Search

Your search keyword '"Paparo, F."' showing total 84 results
Start Over Author "Paparo, F." Database OpenAIRE

Refine your results

more »

more »

more »
84 results on '"Paparo, F."'

1. Serum immunoglobulins A and G, and Monoclonal antibodies anti tissue transglutaminase from coeliac patients inhibit the catalytic activity both in vitro and in situ

Author

ESPOSITO C., PAPARO F., CAPUTO I., ROSSI M., MAGLIO M., SBLATTERO D., NOT T., PORTA R., MARZARI R., TRONCONE, RICCARDO, AURICCHIO, SALVATORE, MAKI M, TOSSAVAINEN M., Esposito, C, Paparo, F, Caputo, I, Rossi, M, Maglio, M, Sblattero, D, Not, T, Porta, Raffaele, Auricchio, S, Marzari, R, Troncone, Riccardo, Esposito, C., Paparo, F., Caputo, I., Rossi, M., Maglio, M., Sblattero, D., Not, T., Porta, R., Auricchio, Salvatore, and Marzari, R.

Published
2001

4. Magnetic resonance imaging of the hand in psoriatic arthritis

Author

Cimmino MA, Parodi M, Zampogna G, Paparo F, Silvestri E, Garlaschi G, SCARPA, RAFFAELE, Scarpa R, Olivieri I, Salvarano C, Ayala F, Moll JHM, Cimmino, Ma, Parodi, M, Zampogna, G, Paparo, F, Silvestri, E, Garlaschi, G, and Scarpa, Raffaele

Published
2009

6. Dynamic contrast-enhanced, extremity-dedicated MRI identifies synovitis changes in the follow-up of rheumatoid arthritis patients treated with rituximab

Author

Parodi, M, Zampogna, G, Boesen, M, Kubassova, O, Barbieri, Francesca, Paparo, F, and Cutolo, M.

Subjects
Adult, Murine-Derived, Male, Wrist Joint, Synovitis, Time Factors, Arthritis, Synovial Membrane, Contrast Media, Middle Aged, Severity of Illness Index, Magnetic Resonance Imaging, Antibodies, Treatment Outcome, Predictive Value of Tests, Antirheumatic Agents, Rheumatoid, Monoclonal, Humans, Aged, Antibodies, Monoclonal, Murine-Derived, Arthritis, Rheumatoid, Female, Prospective Studies
Published
2014

7. Growth-factor like activity of gliadin, an alimentary protein: implications for celiac disease

Author

BARONE MV, GIMIGLIANO A, CASTORIA G, MAURANO F, PAPARO F, MAGLIO M, MINEO A, NANAYAKKARA M, TRONCONE R, AURICCHIO S., PAOLELLA, GIOVANNI, MIELE, ERASMO, Barone, Mv, Gimigliano, A, Castoria, G, Paolella, Giovanni, Maurano, F, Paparo, F, Maglio, M, Mineo, A, Miele, Erasmo, Nanayakkara, M, Troncone, R, and Auricchio, S.

Abstract

Background: Gliadins, a family of wheat proteins, are central to the pathogenesis of celiac disease (CD). In addition to 'immunogenic' effects, gliadin directly affects cultured cells and intestine preparations, and produces damage in vivo, via a separate 'toxic' peptide, such as A-gliadin p31-43 (P31-43). Aims: Understanding the molecular mechanisms underlying direct non T-cell mediated effects of gliadin peptides, and assessing their potential role in promoting CD. Method: Gliadin effects were tested on a number of cell lines and on cultured mucosa samples by evaluating cytoskeleton rearrangements, endocytosis, proliferation and apoptosis. Standard biochemical methods were used to assess prolonged epidermal growth factor receptor (EGFR) activation. Results: Crude gliadin peptic-tryptic peptides [PTG], or P31-43 alone, fully reproduce the effects of epidermal growth factor [EGF] on actin cytosketon, cell cycle and cell proliferation of various cell lines. Inhibitor studies demonstrate the role of EGFR in the early response to gliadin exposure, pointing to activation of the EGFR pathway. Peptide P31-43 is not similar to any EGFR ligand, but can delay inactivation of the EGFR interfering with its endocytosis. Gliadin-induced delay of EGFR endocytosis in cultured intestinal biopsies, together with S-phase entry of epithelial intestinal cells, confirm a role for EGFR activation in CD. Conclusion: The ability of gliadin peptides to delay EGFR inactivation through interference with the endocytic pathway suggests a model where gliadin fragments amplify the effects of trace amounts of EGF, and possibly of other growth factors, by prolonging receptor activation. The results, using cultures of coeliac intestinal biopsies, highlight the role of the EGF pathway in establishing and maintaining the typical atrophic and proliferative alterations of the small intestine in CD.

