432 results on '"Philippe Pierre"'
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2. Au-delà de la réparation : les nouvelles sanctions
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Philippe Pierre
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- 2022
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3. Ukrainian refugees in Germany: Escape, arrival and everyday life
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Brücker, Herbert, Ette, Andreas, Grabka, Markus, Kosyakova, Yuliya, Niehues, Wenke, Rother, Nina, Spieß, C. Katharina, Zinn, Sabine, Bujard, Martin, Cardozo, Adriana, Decieux, Jean Philippe Pierre, Maddox, Amrei, Milewski, Nadja, Naderi, Robert, Sauer, Lenore, Schmitz, Sophia, Schwanhäuser, Silvia, Siegert, Manuel, and Tanis, Kerstin
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Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie] ,Refugee ,Sociology & social sciences [H10] [Social & behavioral sciences, psychology] ,Ukrainian refugees ,Ukraine ,Forced Migration - Abstract
Das Institut für Arbeitsmarkt- und Berufsforschung (IAB), das Bundesinstitut für Bevölkerungsforschung (BiB), das Forschungszentrum des Bundesamts für Migration und Flüchtlinge (BAMF-FZ) und das Sozio-oekonomische Panel (SOEP) am Deutschen Institut für Wirtschaftsforschung (DIW Berlin) haben 11.225 geflüchtete Ukrainerinnen und Ukrainer zwischen August und Oktober 2022 befragt. Die Befragung kann auf die Grundgesamtheit der ukrainischen Geflüchteten, die seit Kriegsausbruch am 24.2.2022 bis zum 8. Juni 2022 nach Deutschland zugezogen sind, hochgerechnet werden. Die Ergebnisse zeigen, dass die meisten Geflüchteten wegen der Kriegshandlungen aus der Ukraine geflohen und aufgrund bestehender persönlicher Netzwerke und der Achtung der Menschenrechte nach Deutschland gezogen sind. Rund 80 Prozent der erwachsenen Geflüchteten sind weiblich. Knapp die Hälfte lebt mit minderjährigen Kindern und vier Fünftel ohne Partner oder Partnerin in Deutschland. Gut 70 Prozent verfügen über Hochschul- oder vergleichbare Bildungsabschlüsse. Nur 4 Prozent verfügen über gute oder sehr gute, weitere 14 Prozent über mittlere deutsche Sprachkenntnisse. Allerdings hatte zum Befragungszeitpunkt bereits die Hälfte einen Sprachkurs begonnen oder abgeschlossen. 17 Prozent waren zum Befragungszeitpunkt erwerbstätig. Unter den Erwerbstätigen übten rund 70 Prozent eine qualifizierte Tätigkeit aus. Der Gesundheitszustand der Geflüchteten ist im Durchschnitt gut, die Lebenszufriedenheit aber viel geringer als im deutschen Bevölkerungsdurchschnitt. Gut ein Drittel der Geflüchteten wollen dauerhaft oder für mehrere Jahre in Deutschland bleiben, ebenfalls ein Drittel Deutschland nach Kriegsende wieder verlassen, 27 Prozent können noch keine Aussagen über ihre Bleibeabsichten treffen., IAB-Forschungsbericht
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- 2023
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4. Enhancing Participation in Probability-Based Online Panels: Two Incentive Experiments and Their Effects on Response and Panel Recruitment
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Jette Schröder, Andreas Ette, Nils Witte, Ines Schauer, Jean Philippe Pierre Decieux, and German Research Foundation (DFG) [sponsor]
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SocArXiv|Social and Behavioral Sciences|Sociology|Methodology ,Online-Befragung ,Umfrageforschung ,Library and Information Sciences ,incentive system ,SocArXiv|Social and Behavioral Sciences|Sociology ,Microeconomics ,generous lottery ,Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie] ,survey research ,mobile populations ,Soziologie, Sozialwissenschaften ,combined incentives ,Social sciences, sociology, anthropology ,Erhebungstechniken und Analysetechniken der Sozialwissenschaften ,Teilnehmer ,recruitment costs ,Motivation ,Sozialwissenschaften, Soziologie ,demographic bias ,General Social Sciences ,money-in-hand ,Probability-based panel recruitment ,prepaid cash ,Computer Science Applications ,bepress|Social and Behavioral Sciences|Sociology ,Methods and Techniques of Data Collection and Data Analysis, Statistical Methods, Computer Methods ,Incentive ,bepress|Social and Behavioral Sciences|Sociology|Quantitative, Qualitative, Comparative, and Historical Methodologies ,Sociology & social sciences [H10] [Social & behavioral sciences, psychology] ,incentive experiment ,bepress|Social and Behavioral Sciences ,ddc:300 ,Panel ,online survey ,SocArXiv|Social and Behavioral Sciences ,Business ,Law ,participant ,probability-based panel recruitment ,Anreizsystem - Abstract
This article investigates how mail-based online panel recruitment can be facilitated through incentives. The analysis relies on two incentive experiments and their effects on panel recruitment, and the intermediate participation in the recruitment survey. The experiments were implemented in the context of the German Emigration and Remigration Panel Study and encompass two samples of randomly sampled persons. Tested incentives include a conditional lottery, conditional monetary incentives, and the combination of unconditional money-in-hand with conditional monetary incentives. For an encompassing evaluation of the link between incentives and panel recruitment, the article further assesses the incentives’ implications for demographic composition and panel recruitment unit costs. Multivariate analysis indicates that low combined incentives (€5/€5) or, where unconditional disbursement is unfeasible, high conditional incentives (€20) are most effective in enhancing panel participation. In terms of demographic bias, low combined incentives (€5/€5) and €10 conditional incentives are the favored options. The budget options from the perspective of panel recruitment include the lottery and the €10 conditional incentive which break-even at net sample sizes of 1000.
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- 2023
5. On the erosion of cohesive granular soils by a submerged jet: a numerical approach
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Benseghier, Zeyd, Luu, Li-Hua, Cuéllar, Pablo, Bonelli, Stéphane, Philippe, Pierre, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Federal Institute for Materials Research and Testing - Bundesanstalt für Materialforschung und -prüfung (BAM), and Région Sud, Provence-Alpes-Côte d'Azur
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[SPI]Engineering Sciences [physics] ,Mechanics of Materials ,[SDE]Environmental Sciences ,General Physics and Astronomy ,General Materials Science - Abstract
International audience; This paper presents an erosion interpretation of cohesive granular materials stressed by an impinging jet based on the results of a micromechanical simulation model. The numerical techniques are briefly described, relying on a two-dimensional Lattice Boltzmann Method coupled with a Discrete Element Methods including a simple model of solid intergranular cohesion.These are then used to perform a parametric study of a planar jet in the laminar regime impinging the surface of granular samples with different degrees of cohesive strength. The results show the pertinence of using a generalized form of the Shields criterion for the quantification of the erosion threshold, which is valid for cohesionless samples, through empirical calibration, and also for cohesive ones. Furthermore, the scouring kinetics are analysed here from the perspective of a self-similar expansion of the eroded crater leading to the identification of a characteristic erosion time and the quantification of the classical erosion coefficient. However, the presented results also challenge the postulate of a local erosion law including erodibility parameters as intrinsic material properties. The paper then reviews the main limitations of the simulation and current interpretation models, and discusses the potential causes for the observed discrepancies, questioning the pertinenceof using time-averaged macroscopic relations to correctly describe soil erosion. The paper concludes addressing this question with a complementary study of the presented simulations re-assessed at the particle-scale. The resulting local critical shear stress of single grains reveals a very wide dispersion of the data but nevertheless appears to confirm the general macroscopic trend derived for the cohesionless samples, while the introduction of cohesion implies a significant but systematic quantitative deviation between the microscopic and macroscopic estimates. Nevertheless, the micro data still shows consistently that the critical shear stress does actually vary approximately in linear proportion of the adhesive force.
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- 2022
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6. Chlordécone, un crime d’État impuni ?
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Patrick Le Moal and Philippe Pierre-Charles
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- 2022
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7. Rufy3 regulates anti-bacterial responses by controlling endolysosomes perinuclear positioning in activated phagocytes
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Remy Char, Zhuangzhuang Liu, Marion Davieau, Cedric Jacqueline, Maria-Graciela Delgado, Raphael Chapuy, Mathieu Fallet, Lionel Chasson, Voahirana Camosseto, Eva Strock, Rejane Rua, Catarina Almeida, Bing Su, Ana-Maria Lennon-Dumenil, Antoine Roquilly, Yinming Liang, Stéphane Méresse, Evelina Gatti, and philippe pierre
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Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 exists as two alternative isoforms distinguishable by the presence of a C-terminal FYVE domain and by their affinity for PtdIns(3)P on endosomal membranes. The FYVE domain-bearing isoform (iRUFY3) is preferentially expressed in immune cells and up-regulated upon activation by microbes and cytokines. iRUFY3 is necessary for ARL8b+/LAMP1+ endo-lysosomes positioning in the pericentriolar organelles cloud of LPS-activated macrophages. We show that iRUFY3 controls macrophages migration, MHC II presentation and responses to Interferon-γ while being required for Intracellular Salmonella replication. Specific inactivation of Rufy3 in phagocytes leads to aggravated pathologies in mouse upon LPS injection or bacterial pneumonia. This study highlights iRUFY3 function, as a novel modulator of immunity, controlling endo-lysosomes dynamics, and ultimately regulating the function of activated phagocytes.
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- 2022
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8. Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells
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Juraj Adamik, Paul V. Munson, Felix J. Hartmann, Alexis J. Combes, Philippe Pierre, Matthew F. Krummel, Sean C. Bendall, Rafael J. Argüello, Lisa H. Butterfield, Parker Institute for Cancer Immunotherapy [San Francisco, CA] (PICI), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University of California [San Francisco] (UC San Francisco), University of California (UC), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Stanford University, and DUMENIL, Anita
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Cell biology ,Multidisciplinary ,1.1 Normal biological development and functioning ,Inflammatory and immune system ,[SDV]Life Sciences [q-bio] ,Translational immunology ,General Physics and Astronomy ,Cell Differentiation ,Dendritic Cells ,General Chemistry ,Monocytes ,Oxidative Phosphorylation ,General Biochemistry, Genetics and Molecular Biology ,[SDV] Life Sciences [q-bio] ,Vaccine Related ,Underpinning research ,2.1 Biological and endogenous factors ,Humans ,Aetiology ,Glycolysis ,Metabolic and endocrine - Abstract
Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic influences in human dendritic cell biology and their ability to orchestrate immune responses is poorly developed. Here, we map single-cell metabolic states and immune profiles of inflammatory and tolerogenic monocytic dendritic cells using recently developed multiparametric approaches. Single-cell metabolic pathway activation scores reveal simultaneous engagement of multiple metabolic pathways in distinct monocytic dendritic cell differentiation stages. GM-CSF/IL4-induce rapid reprogramming of glycolytic monocytes and transient co-activation of mitochondrial pathways followed by TLR4-dependent maturation of dendritic cells. Skewing of the mTOR:AMPK phosphorylation balance and upregulation of OXPHOS, glycolytic and fatty acid oxidation metabolism underpin metabolic hyperactivity and an immunosuppressive phenotype of tolerogenic dendritic cells, which exhibit maturation-resistance and a de-differentiated immune phenotype marked by unique immunoregulatory receptor signatures. This single-cell dataset provides important insights into metabolic pathways impacting the immune profiles of human dendritic cells.
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- 2022
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9. Multi-scale granular mechanics using MPM x DEM
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Duverger, Sacha, Duriez, Jérôme, Philippe, Pierre, Bonelli, Stéphane, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), and Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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[SPI]Engineering Sciences [physics] ,MPM ,granular materials ,DEM ,large deformations ,Multi-scale DEM MPM granular materials large deformations ,Multi-scale - Abstract
International audience; Une méthode numérique multi-échelles est proposée afin de modéliser de manière précise les matériaux granulaires soumis à des chargements importants. En effet, les mécanismes agissant à l'échelle microscopique dans le matériau sont décrits à l'aide de la Méthode des Éléments discrets (DEM), traduisant rigoureusement le comportement du matériau. De plus grandes échelles sont atteintes en couplant la DEM avec la Méthode du Point Matériel (MPM), dévelopée pour des matériaux sujets à de grandes déformations, et dont le comportement dépend de leur histoire. Le couplage MPMxDEM est comparé à une simulation pure DEM contenant 30,000 sphères dans le but d'évaluer la fiabilité et l'efficatité du couplage. Un aperçu du comportement du matériau est donné à différents endroits dans l'échantillon, en tirant profit de la modélisation précise des structures microscopiques par la DEM.
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- 2022
10. Erosion de surface d'un sol : influence des propriétés du sol sur la résistance à l'érosion
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Youssef, Shadi, Nicaise, Sylvie, Benahmed, Nadia, Philippe, Pierre, Bennabi, Abdelkrim, Poupardin, Adrien, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École Spéciale des Travaux Publics, du Bâtiment et de l'Industrie [Paris] (ESTP ), and Association Française de Mécanique
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[SPI]Engineering Sciences [physics] ,Internal erosion ,cohesive soils ,hole erosion test ,erosion characteristics ,parametric study - Abstract
International audience; One type of internal erosion, identified as concentrated leak erosion, consists in loss of particles of soil along a preferential flow paths existing in hydraulic earthen work. To assess the vulnerability of soils to this phenomenon, and more generally to surface erosion, several experimental devices exist, among them the Hole Erosion Test. We investigate here the effect of several parameters depending on the nature of soil considered, on erosion characteristics. A comprehensive campaign was conducted on soil, varying clay content, coarse grain shape and degree of compaction. In agreement with previous results, it is shown that presence of clay allows a better resistance to erosion; in the same way, the denser the sample, the more resistant it is. Concerning the grains shape, the experiments show two results: samples with sub-rounded to rounded particles exhibit a better resistance concerning the critical shear stress, (i.e. the shear stress needed to initiate erosion), but when erosion begins, these samples are eroded faster than those with sub-angular to angular particles.; L’érosion de conduit se produit lorsqu’il y a départ de particules de sol le long d'un chemin d'écoulement préférentiel existant dans un ouvrage hydraulique. Pour évaluer la vulnérabilité des sols vis-à-vis de ce phénomène, et plus généralement à l’érosion de surface, plusieurs dispositifs expérimentaux de laboratoire existent, parmi lesquels le Hole Erosion Test. Nous étudions ici l'impact de plusieurs paramètres constitutifs du sol sur sa résistance à l’érosion, à l’aide d’une campagne expérimentale réalisée sur des sols de teneur en argile, forme des grains grossiers et taux de compactage variables. En accord avec des résultats antérieurs, il est montré que la présence d'argile confère une meilleure résistance à l'érosion ; de même, plus l'échantillon est dense, plus il est résistant. Concernant la forme des grains, les essais réalisés montrent deux résultats : d’une part, et contre intuitivement, les échantillons avec des particules sub-arrondies à arrondies présentent une meilleure résistance vis-à-vis de l’initiation de l’érosion, cependant, une fois l'érosion enclenchée, ces échantillons s’érodent plus rapidement que ceux ayant des particules de forme sub-angulaire à angulaire.
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- 2022
11. Vingt ans après la loi Kouchner : articulation entre les CCI et les juridictions du contentieux en matière d’expertise de responsabilité médicale
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Arnaud Léger, Cécile Manaouil, Dominique Montpellier, Marie-Laure Moquet-Anger, and Philippe. Pierre
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Pathology and Forensic Medicine - Published
- 2023
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12. Jean-François Chanlat, penseur interculturel de la relation
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PHILIPPE PIERRE
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- 2022
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13. Pathogenic variants carrier screening in New Brunswick: Acadians reveal high carrier frequency for multiple genetic disorders
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Philippe Pierre, Robichaud, Eric P, Allain, Sarah, Belbraouet, Claude, Bhérer, Jean, Mamelona, Jason, Harquail, Stéphanie, Crapoulet, Nicolas, Crapoulet, Mathieu, Bélanger, and Mouna, Ben Amor
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Canada ,Exome Sequencing ,Ethnicity ,Infant, Newborn ,Genetics ,Humans ,New Brunswick ,Pilot Projects ,Genetics (clinical) - Abstract
Background Founder populations that have recently undergone important genetic bottlenecks such as French-Canadians and Ashkenazi Jews can harbor some pathogenic variants at a higher carrier rate than the general population, putting them at a higher risk for certain genetic diseases. In these populations, there can be considerable benefit to performing ethnic-based or expanded preconception carrier screening, which can help in the prevention or early diagnosis and management of some genetic diseases. Acadians are descendants of French immigrants who settled in the Atlantic Coast of Canada in the seventeenth century. Yet, the Acadian population has never been investigated for the prevalence/frequency of disease-causing genetic variants. Methods An exome sequencing panel for 312 autosomal recessive and 30 X-linked diseases was designed and specimens from 60 healthy participants were sequenced to assess carrier frequency for the targeted diseases. Results In this study, we show that a sample population of Acadians in South-East New Brunswick harbor variants for 28 autosomal recessive and 1 X-linked diseases, some of which are significantly more frequent in comparison to reference populations. Conclusion Results from this pilot study suggests a need for further investigation of genomic variation in this population and possibly implementation of targeted carrier and neonatal screening programs.
