efficacy of rabeprazole and omeprazole in inducing complete endoscopic healing and symptom relief in patients with reflux oesophagitis.Patients (n=560) with Savary-Miller grade I-III reflux oesophagitis were randomised in a double-blind, double-dummy fashion to rabeprazole or omeprazole 20 mg once daily for 4-8 weeks. Then, patients endoscopically healed and symptomatically relieved were openly maintained with rabeprazole 10 mg or 2x10 mg once daily (in the event of clinical and/or endoscopic relapse) for a maximum of 48 weeks.After 4-8 weeks of treatment, healing (primary end-point) was observed in 228/233 (97.9%) patients in the rabeprazole group and in 231/237 (97.5%) in the omeprazole one (equivalence effect demonstrated by p0.0001 at Blackwelder test and an upper confidence limit at 97.5% of 0.023). However, rabeprazole was faster in inducing heartburn relief than omeprazole (2.8+/-0.2 versus 4.7+/-0.5 days of therapy to reach the first day with satisfactory heartburn relief, p=0.0045 at log-rank test). In the maintenance phase, 15.2% of patients had an endoscopic and/or clinical relapse.Rabeprazole is equivalent to omeprazole in healing reflux oesophagitis, but shows a faster activity on reflux symptoms in the early treatment phase. more...

