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4 results on '"Paramo JA"'

1. Cardiovascular Risk Management Recommendations for Patients with Chronic Myeloid Leukaemia who are Candidates for Ponatinib: Multidisciplinary Delphi Analysis

Author

Paramo Ja, Gonzalez-Porras, Pardo A, Zamorano Jl, Fernandez E, Lopez-Fernandez T, de Haro J, Alvarez-Larran A, Steegmann Jl, Hernandez-Boluda Jc, Perez R, Roa-Chamorro R, and Garcia-Gutierrez

Subjects
medicine.medical_specialty, business.industry, Ponatinib, General Medicine, Chronic myeloid leukaemia, chemistry.chemical_compound, chemistry, Multidisciplinary approach, hemic and lymphatic diseases, Medicine, business, Intensive care medicine, computer, Delphi, Risk management, computer.programming_language
Abstract

Progress in the treatment of Chronic Myeloid Leukaemia (CML) has significantly improved the survival rates and prognosis of these patients. As a result, there is a growing awareness of the adverse effects that the treatments used can have on the Cardiovascular (CV) system. A high percentage of patients develop sequential resistance to CML treatments and, in these cases, ponatinib represents a good therapeutic option that has been associated with cardiovascular events. This required the development of recommendations for its management. A Delphi analysis conducted by a multidisciplinary panel of experts developed and agreed on clinical practice recommendations to optimize cardiovascular risk control in CML patients requiring ponatinib treatment.

Published
2021

2. Changes in the fibrinolytic components of cultured human umbilical vein endothelial cells induced by endotoxin, tumor necrosis factor-alpha and interleukin-1alpha

Author

Josune Orbe, Chorda, C., Montes, R., and Paramo, Ja

Subjects
Plasminogen activators, Tumor Necrosis Factor-alpha, Fibrinolysis, PAI, Urokinase-Type Plasminogen Activator, Endotoxins, Plasminogen Activators, Endotoxin, Culture Media, Conditioned, Tissue Plasminogen Activator, Plasminogen Activator Inhibitor 1, Cytokines, Humans, Endothelium, Endothelium, Vascular, Cells, Cultured, Interleukin-1
Abstract

BACKGROUND AND OBJECTIVE: Vascular fibrinolysis, a major natural defense mechanism against thrombosis, is a highly regulated process. The aim of this study was to evaluate the effect of endotoxin, tumor necrosis factor-alpha (TNFalpha) and interleukin-1alpha (IL-1alpha), on the fibrinolytic potential of cultured human umbilical vein endothelial cells (HUVEC). DESIGN AND METHODS: Samples of stimulated conditioned media were collected over a period of 24 hours to determine: plasminogen activator (PA) and plasminogen activator inhibitor (PAI) activity, PAI-1 mRNA, tissue-type plasminogen activator (t-PA) antigen and urokinase-type plasminogen activator (u-PA) antigen. RESULTS: Similar changes were observed after endotoxin and cytokine stimulation: there was a significant increase of PAI activity (p

Published
1999

3. [The role of PAI-1 in thrombotic events]

Author

Josune Orbe, Montes, R., and Paramo, Ja

Subjects
Polymorphism, Genetic, Fibrinolytic Agents, Heparin, Plasminogen Activator Inhibitor 1, Humans, Thrombosis, Vitronectin

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