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- 2022
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14. The Impact of Forced Answering and Reactance on Answering Behavior in Online Surveys
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Jean Philippe Pierre Decieux, Alexander F. Schmidt, Philipp Sischka, Alexandra Mergener, and Kristina Neufang
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Computer science ,05 social sciences ,Reactance ,General Social Sciences ,Library and Information Sciences ,Computer Science Applications ,Order (business) ,0502 economics and business ,Soziologie, Sozialwissenschaften ,Mathematics education ,050211 marketing ,Law ,050203 business & management ,Dropout (neural networks) - Abstract
Forced answering (FA) is a frequent answer format in online surveys that forces respondents to answer each question in order to proceed through the questionnaire. The underlying rationale is to decrease the amount of missing data. Despite its popularity, empirical research on the impact of FA on respondents’ answering behavior is scarce and has generated mixed findings. In fact, some quasi-experimental studies showed that FA has detrimental consequences such as increased survey dropout rates and faking behavior. Notably, a theoretical psychological process driving these effects has hitherto not been identified. Therefore, the aim of the present study was twofold: First, we sought to experimentally replicate detrimental effects of FA on online questionnaire data quality. Second, we tried to uncover an explanatory psychological mechanism. Specifically, we hypothesized that FA effects are mediated through reactance. Zero-order effects showed that FA increased state reactance and questionnaire dropout as well as reduced answer length in open-ended questions. Results of survival and mediation analyses corroborate negative FA effects on data quality and the proposed psychological process.
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- 2020
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15. Psychometrical Properties of a French Version of the General Self-Efficacy Short Scale (ASKU)
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Jean Philippe Pierre Decieux, Philipp Sischka, Helmut Willems, and Anette Schumacher
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Self-efficacy ,Coping (psychology) ,Psychometrics ,media_common.quotation_subject ,05 social sciences ,Context variable ,050401 social sciences methods ,Short scale ,0504 sociology ,0502 economics and business ,Soziologie, Sozialwissenschaften ,Trait ,Personality ,Psychology ,Social psychology ,050203 business & management ,General Psychology ,media_common - Abstract
Abstract. General self-efficacy is a central personality trait often evaluated in surveys as context variable. It can be interpreted as a personal coping resource reflecting individual belief in one’s overall competence to perform across a variety of situations. The German-language Allgemeine-Selbstwirksamkeit-Kurzskala (ASKU) is a reliable and valid instrument to assess this disposition in the German-speaking countries based on a three-item equation. This study develops a French version of the ASKU and tests this French version for measurement invariance compared to the original ASKU. A reliable and valid French instrument would make it easy to collect data in the French-speaking countries and allow comparisons between the French and German results. Data were collected on a sample of 1,716 adolescents. Confirmatory factor analysis resulted in a good fit for a single-factor model of the data (in total, French, and German version). Additionally, construct validity was assessed by elucidating intercorrelations between the ASKU and different factors that should theoretically be related to ASKU. Furthermore, we confirmed configural and metric as well as scalar invariance between the different language versions, meaning that all forms of statistical comparison between the developed French version and the original German version are allowed.
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- 2020
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16. Une démarche prospective fondatrice d'une stratégie agro-écologique
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Philippe, Pierre, Hannin, Hervé, Les Vignerons de Buzet, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), IHEV Institut des hautes études de la vigne et du vin, and Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)
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[SDV.EE]Life Sciences [q-bio]/Ecology, environment ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
National audience
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- 2022
17. Loss of detection of fatty acid-metabolizing proteins in Western blot analyses - Impact of sample heating
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Roody S. Biam, Philippe-Pierre Robichaud, Maroua Mbarik, Paskale Pineau, and Marc E. Surette
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Heating ,HEK293 Cells ,Blotting, Western ,Fatty Acids ,Biophysics ,Humans ,Proteins ,Electrophoresis, Polyacrylamide Gel ,Cell Biology ,Molecular Biology ,Biochemistry - Abstract
When performing western blots for protein detection using the classical Laemmli method, experimenters often encounter difficulties with the detection of transmembrane proteins involved in lipid or fatty acid metabolism. A crucial phase in sample preparation is heating the samples to 100 °C in a Laemmli sample buffer containing SDS before separation by polyacrylamide gel electrophoresis (PAGE). In the current study, the analysis of several proteins was performed following modifications of the heating step during sample preparation. Multiple samples of the human Jurkat cell line were prepared using commercial or homemade Laemmli sample buffer. Samples were subjected to incubation at different temperatures for varying periods of time prior to separation by SDS-PAGE, transfer onto PVDF membranes and detection with specific antibodies. In samples incubated at temperatures of 25 °C, 40 °C, 70 °C and 100 °C, detection of the transmembrane protein elongase of long chain fatty acids 5 (ELOVL5) significantly decreased with temperature to a near total absence of signal at 100 °C. Heating (100 °C) the samples even for 1 min resulted in significant loss of ELOVL5 band intensity that was associated with the appearance of higher molecular weight immunoreactive materials. Loss of ELOVL5 band intensity was also observed with heating of samples at 100 °C prepared from HepG2, HEK293, MCF-7 and SKRB cells. The robust induction of ELOVL5 in stimulated primary T cells was not detected when sample were heated. The detection of fatty acid-metabolizing enzymes stearoyl-CoA desaturase-1 and long-chain-fatty-acid-CoA ligases 3 and 4 showed bands with significantly less intensity after heating at 100 °C compared to samples prepared at room temperature. Heating samples at 100 °C did not affect the detection of transmembrane proteins ERBB2 and five-lipoxygenase activating protein, or the soluble 5-lipoxygenase protein. Overall, the number of transmembrane passes of a protein was not predictive of loss of band intensity after heating, however this study indicates that sample heating can drastically affect the ability to detect proteins following separation by SDS-PAGE. This has implications for any detection methods that follow SDS-PAGE.
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- 2022
18. German Emigration and Remigration Panel Study (GERPS) : Documentation of the Third Wave
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Witte, Nils, Décieux, Jean Philippe Pierre, Erlinghagen, Marcel, Ette, Andreas, Genoni, Andreas, Guedes Auditor, Jean, Knirsch, Frederik, Kühne, Simon, Mansfeld, Lisa, and Schneider, Norbert
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Soziologie, Sozialwissenschaften - Abstract
International migration originating from highly developed countries is a crucial component of global migration flows. There are, however, surprisingly little data about the international mobility of the populations of affluent countries. The German Emigration and Remigration Panel Study (GERPS) aims to provide a resource that enables the analysis of individual consequences of international migration as well as the socio-structural consequences for the country of origin. GERPS is based on an origin-based multistage probability sample using the German population registers as a sampling frame. The third wave yields a net sample of roughly 5,800 persons who recently moved abroad from Germany and persons who returned from Germany after having lived abroad. The study applies a multidestination-country-design and enables the comparative analysis of migrants and individuals who stayed in the country of origin. GERPS is a panel study with five waves covering a period of 36 months. This documentation presents the methods and data of the third wave of the panel. It provides information for researchers and invites them to use the new data infrastructure for their own research.
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- 2022
19. Additional file 2 of Pathogenic variants carrier screening in New Brunswick: Acadians reveal high carrier frequency for multiple genetic disorders
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Robichaud, Philippe Pierre, Allain, Eric P., Belbraouet, Sarah, Bhérer, Claude, Mamelona, Jean, Harquail, Jason, Crapoulet, Stéphanie, Crapoulet, Nicolas, Bélanger, Mathieu, and Ben Amor, Mouna
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Additional file 2. Figure S1. Probability of detecting at least one variant as a function of allele frequency for a sample of 60 individuals. The minor allele frequencies in the reference population for the variants observed in our sample range from 9 × 10-6to 0.5.
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- 2022
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20. A transmissão oral de doenças sanguíneas como o HIV, o HBV e o HCV durante uma consulta dentária
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Geraud, Philippe Pierre Jacques and PINTO, RUI MANUEL SIMÕES
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Infectious Disease Transmission Patient-to-Professional ,Blood-Borne Infections ,Dentists ,Bites Humans ,Blood-Borne Pathogens ,HIV - Abstract
Introdução: A exposição de DTS é um risco profissional importante que pode afetar os médicos dentárias. Objetivos: Tem como objetivo agregar uma visão geral de DTS como o HIV, o HBV e o HCV no consultório dentária sobre a apreensão e os conhecimentos das pessoas, a prevalência da transmissão, o tipo de acidente o mais frequente e as precauções usadas. Material e métodos: Foi realizada uma pesquisa bibliográfica no PubMed utilizando a seguinte combinação de termos de pesquisa: ((("Blood-Borne Pathogens"[Mesh]) AND (( "Dentists"[Mesh]) OR ("Infectious Disease Transmission, Patient-to-Professional »[Mesh])) OR (("Infectious Disease Transmission, Patient-to-Professional »[Mesh]) AND (« HIV"[Mesh])) OR (("Bites, Human"[Mesh]) AND ("Blood-Borne Infections"[Mesh])) Resultados: Foram incluídos 19 estudos selecionados em função dos critérios de inclusão e de exclusão. 5 trataram da prevalência de transmissão do HIV, do HBV e do HCV, 4 sobre os acidentes, 1 sobre os aerossóis, 4 sobre as precauções, 3 sobre a apreensão e os conhecimentos dos dentistas e dos pacientes e 2 sobre o risco de transmissão conjuntival. Conclusões: Existem lacunas no conhecimento dos dentistas e há uma ansiedade por parte dos pacientes para ir no mesmo consultório que um paciente infetado. A prevalência da transmissão dos DTS é baixa mas existe, onde o principal risco é a lesão com a agulha durante a anestesia. A proteção pessoal durante a consulta e a vacinação são adoptadas pela maioria dos dentistas. No entanto, não há profissionais suficientes que sinalizam os incidentes depois e a fazer o rastreio.
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- 2022
21. Fiction and Cross-Cultural Understanding
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Pierre Robert Cloet, Alain Max Guénette, Marie-Anne Mirabeau Paquiry, Philippe Pierre, and Michel Sauquet
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- 2022
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22. Passive Smartphone Contact Tracing and Continuous COVID-19 Infection Risk Assessment
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Caitlin Enright, Theodoros Konstantopoulos, Orlando Pinel Aviles, Jean-Philippe Pierre, and Emmanuel Agu
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- 2021
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23. Optimizing Distributed Load Balancing for Workloads with Time-Varying Imbalance
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Phil Miller, Philippe Pierre Pebay, Matthew Tyler Bettencourt, Nicole Lemaster Slattengren, Francesco Rizzi, and Jonathan Lifflander
- Subjects
Dynamic programming ,Load management ,Speedup ,Computer science ,Distributed computing ,Scalability ,Programming paradigm ,Load balancing (computing) ,Protocol (object-oriented programming) ,Domain (software engineering) - Abstract
This paper explores dynamic load balancing algorithms used by asynchronous many-task (AMT), or ‘taskbased’, programming models to optimize task placement for scientific applications with dynamic workload imbalances. AMT programming models use overdecomposition of the computational domain. Overdecompostion provides a natural mechanism for domain developers to expose concurrency and break their computational domain into pieces that can be remapped to different hardware. This paper explores fully distributed load balancing strategies that have shown great promise for exascale-level computing but are challenging to theoretically reason about and implement effectively. We present a novel theoretical analysis of a gossip-based load balancing protocol and use it to build an efficient implementation with fast convergence rates and high load balancing quality. We demonstrate our algorithm in a next-generation plasma physics application (EMPIRE) that induces time-varying workload imbalance due to spatial non-uniformity in particle density across the domain. Our highly scalable, novel load balancing algorithm, achieves over a 3x speedup (particle work) compared to a bulk-synchronous MPI implementation without load balancing.