Published
2005

19. Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry

Author

Guillevin, L, Hunsche, E, Denton, Cp, Krieg, T, Schwierin, B, Rosenberg, D, Matucci-Cerinic, M, Raffier, B, Hirschi, M, Trautinger, F, Schmidt, P, Stetter, M, Hundstorfer, M, Reinhart, V, Monshi, B, Pirkhammer, D, Richter, L, Hamberger, N, Metz, S, Feldmann, R, Semmelweis, K, Lackner, K, Tomi, N, Kolle, H, Hafner, F, Brodmann, M, Kuen-Spiegel, M, Minmair, G, Heil, Pm, Broil, H, Holzer, G, Illmer, X, Rintelen, B, Sautner, J, Takacs, M, Thun, M, Zemanova, I, Soukup, T, Smrzova, A, Bohmova, J, Prochazkova, L, Nemec, P, Fojtik, Z, Suchy, D, Becvar, R, Olsen, Ab, Sondergaard, Kh, Luosu jarvi, R, Vidqvist, Kl, Madaule, S, Beneton, N, Maillard, H, Charlanne, H, Granelbrocard, F, Hachulla, E, Hatron, Py, Jourdain, N, Lambert, M, Launay, D, Morell, S, Woijtasik, G, Skowron, F, Zenone, T, Dadban, A, Lok, C, Ferrandiz, D, Magybertrand, N, Moiton, Mp, Taieb, A, Balquiere, S, Belin, E, Droitcourt, C, Julien, S, Prey, S, Boulon, C, Constans, J, Doutre, Ms, Kostrzwewa, E, Richez, C, Greco, M, Misery, L, Sassolas, B, Collet, E, Berthier, S, Leguy-Seguin, V, Imbert, B, Carpentier, P, Blaise, S, Couraud, A, Doeffel-Hantz, V, Spars, A, Bezanahary, H, Boussely, N, Dumonteil, S, Fauchais, Al, Goudran, G, Loustaud-Ratti, V, Manea, P, Vidal, E, Coppere, B, Desmursclavel, H, Girard-Madoux, Mh, Hot, A, Ninet, J, Granel, B, Cohen, Jd, Keynote, A, Khau van Kien, A, Le Quellec, A, Riviere, S, Rullier, P, Bessis, D, Farcas, C, Bravetti, V, Moline, T, Wahl, D, Zuily, S, Granel-Brocard, F, Agard, C, Durant, C, Fuzibet, Jg, Queyrel, V, Berezne, A, Mouthon, L, Cabane, J, Tiev, K, Toledano, C, Lazareth, I, Michon-Pasturel, U, Priollet, P, Reguiai, Z, Cazaletslacoste, C, Jego, P, Letremy, A, Perlat, A, Duval-Modeste, Ab, Chatelus, E, Chiffot, H, Sibillia, J, Sordet, C, Adoue, D, Couret, B, Moulis, G, Pugnet, G, Sailler, L, Diot, E, Gaches, F, Farge, D, Keshtmand, H, Frances, C, von Elling, A, Bora, D, Ebel, J, Ahmadi-Simab, K, Klein, E, Hahn, K, Schulze, K, Rasche, C, Riemekasten, G, Lee, Hh, Deuschle, K, Mattat, K, Becker, M, Worm, M, Mensing, C, Klings, D, Mensing, H, Messall, J, Zuper, R, Eilbacher, P, Saar, P, Kaufmann, P, Hallermann, C, Schmidt, K, Wahn, H, Schildt, K, Schuart, T, Kaczmarczyk, A, Kellner, C, von Oelhafen, J, Baron von Bildering, P, Kunze, S, Kleiner, Hj, Alsheimer, B, Schuetz, N, Miirker-Hermann, E, Gottl, Kh, Weiss, E, Reischel, N, Kern, S, Goettl, Kh, Goetheuniversitiitsklinikum, Jw, Himsel, A, Henkemeier, U, Schwarting, A, Hazenbiller, A, Nichelmann, V, Rumbaur, C, Boesenberg, I, Schmeiser, T, Mueller-Ladner, U, Unholzer, A, Starz, H, Welzel, J, Plaumann, K, Stoeckl, F, Sperling, S, Podda, M, Wagner, N, Rapprich, H, Niedermeier, A, Messer, G, Sardy, M, Bekou, V, Dill-MUller, D, Wlodarz, M, Belloni, B, Huettig, B, Ziai, M, Hein, R, Kneitz, C, Federow, I, Schneider, K, Semmler, M, Hapke, S, Metzler, C, Stein, T, Enderlein, M, Kayser, M, Werthmann, M, Guenther, Cu, Neul, S, Hellmich, B, Loeffler, C, Pflugfelder, J, Karaenke, P, Mueglich, C, Tony, Hp, Marina, P, Popp, M, Mittag, M, Baumann, C, Scheib, Eg, Brand, H, Wilhelm, Hu, Bohm, J, Dyballa, J, Boehm, J, Taggeselle, J, Luthke, K, Wuerzburg, I, Niefanger, K, Mayer, L, Drabek, J, Harmuth, W, Dietl, S, Moritz, D, Gause, A, Gaubitz, M, Hallecker, A, Krupp, E, Rumpel, H, Moosig, F, Frey, P, Kahl, S, Linke, M, Merk, B, Bloching, Hh, Ochs, W, Kurthen, R, Eiden, E, Guertler, I, Aries, Pm, Kirchberg, S, Jahnke, K, Mettler, S, Toeller, S, Zwenger, S, Langer, He, Deininger, F, Hartmann, F, Neeck, G, Neek, G, Wernitzsch, H, Meier, L, Herr, U, Meier, U, Aaig, W, Bruckner, L, Sheikh, N, Wollenhaupt, J, Krog, B, Wollersdorfer, E, Hall, R, Diehm, C, Tiggers, C, Peters, J, Kirschke, J, Schroeder, Jo, Zeuner, R, Uhlig, S, Barth, S, Huegel, R, Glaeser, R, Schaefer, C, Monshausen, M, Mengden, T, Funkert, A, Blank, N, Lupaschko, S, Voss, B, Megahed, M, Sadeghlar, F, Seidel, M, Wasmuth, Jc, Kreuter, A, Vosswinkel, J, Pfoehler, C, Gerber, A, Haust, M, Hoff, Np, Mota, R, Akanay-Diesel, S, Homey, B, Katzemich, A, Erfurt-Berge, C, Sticherling, M, Beyer, C, Distler, J, Mitchell, A, Freundlieb, C, Rushentsova, U, Hermanns, G, Blaschke, S, Fiene, M, Wessel, C, Norgauer, J, Rabe, B, Schuster, J, Scholz, J, Kremer, K, Robakidze-Torbahn, M, Moinzadeh, P, Dohse, A, Muhlack, A, Schultz, L, Schult, S, Frambach, Y, Kruse, S, Kettenbach, A, Fell, I, Schweda, K, Steinbrink, K, Podobinska, M, Fieri beck, G, Schanz, S, Pfeiffer, C, Hassel, R, Herrgott, I, Sunderkoetter, C, Guenzel, J, Athanassiou, P, Dimitroulas, T, Settas, L, Kritikos, I, Tsifetaki, N, Garyfallos, A, Vasilopoulos, D, Boura, P, Kamali, S, Aslanidis, S, Vlachoyannopoulos, P, Galanopoulo, V, Sakkas, L, Koutroubas, A, Elezoglou, T, Galanopoulos, N, Grier, A, Murray, M, O'Rourke, M, Del Papa, N, Maglione, W, Zeni, S, Foti, R, Benenati, A, De Vita, S, Ferraccioli, G, Grassi, W, de Angeli, R, Pomponio, G, Mussi, A, Colonna, L, Airo, P, Zingarelli, S, Scorza, R, Serverino, A, Puppo, F, Negrini, S, Roma, I, Salsano, F, Triolo, G, Mazzuca, S, Carignola, R, Gatti, S, Lunardi, G, Riccieri, V, Salvarani, C, Bajocchi, G, Varcasia, G, Marasini, B, Belloll, L, de Luca, R, Stisi, S, Bellissimo, S, Fusaro, E, Pellerito, R, Cozzi, F, Rizzo, M, Bartoluzzi, A, Trotta, F, Cantatore, F, Corrado, A, Ferri, C, Colaci, M, Malavolta, N, Mule, R, Galeazzi, M, Lapadula, G, Mathieu, A, Vacca, A, Giacomelli, R, Cipriani, P, Montecucco, Cm, Codullo, V, Bucci, R, Battaglia, E, Valentini, G, Cuomo, G, Terlizzi, N, Serafino, L, Reumatologia, Uo, Bombardieri, S, Della Rossa, A, Doveri, M, Perricone, R, de Mattia, M, Pallotta, S, Groenendael, Jh, Seys, P, Goekoop, Rj, Han, Kh, Wlarvens, M, Bonte-Mineur, F, de Bois MH, de Beus WM, van Zeben, D, Vonk, M, Knaapen, Hk, Smit, A, Bootsma, H, Ton, E, Voskuyl, A, Dutmer, Ea, Stalk, Jn, Madland, Tm, Seip, M, Hoffmann Vold AM, Bitter, H, Stocklund Thomsen, R, Resende, C, Ponte, C, Martinho, S, Silva, F, Ferreira, P, Grilo, A, Riso, N, Santos, C, Camara, I, Costa, J, Alves, J, Oliveira, S, Almeida, I, Silva, I, Cordeiro, A, Coelho, P, Lukac, J, Dolnicar, As, Espinosa, G, Mejia, Jc, Ramos, M, Plasin Rodriguez MA, Mera, A, Blanco, Js, Diaz, Jj, Losada, L, Perez, E, Maneiro, Jr, Caamano, M, Fermindez, S, Insua, Sa, Barbado, J, Fonseca, Em, Nufio, Fj, Castellvi, I, Garcia de Ia Pena, P, Bellido, D, Paulino, M, Garcia, Pv, Salas, V, Minguez, Md, Sanchez, Ma, Urrego, C, Martin, I, Rueda, A, Calvo, J, Ripoll, Mm, Torres, Mc, Corteguera, M, Maceiras, F, Cruz, J, Mosquera, Ja, Gomez, R, Area, B, Carrio, I, Rubio, M, Castellvi Barranco, I, Santos, P, Simeon, Cp, Fonollosa, V, Egurbide, Mv, Garcia