Published
2007

8. Diagnostic Value of fecal calprotectin in pediatric clinical practice

Author

BERNI CANANI, ROBERTO, RAPACCIUOLO L, ROMANO MT, TANTURRI DE HORATIO L, TERRIN G, MANGUSO F, CIRILLO P, PAPARO F, TRONCONE, RICCARDO, BERNI CANANI, Roberto, Rapacciuolo, L, Romano, Mt, TANTURRI DE HORATIO, L, Terrin, G, Manguso, F, Cirillo, P, Paparo, F, and Troncone, Riccardo

Published
2004

11. AN IMMUNODOMINANT DQ8 RESTRICTED GLIADIN PEPTIDE ACTIVATES SMALL INTESTINAL IMMUNE RESPONSE IN 'IN VITRO' CULTURED MUCOSA FROM HLA-DQ8 POSITIVE BUT NOT HLA-DQ8 NEGATIVE CELIAC PATIENTS

Author

MAZZARELLA G., MAGLIO M., PAPARO F., NARDONE, GERARDO ANTONIO PIO, STEFANILE R., GRECO, LUIGI, VAN DE WAL Y., KOOY Y., TRONCONE R., AURICCHIO, SALVATORE, Mazzarella, G., Maglio, M., Paparo, F., Nardone, GERARDO ANTONIO PIO, Stefanile, R., Greco, Luigi, VAN DE WAL, Y., Kooy, Y., Auricchio, Salvatore, and Troncone, R.

Published
2003

12. AN IMMUNODOMINANT DQ8-RESTRICTED GLIADIN PEPTIDE ACTIVATES SMALL INTESTINAL IMMUNE RESPONSE IN 'IN VITRO' CULTURED MUCOSA FROM HLA-DQ8, BUT NOT HLA-DQ2 POSITIVE COELIAC PATIENTS

Author

MAZZARELLA G., MAGLIO M., PAPARO F., STEFANILE R., GRECO, LUIGI, VAN DE WAL Y., KOOY Y., KONING F., AURICCHIO S., NARDONE, GERARDO ANTONIO PIO, TRONCONE, RICCARDO, Mazzarella, G., Maglio, M., Paparo, F., Nardone, GERARDO ANTONIO PIO, Stefanile, R., Greco, Luigi, VAN DE WAL, Y., Kooy, Y., Koning, F., Auricchio, S., and Troncone, Riccardo

Published
2003

15. Serum immunoglobulin A and G, and monoclonal antibodies anti-tissue transglutaminase from coeliac patients inhibit the catalytic activity both in vitro and in situ

Author

ESPOSITO C, PAPARO F, CAPUTO I, ROSSI M, MAGLIO D, SBLATTERO D, NOT, TARCISIO, PORTA S, TRONCONE R., MARZARI, ROBERTO, Esposito, C, Paparo, F, Caputo, I, Rossi, M, Maglio, D, Sblattero, D, Not, Tarcisio, Porta, S, Marzari, Roberto, and Troncone, R.

Subjects
Celiac disease Transglutaminase Cloned antibodies Phage display
Published
2002

22. Coeliac disease and unfavorable outcome of pregnancy

Author

MARTINELLI, PASQUALE, NARDONE, GERARDO ANTONIO PIO, GRECO, LUIGI, TRONCONE, RICCARDO, PAPARO F., TORRE P., TRAPANESE E., FASANO C., LAMBERTI A., BUDILLON G., Martinelli, Pasquale, Troncone, Riccardo, Paparo, F., Torre, P., Trapanese, E., Fasano, C., Lamberti, A., Budillon, G., Nardone, GERARDO ANTONIO PIO, and Greco, Luigi

Published
2000

24. The spectrum of gluten sensitivity

Author

TRONCONE, RICCARDO, PAPARO F, MAZZARELLA G, MAGLIO M, IOVINE G, MAYER M, GRECO, LUIGI, AURICCHIO S., AURICCHIO S, GRECO L, MAIURI L, TRONCONE R., Troncone, Riccardo, Paparo, F, Mazzarella, G, Maglio, M, Iovine, G, Mayer, M, Greco, Luigi, and Auricchio, S.