- Published
- 2021
- Full Text
- View/download PDF
24. Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector
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Aad, Georges, Abbott, Braden Keim, Avner, Gal, Fadol Mohammed, Abdualazem, Fusayasu, T., Fuster Verdu, Juan Antonio, Gabrielli, Alessandro, Gabrielli, Andrea, Gadatsch, S., Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-guillaume, Gallardo, Gabriel Emmanuel, Gallas, Elizabeth Jean, Mokgatitswane, Gaogalalwe, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Garcia, Carmen, Garcia Navarro, Jose Enrique, Mondal, Santu, Garcia Pascual, Juan Antonio, Garcia-Argos, C., Garcia-sciveres, Mauricio Andres, Gardner Jr, Robert William, Garelli, N., Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Mullin, Joseph James, Gaudiello, A., Gaudio, Gabriella, Gauzzi, Paolo, Gavrilenko, Igor, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz Frieder, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn Mei, Murin, Martin, Gee, Charles Norman, Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-helene, Geng, C., Gentile, Simonetta, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Higuchi, Yu, Gessinger-befurt, Paul, Gessner, G., Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza Mohammad A, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Nass, Christian, Giannini, Antonio, Giannini, G., Gibson, Stephen Michael, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag Ingemar, Gilles, Geoffrey, Gillwald, Nils Ernst Klaus, Gingrich, Douglas, Navarro Gonzalez, Josep, Giordani, Mario, Giraud, Pierre-francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, S., Gkialas, Ioannis, Gkougkousis, Evangelos Leonidas, Gkountoumis, Panagiotis, Gladilin, Leonid, Nelson, Kevin Michael, Glasman Kuguel, Claudia Beatriz, Glatzer, J., Glazov, A., Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Golling, Tobias Felix, Golubkov, Dmitry, Neundorf, Jonas, Da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Gonzalez De La Hoz, Santiago, Gonzalez Fernandez, Sergio, Badea, Anthony, Ng, Yan Wing, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Gordon, Howard, Gorini, Benedetto, Norfolk, Mitchell Bradley, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred Thomas, Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-bold, Iwona Agnieszka, Bin Norisam, Raif Rafideen, Graham, E. 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M., Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Hansen, Joergen Beck, Hansen, Joern Dines, Bahrasemani, Sina, Achkar, Baida, Hansen, Maike Christina, Hansen, Peter Henrik, Hanson, E. C., Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Hartmann, Nikolai, Hasegawa, Yoji, Adam, Lennart, Hasib, A. A., Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Christopher, Hawkings, Richard John, Hayashida, Shota, Hayden, Daniel Adam, Hayes, Christopher Robyn, Adam Bourdarios, Claire, Hayes, Robin, Hays, Christopher Paul, Hays, Jonathan Michael, Hayward, Helen Sarah, Haywood, Stephen James, He, Fudong, He, Yunjian, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Adamczyk, Leszek, Hehir, Natasha Domenica, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon Frank-thomas, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Adamek, Lukas, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten Lennart, Helsens, Clement, Henderson, R. C. 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W., Muanza, Steve Guy, Mueller, James Alfred, Muenstermann, Daniel, Mullier, Geoffrey, Mungo, Davide Pietro, Antonelli, Mario, Munoz Martinez, Jose Luis, Munoz Sanchez, Francisca Javiela, Murin, Pavel, Murray, William John, Murrone, Alessia, Muse, Joseph M, Muskinja, Miha, Mwewa, Chilufya, Myagkov, Alexey, Myers, Ava Anne, Antrim, Daniel Joseph, Myers, Gregory William, Myers, J., Myska, Miroslav, Nachman, Benjamin Philip, Nackenhorst, Olaf, Nag, Abhishek, Nagai, Koichi, Nagano, Kunihiro, Nagasaka, Y., Nagle, James Lawrence, Anulli, Fabio, Nagy, Elemer, Nairz, Armin Michael, Nakahama, Y., Nakamura, Koji, Nakamura, T., Nanjo, Hajime, Napolitano, Fabrizio, Narayan, Rohin Thampilali, Naryshkin, Iurii, Naseri, Mohsen, Aoki, Masato, Naumann, Thomas, Navarro, Gabriela Alejandra, Nechaeva, Polina, Nechansky, Filip, Neep, Thomas James, Negri, Andrea, Negrini, Matteo, Nellist, Clara Jean May, Nelson, Christina, Nelson, Michael Edward, Abbott, Dale Charles, Bouquet, Romain, Aparo, Marco, Nemecek, Stanislav, Nessi, Marzio, Neubauer, Mark Stephen, Neuhaus, Friedemann, Neumann, M., Newhouse, Robin, Newman, Paul Richard, Ng, Chi Wing, Ng, Y. 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P. C., Sannino, Mario, Sano, Yuta, Sansoni, Andrea, Santoni, Claudio, Santos, Helena Fatima, Santpur, Sai Neha, Santra, Arka, Carnesale, Maria, Bagnaia, Paolo, Saoucha, Kamal Abdelouadoud, Sapronov, Andrey, Mendes Saraiva, Joao Gentil, Sasaki, Osamu, Sato, Koji, Sauerburger, Frank Tobias, Sauvan, Emmanuel Jean, Savard, Pierre, Sawada, Ryu, Sawyer, Craig Anthony, Bahmani, M., Sawyer, Lee Hughie, Sayago Galvan, Ivan, Sbarra, Carla, Sbrizzi, Antonio, Scanlon, Timothy Paul, Schaarschmidt, Jana, Schacht, Peter, Schaefer, Douglas Michael, Schaefer, Leigh Catherine, Schaefer, Ulrich, Bahrasemani, H., Schaffer, Arthur Cornelius, Schaile, Dorothee Anne, Schamberger Jr, Robert Dean, Schanet, Eric, Scharf, Christian, Scharmberg, Nicolas, Schegelsky, V. 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A., Vigani, Luigi, Villa, Mauro, Villaplana Perez, Miguel, Villhauer, Elena Michelle, Vilucchi, Elisabetta, Chtcheguelski, Valeri, Vincter, Manuella, Virdee, Govindraj Singh, Vishwakarma, Akanksha, Vittori, Camilla, Vivarelli, Iacopo, Vogel Gonzalez, Marcelo Alonso, Vokac, Petr, Von Ahnen, Janik, Von Buddenbrock, Stefan Erich, Von Torne, Eckhard, Schlag, Bastian, Vorobel, Vit, Vorobev, Konstantin, Vos, Marcel Andre, Vossebeld, Joost Herman, Vozak, Matous, Vranjes, Nenad, Vranjes Milosavljevic, Marija, Vrba, Vaclav, Vreeswijk, Marcel, Vu, Ngoc Khanh, Schune, Philippe, Vuillermet, Raphael, Vukotic, Ilija, Wada, Sayaka, Wagner, Peter Heinrich, Wagner, Wolfgang, Yamauchi, Hiroki, Wagner-Kuhr, J., Wahdan, Shayma, Wahlberg, Hernan Pablo, Wakasa, Rena, Schwemling, Philippe, Walbrecht, Verena Maria, Walder, James William, Walker, Rodney, Walker, Stuart Derek, Walkowiak, Wolfgang Andreas, Wallangen, V., Wang, Ann Miao, Wang, Alex Zeng, Wang, Chen, Wang, Chenliang, Selem, Luka Pierre, Wang, Haichen, Wang, H., Wang, Jiawei, Wang, Peilong, Wang, Q., Wang, Renjie, Wang, Rongkun, Wang, Rui, Wang, Song-ming, Wang, Weitao, Cheng, Chi Lung, Shaheen, Rabia, Wang, W., Wang, Wenxiao, Wang, Yufeng, Wang, Zirui, Wanotayaroj, Chaowaroj, Warburton, Andreas Thomas, Ward, Patricia, Ward, Robert James, Warrack, Neil, Watson, Alan, Ahlgren, Nabila Wahab, Watson, Miriam Frances, Watts, Gordon Thomas, Waugh, Benedict Martin, Webb, Aaron Foley, Weber, Christian, Weber, Michael Simon, Weber, Stephen, Weber, Sebastian Mario, Wei, Yingjie, Weidberg, Anthony Robin, Sharma, Surabhi, Weingarten, Jens Carsten, Weirich, Marcel, Weiser, Christian Uwe, Wells, Phillippa, Wenaus, Torre James, Wendland, Bjorn Volker, Wengler, Thorsten, Wenig, Siegfried, Wermes, Norbert, Wessels, Martin, Shojaii, Seyed Ruhollah, Zenz, Seth Conrad, Zerradi, Soufiane, Weston, T. D., Whalen, Kathleen Charlotte, Wharton, Andrew Mark, White, Aaron Stephen, White, Andrew Paul, White, Martin John, Whiteson, Daniel Ofir, Whitmore, B. W., Sijacki, Dorde, Wiedenmann, Werner, Wiel, Christian, Wielers, Monika Bernardine, Wieseotte, Natalie, Wiglesworth, Craig, Wiik-fuchs, Liv Antje Mari, Wilkens, Henric George, Wilkins, Lewis Joseph, Williams, Daniel Mays, Williams, Hugh Harrison, Sinha, Supriya, Williams, Sarah Louise, Willocq, Stephane Yves G, Windischhofer, Philipp Jonas, Wingerter, Isabelle, Winkels, E., Winklmeier, Frank, Winter, Benedict Tobias, Wittgen, Matthias Michael, Wobisch, Markus, Wolf, Anton, Solomon, Shalu, Woelker, Ricardo, Wollrath, Julian, Wolter, Marcin Wladyslaw, Wolters, Helmut, Wong, Vincent Wai Sum, Wongel, Alicia Franziska, Worm, Steven Duane, Wosiek, Barbara Krystyna, Wozniak, Krzysztof Wieslaw, Wraight, Kenneth Gibb, Soumaimi, Zainab, Wu, Sau Lan, Wu, Xin, Wu, Yusheng, Wurzinger, Jonas, Wyatt, Terence Richard, Wynne, Benjamin Michael, Xella, Stefania, Zormpa, Olga, Zou, Wenkai, Xia, L., Standke, Mark, Xiang, Jianhuan, Xiao, Xiong, Xie, Xiangyu, Xiotidis, Ioannis, Xu, Da, Xu, Hao, Xu, Hanlin, Xu, Lailin, Xu, Riley, Xu, T., Starko, Darij Markian, Xu, Wenhao, Xu, Yue, Xu, Zhongyukun, Xu, Zijun, Yabsley, Bruce Donald, Yacoob, Sahal, Yamaguchi, Naoki, Yamaguchi, Yohei, Yamamoto, A., Yamatani, Masahiro, Abed Abud, Adam, Clavijo Columbie, Jose Manuel, Strom, Lars Rickard, Yamazaki, Tomohiro, Yamazaki, Yuji, Yan, Jun, Yan, Zhen, Yang, Haijun, Yang, Hongtao, Yang, Siqi, Yang, Tianyi, Yang, Xiao, Yang, Xuan, Su, Shixiang, Yang, Yi-lin, Yang, Zhe, Yao, Weiming, Yap, Yee Chinn, Ye, Hanfei, Ye, Jingbo, Ye, Shuwei, Yeletskikh, Ivan, Yexley, Melissa Rebecca, Yigitbasi, E., Sugizaki, Kaito, Yin, Pengqi, Yorita, Kohei, Yoshihara, Keisuke, Young, Christopher, Young, Charles Chunghoi, Yu, J., Yuan, Rui, Yue, Xiaoguang, Zaazoua, Mohamed, Zabinski, Bartlomiej Henryk, Sultanov, Saleh, Zacharis, Georgios, Zaffaroni, Ettore, Zahreddine, Jad, Zaytsev, Alexander, Zakareishvili, Tamar, Zakharchuk, Nataliia, Zambito, Stefano, Zanzi, Daniele, Zeissner, Sonja Verena, Zeitnitz, Christian, Sun, Shaojun, Zemaityte, Gabija, Zeng, Jiancong, Zenin, Oleg, Zenis, Tibor, Zerwas, Dirk, Zgubic, Miha, Zhang, Bowen, Zhang, Dengfeng, Zhang, Gang, Zhang, Jinlong, Gudnadottir, Olga, Zhang, Kaili, Zhang, Lei, Zhang, L., Zhang, Matt, Zhang, Rui, Zhang, Shuzhou, Zhang, Xiangke, Zhang, Xueyao, Zhang, Y., Zhang, Zhiqing Philippe, Tanaka, Aoto, Zhang, Z., Zhao, Pingchuan, Zhao, Yuzhan, Zhao, Zhengguo, Zhemchugov, Alexey, Zheng, Zhi, Zhong, Dewen, Zhou, Bing, Zhou, Chen, Zhou, Hao, Tao, Zhengcheng, Zhou, M., Zhou, Ning, Zhou, You, Zhu, Chengguang, Zhu, Chenzheng, Zhu, Heling, Zhu, Hongbo, Zhu, Junjie, Zhu, Yingchun, Zhuang, Xuai, Thielmann, Oliver, Zhukov, Konstantin, Zhulanov, Vladimir, Zieminska, Daria, Zimine, Nikolai, Zimmermann, Stephanie Ulrike, Zinonos, Z., Ziolkowski, Michael, Zivkovic, Lidija, Zobernig, G., Zoccoli, Antonio, Tian, Yusong, Zoch, Knut, Zorbas, Theodoros Georgio, Zou, R., Zwalinski, Lukasz Krzysztof, ATLAS Collaboration, Coelho Barrue, Ricardo Filipe, Tikhonov, Yuriy, Tlou, Sijiye Humphry, Tnourji, Abdellah, Togawa, Manabu, Tsiamis, Angelos, Tsur, Omer, Tzanis, Polyneikis, Ushioda, Risa, Valls Ferrer, Juan Antonio, Van De Wall, Evan Richard, Coelli, Simone, Vannoli, Leonardo, Mete, Tulin, Vaslin, Louis, Veliscek, Iza, Verissimo De Araujo, Micael, Vesterbacka Olsson, Minna Leonora, Vetterli, Michel Joseph, Vladimirov, Vangelis, Voevodina, Elena, Vozdecky, Lubos, Conroy, Eimear Isobel, Wagner, Cooper, Wakida, Moe, Barberio, Elisabetta Luigia, Barberis, Dario, Barbero, Marlon Benoit, Barbour, Gregory, Barillari, Teresa, Barisits, Martin-stefan, Barkeloo, Jason Tyler Colt, Barklow, Timothy Laurence, Cooke, Harry George, Barnea, R., Barnett, Bruce Macleod, Barnett, Michael Ralph, Barnovska-Blenessy, Z., Baroncelli, Antonio, Barone, Gaetano, Barr, Alan James, Barranco Navarro, Laura, Barreiro Alonso, Fernando, Barreiro Guimaraes Da Costa, Joao Pedro, Cote, Benjamin Michael, Barron, Uriel, Barsov, Sergey, Bartels, Falk, Bartoldus, Rainer, Bartolini, Giovanni, Barton, Adam Edward, Bartos, Pavol, Basalaev, Artem, Basan, Alexander, Bassalat, Ahmed, Cristoforetti, Marco, Basso, Matthew Joseph, Bates, Richard Laurence, Batlamous, Souad, Batley, John Richard, Batool, Binish, Battaglia, Marco, Bauce, Matteo, Bauer, Florian, Bauer, Patrick, Bawa, Harinder Singh, Darmora, Smita, Bayirli, Arif, Beacham, James Baker, Beau, Tristan, Beauchemin, Pierre-hugues, Becherer, Fabian Horst, Bechtle, Philip, Beck, H. 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Bessidskaia, Besson, N., Bethke, Siegfried, Betti, Alessandra, Bevan, Adrian John, Beyer, J., Bhatta, Somadutta, Ehrke, Lukas Fabian, Bhattacharya, Deb Sankar, Bhattarai, Prajita, Bhopatkar, Vallary Shashikant, Bi, R., Bianchi, Riccardo Maria, Biebel, Otmar, Biedermann, D., Bielski, Rafal Pawel, Bierwagen, K., Biesuz, N. V., El Ghazali, Yassine, Biglietti, Michela, Billoud, Thomas Remy Victor, Bindi, Marcello, Bingul, Ahmet, Bini, Cesare, Biondi, Silvia, Birch-sykes, Callum Jacob, Birman, Mattias, Bisanz, Tobias, Biswal, Jyoti Prakash, El Moussaouy, Ali, Biswas, Diptaparna, Bitadze, Alexander, Bittrich, Carsten Andreas, Bjoerke, Kristian, Blazek, T., Bloch, Ingo, Blocker, Craig Alan, Blue, Andrew James, Blumenschein, U., Bobbink, Gerard, Gaspar De Andrade Evans, Guiomar, Bobrovnikov, Viktor, Bogavac, Danijela, Bogdanchikov, Alexander, Bohm, Christian, Boisvert, Veronique, Bokan, Petar, Bold, Tomasz, Arena, Eloisa, Bomben, Marco, Bona, Marcella, Fadeyev, Vitaliy, Bonilla, J. S., Boonekamp, Maarten, Booth, Callum Dale, Borbely, Albert Gyorgy, Borecka-bielska, Hanna Maria, Borgna, Lucas Santiago, Borisov, A., Borissov, Guennadi, Bortoletto, Daniela, Boscherini, Davide, Fan, Yunyun, Fernandez-bosman, Martine, Bossio Sola, Jonathan David, Bouaouda, Khalil, Boudreau, Joseph Francis, Bouhova-thacker, Evelina Vassileva, Boumediene, Djamel Eddine, Boveia, Antonio Jay, Boyd, James, Boye, Diallo, Boyko, Igor, Freegard, Arran Charles, Bozson, Adam James, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Brau, Benjamin Paul, Brau, James Edward, Breaden Madden, William Dmitri, Brendlinger, Kurt Thurman, Abhayasinghe, Deshan Kavishka, Fu, Yao, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Britton, David, Britzger, Daniel Andreas, Brock, Ian Clarkson, Brock, Raymond, Garg, Diksha, Brooijmans, Gustaaf Henricus, Brooks, William King, Brost, Elizabeth Caitlin, Bruckman De Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Glisic, Marija, Bryngemark, Lene, Buanes, Trygve, Buat, Quentin Olivier, Buchholz, Peter, Buckley, Andrew Gordon, Budagov, I. A., Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon Aurele, Burch, Tyler James, Gombas, Jason Peter, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jonathan, Burton, Charles Davis, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, E., Bussey, Peter John, Gonzalez Andana, Richards Yeremayar, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan Mark, Butti, P., Buttinger, William, Buzatu, A., Buzykaev, Aleksey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Goumarre, Vincent, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Calderini, Giovanni, Calfayan, Philippe Pierre, Callea, Giuseppe, Caloba, Luiz Pereira, Caltabiano, Alessandro, Graham, Kevin Robert, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel Pierre Jean, Calvet, Thomas Philippe, Calvetti, Milene, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Guo, Linghua, Cameron, David Gordon, Camincher, Clement, Campana, S., Campanelli, Mario, Camplani, Alessandra, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, T., Gutierrez Zagazeta, Luis Felipe, Cao, Yumeng, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, I., Carli, Tancredi, Carlino, Gianpaolo, Carlson, Benjamin Taylor, Carlson, Evan Michael, Habedank, Martin Steffen, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson Leonardo, Carra, Sonia, Carratta, Giuseppe, Carter, J. W. S., Carter, Thomas Michael, Casado Lechuga, Pilar Maria, Casha, Albert Francis, Abidi, Syed Haider, Halser, Lea, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno Filipe, Catinaccio, Andrea, Catmore, James Richard, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Harris, Ynyr Theophilus, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alessandro, Cerrito, Lucio, Cerutti, Fabio, Cervelli, Alberto, Cetin, Serkant Ali, Chadi, Zakaria, He, Yajun, Chakraborty, Dhiman, Chan, J., Chan, Wing Sheung, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, David, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Hodkinson, Benjamin Haslum, Che, S., Chekanov, Sergei, Chekulaev, Sergey, Shelkov, Georgy, Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Chen, Hucheng, Chen, Jing, Hofer, Judith, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-heng, Cheng, Hok Chuen, Cheng, Huajie, Cheplakov, Alexander, Honan, Benjamin Paul, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott Curtis, Cheung, Kingman, Chevalier, Laurent Pascal, Chiarella, Vitaliano, Chiarelli, Giorgio, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Hong, Jiangliu, Chiu, I-huan, Chiu, Yu Him Justin, Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur Rene, Chou, Yuan-tang, Chow, Yun Sang, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Hsu, Pai-hsien, Chudoba, Jiri, Chwastowski, Janusz Jerzy, Chytka, L., Cieri, Davide, Ciesla, Krzysztof Marcin, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Cirotto, Francesco, Citron, Zvi Hirsh, Ingebretsen Carlson, Tom, Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip James, Clawson, Savannah Ellen, Clement, Christophe, Clissa, Luca, Coadou, Yann, Cobal, Marina, Jagfeld, Christoph, Coccaro, Andrea, Cochran Jr, James Herbert, Coelho Lopes De Sa, Rafael, Cohen, Hadar Yosef, Cardoso Coimbra, Artur Emanuel, Cole, Brian, Colijn, A. P., Collot, Johann, Conde Muino, Patricia, Connell, Simon Henry, Abusleme Hoffman, Angel Christian, Jones, Dominic Matthew, Connelly, Ian Allan, Constantinescu, S., Conventi, Francesco, Sarkar, Amanda Margaret, Cormier, Felix, Cormier, K. J. R., Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Corriveau, Francois, Ke, Yan, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen Douglas, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-renaudin, Sabine, Crescioli, Francesco, Kilgallon, Aaron Joseph, Cristinziani, Markus, Croft, Vincent Alexander, Crosetti, Giovanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Cui, Han, Cukierman, Aviv Ruben, Cunningham, William Reilly, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Klein, Lucas, Czurylo, Marta Maja, Da Cunha Sargedas De Sousa, Mario Jose, Da Fonseca Pinto, Joao