de Vicuna, R, Vicente, E, Villaverde, V, Fernandez, C, Garcia, E, Uson, J, Miguelez, R, Callejas, Jl, Ortego, N, Roman, J, Alegre-Sancho, Jj, Robles, A, Rios, Jj, Bonilla, Mg, Sanchez Andrade, A, Vazquez, Tr, Miranda, Ja, Saez, L, Zea, A, De la Puente, C, Martinez, Fg, Aguirre, Ma, Collado, P, Cruz, A, Crespo, M, Sanchez-Roman, J, Castillo, Mj, Garcia, Am, Muniz, G, Hedin, Pj, Stahl, C, Bracin, T, Nordin, A, Albertsson, K, Rydvald, Y, Thorsson, C, Hermansson, E, Maurer, B, Verner, D, Schmidt Bosshard, R, Hall, F, Murphy, K, Lamb, J, Anderson, M, Moots, R, Buch, M, Bissell, L, Madhok, R, Hampson, R, D'Cruz, D, Choong, Lm, Gordon, P, Dobson, J, Salerno, R, Nisar, M, Williams, C, Wilcox, L, Denton, C, Ochiel, R, Ngcozana, T, Parker, L, Vincent, R, Mchugh, N, Cole, S, Brown, S, James, J, Herrick, A, Manning, J, Moore, T, Faizal, A, Skyes, H, Smythe, A, Hamilton, A., L., Guillevin, E., Hunsche, C. P., Denton, T., Krieg, B., Schwierin, D., Rosenberg, DUO Registry Group: B Raffier, Matucci-Cerinic M., Hirschi, M, Trautinger, F, Schmidt, P, Stetter, M, Hundstorfer, M, Reinhart, V, Monshi, B, Pirkhammer, D, Richter, L, Hamberger, N, Metz, S, Feldmann, R, Semmelweis, K, Lackner, K, Tomi, N, Kolle, H, Hafner, F, Brodmann, M, Kuen-Spiegel, M, Minmair, G, M Heil, P, Broil, H, Holzer, G, Illmer, X, Rintelen, B, Sautner, J, Takacs, M, Thun, M, Zemanova, I, Soukup, T, Smrzova, A, Bohmova, J, Prochazkova, L, Nemec, P, Fojtik, Z, Suchy, D, Becvar, R, B Olsen, A, H Sondergaard, K, Luosu jarvi, R, Vidqvist, K-L, Madaule, S, Beneton, N, Maillard, H, Charlanne, H, Granelbrocard, F, Hachulla, E, Y Hatron, P, Jourdain, N, Lambert, M, Launay, D, Morell, S, Woijtasik, G, Skowron, F, Zenone, T, Dadban, A, Lok, C, Ferrandiz, D, Magybertrand, N, P Moiton, M, Taieb, A, Balquiere, S, Belin, E, Droitcourt, C, Julien, S, Prey, S, Boulon, C, Constans, J, S Doutre, M, Kostrzwewa, E, Richez, C, Greco, M, Misery, L, Sassolas, B, Collet, E, Berthier, S, Leguy-Seguin, V, Imbert, B, Carpentier, P, Blaise, S, Couraud, A, Doeffel-Hantz, V, Spars, A, Bezanahary, H, Boussely, N, Dumonteil, S, L Fauchais, A, Goudran, G, Loustaud-Ratti, V, Manea, P, Vidal, E, Coppere, B, Desmursclavel, H, H Girard-Madoux, M, Hot, A, Ninet, J, Granel, B, D Cohen, J, Keynote, A, Khau van Kien, A, Le Quellec, A, Riviere, S, Rullier, P, Bessis, D, Farcas, C, Bravetti, V, Moline, T, Wahl, D, Zuily, S, Granel-Brocard, F, Agard, C, Durant, C, G Fuzibet, J, Queyrel, V, Berezne, A, Guillevin, L, Mouthon, L, Cabane, J, Tiev, K, Toledano, C, Lazareth, I, Michon-Pasturel, U, Priollet, P, Reguiai, Z, Cazaletslacoste, C, Jego, P, Letremy, A, Perlat, A, B Duval-Modeste, A, Chatelus, E, Chiffot, H, Sibillia, J, Sordet, C, Adoue, D, Couret, B, Moulis, G, Pugnet, G, Sailler, L, Diot, E, Gaches, F, Farge, D, Keshtmand, H, Frances, C, von Elling, A, Bora, D, Ebel, J, Ahmadi-Simab, K, Klein, E, Hahn, K, Schulze, K, Rasche, C, Riemekasten, G, H Lee, H, Deuschle, K, Mattat, K, Becker, M, Worm, M, Mensing, C, Klings, D, Mensing, H, Messall, J, Zuper, R, Eilbacher, P, Saar, P, Kaufmann, P, Hallermann, C, Schmidt, K, Wahn, H, Schildt, K, Schuart, T, Kaczmarczyk, A, Kellner, C, von Oelhafen, J, Baron von Bildering, P, Kunze, S, J Kleiner, H, Alsheimer, B, Schuetz, N, Miirker-Hermann, E, Gottl, K-H, Weiss, E, Reischel, N, Kern, S, H Goettl, K, Goetheuniversitiitsklinikum, J-W, Himsel, A, Henkemeier, U, Schwarting, A, Hazenbiller, A, Nichelmann, V, Rumbaur, C, Boesenberg, I, Schmeiser, T, Mueller-Ladner, U, Unholzer, A, Starz, H, Welzel, J, Plaumann, K, Stoeckl, F, Sperling, S, Podda, M, Wagner, N, Rapprich, H, Niedermeier, A, Messer, G, Sardy, M, Bekou, V, Dill-MUller, D, Wlodarz, M, Belloni, B, Huettig, B, Ziai, M, Hein, R, Kneitz, C, Federow, I, Schneider, K, Semmler, M, Hapke, S, Metzler, C, Stein, T, Enderlein, M, Kayser, M, Werthmann, M, U Guenther, C, Neul, S, Hellmich, B, Loeffler, C, Pflugfelder, J, Karaenke, P, Mueglich, C, P Tony, H, Marina, P, Popp, M, Mittag, M, Baumann, C, G Scheib, E, Brand, H, U Wilhelm, H, Bohm, J, Dyballa, J, Boehm, J, Taggeselle, J, Luthke, K, Wuerzburg, I, Niefanger, K, Mayer, L, Drabek, J, Harmuth, W, Dietl, S, Moritz, D, Gause, A, Gaubitz, M, Hallecker, A, Krupp, E, Rumpel, H, Moosig, F, Frey, P, Kahl, S, Linke, M, Merk, B, H Bloching, H, Ochs, W, Kurthen, R, Eiden, E, Guertler, I, M Aries, P, Kirchberg, S, Jahnke, K, Mettler, S, Toeller, S, Zwenger, S, E Langer, H, Deininger, F, Hartmann, F, Neeck, G, Neek, G, Wernitzsch, H, Meier, L, Herr, U, Meier, U, Aaig, W, Bruckner, L, Sheikh, N, Wollenhaupt, J, Krog, B, Wollersdorfer, E, Hall, R, Diehm, C, Tiggers, C, Peters, J, Kirschke, J, O Schroeder, J, Zeuner, R, Uhlig, S, Barth, S, Huegel, R, Glaeser, R, Schaefer, C, Monshausen, M, Mengden, T, Funkert, A, Blank, N, Lupaschko, S, Voss, B, Megahed, M, Sadeghlar, F, Seidel, M, C Wasmuth, J, Kreuter, A, Vosswinkel, J, Pfoehler, C, Gerber, A, Haust, M, P Hoff, N, Mota, R, Akanay-Diesel, S, Homey, B, Katzemich, A, Erfurt-Berge, C, Sticherling, M, Beyer, C, Distler, J, Mitchell, A, Freundlieb, C, Rushentsova, U, Hermanns, G, Blaschke, S, Fiene, M, Wessel, C, Norgauer, J, Rabe, B, Schuster, J, Scholz, J, Kremer, K, Robakidze-Torbahn, M, Moinzadeh, P, Dohse, A, Muhlack, A, Schultz, L, Schult, S, Frambach, Y, Kruse, S, Kettenbach, A, Fell, I, Schweda, K, Steinbrink, K, Podobinska, M, Fieri beck, G, Schanz, S, Pfeiffer, C, Hassel, R, Herrgott, I, Sunderkoetter, C, Guenzel, J, Athanassiou, P, Dimitroulas, T, Settas, L, Kritikos, I, Tsifetaki, N, Garyfallos, A, Vasilopoulos, D, Boura, P, Kamali, S, Aslanidis, S, Vlachoyannopoulos, P, Galanopoulo, V, Sakkas, L, Koutroubas, A, Elezoglou, T, Galanopoulos, N, Grier, A, Murray, M, O'Rourke, M, Del Papa, N, Maglione, W, Zeni, S, Foti, R, Benenati, A, De Vita, S, Ferraccioli, G, Grassi, W, de Angeli, R, Pomponio, G, Mussi, A, Colonna, L, Airo, P, Zingarelli, S, Scorza, R, Serverino, A, Puppo, F, Negrini, S, Roma, I, Salsano, F, Triolo, G, Mazzuca, S, Carignola, R, Gatti, S, Lunardi, G, Riccieri, V, Salvarani, C, Bajocchi, G, Varcasia, G, Marasini, B, Belloll, L, Matucci-Cerinic, M, de Luca, R, Stisi, S, Bellissimo, S, Fusaro, E, Pellerito, R, Cozzi, F, Rizzo, M, Bartoluzzi, A, Trotta, F, Cantatore, F, Corrado, A, Ferri, C, Colaci, M, Malavolta, N, Mule, R, Galeazzi, M, Lapadula, G, Mathieu, A, Vacca, A, Giacomelli, R, Cipriani, P, M Montecucco, C, Codullo, V, Bucci, R, Battaglia, E, Valentini, G, Cuomo, G, Terlizzi, N, Serafino, L, O Reumatologia, U, Bombardieri, S, Della Rossa, A, Doveri, M, Perricone, R, de Mattia, M, Pallotta, S, M Groenendael, J H L, Seys, P, J Goekoop, R, H Han, K, Wlarvens, M, Bonte-Mineur, F, and W de Bois, M H more...