Published
2000

28. Prevalence of coeliac disease in patients with thyroid autoimmunity

Author

VALENTINO R, TOMMASELLI AP, DORATO M, SCARPITTA MT, GIGANTE M, MICILLO M, PAPARO F, LOMBARDI G, SAVASTANO, SILVIA, TRONCONE, RICCARDO, Valentino, R, Savastano, Silvia, Tommaselli, Ap, Dorato, M, Scarpitta, Mt, Gigante, M, Micillo, M, Paparo, F, Lombardi, G, and Troncone, Riccardo

Published
1999

29. Dactylitis in gout

Author

Andracco, R, Zampogna, G, Parodi, M, Paparo, F, and Cimmino, MARCO AMEDEO

Published
2010

34. Diagnostic criteria for coeliac disease

Author

TRONCONE, RICCARDO, MAURANO F, IOVINE G, PETRONE E, PAPARO F., LOHINIEMI S, COLLIN P, MAKI M., Troncone, Riccardo, Maurano, F, Iovine, G, Petrone, E, and Paparo, F.

Published
1998

35. The rectal mucosa in coeliac disease

Author

TRONCONE, RICCARDO, GRECO, LUIGI, MAYER M, MAZZARELLA G, LEONE A, PAPARO F, MUGIONE P, AURICCHIO S., MAKI M, COLLIN P, VISAKORPI J., Troncone, Riccardo, Greco, Luigi, Mayer, M, Mazzarella, G, Leone, A, Paparo, F, Mugione, P, and Auricchio, S.

Published
1997

36. Growth factor-like activity of gliadin, an alimentary protein: implications for celiac disease (CD)

Author

Barone MV, Gimigliano A, Castoria G, Paolella G, Maurano F, Paparo F, Maria M, Nanayakkara M, Mineo A, Miele E, Troncone R, and Auricchio S.

Subjects
food and beverages, nutritional and metabolic diseases, digestive system diseases
Abstract

BACKGROUND: Gliadins, a family of wheat proteins, are central to the pathogenesis of celiac disease (CD). In addition to 'immunogenic' effects, gliadin directly affects cultured cells and intestine preparations, and produces damage in vivo, via a separate 'toxic' peptide, such as A-gliadin p31-43 (P31-43). AIMS: Understanding the molecular mechanisms underlying direct non T-cell mediated effects of gliadin peptides, and assessing their potential role in promoting CD. METHOD: Gliadin effects were tested on a number of cell lines and on cultured mucosa samples by evaluating cytoskeleton rearrangements, endocytosis, proliferation and apoptosis. Standard biochemical methods were used to assess prolonged epidermal growth factor receptor (EGFR) activation. RESULTS: Crude gliadin peptic-tryptic peptides (PTG], or P31-43 alone, fully reproduce the effects of epidermal growth factor (EGF] on actin cytosketon, cell cycle and cell proliferation of various cell lines. Inhibitor studies demonstrate the role of EGFR in the early response to gliadin exposure, pointing to activation of the EGFR pathway. Peptide P31-43 is not similar to any EGFR ligand, but can delay inactivation of the EGFR interfering with its endocytosis. Gliadin-induced delay of EGFR endocytosis in cultured intestinal biopsies, together with S-phase entry of epithelial intestinal cells, confirm a role for EGFR activation in CD. CONCLUSION: The ability of gliadin peptides to delay EGFR inactivation through interference with the endocytic pathway suggests a model where gliadin fragments amplify the effects of trace amounts of EGF, and possibly of other growth factors, by prolonging receptor activation. The results, using cultures of coeliac intestinal biopsies, highlight the role of the EGF pathway in establishing and maintaining the typical atrophic and proliferative alterations of the small intestine in CD.

Published
2007

45. A large twin's study in coeliac disease

Author

Coto, I, Percopo, S, Limongelli, Mg, Gasperi, V, Maglio, M, Paparo, F, Tinto, N, Sacchetti, A, D'Alfonso, A, SOMIGLIANO RICHIARDI, P, Scoglio, R, and Magazzu', Giuseppe

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results