Victor, Da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, F., Dado, Tomas, Dahbi, Salah-eddine, Dai, Tiesheng, Dallapiccola, Carlo James, Knight, Timothy Michael, Dam, Mogens, D'amen, Gabriele, D'amico, Valerio, Damp, Johannes Frederic, Dandoy, Jeffrey Rogers, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Giovanni, Dartsi, O., Korn, Steffen, Dattagupta, Aparajita, Daubney, T., D'auria, Saverio, David, Claire Anne Sophie, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, De Asmundis, Riccardo, De Beurs, Marcus, Kortman, Bryan, De Castro, Stefano, De Groot, Nicolo, De Jong, Paulus Johannes, De La Torre Perez, Hector, De Maria, Antonio, De Pedis, Daniele, De Salvo, Alessandro, De Sanctis, Umberto, De Santis, M., De Santo, Antonella, Kuhn, Susanne Sabine, De Vivie De Regie, Jean-baptiste, Dedovich, Dmitry, Deiana, Allison Mccarn, Del Peso, Jose, Delabat Diaz, Yasiel, Delgove, D., Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Koultchitski, Iouri, Dell'acqua, Andrea, Dell'asta, Lidia, Delmastro, Marco, Delporte, C., Delsart, Pierre-antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, G., Denisov, Sergei Petrovich, D'eramo, Louis, Kumar, Mukesh, Derendarz, Dominik Karol, Derkaoui, Jamal Eddine, Derue, Frederic, Dervan, Paul John, Desch, Klaus Kurt, Dette, Karola, Deutsch, Christopher, Devesa, M. R., Deviveiros, Pier-olivier, Di Bello, Francesco Armando, Agarwala, Jinky, Kumari, Neelam, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Donato, Camilla, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Petrillo, K. F., Di Sipio, R., Lad, Nisha Nareshbhai, Diaconu, Cristinel, De Almeida Dias, Flavia, Dias Do Vale, Tiago, Diaz Gutierrez, Marco Aurelio, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward Brereton, Dietrich, Janet, Diez Cornell, Sergio, Lalloue, Nathan, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Dittmeier, Sebastian, Dittus, Fridolin, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros Do Vale, Maria Aline, Leban, Blaz, Dobre, M., Dodsworth, D., Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, D'onofrio, Adelina, D'onofrio, Monica, Le Compte, Thomas Joseph, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Anthony Terence, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Du Pree, Tristan Arnoldus, Leeuw, Lerothodi Leonard, Duan, Y., Dubinin, Filipp, Dubovsky, Michal, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Gunter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Duffield, E. M., Li, Chihao, D'uffizi, Matteo, Duflot, Laurent, Duehrssen-debling, Karl-michael, Dulsen, Carsten, Dumancic, M., Dumitriu, Ana Elena, Dunford, Monica Lynn, Dungs, Sascha, Duperrin, Arnaud Joel Yann, Yildiz, H. Duran, Lionti, Anthony Eric, Dueren, Michael Johannes, Durglishvili, Archil, Duschinger, D., Dutta, Baishali, Duvnjak, Damir, Dyckes, George Ian, Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Liss, Anthony Michael, Eifert, Till Felix, Eigen, Gerald, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, Ellajosyula, Venugopal, Ellert, Mattias Fredrik, Ellinghaus, Frank, Elliot, Alison Anne-marie, Ellis, Nicolas, Longo, Riccardo, Elmsheuser, Johannes, Elsing, Markus, Emeliyanov, Dmitry, Emerman, Alexander Zack, Enari, Yuji, Mondal, Buddhadeb, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Aparisi Pozo, Javier Alberto, Lu, Gangcheng, Escalier, Marc Achille, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Evans, G. E., Evans, Harold, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Macdonell, Danika Marina, Fabiani, Veronica, Facini, Gabriel John, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Malecki, Pawel, Fanti, Marcello, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead Marie, Farthouat, Philippe, Fassi, Farida, Fassnacht, P., Manisha, Manisha, Fassouliotis, Dimitrios, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Fedorko, W., Fehr, Armin, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alexandra, Mathisen, Thomas, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexander, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferreira de Lima, D. E., Mc Ginn, Christopher, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank Matthias, Filipcic, Andrej, Filthaut, Frank, Finelli, K. D., Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fischer, Julian, Mc Kay, Madalyn Ann, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor John, Fleischmann, Philipp, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Mentink, Matthias, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel Andre, Fox, Harald, Miralles Lopez, Marcos, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Fray, A. N., Miyazaki, Yuta, Freeman, Patrick Moriishi, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Casadei, Diego, Froidevaux, Daniel, Frost, James Alexander, Fujimoto, Minori, Fukunaga, C., Fullana Torregrosa, Esteban, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, UAM. Departamento de Física Teórica, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aad, G., Abbott, B., Abbott, D. C., Abud, A. A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Zeid, O. S. A., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Bourdarios, C. A., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Akesson, T. P. A., Akilli, E., Akimov, A. V., Khoury, K. A., Alberghi, G. L., Albert, J., Verzini, M. J. A., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Camelia, E. A., Estevez, M. A., Alviggi, M. G., Coutinho, Y. A., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Dos Santos, S. P. A., Amoroso, S., Amrouche, C. S., An, F., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Pozo, J. A. A., Aparo, M. A., Bella, L. A., Aranzabal, N., Ferraz, V. A., Pereira, R. A., Arcangeletti, C., Arce, A. T. H., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Tame, Z. P. A., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Gupta, D. B., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Banerjee, S., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barillari, T., Barisits, M. -S., Barkeloo, J., Barklow, T., Barnea, R., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Navarro, L. B., Barreiro, F., Guimaraes da Costa, J. B., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bassalat, A., Basso, M. J., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. C., Beck, H. P., Becker, K., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Belfkir, M., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Kuutmann, E. B., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bylund, O. B., Besson, N., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-sykes, C. J., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjorke, K., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bolz, A. E., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Booth, C. D., Borbely, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borisov, A., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Sola, J. D. B., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Madden, W. D. B., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., Bruckman de Renstrom, P. A., Bruers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Buscher, V., Buschmann, E., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Vazquez, C. J. B., Buzatu, A., Buzykaev, A. R., Cabras, G., Urban, S. C., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Lopez, S. C., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Toro, R. C., Camarda, S., Munoz, D. C., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Bret, M. C., Cantero, J., Cao, T., Cao, Y., Capua, M., Cardarelli, R., Cardillo, F., Carducci, G., Carli, I., Carli, T., Carlino, G., Carlson, B. T., Carlson, E. M., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carra, S., Carratta, G., Carter, J. W. S., Carter, T. M., Casado, M. P., Casha, A. F., Castiglia, E. G., Castillo, F. L., Garcia, L. C., Gimenez, V. C., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Cavaliere, V., Cavasinni, V., Celebi, E., Celli, F., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chadi, Z., Chakraborty, D., Chan, J., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chau, C. C., Che, S., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, B., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y. -H., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., El Moursli, R. C., Cheu, E., Cheung, K., Chevalerias, T. J. A., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chou, Y., Chow, Y. S., Christopher, L. D., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Chytka, L., Cieri, D., Ciesla, K. M., Cindro, V., Cioara, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, P. J., Clawson, S. E., Clement, C., Clissa, L., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., De Sa, R. C. L., Cohen, H., Coimbra, A. E. C., Cole, B., Colijn, A. P., Collot, J., Muino, P. C., Connell, S. H., Connelly, I. A., Constantinescu, S., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corpe, L. D., Corradi, M., Corrigan, E. E., Corriveau, F., Costa, M. J., Costanza, F., Costanzo, D., Cowan, G., Cowley, J. W., Crane, J., Cranmer, K., Creager, R. A., Crepe-Renaudin, S., Crescioli, F., Cristinziani, M., Croft, V., Crosetti, G., Cueto, A., Donszelmann, T. C., Cui, H., Cukierman, A. R., Cunningham, W. R., Czekierda, S., Czodrowski, P., Czurylo, M. M., Da Cunha Sargedas De Sousa, M. J., Da Fonseca Pinto, J. V., Da Via, C., Dabrowski, W., Dachs, F., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D'Amen, G., D'Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Dartsi, O., Dattagupta, A., Daubney, T., D'Auria, S., David, C., Davidek, T., Davis, D. R., Dawson, I., De, K., De Asmundis, R., De Beurs, M., De Castro, S., De Groot, N., de Jong, P., De la Torre, H., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santis, M., De Santo, A., De Vivie De Regie, J. B., Dedovich, D. V., Deiana, A. M., Del Peso, J., Diaz, Y. D., Delgove, D., Deliot, F., Delitzsch, C. M., Della Pietra, M., Della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demers, S., Demichev, M., Demontigny, G., Denisov, S. P., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Dette, K., Deutsch, C., Devesa, M. R., Deviveiros, P. O., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Luca, A., Di Micco, B., Di Nardo, R., Di Petrillo, K. F., Di Sipio, R., Diaconu, C., Dias, F. A., Dias Do Vale, T., Diaz, M. A., Capriles, F. G. D., Dickinson, J., Didenko, M., Diehl, E. B., Dietrich, J., Cornell, S. D., Pardos, C. D., Dimitrievska, A., Ding, W., Dingfelder, J., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Vale, M. A. B. D., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Dong, B., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dreyer, E., Dreyer, T., Drobac, A. S., Du, D., du Pree, T. A., Duan, Y., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. C., Duffield, E. M., D'Uffizi, M., Duflot, L., Duhrssen, M., Dulsen, C., Dumancic, M., Dumitriu, A. E., Dunford, M., Dungs, S., Duperrin, A., Yildiz, H. D., Duren, M., Durglishvili, A., Duschinger, D., Dutta, B., Duvnjak, D., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Eggleston, M. G., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Jarrari, H., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Emerman, A., Enari, Y., Epland, M. B., Erdmann, J., Ereditato, A., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Pastor, O. E., Etzion, E., Evans, G. E., Evans, H., Evans, M. O., Ezhilov, A., Fabbri, F., Fabbri, L., Fabiani, V., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falke, P. J., Falke, S., Faltova, J., Fang, Y., Fanourakis, G., Fanti, M., Faraj, M., Farbin, A., Farilla, A., Farina, E. M., Farooque, T., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Giannelli, M. F., Fawcett, W. J., Fayard, L., Fedin, O. L., Fedorko, W., Fehr, A., Feickert, M., Feligioni, L., Fell, A., Feng, C., Feng, M., Fenton, M. J., Fenyuk, A. B., Ferguson, S. W., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., Ferreira de Lima, D. E., Ferrer, A., Ferrere, D., Ferretti, C., Fiedler, F., Filipcic, A., Filthaut, F., Finelli, K. D., Fiolhais, M. C. N., Fiorini, L., Fischer, F., Fischer, J., Fisher, W. C., Fitschen, T., Fleck, I., Fleischmann, P., Flick, T., Flierl, B. M., Flores, L., Castillo, L. R. F., Follega, F. M., Fomin, N., Foo, J. H., Forcolin, G. T., Forland, B. C., Formica, A., Forster, F. A., Forti, A. C., Fortin, E., Foti, M. G., Fournier, D., Fox, H., Francavilla, P., Francescato, S., Franchini, M., Franchino, S., Francis, D., Franco, L., Franconi, L., Franklin, M., Frattari, G., Fray, A. N., Freeman, P. M., Freund, B., Freund, W. S., Freundlich, E. M., Frizzell, D. C., Froidevaux, D., Frost, J. A., Fujimoto, M., Fukunaga, C., Torregrosa, E. F., Fusayasu, T., Fuster, J., Gabrielli, A., Gadatsch, S., Gadow, P., Gagliardi, G., Gagnon, L. G., Gallardo, G. E., Gallas, E. J., Gallop, B. J., Goni, R. G., Gan, K. K., Ganguly, S., Gao, J., Gao, Y., Gao, Y. S., Walls, F. M. G., Garcia, C., Navarro, J. E. G., Pascual, J. A. G., Garcia-Argos, C., Garcia-Sciveres, M., Gardner, R. W., Garelli, N., Gargiulo, S., Garner, C. A., Garonne, V., Gasiorowski, S. J., Gaspar, P., Gaudiello, A., Gaudio, G., Gauzzi, P., Gavrilenko, I. L., Gavrilyuk, A., Gay, C., Gaycken, G., Gazis, E. N., Geanta, A. A., Gee, C. M., Gee, C. N. P., Geisen, J., Geisen, M., Gemme, C., Genest, M. H., Geng, C., Gentile, S., George, S., Geralis, T., Gerlach, L. O., Gessinger-Befurt, P., Gessner, G., Bostanabad, M. G., Ghneimat, M., Ghosh, A., Giacobbe, B., Giagu, S., Giangiacomi, N., Giannetti, P., Giannini, A., Giannini, G., Gibson, S. M., Gignac, M., Gil, D. T., Gilbert, B. J., Gillberg, D., Gilles, G., Gillwald, N. E. K., Gingrich, D. M., Giordani, M. P., Giraud, P. F., Giugliarelli, G., Giugni, D., Giuli, F., Gkaitatzis, S., Gkialas, I., Gkougkousis, E. L., Gkountoumis, P., Gladilin, L. K., Glasman, C., Glatzer, J., Glaysher, P. C. F., Glazov, A., Gledhill, G. R., Gnesi, I., Goblirsch-Kolb, M., Godin, D., Goldfarb, S., Golling, T., Golubkov, D., Gomes, A., Gama, R. G., Goncalo, R., Gonella, G., Gonella, L., Gongadze, A., Gonnella, F., Gonski, J. L., Gonzalez de la Hoz, S., Fernandez, S. G., Lopez, R. G., Renteria, C. G., Suarez, R. G., Gonzalez-Sevilla, S., Rodriguez, G. R. G., Goossens, L., Gorasia, N. A., Gorbounov, P. A., Gordon, H. A., Gorini, B., Gorini, E., Gorisek, A., Goshaw, A. T., Gostkin, M. I., Gottardo, C. A., Gouighri, M., Goussiou, A. G., Govender, N., Goy, C., Grabowska-Bold, I., Graham, E. C., Gramling, J., Gramstad, E., Grancagnolo, S., Grandi, M., Gratchev, V., Gravila, P. M., Gravili, F. G., Gray, C., Gray, H. M., Grefe, C., Gregersen, K., Gregor, I. M., Grenier, P., Grevtsov, K., Grieco, C., Grieser, N. A., Grillo, A. A., Grimm, K., Grinstein, S., Grivaz, J. -F., Groh, S., Gross, E., Grosse-Knetter, J., Grout, Z. J., Grud, C., Grummer, A., Grundy, J. C., Guan, L., Guan, W., Gubbels, C., Guenther, J., Guerguichon, A., Rojas, J. G. R. G., Guescini, F., Guest, D., Gugel, R., Guida, A., Guillemin, T., Guindon, S., Guo, J., Guo, W., Guo, Y., Guo, Z., Gupta, R., Gurbuz, S., Gustavino, G., Guth, M., Gutierrez, P., Gutschow, C., Guyot, C., Gwenlan, C., Gwilliam, C. B., Haaland, E. S., Haas, A., Haber, C., Hadavand, H. K., Hadef, A., Haleem, M., Haley, J., Hall, J. J., Halladjian, G., Hallewell, G. 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L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Zivkovic, L., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zwalinski, L., Universidade do Minho, De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2934, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), and Other Research IHEF (IoP, FNWI)
- Subjects
Experimental Evidence ,LHC, ATLAS, High Energy Physics, Lepton universality ,Physics::Instrumentation and Detectors ,13000 GeV-cms ,Z0: branching ratio: upper limit ,Flavour ,General Physics and Astronomy ,01 natural sciences ,+electron+tau%22">Z0 --> electron tau ,High Energy Physics - Experiment ,law.invention ,Subatomär fysik ,High Energy Physics - Experiment (hep-ex) ,law ,branching ratio: upper limit [Z0] ,Subatomic Physics ,scattering [p p] ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Fundamental Principles ,Settore FIS/01 ,8000 GeV-cms ,Physics ,Large Hadron Collider ,lepton flavor violation ,new physics: search for ,ATLAS experiment ,lepton: flavor: violation ,Branching Fractions ,ATLAS ,The Standard Model ,CERN LHC Coll ,colliding beams [p p] ,Neutrino ,Proton Collisions ,Particle Physics - Experiment ,Z boson ,p p: scattering ,Particle physics ,+muon+tau%22">Z0 --> muon tau ,CERN Lab ,flavor: violation [lepton] ,530 Physics ,Ciências Naturais::Ciências Físicas ,Ciências Físicas [Ciências Naturais] ,Weak Interactions ,FOS: Physical sciences ,Weak interaction ,Standard Model ,weak interaction ,0103 physical sciences ,Centre-of-Mass Energies ,ddc:530 ,rare decay [Z0] ,High Energy Physics ,flavor: oscillation ,010306 general physics ,Collider ,tau: hadronic decay ,Bosons ,Science & Technology ,charge: electric ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,family: 3 ,Física ,leptonic decay [Z0] ,sensitivity ,family: conservation law ,LHC ,Particle Physics ,charged-lepton-flavour violation ,Z0: leptonic decay ,Physics::Accelerator Physics ,High Energy Physics::Experiment ,Z0: rare decay ,hadronic decay [tau] ,Hadron-hadron collisions ,p p: colliding beams ,new particle ,experimental results ,Lepton - Abstract