Subjects
Adult, Employment, Male, Registrie, Scleroderma, Systemic, Systemic, Middle Aged, Scleroderma, Fingers, Disability Evaluation, Cost of Illness, Skin Ulcer, Activities of Daily Living, Finger, Humans, Female, Registries, Self Report, Human
Abstract

Digital ulcers (DUs) are frequent manifestations of systemic scleroderma (SSc). This study assessed functional limitations due to DUs among patients enrolled in the Digital Ulcer Outcome (DUO) Registry, an international, multicentre, observational registry of SSc patients with DU disease.Patients completed at enrolment a DU-specific functional assessment questionnaire with a 1-month recall period, measuring impairment in work and daily activities, and hours of help needed from others. Physician-reported clinical parameters were used to describe the population. For patients who completed at least part of the questionnaire, descriptive analyses were performed for overall results, and stratified by number of DUs at enrolment.This study included 2327 patients who completed at least part of the questionnaire. For patients with 0, 1-2, and ≥3 DUs at enrolment, mean overall work impairment during the prior month among employed/self-employed patients was 28%, 42%, and 48%, respectively. Across all included patients, ability to perform daily activities was impaired on average by 35%, 54%, and 63%, respectively. Patients required a mean of 2.0, 8.7, and 8.8 hours of paid help and 17.0, 35.9, and 63.7 hours of unpaid help, respectively, due to DUs in the prior month. Patients with DUs had more complications and medication use than patients with no DUs.With increasing number of DUs, SSc patients reported more impairment in work and daily activities and required more support from others. more...

25. PRIMA Proton Imaging for Clinical Application

Author

Talamonti, C., Mara Bruzzi, Bucciolini, M., Carpinelli, M., Cirrone, G. A. P., Civinini, C., Cuttone, G., Lo Presti, D., Pallotta, S., Randazzo, N., Romano, F., Scaringella, M., Sipala, V., Stancampiano, C., Vanzi, E., Zani, M., and Yu, B. more...

26. Community approach for reducing small field measurement errors: Experience over 24 centres

Author

Pietro Mancosu, Michele Stasi, Serenella Russo, Maria Daniela Falco, Maria Pimpinella, Elisabetta Cagni, Stefania Pallotta, Cinzia Talamonti, Talamonti, C., Russo, S., Pimpinella, M., Falco, M. D., Cagni, E., Pallotta, S., Stasi, M., and Mancosu, P. more...

Subjects
Silicon, medicine.medical_specialty, Computer science, media_common.quotation_subject, Multicentre evaluation, Radiosurgery, 030218 nuclear medicine & medical imaging, Small field, 03 medical and health sciences, Consistency (database systems), 0302 clinical medicine, Silicon diode detector, medicine, Humans, Dosimetry, Radiology, Nuclear Medicine and imaging, Quality (business), Medical physics, Crowd knowledge method, Community approach, Radiometry, Radiation treatment planning, media_common, Observational error, business.industry, Small field output factor, Hematology, Oncology, 030220 oncology & carcinogenesis, Particle Accelerators, business, Quality assurance
Abstract

Purpose The complexity of the modern Stereotactic Body Radiation Therapy (SBRT) techniques requires comprehensive quality assurance programs, to ensure the right treatment to the patient. Dosimetry of small radiation fields is a challenge especially for radiotherapy centres starting to work on this issue. The matter to be discussed here concerns the need of detailed measurement procedures and cross checks to be paired to the usual recommendations on detectors and correction factors. Materials and Methods The presented work involved 24 Italian radiotheraphy centres, with the specific purpose to minimize systematic errors in output factor measurements over different radiotherapy centres. Using the unshielded silicon diode IBA Razor, reference curves for the relative signal ratio (RSR) as a function of beam size were created for each Linac family. Results With this study we have demonstrated consistency of small field dosimetry on all the centres involved, moreover all radiotherapy centres using Razor are allowed to compare measurements amongst each other and centres with values deviating more than 5% from the reference curve are advised to repeat their measurements. With this procedure, some critical issues were detected from two centres in RSR measurements, that, if implemented into the own treatment planning system, would induce an unwanted overdosage larger than 5%. Conclusions The proposed approach could allow one to envision high-skilled therapy centres providing support to those featuring minor experience and could represent an important strategy for the clinical implementation of emerging technologies at high quality levels. The methodology adopted exploits crowd knowledge methods which could be applied in others areas of radiation dosimetry. more...

