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Objectives - Evaluation of the demonstrator phase and first wave roll-out of the National Health Service (NHS) Diabetes Prevention Programme (DPP) in England. To examine: (1) intervention design, provision and fidelity assessment procedures; (2) risk assessment and recruitment pathways and (3) data collection for monitoring and evaluation. To provide recommendations informing decision makers on programme quality, improvements and future evaluation.\ud \ud Design - We reviewed programme documents, mapping against the NHS DPP specification and National Institute for Health and Care Excellence (NICE) public health guideline: Type 2 diabetes (T2D) prevention in people at high risk (PH38), conducted qualitative research using individual interviews and focus group discussions with stakeholders and examined recruitment, fidelity and data collection procedures.\ud \ud Setting - Seven NHS DPP demonstrator sites and, subsequently, 27 first wave areas across England.\ud \ud Interventions - Intensive behavioural intervention with weight loss, diet and physical activity goals. The national programme specifies at least 13 sessions over 9 months, delivered face to face to groups of 15–20 adults with non-diabetic hyperglycaemia, mainly recruited from primary care and NHS Health Checks.\ud \ud Participants - Participants for qualitative research were purposively sampled to provide a spread of stakeholder experience. Documents for review were provided via the NHS DPP Management Group.\ud \ud Findings - The NHS DPP specification reflected current evidence with a clear framework for service provision. Providers, with national capacity to deliver, supplied intervention plans compliant with this framework. Stakeholders highlighted limitations in fidelity assessment and recruitment and retention challenges, especially in reach and equity, that could adversely impact on implementation. Risk assessment for first wave eligibility differed from NICE guidance.\ud \ud Conclusions - The NHS DPP provides an evidence-based behavioural intervention for prevention of T2D in adults at high risk, with capacity to deliver nationally. Framework specification allows for balance between consistency and contextual variation in intervention delivery, with session details devolved to providers. Limitations in fidelity assurance, data collection procedures and recruitment issues could adversely impact on intervention effectiveness and restrict evaluation.

Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essential carboxyl-terminal region harbors structural motifs (a basic region, a helix-loop-helix motif, and a "leucine zipper"), which, in other proteins, can mediate dimerization and sequence-specific DNA binding.

The effect of serial position was examined in a study of habituation of the vasoconstrictive orienting response in rabbits. In a procedure analogous to a recognition memory test, subjects received multiple exposures to an invariant list of stimuli before their response was assessed to an isolated item that had consistently occupied either the first, middle, or last position in the list. A reliably bowed serial-position function was obtained, with the least habituation (poorest retention) occurring for the item that had occupied the middle position in the list. The finding of both a primacy and a recency effect parallels the most general finding in studies of human memory and encourages a compatible account of habituation in infrahuman subjects. The result was discussed in terms of the opportunities for differential rehearsal of list items and contextual cues at different positions in the list.

Two experiments employing a conditioned emotional response procedure with rats evaluated the associative tendencies acquired by a target CS when a compound of that stimulus and another CS was reinforced by a low-intensity US whereas the latter CS alone was reinforced by a higher intensity US. Experiment 1 involved a blocking sequence in which the element and compound trials occurred in successive phases, followed by eventual testing of the responding to the target CS alone. Less evidence of excitatory conditioning was observed than in a comparison group which had the element and compound paired with the same low-intensity US. Experiment 2 included contemporaneous differential reinforcement of the element and compound CSs and periodic summation tests in which the target CS was compounded with another independently trained CS. Clear evidence was obtained of the development of inhibitory tendencies by the target CS. The results are consistent with the predictions of the Rescorla-Wagner model and are discussed in relation to the several determining assumptions of the model.

Conditioned responding to a well-trained conditioned stimulus (CS) was assessed in an eyelid conditioning situation under three conditions of prior stimulation: when preceded by recent presentation of the same CS, when preceded by recent presentation of a different CS, and when preceded by no recent stimulation. As compared to the latter condition, prior presentation of the same CS depressed responding, while prior presentation of a different CS augmented responding. Both effects diminished as the interval separating the test stimulus from the preceding CS was lengthened over the range of 2.5 to 10 sec. The results were discussed in terms of the interaction of short-term memory representations with subsequent stimulation, and a specific theory concerning the effects of “priming.”

$\textbf{Objectives:}$ To determine if the amount of salt delivered by standard salt shakers commonly used in English independent takeaways varies between those with five and 17 holes; and to determine if any differences are robust to variations in: the amount of salt in the shaker, the length of time spent shaking, and the person serving. $\textbf{Design:}$ Four laboratory experiments comparing the amount of salt delivered by shakers. Independent variables considered were: type of shaker used (five or 17 holes), amount of salt in the shaker before shaking commences (shaker full, half full or nearly empty), time spent shaking (3s, 5s or 10s), and individual serving. $\textbf{Setting:}$ Controlled, laboratory, conditions. $\textbf{Participants:}$ A quota-based convenience sample of 10 participants (five women) aged 18-59 years. $\textbf{Main Outcome Measures:}$ Amount of salt delivered by salt shakers. $\textbf{Results:}$ Across all trials, the 17 holed shaker delivered a mean (SD) of 7.86g (4.54) per trial, whilst the five holed shaker delivered 2.65g (1.22). The five holed shaker delivered a mean of 33.7% of the salt of the 17 holed shaker. There was a significant difference in salt delivered between the five and 17 holed salt shakers when time spent shaking, amount of salt in the shaker and participant were all kept constant (p