We acknowledge our late colleague, Olga Igonkina (1973-2019), for inspiring and driving this and other searches for lepton flavour violation within the ATLAS experiment. Her curiosity and intelligence remain an inspiration to the ATLAS Collaboration. We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions, without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, and and NRC KI, Russia Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, UK; DOE and NSF, United States. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; ERC, ERDF, Horizon 2020, Marie Sklodowska-Curie Actions and COST, EU; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, UK. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. 54., Leptons with essentially the same properties apart from their mass are grouped into three families (or flavours). The number of leptons of each flavour is conserved in interactions, but this is not imposed by fundamental principles. Since the formulation of the standard model of particle physics, the observation of flavour oscillations among neutrinos has shown that lepton flavour is not conserved in neutrino weak interactions. So far, there has been no experimental evidence that this also occurs in interactions between charged leptons. Such an observation would be a sign of undiscovered particles or a yet unknown type of interaction. Here the ATLAS experiment at the Large Hadron Collider at CERN reports a constraint on lepton-flavour-violating effects in weak interactions, searching for Z-boson decays into a tau lepton and another lepton of different flavour with opposite electric charge. The branching fractions for these decays are measured to be less than 8.1 x 10(-6) (e tau) and 9.5 x 10(-6) (mu tau) at the 95% confidence level using 139 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = 13 TeV and 20.3 fb(-1) at root s = 8 TeV. These results supersede the limits from the Large Electron-Positron Collider experiments conducted more than two decades ago., ANPCyT, YerPhI, Armenia, Australian Research Council, BMWFW, Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), SSTC, Belarus, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), Canada Foundation for Innovation, CERN, ANID, Chile, Chinese Academy of Sciences, MOST, National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Ministry of Education, Youth & Sports - Czech Republic, MPO CR, Czech Republic Government, DNRF, Danish Natural Science Research Council, NRC KI, Russia Federation, JINR, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia, MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Wallenberg Foundation, Sweden, SERI, Swiss National Science Foundation (SNSF), Cantons of Bern and Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE), National Science Foundation (NSF), BCKDF, CANARIE, Compute Canada and CRC, Canada, European Research Council (ERC), European Commission European Commission Horizon Marie Sklodowska-Curie Actions and COST, EU, French National Research Agency (ANR), German Research Foundation (DFG), European Commission, Alexander von Humboldt Foundation, Thales Group, Aristeia programmes, Greek NSRF, Greece, BSF-NSF, German-Israeli Foundation for Scientific Research and Development, La Caixa Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO, GenT Programmes Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, The Royal Society and Leverhulme Trust, UK, WLCG, ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), Netherlands Government, PIC (Spain), ASGC (Taiwan), RAL (UK), BNL (USA), Tier-2 facilities worldwide and large non-WLCG, National Research Centre (NRC)
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- 2021
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25. RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages
- Author
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Bing Su, Ivan Dikic, Zhuangzhuang Liu, Jan Valečka, Eva Strock, Evelina Gatti, David G. McEwan, Catarina R. Almeida, Voahirana Camosseto, Seigo Terawaki, Philippe Pierre, Yinming Liang, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), The Beatson Institute for Cancer Research, University of Glasgow, Osaka City University (OCU), Xinxiang Medical University, Institute for Research in Biomedicine ( iBiMED), Universidade de Aveiro, Shangaï Jiao Tong University [Shangaï], Université Johann Wolfgang Goethe de Francfort-sur-le-Main, ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), DUMENIL, Anita, and Développment d'une infrastructure française distribuée coordonnée - - France-BioImaging2010 - ANR-10-INBS-0004 - INBS - VALID
- Subjects
0301 basic medicine ,Alveolar macrophages ,LPS ,[SDV]Life Sciences [q-bio] ,Science ,Mitochondrion ,RUN domain ,03 medical and health sciences ,0302 clinical medicine ,Eukaryotic translation ,Mitophagy ,Organelle ,Biochemistry, Cellular and Molecular Biology ,Research Articles ,Messenger RNA ,Multidisciplinary ,Chemistry ,Autophagy ,RUFY ,alveolar macrophages ,Skp ,Cell biology ,[SDV] Life Sciences [q-bio] ,030104 developmental biology ,mitophagy ,FYVE domain ,030217 neurology & neurosurgery - Abstract
We report here that RUFY4, a newly characterized member of the ‘RUN and FYVE domain-containing’ family of proteins previously associated with autophagy enhancement, is highly expressed in alveolar macrophages (AM). We show that RUFY4 interacts with mitochondria upon stimulation by microbial-associated molecular patterns of AM and dendritic cells. RUFY4 interaction with mitochondria and other organelles is dependent on a previously uncharacterized OmpH domain located immediately upstream of its C-terminal FYVE domain. Further, we demonstrate that rufy4 messenger RNA can be translated from an alternative translation initiation codon, giving rise to a N-terminally truncated form of the molecule lacking most of its RUN domain and with enhanced potential for its interaction with mitochondria. Our observations point towards a role of RUFY4 in selective mitochondria clearance in activated phagocytes.
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- 2021
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26. 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4-mediated responses of human neutrophils and eosinophils
- Author
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Michel Laviolette, Marie-Chantal Larose, Anne-Sophie Archambault, Cyril Martin, Caroline Turcotte, Samuel J. Poirier, Julie-S Lefebvre, Véronique Provost, Philippe-Pierre Robichaud, Nicolas Flamand, Patrick P. McDonald, Luc H. Boudreau, and Marc E. Surette
- Subjects
0301 basic medicine ,Phagocyte ,Leukotriene B4 ,Immunology ,Pharmacology ,Granulocyte ,Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Immunology and Allergy ,Receptor ,Leukotriene ,Innate immune system ,Degranulation ,hemic and immune systems ,Chemotaxis ,Cell Biology ,respiratory system ,biological factors ,respiratory tract diseases ,3. Good health ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,lipids (amino acids, peptides, and proteins) - Abstract
Leukotriene B4 (LTB4) plays a prominent role in innate immunity as it induces phagocyte recruitment, the release of antimicrobial effectors, and as it potentiates the ingestion and killing of pathogens. In humans, LTB4 has a short half-life and is rapidly metabolized by leukocytes, notably into 20-OH- and 20-COOH-LTB4 by neutrophils. Although these LTB4 metabolites bind to the BLT1 receptor with high affinity, they activate neutrophils to a much lower extent than LTB4. We thus postulated that LTB4 metabolites could dampen BLT1-mediated responses, therefore limiting the impact of LTB4 on human neutrophil functions. We found that 20-OH-LTB4 and 20-COOH-LTB4 inhibited all of the LTB4-mediated neutrophil responses we tested (migration, degranulation, leukotriene biosynthesis). The potencies of the different compounds at inhibiting LTB4-mediated responses were 20-OH-LTB4 = CP 105,696 (BLT1 antagonist) > > 20-COOH-LTB4 ≥ resolvin E1 (RVE1). In contrast, the fMLP- and IL-8-mediated responses we tested were not affected by the LTB4 metabolites or RVE1. 20-OH-LTB4 and 20-COOH-LTB4 also inhibited the LTB4-mediated migration of human eosinophils but not that induced by 5-KETE. Moreover, using 20-COOH-LTB4, LTB4, and LTB4-alkyne, we show that LTB4 is a chemotactic, rather than a chemokinetic factor for both human neutrophils and eosinophils. In conclusion, our data indicate that LTB4 metabolites and RVE1 act as natural inhibitors of LTB4-mediated responses. Thus, preventing LTB4 ω-oxidation might result in increased innate immunity and granulocyte functions.
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- 2019
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27. Response to Naudet et al
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Joachim Forget, Philippe Pierre Pébaÿ, Jean-Laurent Picard, Edouard Lansiaux, Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Assemblée Nationale
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Epidemiology ,business.industry ,Health, Toxicology and Mutagenesis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,[SDV]Life Sciences [q-bio] ,Geography, Planning and Development ,030209 endocrinology & metabolism ,Virology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,030220 oncology & carcinogenesis ,Medicine ,business - Published
- 2021
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28. Experimental Efficacy of the Face Shield and the Mask against Emitted and Potentially Received Particles
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Jean Michel Wendling, Philippe Pierre Pébaÿ, Thibaut Fabacher, Isabelle Cosperec, Michaël Rochoy, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Face shield ,business.product_category ,Materials science ,masks ,experimental setup ,Particle number ,receiver ,Health, Toxicology and Mutagenesis ,Airflow ,lcsh:Medicine ,pandemics ,Article ,covid19 ,03 medical and health sciences ,coronavirus infections ,0302 clinical medicine ,Optics ,Aerosol generator ,Humans ,pneumonia ,prevention and control ,030212 general & internal medicine ,face shields ,aerosolization ,Personal Protective Equipment ,Reduction factor ,Common emitter ,Aerosols ,emitter ,particles ,Inhalation Exposure ,protective devices ,business.industry ,coronavirus infections, aerosols ,lcsh:R ,Public Health, Environmental and Occupational Health ,COVID-19 ,covid ,Short distance ,Face masks ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,Communicable Disease Control ,030221 ophthalmology & optometry ,Barrier effect ,Community setting ,Particle ,business ,Particle counter - Abstract
There is currently not sufficient evidence to support the effectiveness of face shields for source control. In order to evaluate the comparative barrier performance effect of face masks and face shields, we used an aerosol generator and a particle counter to evaluate the performance of the various devices in comparable situations. We tested different configurations in an experimental setup with manikin heads wearing masks (surgical type I), face shields (22.5 cm high with overhang under the chin of 7 cm and circumference of 35 cm) on an emitter or a receiver manikin head, or both. The manikins were face to face, 25 cm apart, with an intense particle emission (52.5 L/min) for 30 s. The particle counter calculated the total cumulative particles aspirated on a volume of 1.416 L In our experimental conditions, when the receiver alone wore a protection, the face shield was more effective (reduction factor = 54.8%), while reduction was lower with a mask (reduction factor = 21.8%) (p = 0.002). The wearing of a protective device by the emitter alone reduced the level of received particles by 96.8% for both the mask and face shield (p = NS). When both the emitter and receiver manikin heads wore a face shield, the protection allowed for better results in our experimental conditions: 98% reduction for the face shields versus 97.3% for the masks (p = 0.01). Face shields offered an even better barrier effect than the mask against small inhaled particles (<, 0.3 µm–0.3 to 0.5 µm–0.5 to 1 µm) in all configurations. Therefore, it would be interesting to include face shields as used in our experimental study as part of strategies to reduce transmission within the community setting.
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- 2021
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29. EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex
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Andrew P. Joy, Rodney J. Ouellette, David Barnett, Charles E. Bullerwell, Philippe Pierre Robichaud, Pierre M. L. Deprez, Gabriel Wajnberg, Darwin D’Souza, Simi Chacko, Stephen M. Lewis, Stéphanie Fournier, and Nicolas Crapoulet
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0301 basic medicine ,Lymphoma, B-Cell ,Molecular biology ,Science ,Antigens, CD19 ,Gene Expression ,Diseases ,Lymphocyte Activation ,Article ,CD19 ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Transcription (biology) ,Cell Line, Tumor ,hemic and lymphatic diseases ,Gene expression ,Transcriptional regulation ,medicine ,Humans ,Gene silencing ,Cell Lineage ,B cell ,Cancer ,B-Lymphocytes ,Multidisciplinary ,biology ,Methyltransferase complex ,Chemistry ,PAX5 Transcription Factor ,Cell Differentiation ,Methyltransferases ,Cell biology ,030104 developmental biology ,Histone ,medicine.anatomical_structure ,Oncology ,Gene Expression Regulation ,030220 oncology & carcinogenesis ,Trans-Activators ,biology.protein ,Medicine - Abstract
PAX5 and EBF1 work synergistically to regulate genes that are involved in B lymphocyte differentiation. We used the KIS-1 diffuse large B cell lymphoma cell line, which is reported to have elevated levels of PAX5 expression, to investigate the mechanism of EBF1- and PAX5-regulated gene expression. We demonstrate the lack of expression of hallmark B cell genes, including CD19, CD79b, and EBF1, in the KIS-1 cell line. Upon restoration of EBF1 expression we observed activation of CD19, CD79b and other genes with critical roles in B cell differentiation. Mass spectrometry analyses of proteins co-immunoprecipitated with PAX5 in KIS-1 identified components of the MLL H3K4 methylation complex, which drives histone modifications associated with transcription activation. Immunoblotting showed a stronger association of this complex with PAX5 in the presence of EBF1. Silencing of KMT2A, the catalytic component of MLL, repressed the ability of exogenous EBF1 to activate transcription of both CD19 and CD79b in KIS-1 cells. We also find association of PAX5 with the MLL complex and decreased CD19 expression following silencing of KMT2A in other human B cell lines. These data support an important role for the MLL complex in PAX5-mediated transcription regulation.
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- 2021
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30. Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis
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Binhui Zhou, Wenyi Yang, Wushan Li, Le He, Liaoxun Lu, Lichen Zhang, Zhuangzhuang Liu, Ying Wang, Tianzhu Chao, Rong Huang, Yanrong Gu, Tingting Jia, Qiaoli Liu, Shuanghua Tian, Philippe Pierre, Takahiro Maeda, Yinming Liang, Eryan Kong, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Henan, China, Xinxiang Medical University, Henan - Laboratory of Genetic Regulators in the Immune System, Institute for Research in Biomedicine ( iBiMED), Universidade de Aveiro, E-institute of Shanghai University Immunology Division, Shanghai University, Graduate School of Biomedical Sciences [Nagasaki University, Japan], Nagasaki University, National Natural ScienceFoundation of China (Grant No. 31770824 and 32000491), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and DUMENIL, Anita
- Subjects
Male ,0301 basic medicine ,T-Lymphocytes ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Plasmacytoid dendritic cell ,Lymphocyte Activation ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Immunology and Allergy ,ComputingMilieux_MISCELLANEOUS ,Skin ,Original Research ,Zdhhc2 ,Mice, Knockout ,Imiquimod ,Chemistry ,autoimmunity ,psoriasis ,inflammatory response ,Up-Regulation ,3. Good health ,[SDV] Life Sciences [q-bio] ,Cytokine ,plasmacytoid dendritic cells ,medicine.symptom ,Signal Transduction ,lcsh:Immunologic diseases. Allergy ,Immunology ,Inflammation ,Cell Line ,03 medical and health sciences ,Immune system ,Psoriasis ,medicine ,Animals ,Humans ,Tumor Suppressor Proteins ,Interferon-alpha ,Dendritic Cells ,medicine.disease ,Mice, Inbred C57BL ,Disease Models, Animal ,030104 developmental biology ,Cancer research ,IRF7 ,lcsh:RC581-607 ,Acyltransferases ,CD80 ,Interferon regulatory factors - Abstract
Zdhhc family genes are composed of 24 members that regulate palmitoylation, a post-translational modification process for proteins. Mutations in genes that alter palmitoylation or de-palmitoylation could result in neurodegenerative diseases and inflammatory disorders. In this study, we found that Zdhhc2 was robustly induced in psoriatic skin and loss of Zdhhc2 in mice by CRISPR/Cas9 dramatically inhibited pathology of the ear skin following imiquimod treatment. As psoriasis is an inflammatory disorder, we analyzed tissue infiltrating immune cells and cytokine production. Strikingly we found that a master psoriatic cytokine interferon-α (IFN-α) in the lesioned skin of wildtype (WT) mice was 23-fold higher than that in Zdhhc2 deficient counterparts. In addition, we found that CD45+ white blood cells (WBC) infiltrating in the skin of Zdhhc2 deficient mice were also significantly reduced. Amelioration in psoriasis and dramatically reduced inflammation of Zdhhc2 deficient mice led us to analyze the cellular components that were affected by loss of Zdhhc2. We found that imiquimod induced plasmacytoid dendritic cell (pDC) accumulation in psoriatic skin, spleen, and draining lymph nodes (DLN) were drastically decreased in Zdhhc2 deficient mice, and the expression of pDC activation marker CD80 also exhibited significantly inhibited in psoriatic skin. In further experiments, we confirmed the cell intrinsic effect of Zdhhc2 on pDCs as we found that loss of zDHHC2 in human CAL-1 pDC dampened both interferon regulatory factor 7 (IRF7) phosphorylation and IFN-α production. Therefore, we identified novel function of Zdhhc2 in controlling inflammatory response in psoriasis in mice and we also confirmed that crucial role of Zdhhc2 in pDCs by regulating IRF7 activity and production of the critical cytokine. Our results finding the dependence of IFN-α production on Zdhhc2 in inflamed murine skin and in human pDCs provide rationale for targeting this new molecule in treatment of inflammation.