Published
2019
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27. The PRIMA (PRoton IMAging) collaboration: Development of a proton Computed Tomography apparatus

Author

C. Civinini, M. Carpinelli, D. Lo Presti, M. Tesi, Monica Scaringella, N. Randazzo, Cinzia Talamonti, M. Brianzi, Stefania Pallotta, Giacomo Cuttone, Fabrizio Romano, Mara Bruzzi, C. Stancampiano, E. Vanzi, Marta Bucciolini, Margherita Zani, G.A.P. Cirrone, C. Pugliatti, Valeria Sipala, Scaringella, M, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, and Zani, M more...

Subjects
Physics, Proton computed tomography, Nuclear and High Energy Physics, Proton, Calorimeter (particle physics), Physics::Instrumentation and Detectors, business.industry, pCT (proton Computed Tomography), Calorimetry, Stopping power, Silicon microstrip, Nuclear magnetic resonance, Optics, Trajectory, Physics::Accelerator Physics, Upstream (networking), Development (differential geometry), Nuclear Experiment, business, Instrumentation, Proton therapy
Abstract

This paper describes the development of a proton Computed Tomography (pCT) apparatus able to reconstruct a map of stopping power useful for accurate proton therapy treatment planning and patient positioning. This system is based on two main components: a silicon microstrip tracker and a YAG:Ce crystal calorimeter. Each proton trajectory is sampled by the tracker in four points: two upstream and two downstream the object under test; the particle residual energy is measured by the calorimeter. The apparatus is described in details together with a discussion on the characterization of the hardware under proton beams with energies up to 175 MeV. more...

Published
2013
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28. Temperature control of an innovative aluminium-steel molds induction preheat process placed on automated laser guided vehicles

Author

Mariorosario Prist, Andrea Monteriù, E. Pallotta, Anna Costanza Russo, Sauro Longhi, Paolo Cicconi, Francesco Ferracuti, M. Prist, P. Cicconi, F. Ferracuti, A. C. Russo, A. Monteriù, E. Pallotta, S. Longhi, Prist, M., Cicconi, P., Ferracuti, F., Russo, A. C., Monteriu, A., Pallotta, E., and Longhi, S. more...

Subjects
010302 applied physics, Engineering, Temperature control, Induction heating, business.industry, Preheating Mold, PID controller, Mechanical engineering, Automated Laser Guided Vehicle, 02 engineering and technology, Molding (process), Temperature Control, 021001 nanoscience & nanotechnology, 01 natural sciences, Setpoint, Heating system, Footwear Industry, Control system, 0103 physical sciences, Model Predictive Controller, Process optimization, Injection Molding, 0210 nano-technology, business, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

In the production of plastic components based on injection molding, like shoe sole manufacturing, the temperature control and the on-line process optimization are important issues in order to preserve the quality of the plastic components and improve the time performance, while maintaining high product quality. This research proposes an induction preheating control technique based on Model Predictive Controller (MPC) for a steel-aluminium mold for production of soles, performed on an automated Laser Guided Vehicle (LGV) with an innovative induction heating functionality. A thermal model has been studied using a finite-difference approach to describe the mold heating system. The resulting system has been simulated using Simulink/MATLAB. Then, three types of controllers have been modelled in the proposed simulation workflow, in order to compare the different behavior of the system. Due to the high mold thermal inertia, which increases the mold temperature even if the control system turns off the thermal power, innovative controllers are needed in order to track the desired temperature setpoint. The comparison with standard industrial controllers, based on PI and PID controllers, shows the effectiveness of proposed solution. more...

Published
2017

29. Proof-of-principle results of proton Computed Tomography

Author

Domenico Lo Presti, Francesco Romano, M. Brianzi, E. Vanzi, Giorgia Maccioni, Mara Bruzzi, G. A. Pablo Cirrone, M. Rovituso, Cinzia Talamonti, Danilo Bonanno, Giacomo Cuttone, Francesco Tommasino, Nunzio Randazzo, Carlo Civinini, Valeria Sipala, Monica Scaringella, Stefania Pallotta, M. Carpinelli, Civinini, C, Scaringella, M, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Romano, F, Rovituso, M, Sipala, V, Talamonti, C, Tommasino, F, Vanzi, E, and Bruzzi, M more...

Subjects
Nuclear and High Energy Physics, Computation, Physics::Medical Physics, Iterative reconstruction, 01 natural sciences, Imaging phantom, The Svedberg Laboratory, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, Nuclear Medicine and Imaging, 0103 physical sciences, Electronic, Optical and Magnetic Materials, Nuclear Experiment, Proton therapy, Instrumentation, Nuclear and High Energy Physic, Physics, Human head, 010308 nuclear & particles physics, business.industry, Radiology, Nuclear Medicine and Imaging, Electronic, Optical and Magnetic Materials, Beamline, Physics::Accelerator Physics, Tomography, business, Radiology
Abstract

A proof of principle proton Computed Tomography (pCT) apparatus, based on a silicon microstrip tracker and a YAG:Ce calorimeter, has been manufactured. Tests with a 175 MeV proton beam at The Svedberg Laboratory (TSL, Uppsala, Sweden) aiming at collecting data for reconstructing a tomographic image have been carried out. Algebraic iterative reconstruction methods, together with the most likely path formalism, have been used to obtain non-homogeneous phantom images to eventually extract density and spatial resolutions. The heavy computation load required by the algebraic algorithms has been approached fully exploiting the high calculation parallelism of Graphics Processing Units. The dose delivered to the phantom during the tomographic data-taking has been estimated as well as spatial and density resolutions dependence on dose. An upgraded pCT apparatus with an extended field-of-view able to reconstruct objects of the size of a human head, thus suitable to be used in pre-clinical tests, is now at an advanced construction stage. Using this new apparatus radiographies of an anthropomorphic phantom have been taken at the proton experimental beam line of the 'Trento Proton Therapy Center' (Trento, Italy). more...

Published
2017

30. Proton Computed Tomography: Iterative image reconstruction and dose evaluation

Author

E. Vanzi, M. Carpinelli, M. Brianzi, G.A.P. Cirrone, N. Randazzo, Danilo Bonanno, C. Civinini, Mara Bruzzi, G. Maccioni, Fabrizio Romano, D. Lo Presti, Valeria Sipala, Cinzia Talamonti, Stefania Pallotta, Monica Scaringella, Giacomo Cuttone, Civinini, C, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Scaringella, M, Romano, F, Sipala, V, Talamonti, C, Vanzi, E, and Bruzzi, M more...

Subjects
medicine.medical_specialty, Image quality, Image processing, Iterative reconstruction, 01 natural sciences, Imaging phantom, The Svedberg Laboratory, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Instrumentation for hadron therapy, 0103 physical sciences, Medical imaging, medicine, Computer vision, Medical physics, Instrumentation, Image resolution, Mathematical Physics, Physics, 010308 nuclear & particles physics, business.industry, Artificial intelligence, Tomography, Medical-image reconstruction methods and algorithms, computer-aided software, Instrumentation for particle-beam therapy, business
Abstract

Proton Computed Tomography (pCT) is a medical imaging method with a potential for increasing accuracy of treatment planning and patient positioning in hadron therapy. A pCT system based on a Silicon microstrip tracker and a YAG:Ce crystal calorimeter has been developed within the INFN Prima-RDH collaboration. The prototype has been tested with a 175 MeV proton beam at The Svedberg Laboratory (Uppsala, Sweden) with the aim to reconstruct and characterize a tomographic image. Algebraic iterative reconstruction methods (ART), together with the most likely path formalism, have been used to obtain tomographies of an inhomogeneous phantom to eventually extract density and spatial resolutions. These results will be presented and discussed together with an estimation of the average dose delivered to the phantom and the dependence of the image quality on the dose. Due to the heavy computation load required by the algebraic algorithms the reconstruction programs have been implemented to fully exploit the high calculation parallelism of Graphics Processing Units. An extended field of view pCT system is in an advanced construction stage. This apparatus will be able to reconstruct objects of the size of a human head making possible to characterize this pCT approach in a pre-clinical environment. more...

Published
2017

31. Proton computed tomography images with algebraic reconstruction

Author

Giacomo Cuttone, E. Vanzi, M. Brianzi, Mara Bruzzi, N. Randazzo, Stefania Pallotta, Danilo Bonanno, M. Scaringella, C. Civinini, D. Lo Presti, Fabrizio Romano, G. Maccioni, Valeria Sipala, M. Carpinelli, G.A.P. Cirrone, Cinzia Talamonti, Bruzzi, M, Civinini, C, Scaringella, M, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Romano, F, Sipala, V, Talamonti, C, and Vanzi, E more...

Subjects
Nuclear and High Energy Physics, Algebraic Reconstruction Technique, Proton, Nuclear Theory, Physics::Medical Physics, Iterative reconstruction, 01 natural sciences, Imaging phantom, 030218 nuclear medicine & medical imaging, Proton beam, 03 medical and health sciences, Hadron therapy, 0302 clinical medicine, Optics, 0103 physical sciences, Algebraic number, Nuclear Experiment, Instrumentation, Tomography, Physics, Tomographic reconstruction, Proton beams, Silicon radiation detectors, Silicon radiation detector, 010308 nuclear & particles physics, business.industry, Physics::Accelerator Physics, business, Beam (structure)
Abstract

A prototype of proton Computed Tomography (pCT) system for hadron-therapy has been manufactured and tested in a 175 MeV proton beam with a non-homogeneous phantom designed to simulate high-contrast material. BI-SART reconstruction algorithms have been implemented with GPU parallelism, taking into account of most likely paths of protons in matter. Reconstructed tomography images with density resolutions r.m.s. down to ~1% and spatial resolutions more...

Published
2017

32. Design and characterisation of a YAG(Ce) calorimeter for proton Computed Tomography application

Author

E. Vanzi, Marta Bucciolini, D. Lo Presti, Cinzia Talamonti, N. Randazzo, M. Carpinelli, Sebastiano Aiello, Stefania Pallotta, C. Pugliatti, Mara Bruzzi, Valeria Sipala, Emanuele Leonora, G.A.P. Cirrone, C. Civinini, C. Stancampiano, Monica Scaringella, Giacomo Cuttone, Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Pugliatti, C, Scaringella, M, Stancampiano, C, Talamonti, C, and Vanzi, E more...

Subjects
Physics, Calorimeter, Proton, Physics::Instrumentation and Detectors, business.industry, Instrumentation, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators), Scintillator, Particle detector, Charged particle, Photodiode, law.invention, Nuclear physics, Optics, Instrumentation for hadron therapy, law, Measuring instrument, Physics::Accelerator Physics, business, Mathematical Physics
Abstract

The design and the characterization of a calorimeter system, aimed at measuring the residual energy in a proton Computed Tomography (pCT) apparatus, is described. The calorimeter has a 6 × 6 cm2 active area to fully cover the tracker area of the pCT system, being 10 cm thick it is able to stop up to 200 MeV protons and sustain 1 MHz particle rate (average rate on the whole area). The YAG(Ce) scintillator is promising for charged particle detection applications where high-count rate, good energy resolution and compact photodiode readout, not influenced by magnetic fields, are of importance. The aim of this work is to show data acquired with proton beam energy up to 175 MeV and to discuss the performances of this calorimeter. more...

Published
2015

33. A proton Computed Tomography based medical imaging system

Author

C. Pugliatti, Margherita Zani, C. Civinini, G.A.P. Cirrone, E. Vanzi, Marta Bucciolini, Cinzia Talamonti, Valeria Sipala, C. Stancampiano, Giacomo Cuttone, D. Lo Presti, Monica Scaringella, N. Randazzo, Stefania Pallotta, Fabrizio Romano, M. Carpinelli, Mara Bruzzi, Scaringella, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, and Zani, M more...

Subjects
Physics, Proton, Calorimeter (particle physics), Si microstrip and pad detectors, Particle detector, The Svedberg Laboratory, Semiconductor detector, Nuclear physics, Nuclear magnetic resonance, Instrumentation for hadron therapy, Mockup, Measuring instrument, Tomography, Instrumentation, Mathematical Physics
Abstract

This paper reports on the activity of the INFN PRIMA/RDH collaboration in the development of proton Computed Tomography (pCT) systems based on single proton tracking and residual energy measurement. The systems are made of a silicon microstrip tracker and a YAG:Ce crystal calorimeter to measure single protons trajectory and residual energy, respectively. A first prototype of pCT scanner, with an active area of about 5 × 5 cm2 and a data rate capability of 10 kHz, has been constructed and characterized with 62 MeV protons at INFN Laboratori Nazionali del Sud in Catania (Italy) and with 180 MeV protons at The Svedberg Laboratory (TSL) in Uppsala (Sweden). Results of these measurements, including tomographic reconstructions of test phantoms, will be shown and discussed. An upgraded system with an extended field of view (up to ~ 5 × 20 cm2) and an increased event rate capability up to one MHz, presently under development, will be also described. more...