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- 2021
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31. Is There More Than the Answer to the Question? Device Use and Completion Time as Indicators for Selectivity Bias and Response Convenience in Online Surveys
- Author
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Jean Philippe Pierre Decieux
- Subjects
Computer science ,05 social sciences ,050401 social sciences methods ,Sample (statistics) ,Paradata ,Device Usage ,Field (computer science) ,0506 political science ,0504 sociology ,Order (exchange) ,Data quality ,Respondent ,Soziologie, Sozialwissenschaften ,050602 political science & public administration ,Econometrics ,Set (psychology) - Abstract
The main objective of the German Emigration and Remigration Panel Study (GERPS) is to establish a longitudinal data set that provides information on life trajectories of international migrants. However, a large amount of paradata were also collected in order to obtain meta-information on respondents’ survey participation. This auxiliary information can help to optimize data quality at all stages of the survey process. By continuing the existing discussion in the field of online surveys, this chapter pursues a twofold objective: it reflects device usage (mobile vs. computer) and elucidates determinants of device choice. In particular, it analyses whether selectivity effects due to respondent’s device choices bias the sample. Moreover, this chapter investigates differences in response time between devices to detect differences in response burden. The analysis of response burden differences by device is an important issue, since an increased device-specific response burden can be a predictor of actual and further panel dropouts. In both device-specific selectivity and survey burden, only slight differences were found between mobile and desktop devices. Using these data, the following paper addresses the need to analyse potential sources of survey error and provides evidence that GERPS data do not appear to contain noteworthy bias attributed to device usage.
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- 2021
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32. FASKU. French version of the General Self-Efficacy Short Scale
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Décieux, Jean Philippe Pierre, Sischka, P. E., Schumacher, A., and Willems, H.
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Soziologie, Sozialwissenschaften - Abstract
The FASKU is an economical instrument for recording individual competence expectations of dealing with difficulties and obstacles in daily life. It was originally developed and validated in German by Beierlein, Kemper, Kovaleva, and Rammstedt (2013). In 2019, the authors developed and tested a French version of this scale (FASKU) and tested it for reliability (internal consistency), validity, and measurement equivalence towards the original German Version (see Décieux et al., 2020a). The provided evidence on the quality of the German and the French Version of ASKU (FASKU) indicates that the scales allow a reliable, valid, and economical assessment of subjective competence expectations and that the two language versions can be used to assess and compare self-efficacy in German- and French-speaking populations.
- Published
- 2021
33. Emigration, friends, and social integration : The determinants and development of friendship network size after arrival
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Jean Philippe Pierre Decieux and Luisa Mörchen
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Bond ,media_common.quotation_subject ,05 social sciences ,0507 social and economic geography ,Intension ,Context (language use) ,language.human_language ,0506 political science ,Emigration ,German ,Identification (information) ,Friendship ,Social integration ,050602 political science & public administration ,language ,Soziologie, Sozialwissenschaften ,Demographic economics ,Sociology ,050703 geography ,media_common - Abstract
Friendships can be interpreted as voluntary relationships between individuals and characterised as relatively amorphous bond. Since migration usually diversifies people’s social bonds, it can be suggested that in this context friendships have to be reconfigured. Even though friendships are important for societal integration and related to individual well-being, migration research has treated friendships as a side issue. This chapter aims to narrow this gap by answering three questions: Are there significant differences between emigrants and non-mobiles in their number of close friends? What are important factors influencing emigrants’ number of close friends abroad? How does this number develop during the first years after emigration? Based on data from the German Emigration and Remigration Panel Study and the German Socio-Economic Panel, the results show that emigrants have more friends than non-mobiles. Additionally, we find that individual characteristics and cultural distance between emigrant and host society or the intension to stay in the emigration country are significantly related to emigrants’ friendship network size. Furthermore, we find that identification with the emigration country is the most influential factor on the size of the friendship networks during the first 2 years after arrival. Our results also provide some evidence that there is an optimal size of the close-friendship-network.
- Published
- 2021
34. Setting up probability-based online panels of migrants with a push-to-web approach : Lessons learned from the german emigration and remigration panel study (GERPS)
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Andreas Genoni, Jean Philippe Pierre Decieux, Andreas Ette, and Nils Witte
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Response rate (survey) ,05 social sciences ,050401 social sciences methods ,Regression analysis ,Sample (statistics) ,medicine.disease ,Logistic regression ,language.human_language ,0506 political science ,Unit (housing) ,German ,Ballot ,0504 sociology ,050602 political science & public administration ,medicine ,language ,Soziologie, Sozialwissenschaften ,Attrition ,Demographic economics ,Psychology - Abstract
We address two major challenges in setting up probability-based online panels of migrants, using the German Emigration and Remigration Panel Study (GERPS) as an example. The first challenge is potential spatial and social selectivity in unit response when using push-to-web recruitment. To address the first challenge, we draw on a split ballot experiment with return migrants in wave 1 of GERPS. The related analysis uses population register data and geo data. We use logistic regressions to compare unit nonresponse between a push-to-web-only control group (n = 5999) and two sub-samples (each n = 1000) with optional paper and pencil interviews (PAPI). The second challenge is panel attrition. To address the second challenge, we investigate the role of individual-level and survey-related factors for panel consent. The regression analysis uses GERPS data of first-wave respondents, estimating panel consent rates for responding remigrants in general (n = 6395) and in the experiment sample (n = 2130). We find that the provision of an optional paper questionnaire marginally increases the likelihood of response. The positive correlation of PAPI and response rate, however, is counterbalanced by a negative correlation with the likelihood of panel consent. This suggests a trade-off scenario to the detriment of either response rates or panel participation rates.
- Published
- 2021
35. German Emigration and Remigration Panel Study (GERPS) : Documentation of the Second Wave
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Décieux, Jean Philippe Pierre, Witte, Nils, Erlinghagen, Marcel, Ette, Andreas, Genoni, Andreas, Auditor, Jean Guedes, Knirsch, Frederik, Kühne, Simon, Mansfeld, Lisa, and Schneider, Norbert F.
- Subjects
Soziologie, Sozialwissenschaften - Published
- 2021
36. German Labor Emigration in Times of Technological Change: Occupational Characteristics and Geographical Patterns
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Décieux, Jean Philippe Pierre and Mergener, Alexandra
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Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie] ,Sociology & social sciences [H10] [Social & behavioral sciences, psychology] ,Soziologie, Sozialwissenschaften - Abstract
Technological change has altered labor market demands within well-developed societies implying global competition for skilled labor and, as a consequence, new forms of labor migration. So far, patterns of this labor migration have been underexplored. Thus, the article analyzes characteristics, geographies and possible underlying drivers of workers migrating from Germany as an exemplary case for a well-developed country. Relying on probability-based and unique data, our findings reveal that, besides demand for people with higher levels of education, performing specific occupational tasks is also in demand in the global competition for talent. Hence, Germans in jobs with a high proportion of analytical non-routine tasks are more likely to emigrate than those with predominantly manual routine tasks. Moreover, the results show that global discrepancies concerning the technological development between the country of origin and the country to which they emigrate are a crucial contextual driver attracting this specifically demanded work force. Workers mainly performing analytical non-routine tasks within their job tend to move to countries which are technologically more developed than Germany while individuals performing jobs with a high share of non-routine manual or interactive tasks tend to emigrate to countries that are less technologically developed than Germany. OA Förderung 2021
- Published
- 2021
37. Personality traits and self-perceived development of friendship in the course of migration
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Décieux, Jean Philippe Pierre
- Subjects
Soziologie, Sozialwissenschaften - Published
- 2021
38. Assessing the efficiency of COVID-19 NPIs in France: a retrospective study using a novel methodology
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Joachim Forget, Philippe Pierre Pébaÿ, Jean-Luc Caut, and Edouard Lansiaux
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Public health ,Psychological intervention ,Retrospective cohort study ,Pearson product-moment correlation coefficient ,symbols.namesake ,Epidemiology ,symbols ,Medicine ,business ,Curfew ,Health policy ,Demography - Abstract
After an initial phase of low reactivity from the French public health authorities, in the face of the emergence of SARS-CoV-2 in February 2020, various Non Pharmaceutical Interventions (NPIs) were put in place (strict stay-at-home orders, followed by mandatory mask wearing in public places, curfews, partial lockdowns, etc.). In our knowledge, no study has independently assessed their respective effectiveness in an independent manner nor a synergistic manner. Our study has retrospectively studied (from 03/01/2020 to 30/01/2021), using metropolitan France data, the association strength (using normalized mutual information) as well as the linear correlation (using Pearson’s correlation) between more restrictive NPIs (mrNPIs) and epidemiological markers of COVID-19. All mrNPIs were moderately associated with a viral reproduction rate decrease but were associated neither with a decrease in COVID-19 daily hospitalizations, nor with COVID-19 daily ICU admissions. This paper is only for academic discussion, conclusions need to be confirmed by further research. Data and codes were available here http://gitlab.com/covid-data-2/lockdown-and-curfew.
- Published
- 2021
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39. Micromechanical framework for a 3D solid cohesion model –implementation, validation and perspectives
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Sanayei, Mohammad, Farhat, Abbas, Luu, Li-Hua, Werner, Lukas, Rettinger, Christoph, Philippe, Pierre, and Cuéllar, Pablo
- Abstract
Natural soil deposits such as carbonate sands in the marine environment may show an effective cohesion due to intergranular solid bridges formed by calcareous precipitation. Such cementation effect endows the granular material with the ability to resist some degree of tensile stress in addition to the compressive and shearing resistance proper of uncemented frictional sands. tensile resistance of such materials may be quantified based on measures of debonding force at the micro-scale and using appropriate homogenization techniques. However, it is still a challenge to assess the influence of solid intergranular cohesion on the mechanical behaviour of soils in many practical engineering problems. Recent advances both in computational hardware and parallelization strategies make it nowadays possible to address such problems from a micromechanical perspective. Here we introduce a simple model for solid cohesion and its implementation within a 3D discrete element framework. The model involves a classical viscoelastic bond rheology and specific debonding modes for tensile, shearing, bending and torsional solicitations. We finally present a calibration of the model to match experimental data from an artificial granular soil made out of cemented glass beads and a validation of the approach with a macro-mechanical application.
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- 2021
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40. Evidence for Higgs boson decays to a low-mass dilepton system and a photon in pp collisions at s=13 TeV with the ATLAS detector
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Aad, Georges, Abbott, Braden Keim, Abreu Aguilar, Henso Javier, Argyropoulos, Spyridon, Hankache, Robert, Hansen, Eva Brottmann, Hansen, Joergen Beck, Hansen, Joern Dines, Hansen, Maike Christina, Hansen, Peter Henrik, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Arling, Jan-Hendrik, Harris, Ynyr Theophilus, Harrison, Paul Fraser, Hartman, Nicole Michelle, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, A. A., Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Armbruster, Aaron James, Hawkes, Christopher, Hawkings, Richard John, Hayashida, Shota, Hayden, Daniel Adam, Hayes, Christopher Robyn, Hayes, Robin, Hays, Christopher Paul, Hays, Jonathan Michael, Hayward, Helen Sarah, Haywood, Stephen James, Armstrong, Alexander, He, Fudong, He, Yunjian, He, Yajun, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha Domenica, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Arnaez, Olivier Ludovic, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon Frank-Thomas, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Arnold, Hannah Ruth, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten Lennart, Helsens, Clement, Henderson, Robert, Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Arrubarrena Tame, Zulit Paola, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Leonhard Gregor, Hertenberger, Ralf, Hervas, Luis, Hessey, Nigel Paul, Hibi, Hiroaki, Higashino, Satoshi, Higon-Rodriguez, Emilio, Hildebrand, Kevin, Artoni, Giacomo, Hill, Kurt Keys, Hiller, Karlheinz, Hillier, Stephen James, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Asada, Haruka, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark Christopher, Hodkinson, Benjamin Haslum, Hoecker, Andreas, Hofer, Judith, Hohn, David, Holm, Tanja, Asai, Kanae, Holmes, Tova Ray, Holzbock, Michael Helmut, Hommels, Bart Leonard Anton, Honan, Benjamin Paul, Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter Howard, Horii, Yasuyuki, Abulaiti, Yiming, Asai, Shoji, Horn, Philipp, Horyn, Lesya Anna, Hou, Suen, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, 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Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Jagfeld, Christoph, Jakel, Gunnar, Astalos, Robert, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof Wojciech, Jarlskog, Goran, Jaspan, Adam Elliott, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Atkin, Ryan Justin, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Jiang, Yi, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Atkinson, Markus Julian, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth Arthur, Johnson, Christian, Jones, Eleanor, Jones, Roger, Atlay, Naim Bora, Jones, Timothy John, Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Kaczmarska, Anna, Kado, Marumi Marcello, Kagan, Harris Peter, Kagan, Michael Aaron, Kahn, Alan Mathew, Abusleme Hoffman, Angel Christian, Atmani, Hicham, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Charles William, Kaluza, Adam, Kamenshchikov, Andrey, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Atmasiddha, Prachi Arvind, Kanzaki, Junichi, Kar, Deepak, Karava, Kla, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Karpova, Zoya, Kartvelishvili, Vakhtang, Karyukhin, Andrey, Kasimi, Eirini, Augsten, Kamil, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis Fawn, Kaya, Fikriye Idil, Kazakos, Stergios, Austrup, Volker Andreas, Kazanin, Vassili, Ke, Yan, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kelsey, Daniel Christopher, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Avolio, Giuseppe, Kersten, Susanne, Kersevan, Borut Paul, Ketabchi Haghighat, Sana, Khalil-Zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Ayoub, Mohamad Kassem, Khoriauli, Gia, Khramov, Evgeny, Khubua, Jemal, Kido, Shogo, Kiehn, Moritz Simon Maria, Kilgallon, Aaron Joseph, Kim, Eunchong, Kim, Young-Kee, Kimura, Naoki, Kirchhoff, Andreas, Azuelos, Georges, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrey, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-Kleingrothaus, Thorwald, Klassen, Martin, Babal, Dominik, Klein, Christoph Thomas, Klein, Lucas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Klimek, Pawel Jan, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Bachacou, Henri, Klitzner, Felix Fidelio, Kluit, Peter Martin, Kluth, Stefan, Kneringer, Emmerich, Knight, Timothy Michael, Knue, Andrea Helen, Kobayashi, Dai, Kobel, Michael, Kocian, Martin Lukas, Kodama, Takafumi, Bachas, Konstantinos, Kodys, Peter, Kock, Daniela Maria, Konig, Philipp Thomas, Koffas, Thomas, Koehler, Nicolas Maximilian, Kolb, Mathis Simon, Koletsou, Iro, Komarek, Tomas, Koeneke, Karsten, Kong, Albert Xing Yi, Acharya, Bobby Samir, Backman, Karl Filip, Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Kordas, Konstantinos, Koren, Guy, Korn, Andreas Michael, Bagnaia, Paolo, Korn, Steffen, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh Vijay, Koulouris, Aimilianos, Bahmani, Marzieh, Kourkoumeli-Charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kowalewski, Robert Victor, Kozanecki, Witold, Kozhin, Anatoly, Kramarenko, Victor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Krasny, Mieczyslaw Witold, Bahrasemani, Sina, Krasznahorkay, Attila, Kremer, Jakub Andrzej, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Krivos, Martin, Krizka, Karol, Bailey, Adam, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Krueger, Hans, Krumnack, Nils Erik, Kruse, Mark Charles, Krzysiak, Janina Anna, Bailey, Virginia Ruth, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, Jan Thomas, Kuhn, Susanne Sabine, Kuhl, Thorsten, Kukhtin, Victor, Koultchitski, Iouri, Kuleshov, Sergey, Baines, John, Kumar, Mukesh, Kumari, Neelam, Kuna, Marine, Kupco, Alexander, Kupfer, Tobias, Kuprash, Oleg, Kurashige, Hisaya, Kurchaninov, Leonid, Kurochkin, Yurii, Kurova, Anastasiia, Bakalis, Christos, Kurth, Matthew Glenn, Kuwertz, Emma Sian, Kuze, Masahiro, Kvam, Audrey Katherine, Kvita, Jiri, Kwan, Tony, Lacasta Llacer, Carlos, Lacava, Francesco, Lack, David Philip John, Lacker, Heiko Markus, Baker, Keith Oliver, Lacour, Didier, Ladygin, Evgeny, Lafaye, Remi, Laforge, Bertrand, Lagouri, Theodota, Lai, Stanley Tsai-Ting, Lakomiec, Inga Katarzyna, Lalloue, Nathan, Lambert, 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Dado, Tomas, Dahbi, Salah-Eddine, Dai, Tiesheng, Dallapiccola, Carlo James, Dam, Mogens, D'Amen, Gabriele, D'Amico, Valerio, Damp, Johannes Frederic, Allaire, Corentin, Dandoy, Jeffrey Rogers, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Giovanni, Dattagupta, Aparajita, D'Auria, Saverio, David, Claire Anne Sophie, Davidek, Tomas, Davis, Douglas Raymond, Allbrooke, Benedict, Davis-Purcell, Benjamin Richard, Dawson, Ian, De, Kaushik, De Asmundis, Riccardo, De Beurs, Marcus, De Castro, Stefano, De Groot, Nicolo, De Jong, Paulus Johannes, De La Torre Perez, Hector, De Maria, Antonio, Allport, Philip Patrick, De Pedis, Daniele, De Salvo, Alessandro, De Sanctis, Umberto, De Santis, Maurizio, De Santo, Antonella, De Vivie De Regie, Jean-Baptiste, Dedovich, Dmitry, Degens, Jordy, Deiana, Allison Mccarn, Del Peso, Jose, Aloisio, Alberto, Delabat Diaz, Yasiel, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'Acqua, Andrea, 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Jean-Francois, Hamer, Matthias, Hamity, Guillermo Nicolas, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hance, Michael, Hank, Michael Donald, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Abusleme Hoffman, A. C., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Akesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M. M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal, N., Araujo Ferraz, V., Arcangeletti, C., Arce, A. T. H., Arena, E., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N. A., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Bakshi Gupta, D., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Ballabene, E., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barends, K. N., Barillari, T., Barisits, M. -S., Barkeloo, J., Barklow, T., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimaraes da Costa, J., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bashta, I., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. 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S., Sharma, S., Shatalov, P. B., Shaw, K., Shaw, S. M., Shehade, M., Shen, Y., Sherwood, P., Shi, L., Shimmin, C. O., Shimogama, Y., Shimojima, M., Shinner, J. D., Shipsey, I. P. J., Shirabe, S., Shiyakova, M., Shlomi, J., Shochet, M. J., Shojaii, J., Shope, D. R., Shrestha, S., Shrif, E. M., Shroff, M. J., Shulga, E., Sicho, P., Sickles, A. M., Sideras Haddad, E., Sidiropoulou, O., Sidoti, A., Siegert, F., Sijacki, D., Silva Oliveira, M. V., Silverstein, S. B., Simion, S., Simoniello, R., Simsek, S., Sinervo, P., Sinetckii, V., Singh, S., Sinha, S., Sioli, M., Siral, I., Sivoklokov, S. Y., Sjolin, J., Skaf, A., Skorda, E., Skubic, P., Slawinska, M., Sliwa, K., Smakhtin, V., Smart, B. H., Smiesko, J., Smirnov, S. Y., Smirnov, Y., Smirnova, L. N., Smirnova, O., Smith, E. A., Smith, H. A., Smizanska, M., Smolek, K., Smykiewicz, A., Snesarev, A. A., Snoek, H. L., Snyder, I. M., Snyder, S., Sobie, R., Soffer, A., Sogaard, A., Sohns, F., Solans Sanchez, C. A., Soldatov, E. Y., Soldevila, U., Solodkov, A. A., Solomon, S., Soloshenko, A., Solovyanov, O. V., Solovyev, V., Sommer, P., Son, H., Sonay, A., Song, W. Y., Sopczak, A., Sopio, A. L., Sopkova, F., Sottocornola, S., Soualah, R., Soukharev, A. M., Soumaimi, Z., South, D., Spagnolo, S., Spalla, M., Spangenberg, M., Spano, F., Sperlich, D., Spieker, T. M., Spigo, G., Spina, M., Spiteri, D. P., Spousta, M., Stabile, A., Stamas, B. L., Stamen, R., Stamenkovic, M., Stampekis, A., Stanecka, E., Stanislaus, B., Stanitzki, M. M., Stankaityte, M., Stapf, B., Starchenko, E. A., Stark, G. H., Stark, J., Starko, D. M., Staroba, P., Starovoitov, P., Starz, S., Staszewski, R., Stavropoulos, G., Steinberg, P., Steinhebel, A. L., Stelzer, B., Stelzer, H. J., Stelzer-Chilton, O., Stenzel, H., Stevenson, T. J., Stewart, G. A., Stockton, M. C., Stoicea, G., Stolarski, M., Stonjek, S., Straessner, A., Strandberg, J., Strandberg, S., Strauss, M., Strebler, T., Strizenec, P., Strohmer, R., Strom, D. M., Strom, L. R., Stroynowski, R., Strubig, A., Stucci, S. A., Stugu, B., Stupak, J., Styles, N. A., Su, D., Su, S., Su, W., Su, X., Suarez, N. B., Sugizaki, K., Sulin, V. V., Sullivan, M. J., Sultan, D. M. S., Sultansoy, S., Sumida, T., Sun, S., Sun, X., Suster, C. J. E., Sutton, M. R., Svatos, M., Swiatlowski, M., Swift, S. P., Swirski, T., Sydorenko, A., Sykora, I., Sykora, M., Sykora, T., Ta, D., Tackmann, K., Taffard, A., Tafirout, R., Tagiev, E., Taibah, R. H. M., Takashima, R., Takeda, K., Takeshita, T., Takeva, E. P., Takubo, Y., Talby, M., Talyshev, A. A., Tam, K. C., Tamir, N. M., Tanaka, J., Tanaka, R., Tapia Araya, S., Tapprogge, S., Tarek Abouelfadl Mohamed, A., Tarem, S., Tariq, K., Tarna, G., Tartarelli, G. F., Tas, P., Tasevsky, M., Tassi, E., Tateno, G., Tayalati, Y., Taylor, G. N., Taylor, W., Teagle, H., Tee, A. S., Teixeira De Lima, R., Teixeira-Dias, P., Ten Kate, H., Teoh, J. J., Terashi, K., Terron, J., Terzo, S., Testa, M., Teuscher, R. J., Themistokleous, N., Theveneaux-Pelzer, T., Thomas, D. W., Thomas, J. P., Thompson, E. A., Thompson, P. D., Thomson, E., Thorpe, E. J., Tian, Y., Tikhomirov, V. O., Tikhonov, Y. A., Timoshenko, S., Tipton, P., Tisserant, S., Tlou, S. H., Tnourji, A., Todome, K., Todorova-Nova, S., Todt, S., Togawa, M., Tojo, J., Tokar, S., Tokushuku, K., Tolley, E., Tombs, R., Tomoto, M., Tompkins, L., Tornambe, P., Torrence, E., Torres, H., Torro Pastor, E., Toscani, M., Tosciri, C., Toth, J., Tovey, D. R., Traeet, A., Treado, C. J., Trefzger, T., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Trischuk, D. A., Trischuk, W., Trocme, B., Trofymov, A., Troncon, C., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tsiamis, A., Tsiareshka, P. V., Tsirigotis, A., Tsiskaridze, V., Tskhadadze, E. G., Tsopoulou, M., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsur, O., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turner, R. J., Turra, R., Tuts, P. M., Tzamarias, S., Tzanis, P., Tzovara, E., Uchida, K., Ukegawa, F., Unal, G., Unal, M., Undrus, A., Unel, G., Ungaro, F. C., Uno, K., Urban, J., Urquijo, P., Usai, G., Ushioda, R., Uysal, Z., Vacek, V., Vachon, B., Vadla, K. O. H., Vafeiadis, T., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valery, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van Gemmeren, P., Van Stroud, S., Van Vulpen, I., Vanadia, M., Vandelli, W., Vandenbroucke, M., Vandewall, E. R., Vannicola, D., Vannoli, L., Vari, R., Varnes, E. W., Varni, C., Varol, T., Varouchas, D., Varvell, K. E., Vasile, M. E., Vaslin, L., Vasquez, G. A., Vazeille, F., Vazquez Furelos, D., Vazquez Schroeder, T., Veatch, J., Vecchio, V., Veen, M. J., Veloce, L. M., Veloso, F., Veneziano, S., Ventura, A., Verbytskyi, A., Verducci, M., Vergis, C., Verissimo De Araujo, M., Verkerke, W., Vermeulen, A. T., Vermeulen, J. C., Vernieri, C., Verschuuren, P. J., Vesterbacka, M. L., Vetterli, M. C., Viaux Maira, N., Vickey, T., Vickey Boeriu, O. E., Viehhauser, G. H. A., Vigani, L., Villa, M., Villaplana Perez, M., Villhauer, E. M., Vilucchi, E., Vincter, M. G., Virdee, G. S., Vishwakarma, A., Vittori, C., Vivarelli, I., Vladimirov, V., Vogel, M., Vokac, P., Von Ahnen, J., von Buddenbrock, S. E., Von Toerne, E., Vorobel, V., Vorobev, K., Vos, M., Vossebeld, J. H., Vozak, M., Vranjes, N., Vranjes Milosavljevic, M., Vrba, V., Vreeswijk, M., Vu, N. K., Vuillermet, R., Vukotic, I., Wada, S., Wagner, C., Wagner, P., Wagner, W., Wahdan, S., Wahlberg, H., Wakasa, R., Wakida, M., Walbrecht, V. M., Walder, J., Walker, R., Walker, S. D., Walkowiak, W., Wallangen, V., Wang, A. M., Wang, A. Z., Wang, C., Wang, H., Wang, J., Wang, P., Wang, R. -J., Wang, R., Wang, S. M., Wang, S., Wang, T., Wang, W. T., Wang, W. X., Wang, X., Wang, Y., Wang, Z., Wanotayaroj, C., Warburton, A., Ward, C. P., Ward, R. J., Warrack, N., Watson, A. T., Watson, M. F., Watts, G., Waugh, B. M., Webb, A. F., Weber, C., Weber, M. S., Weber, S. A., Weber, S. M., Wei, C., Wei, Y., Weidberg, A. R., Weingarten, J., Weirich, M., Weiser, C., Wells, P. S., Wenaus, T., Wendland, B., Wengler, T., Wenig, S., Wermes, N., Wessels, M., Weston, T. D., Whalen, K., Wharton, A. M., White, A. S., White, A., White, M. J., Whiteson, D., Wiedenmann, W., Wiel, C., Wielers, M., Wieseotte, N., Wiglesworth, C., Wiik-Fuchs, L. A. M., Wilkens, H. G., Wilkins, L. J., Williams, D. M., Williams, H. H., Williams, S., Willocq, S., Windischhofer, P. J., Wingerter-Seez, I., Winklmeier, F., Winter, B. T., Wittgen, M., Wobisch, M., Wolf, A., Wolker, R., Wollrath, J., Wolter, M. W., Wolters, H., Wong, V. W. S., Wongel, A. F., Woods, N. L., Worm, S. D., Wosiek, B. K., Wozniak, K. W., Wraight, K., Wu, J., Wu, S. L., Wu, X., Wu, Y., Wu, Z., Wuerzinger, J., Wyatt, T. R., Wynne, B. M., Xella, S., Xiang, J., Xiao, X., Xie, X., Xiotidis, I., Xu, D., Xu, H., Xu, L., Xu, R., Xu, W., Xu, Y., Xu, Z., Yabsley, B., Yacoob, S., Yallup, D. P., Yamaguchi, N., Yamaguchi, Y., Yamatani, M., Yamauchi, H., Yamazaki, T., Yamazaki, Y., Yan, J., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, T., Yang, X., Yang, Y., Yang, Z., Yao, W. -M., Yap, Y. C., Ye, H., Ye, J., Ye, S., Yeletskikh, I., Yexley, M. R., Yin, P., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yuan, R., Yue, X., Zaazoua, M., Zabinski, B., Zacharis, G., Zaffaroni, E., Zahreddine, J., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zambito, S., Zanzi, D., Zeissner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zenin, O., Zenis, T., Zenz, S., Zerradi, S., Zerwas, D., Zgubic, M., Zhang, B., Zhang, D. F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Z., Zhao, P., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Zivkovic, L., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zou, W., and Zwalinski, L.
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p p: scattering ,dilepton: mass spectrum ,Higgs boson ,+electron+positron+photon%22">Higgs particle --> electron positron photon ,13000 GeV-cms ,QC1-999 ,FOS: Physical sciences ,mass spectrum [dilepton] ,High Energy Physics - Experiment ,electron: pair production ,High Energy Physics - Experiment (hep-ex) ,mass spectrum: (electron positron) ,scattering [p p] ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,ddc:530 ,pair production [electron] ,pair production [muon] ,Particle Physics ,Settore FIS/01 ,(muon+ muon-) [mass spectrum] ,radiative decay [Higgs particle] ,Physics ,+muon%2B+muon-+photon%22">Higgs particle --> muon+ muon- photon ,High Energy Physics::Phenomenology ,ATLAS ,LHC, Particle Physics, Higgs boson ,(electron positron) [mass spectrum] ,Higgs particle: radiative decay ,photon: associated production ,channel cross section: branching ratio: measured ,muon: pair production ,mass spectrum: (muon+ muon-) ,production [Higgs particle] ,CERN LHC Coll ,Higgs particle: production ,associated production [photon] ,branching ratio: measured [channel cross section] ,High Energy Physics::Experiment ,LHC ,colliding beams [p p] ,p p: colliding beams ,Particle Physics - Experiment ,experimental results - Abstract
A search for the Higgs boson decaying into a photon and a pair of electrons or muons with an invariant mass $m_{\ell\ell} < 30$ GeV is presented. The analysis is performed using 139 fb$^{-1}$ of proton-proton collision data, produced by the LHC at a centre-of-mass energy of 13 TeV and collected by the ATLAS experiment. Evidence for the $H \rightarrow \ell \ell \gamma$ process is found with a significance of 3.2$\sigma$ over the background-only hypothesis, compared to an expected significance of 2.1$\sigma$. The best-fit value of the signal strength parameter, defined as the ratio of the observed signal yield to the one expected in the Standard Model, is $\mu = 1.5 \pm 0.5$. The Higgs boson production cross-section times the $H \rightarrow\ell\ell\gamma$ branching ratio for $m_{\ell\ell}, Comment: 39 pages in total, author list starting page 23, 5 figures, 1 table, submitted to PLB, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2018-43/
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- 2021
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41. Comparing the Risk Attitudes of Internationally Mobile and Non-Mobile Germans
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Gert G. Wagner, Jean Philippe Pierre Decieux, Christiane Lübke, and Marcel Erlinghagen
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media_common.quotation_subject ,05 social sciences ,0507 social and economic geography ,language.human_language ,Emigration ,German ,Turnover ,Political science ,0502 economics and business ,Soziologie, Sozialwissenschaften ,language ,Personality ,Demographic economics ,Cultural institution ,050207 economics ,050703 geography ,media_common - Abstract
Moving–particularly to a new country–is fraught with risks as migrants leave familiar legal frameworks and cultural institutions behind them. To date, little is known about the psychological determinants of international migration. This chapter helps to fill this gap by analysing data from the first wave of the German Emigration and Remigration Panel Study (GERPS) in combination with data on non-mobile individuals from the German Socio-Economic Panel Study (SOEP). The analyses presented examine whether the risk attitudes of internationally mobile Germans (‘movers’) differ from those of their non-mobile counterparts (‘stayers’). The results show that–with control for key socio-demographic and socio-economic determinants of risk affinity–both emigrants and remigrants report a significantly higher willingness to take risks than stayers. Risk affinity differs within the group of internationally mobile individuals: Emigrants moving to geographically and culturally distant non-European countries report higher risk affinity than those moving to Germany’s neighbouring countries. Emigrants with multiple previous emigration periods are also more willing to take risks. These findings suggest that voluntary emigration from wealthy countries like Germany is only partly a matter of living conditions. Rather, (repeated) emigration seems to be a matter of personality and an expression of a more adventurous lifestyle.