Published
2014

34. Characterization of a YAG:Ce calorimeter with high-energy proton beam

Author

Mara Bruzzi, Valeria Sipala, Monica Scaringella, D. Lo Presti, N. Randazzo, Giacomo Cuttone, G.A.P. Cirrone, Stefania Pallotta, C. Civinini, Sebastiano Aiello, C. Stancampiano, E. Vanzi, Marta Bucciolini, M. Carpinelli, Emanuele Leonora, Cinzia Talamonti, Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Scaringella, M, Stancampiano, C, Talamonti, C, and Vanzi, E more...

Subjects
Materials science, Proton, Physics::Instrumentation and Detectors, Physics::Optics, Scintillator, The Svedberg Laboratory, law.invention, Calorimeters, Nuclear magnetic resonance, law, Nuclear Medicine and Imaging, Nuclear Experiment, Nuclear and High Energy Physic, Calorimeter (particle physics), business.industry, Charged particles, Charged particle, Photodiode, Proton beams, Calorimeters, Charged particles, Proton beams, Physics::Accelerator Physics, Optoelectronics, Particle, business, Radiology, Beam (structure)
Abstract

A YAG:Ce calorimeter with a 6×6 cm2 active area, long 10 cm has been manufactured in order to stop up to 200 MeV protons and to sustain 1MHz particle rate. It consists of four optically separated crystals assembled in the same housing. The YAG:Ce scintillator is promising for charged particle detection applications where high-count rate, good energy resolution and compact photodiode readout, not influenced by magnetic fields, are of importance. The YAG:Ce calorimeter has been characterized with proton beams up to 175MeV a The Svedberg Laboratory (TSL), Uppsala Sweden. Results obtained are shown and discussed. more...

Published
2014

35. A binary readout chip for silicon microstrip detector in proton imaging application

Author

E. Vanzi, M. Tesi, Mara Bruzzi, G.A.P. Cirrone, Danilo Bonanno, C. Civinini, A. Lai, M. Bondì, S. Cadeddu, G. Maccioni, Giacomo Cuttone, Cinzia Talamonti, D. Lo Presti, Valeria Sipala, Emanuele Leonora, M. Carpinelli, Monica Scaringella, Stefania Pallotta, N. Randazzo, Sipala, V, Bruzzi, M, Bondì, M, Bonanno, D, Cadeddu, S, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lai, A, Leonora, E, Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Scaringella, M, Talamonti, C, Tesi, M, and Vanzi, E more...

Subjects
Comparator, Preamplifier, Hardware_PERFORMANCEANDRELIABILITY, VLSI circuits, 01 natural sciences, Particle detector, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Instrumentation for hadron therapy, Front-end electronics for detector readout, Particle tracking detectors, 0103 physical sciences, VLSI circuit, Hardware_INTEGRATEDCIRCUITS, Instrumentation, Mathematical Physics, Physics, Front-end electronics for detector readout, Instrumentation for hadron therapy, Particle tracking detectors, VLSI circuits, Signal processing, 010308 nuclear & particles physics, business.industry, Amplifier, Detector, Electrical engineering, Chip, Particle tracking detector, Semiconductor detector, Optoelectronics, business
Abstract

The mixed-signal PRIMA-chip has been developed for sensitive-position silicon detector in proton imaging application. The chip is based upon the binary readout architecture which, providing fully parallel signal processing, is a good solution for high intensity radiation application. It includes 32-front-end channels with a charge preamplifier, a shaper and a comparator. In order to adjust the comparator thresholds, each channel contains a 8-bit DAC, programmed using an I2C like interface. The PRIMA-chip has been fabricated using the AMS 0.35 μm standard CMOS process and its performances have been tested coupling it to the detectors used in the tracker assembled for the pCT (proton Computed Tomography) apparatus. more...

Published
2017
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36. Recent results on the development of a proton computed tomography system

Author

N. Randazzo, Mara Bruzzi, C. Pugliatti, Giacomo Cuttone, Fabrizio Romano, E. Vanzi, Marta Bucciolini, M. Carpinelli, Stefania Pallotta, D. Lo Presti, Monica Scaringella, C. Stancampiano, Margherita Zani, Valeria Sipala, Cinzia Talamonti, C. Civinini, G.A.P. Cirrone, Civinini, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, and Zani, M more...

Subjects
Proton computed tomography, Physics, Nuclear and High Energy Physics, Scanner, Proton, Calorimeter (particle physics), Physics::Instrumentation and Detectors, business.industry, Silicon microstrip tracker, Physics::Medical Physics, Measure (physics), Stopping power, Calorimetry, Optics, Nuclear magnetic resonance, Medical imaging, Physics::Accelerator Physics, Development (differential geometry), Nuclear Experiment, business, Instrumentation
Abstract

Proton Computed Tomography (pCT) is a medical imaging technique based on the use of proton beams with energies above 200 MeV to directly measure stopping power distributions inside the tissue volume. Prima (PRoton IMAging) is an Italian collaboration working on the development of a pCT scanner based on a tracker and a calorimeter to measure single protons trajectory and residual energy. The tracker is composed of four planes of silicon microstrip detectors to measure proton entry and exit positions and angles. Residual energy is measured by a calorimeter composed of YAG:Ce scintillating crystals. A first prototype of pCT scanner, with an active area of about 5×5 cm2, has been constructed and characterized with 60 MeV protons at the INFN Laboratori Nazionali del Sud, Catania (Italy) and with 180 MeV protons at Svedberg Laboratory, Uppsala (Sweden). A new pre-clinical prototype with an extended active area up to 20×5 cm2, real time data acquisition and a data rate up to 1 MHz is under development. A description of the two prototypes will be presented together with first results concerning tomographic image reconstruction. more...

Published
2013

37. Towards a large area apparatus for Proton Computed Tomography

Author

N. Randazzo, Giacomo Cuttone, D. Lo Presti, E. Vanzi, Marta Bucciolini, C. Civinini, Stefania Pallotta, Margherita Zani, Monica Scaringella, M. Carpinelli, Mara Bruzzi, Fabrizio Romano, M. Tesi, M. Brianzi, Cinzia Talamonti, Valeria Sipala, C. Pugliatti, C. Stancampiano, Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, and Zani, M more...

Subjects
Physics, Proton computed tomography, medicine.medical_specialty, Radiation, medicine.diagnostic_test, Medical treatment, business.industry, Radiography, Patient positioning, Computed tomography, Hadron therapy, Optics, Nuclear Medicine and Imaging, medicine, Medical physics, Radiation treatment planning, business, Radiology, Image-guided radiation therapy, Nuclear and High Energy Physic
Abstract

Proton Computed Tomography (pCT) is a new imaging method with a potential for increasing accuracy of treatment planning and patient positioning in hadron therapy. A pCT system with small active area (5cm×5cm) has been already manufactured by authors. Tested under proton beams gave first promising results on radiography and tomographic reconstructions. Recent developments of a second prototype with large area (5×20cm2) in the perspective of a pre-clinical acquisition system is now being designed, details are given in this paper. more...

Published
2013

38. Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure

Author

Gianpiero Manes, Vincenzo Savarino, Matteo Neri, Annalisa de Leone, S. Pallotta, Luigi Russo, Enzo Grossi, Fabio Pace, Patrizia Zentilin, Rosario Cuomo, Pace, F., Pallotta, S., Manes, G., De Leone, A., Zentilin, P., Russo, Luigi, Savarino, L., Neri, M., Grossi, E., and Cuomo, Rosario more...

Subjects
Adult, Male, medicine.medical_specialty, Esophageal pH Monitoring, Brief Article, Nerd, medicine.drug_class, Epidemiology, Proton-pump inhibitor, Esophagu, Gastroenterology, Surveys and Questionnaires, Internal medicine, medicine, Humans, Esophagus, Nonerosive gastro-esophageal reflux disease, Retrospective Studies, business.industry, digestive, oral, and skin physiology, Reflux, Heartburn, Proton Pump Inhibitors, General Medicine, Gastro-esophageal reflux disease, Hydrogen-Ion Concentration, Middle Aged, medicine.disease, humanities, digestive system diseases, body regions, Treatment Outcome, medicine.anatomical_structure, Disease Progression, Gastroesophageal Reflux, GERD, Female, medicine.symptom, business, Esophagitis, Follow-Up Studies
Abstract

AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up. METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a nega tive endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated endoscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis. RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn and regurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of followup were observed. A progression to erosive gastroesophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy. more...

Published
2009

39. A proposito di Roma e il graffitismo urbano

Author

IAMURRI, Laura, IAMURRI L., ARGENTIERI S., BERNARDINI C., CANCELLIERI C., CARDILLI L., CARERI F., CINELLI B., COSCIA M., MANACORDA D., MARRAFFA M., PALLOTTA S., PUJIA R., TRONCARELLI F., VESCI M.E., ZENO-ZENCOVICH V, IAMURRI L, and Iamurri, Laura more...

Published
2008

40. Application of a surface matching image registration technique to the correlation of cardiac studies in positron emission tomography (PET) by transmission images

Author

Giovanna Rizzo, Maria Carla Gilardi, Claudio Landoni, G. Striano, F. Fazio, Stefania Pallotta, R Masi, Valentino Bettinardi, Pallotta, S, Gilardi, M, Bettinardi, V, Rizzo, G, Landoni, C, Striano, G, Masi, R, and Fazio, F more...

Subjects
Matching (statistics), Materials science, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Phantoms, Imaging, Image registration, Reproducibility of Results, Heart, Thorax, Imaging phantom, Correlation, Positron, Transmission (telecommunications), Positron emission tomography, Robustness (computer science), medicine, Humans, Radiology, Nuclear Medicine and imaging, PET, fluorine-18-deoxyglucose, Computer Simulation, Nuclear medicine, business, Biomedical engineering, Tomography, Emission-Computed
Abstract

The aim of this work is to assess the accuracy of a surface matching registration (SMR) technique for the correlation of cardiac studies in positron emission tomography (PET). Registration parameters were estimated by matching corresponding body surfaces, extracted from transmission studies, aligned to the PET emission images to be correlated. The accuracy of the SMR technique in this specific application was assessed by computer simulations, phantom experiments and on clinical PET data. Registration accuracy was evaluated in relation to the body surfaces (external, internal and the combination of the two) used by the SMR method. Better results were found when matching shaped and irregular surfaces such as internal lung contours. The robustness of the method was verified for different counting statistics recorded in transmission images. A clinical validation of the SMR method was performed on fluorine-18-deoxyglucose PET cardiac studies. more...

Published
1995

41. Development of a Proton Computed Tomography System for Pre-Clinical Tests

Author

Cinzia Talamonti, N. Randazzo, C. Pugliatti, E. Vanzi, Marta Bucciolini, M. Tesi, Mara Bruzzi, Monica Scaringella, M. Brianzi, D. Lo Presti, Valeria Sipala, M. Carpinelli, C. Civinini, G.A.P. Cirrone, Margherita Zani, C. Stancampiano, Stefania Pallotta, Fabrizio Romano, Giacomo Cuttone, Civinini, C, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, and Zani, M more...

Subjects
Proton computed tomography, Data acquisition system, medicine.medical_specialty, Clinical tests, Proton, Computer science, Physics::Instrumentation and Detectors, Patient positioning, Physics::Medical Physics, Proton computed tomography (pCT), Data acquisition, medicine, Medical physics, Radiation treatment planning, Image resolution, Simulation, Measure (data warehouse), Spatial resolution, Crystal calorimeter, Patient treatment, proton theraphy, Instrumentation for hadron therapy, proton radiography, proton computed tomography, Computerized tomography, Calorimeter, Nuclear physic, Silicon tracker, Medical imaging, Treatment planning
Abstract

Proton Computed Tomography (pCT) is an imaging method under investigation with the aim to improve the accuracy of treatment planning and patient positioning in hadron therapy. A pCT system should be capable to measure tissue electron density with an accuracy better than 1% and with a spatial resolution better than 1mm. A first apparatus based on a silicon tracker and a YAG:Ce crystal calorimeter, with a 5×5 cm2 active area, has been already developed by the authors in the framework of the PRIMA (Proton Imaging) collaboration and tested with proton beams with promising results. A second prototype with larger area (5×20 cm2) and improved data acquisition system is being designed. The details about this new prototype will be presented in this work. more...