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- 2021
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42. Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
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Andreia Mendes, Sébastien A Choteau, Evelina Gatti, Voahirana Camosseto, Ana-Maria Lennon-Duménil, James C. Paton, Adrienne W. Paton, Rafael J. Argüello, Daniela Barros, Lionel Chasson, Philippe Pierre, Julien P. Gigan, Catarina R. Almeida, Doriane Sanséau, Christian Rodriguez Rodrigues, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunité et cancer (U932), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie [Paris], Institute for Research in Biomedicine ( iBiMED), Universidade de Aveiro, Institut Curie, PSL Research University, INSERM U932., University of Adelaide, PTDC/BIA-CEL/28791/2017 and POCI-01-0145-FEDER-028791, POCI-01-0145-FEDER-030882 and PTDC/BIA-MOL/30882/2017 and UIDB/04501/2020, ANR-12-ISV3-0002,MISTRAL,Conséquences du contrôle réciproque de l'infidélité de la traduction dans l'immunité anti-fongique(2012), ANR-11-LABX-0054,INFORM,Flux d'inFormation et organisation de la membrane(2011), ANR-11-LABX-0043,DCBIOL,Biologie des cellules dendritiques(2011), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), DUMENIL, Anita, Blanc International II - Conséquences du contrôle réciproque de l'infidélité de la traduction dans l'immunité anti-fongique - - MISTRAL2012 - ANR-12-ISV3-0002 - Blanc International II - VALID, Flux d'inFormation et organisation de la membrane - - INFORM2011 - ANR-11-LABX-0054 - LABX - VALID, Biologie des cellules dendritiques - - DCBIOL2011 - ANR-11-LABX-0043 - LABX - VALID, Initiative d'excellence - Paris Sciences et Lettres - - PSL2010 - ANR-10-IDEX-0001 - IDEX - VALID, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID, and Développment d'une infrastructure française distribuée coordonnée - - France-BioImaging2010 - ANR-10-INBS-0004 - INBS - VALID
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0301 basic medicine ,Lipopolysaccharides ,Health, Toxicology and Mutagenesis ,[SDV]Life Sciences [q-bio] ,Plant Science ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,03 medical and health sciences ,Mice ,eIF-2 Kinase ,0302 clinical medicine ,Cell Movement ,Eukaryotic initiation factor ,Integrated stress response ,Animals ,EIF2AK3 ,Subtilisins ,Antigens ,Phosphorylation ,Research Articles ,ComputingMilieux_MISCELLANEOUS ,Ecology ,Kinase ,Chemistry ,ATF4 ,Membrane Proteins ,Dendritic Cells ,Actin cytoskeleton ,Activating Transcription Factor 4 ,Actins ,Cell biology ,[SDV] Life Sciences [q-bio] ,030104 developmental biology ,Proteostasis ,Gene Knockdown Techniques ,Cytokines ,Protein Multimerization ,030217 neurology & neurosurgery ,Spleen ,Research Article ,Signal Transduction - Abstract
Differentiated dendritic cells display an unusual activation of the integrated stress response, which is necessary for normal type-I Interferon production and cell migration., In stressed cells, phosphorylation of eukaryotic initiation factor 2α (eIF2α) controls transcriptome-wide changes in mRNA translation and gene expression known as the integrated stress response. We show here that DCs are characterized by high eIF2α phosphorylation, mostly caused by the activation of the ER kinase PERK (EIF2AK3). Despite high p-eIF2α levels, DCs display active protein synthesis and no signs of a chronic integrated stress response. This biochemical specificity prevents translation arrest and expression of the transcription factor ATF4 during ER-stress induction by the subtilase cytotoxin (SubAB). PERK inactivation, increases globally protein synthesis levels and regulates IFN-β expression, while impairing LPS-stimulated DC migration. Although the loss of PERK activity does not impact DC development, the cross talk existing between actin cytoskeleton dynamics; PERK and eIF2α phosphorylation is likely important to adapt DC homeostasis to the variations imposed by the immune contexts.
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- 2020
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43. MetamORF: A repository of unique short Open Reading Frames identified by both experimental and computational approaches for gene-level and meta-analysis
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Philippe Pierre, Audrey Wagner, Christine Brun, Lionel Spinelli, and Sébastien A Choteau
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Open reading frame ,Computer science ,Meta-analysis ,Locus (genetics) ,Computational biology ,Genome browser ,Gene ,Genome - Abstract
The development of high-throughput technologies revealed the existence of non-canonical short open reading frames (sORFs) on most eukaryotic RNAs. They are ubiquitous genetic elements highly conserved across species and suspected to be involved in numerous cellular processes. MetamORF (http://metamorf.hb.univ-amu.fr/) aims to provide a repository of unique sORFs identified in the human and mouse genomes with both experimental and computational approaches. By gathering publicly available sORF data, normalizing it and summarizing redundant information, we were able to identify a total of 1,162,675 unique sORFs. Despite the usual characterization of ORFs as short, upstream or downstream, there is currently no clear consensus regarding the definition of these categories. Thus, the data has been reprocessed using a normalized nomenclature. MetamORF enables new analyses at loci, gene, transcript and ORF levels, that should offer the possibility to address new questions regarding sORF functions in the future. The repository is available through an user-friendly web interface, allowing easy browsing, visualization, filtering over multiple criteria and export possibilities. sORFs could be searched starting from a gene, a transcript, an ORF ID, or looking in a genome area. The database content has also been made available through track hubs at UCSC Genome Browser.
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- 2020
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44. Design and Implementation Techniques for an MPI-Oriented AMT Runtime
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Phil Miller, Philippe Pierre Pebay, Jonathan Lifflander, Paul Stickney, Nicolas Morales, and Nicole Lemaster Slattengren
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Runtime system ,Computer architecture ,Computer science ,Asynchronous communication ,Interoperability ,Message passing ,Resource allocation ,Execution model ,PATH (variable) ,Asynchrony (computer programming) - Abstract
We present the execution model of Virtual Transport (VT) a new, Asynchronous Many-Task (AMT) runtime system that provides unprecedented integration and interoperability with MPI. We have developed VT in conjunction with large production applications to provide a highly incremental, high-value path to AMT adoption in the dominant ecosystem of MPI applications, libraries, and developers. Our aim is that the `MPI+X' model of hybrid parallelism can smoothly extend to become `MPI+VT +X'. We illustrate a set of design and implementation techniques that have been useful in building VT. We believe that these ideas and the code embodying them will be useful to others building similar systems, and perhaps provide insight to how MPI might evolve to better support them. We motivate our approach with two applications that are adopting VT and have begun to benefit from increased asynchrony and dynamic load balancing.
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- 2020
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45. 299 Immuno-metabolic signatures of dendritic cells associate with T-cell responses in melanoma patients
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Deena M. Maurer, Lisa H. Butterfield, Rafael J. Argüello, Juraj Adamik, Paul Munson, Alexis J. Combes, Philippe Pierre, and Matthew F. Krummel
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CD86 ,Glutaminolysis ,medicine.diagnostic_test ,Chemistry ,medicine.medical_treatment ,T cell ,CD11c ,Immunotherapy ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,3. Good health ,Flow cytometry ,Immune system ,medicine.anatomical_structure ,Antigen ,medicine ,Cancer research - Abstract
Background The therapeutic efficacy of Dendritic cells (DC) vaccines remains low and there is an unmet need for more effective vaccine design to achieve durable clinical outcomes. Our study analyzed the transcriptomic and energetic metabolism profile of an adenoviral-based DC vaccine targeted against three commonly shared melanoma antigens: Tyrosinase, MART-1 and MAGE-A6 from 35 subjects enrolled in a Phase I study of autologous DC vaccines in late-stage melanoma.1 To further investigate the immuno-metabolic features of monocyte-derived DC vaccines, we are employing a novel flow cytometry-based method, called SCENITH2 to integrate functional metabolic states with multiparametric DC immune phenotypes. Methods iDC were generated from HD and patient monocytes using GM-CSF+IL-4 for 5d. DC were matured (mDC) using IFN?+LPS for additional 24 hrs. Tolerogenic DC (Tol DC) were generated using vitamin-D3 and dexamethasone. Seahorse® was used to measure DC metabolic profile. Cytek/Aurora spectral flow cytometry was used for multiparametric-phenotypic and metabolic analysis by SCENITH™. Results Melanoma patient mDC used for autologous vaccine generation showed significantly altered metabolic gene signatures associated with enhanced oxidative phosphorylation (OXPHOS) and lipid metabolism pathways as compared to HD mDC. Furthermore, increased enrichment for mitochondrial respiration genes involved in the TCA cycle, electron transport chain and fatty acid oxidation (FAO) correlated with inferior tumor antigen-specific T cell responses and clinical outcome in patients. Seahorse analyses confirmed that HD and good outcome patient DC demonstrated the highest maturation-induced reduction in maximal oxygen consumption rate/OXPHOS and exogenous FAO. Interestingly, while the glycolytic rate of non-responding patient DC was the lowest, overall, we observe only a moderate increase in glycolytic capacity during DC maturation. SCENITH analysis showed that unlike monocytes, which are primarily glycolytic, differentiated mono-derived iDC and mDC utilize both glycolysis and mitochondrial respiration. Interestingly, under tolerogenic (Tol) differentiation conditions Tol iDC shift from glucose dependence into FAO and/or glutaminolysis while Tol mDC strongly depend on OXPHOS. Consistent with dependence on mitochondrial respiration, Tol mDC exhibit reduced HIF1a levels together with enhanced p-AMPK:p-mTOR ratio. Additionally, we show that the altered metabolism of Tol mDC is linked to retention of CD14-monocyte antigen with reduced DC markers HLA-DR, CD86, CD206, CD11c, CD33, with increased PD-L1 and ILT3 expression. Furthermore, we show that unlike HD mDC, tolerogenic and melanoma patient-derived mDC populations exhibit similar metabolic and immune characteristics. Conclusions We demonstrate that metabolic profile of DCs is tightly associated to the immuno-stimulatory potential of DC vaccines from cancer patients. Using SCENITH, we linked phenotypic and functional metabolic changes associated to immune signatures that correspond to heathy and immuno-suppressed DC differentiation. Ethics Approval The clinical trial reported was fully approved by the Univ. Pittsburgh PRC and IRB (PRO12010416, #09–021) and had FDA IND #15044 and NCT01622933. References Butterfield LH, Vujanovic L, Santos PM, Maurer DM, Gambotto A, Lohr J, Li C, Waldman J, Chandran U, Lin Y, et al. Multiple antigen-engineered DC vaccines with or without IFNalpha to promote antitumor immunity in melanoma. Journal for immunotherapy of cancer 2019;7:113. Arguello RJ, Combes AJ, Char R, Bousiquot E, Gigan JP, Camosseto V, Samad B, Tsui J, Yan P, et al. SCENITH: A flow cytometry based method for functional profiling energy metabolism with single cell resolution. BioRxiv 2020.03.10.985796; doi: https://doi.org/10.1101/2020.03.10.985796. Cell Metabolism. (Sneak and Peek: under review 10.2139/ssrn.3565001)
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- 2020
46. 7. Devenir une organisation apprenante
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Béatrice Arnaud, Éric Mellet, and Philippe Pierre
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- 2020
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47. LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia
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Mark Wunderlich, Brenay Greenslade, Matthew Burwinkel, Lynn Lee, Gabriel Gracia-Maldonado, Philippe Pierre, Jason Clark, Ashish R Kumar, Evelina Gatti, Dario Leone, Nathan Salomonis, Cincinnati Children's Hospital Medical Center, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), DUMENIL, Anita, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
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medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Interleukin-1 receptor ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Interferon ,hemic and lymphatic diseases ,medicine ,Humans ,neoplasms ,030304 developmental biology ,0303 health sciences ,Acute leukemia ,Leukemia ,Cell growth ,Hematology ,Immunotherapy ,Histone-Lysine N-Methyltransferase ,medicine.disease ,3. Good health ,Leukemia, Biphenotypic, Acute ,[SDV] Life Sciences [q-bio] ,030220 oncology & carcinogenesis ,Cancer research ,IRF7 ,Myeloid-Lymphoid Leukemia Protein ,medicine.drug - Abstract
Although great advances have been made in understanding the pathobiology of mixed lineage leukemia-rearranged (MLL-r) leukemias, therapies for this leukemia have remained limited, and clinical outcomes remain bleak. In order to identify novel targets for immunotherapy treatments, we compiled a lineage-independent MLL-r leukemia gene signature using publicly available data sets. Data from large leukemia repositories were filtered through the in silico human surfaceome, providing a list of highly predicted cell surface proteins overexpressed in MLL-r leukemias. LAMP5, a lysosomal associated membrane protein, is expressed highly and specifically in MLL-r leukemia. We found that LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP-5 is a novel modulator of innate-immune pathways in MLL-r leukemias. Downregulation of LAMP5 led to inhibition of NF-kB signaling and increased activation of type-1 interferon signaling downstream of Toll-like receptor/interleukin 1 receptor activation. These effects were attributable to the critical role of LAMP-5 in transferring the signal flux from interferon signaling endosomes to pro-inflammatory signaling endosomes. Depletion of IRF7 was able to partially rescue the cell growth inhibition upon LAMP5 downregulation. Lastly, LAMP-5 was readily detected on the surface of MLL-r leukemia cells. Targeting surface LAMP-5 using an antibody-drug conjugate leads to significant cell viability decrease specifically in MLL-r leukemias. Overall, based on the limited expression throughout human tissues, we postulate that LAMP-5 could potentially serve as an immunotherapeutic target with a wide therapeutic window to treat MLL-r leukemias.
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- 2020
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48. COVID-19: beta-thalassemia subjects immunised?
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Jean Laurent Picard, Edouard Lansiaux, Philippe Pierre Pébaÿ, and Joachim Son-Forget
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0301 basic medicine ,Male ,thalassemia ,Disease ,medicine.disease_cause ,Hemoglobins ,0302 clinical medicine ,Prevalence ,heme ,Coronavirus ,education.field_of_study ,biology ,immunisation ,Beta thalassemia ,General Medicine ,Middle Aged ,Regression ,Treatment Outcome ,Italy ,statistics ,Regression Analysis ,Female ,Coronavirus Infections ,Heterozygote ,Pneumonia, Viral ,Population ,Sardinia ,Article ,03 medical and health sciences ,Betacoronavirus ,Favipiravir ,Novel Coronavirus ,respiratory distress ,medicine ,Humans ,education ,Pandemics ,SARS-CoV-2 ,business.industry ,beta-Thalassemia ,other ,COVID-19 ,Heterozygote advantage ,biology.organism_classification ,medicine.disease ,030104 developmental biology ,Infectious disease (medical specialty) ,correlation ,Immune System ,Novel virus ,Immunology ,beta ,Immunization ,Hemoglobin ,business ,030217 neurology & neurosurgery - Abstract
The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent pre-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-thalassemia results of a default in the hemoglobin beta- chain synthesis. 1,5% global population are heterozygotes for this disease. In this study, by a multiple linear regression, we have analyzed the evolution of COVID-19 infection in three Italian regions (Puglia, Sardinia, Sicilia) with different beta-thalassemic prevalences, in order to search a link. The results have showed that betathalassemic heterozygote population prevalence is correlated to immunity against COVID-19, by a regression. This paper is only for academic discussion, the hypotheses and conclusions needs to be confirmed by further research .
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- 2020
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49. The RUFYs, a Family of Effector Proteins Involved in Intracellular Trafficking and Cytoskeleton Dynamics
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Rémy Char and Philippe Pierre
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lcsh:Biology (General) ,RUN ,RUFY ,cancer ,FYVE ,neurodegenerative diseases ,immunity ,lcsh:QH301-705.5 - Abstract
Intracellular trafficking is essential for cell structure and function. In order to perform key tasks such as phagocytosis, secretion or migration, cells must coordinate their intracellular trafficking, and cytoskeleton dynamics. This relies on certain classes of proteins endowed with specialized and conserved domains that bridge membranes with effector proteins. Of particular interest are proteins capable of interacting with membrane subdomains enriched in specific phosphatidylinositol lipids, tightly regulated by various kinases and phosphatases. Here, we focus on the poorly studied RUFY family of adaptor proteins, characterized by a RUN domain, which interacts with small GTP-binding proteins, and a FYVE domain, involved in the recognition of phosphatidylinositol 3-phosphate. We report recent findings on this protein family that regulates endosomal trafficking, cell migration and upon dysfunction, can lead to severe pathology at the organismal level.
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- 2020
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50. Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response
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Rafael J. Argüello, Andreia Mendes, Lionel Chasson, Philippe Pierre, Evelina Gatti, Ana-Maria Lennon-Duménil, James C. Paton, Julien P. Gigan, Adrienne W. Paton, Christian Rodriguez Rodrigues, Doriane Sanséau, Catarina R. Almeida, Daniela Barros, Voahirana Camosseto, and Sébastien A Choteau
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0303 health sciences ,Kinase ,Chemistry ,ATF4 ,Actin cytoskeleton ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,Eukaryotic initiation factor ,Integrated stress response ,Phosphorylation ,EIF2AK3 ,Transcription factor ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
In stressed cells, phosphorylation of eukaryotic initiation factor 2α (eIF2α) controls transcriptome-wide changes in mRNA translation and gene expression known as the integrated stress response (ISR). We show here that dendritic cells (DCs) display unusually high eIF2α phosphorylation, which is mostly caused by a developmentally regulated activation of the ER kinase PERK (EIF2AK3). Despite high p-eIF2α levels, differentiated DCs display active protein synthesis and no signs of a chronic ISR. eIF2α phosphorylation does not majorly impact DC differentiation nor cytokines production. It is however important to adapt protein homeostasis to the variations imposed on DCs by the immune or physiological contexts. This biochemical specificity prevents translation arrest and expression of the transcription factor ATF4 during ER-stress induction by subtilase cytotoxin or upon DC stimulation with bacterial lipopolysaccharides. This is also exemplified by the influence of the actin cytoskeleton dynamics on eIF2α phosphorylation and the migratory deficit observed in PERK-deficient DCs.
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- 2020
- Full Text
- View/download PDF
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