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1. Outcome of uterine clear cell carcinomas compared to endometrioid carcinomas and poorly-differentiated endometrioid carcinomas

Author

Patrick Petignat, Usel, M., Gauthier, P., Popowski, Y., Pelte, M. F., Bouchardy, C., and Verkooijen, H. M.

Subjects
Aged, 80 and over, ddc:618, Age Factors, Adenocarcinoma, Clear Cell/pathology/radiotherapy/surgery, Survival Analysis, Carcinoma, Endometrioid/pathology/radiotherapy/surgery, Chemotherapy, Adjuvant, Uterine Neoplasms, Humans, Female, Registries, Uterine Neoplasms/pathology/radiotherapy/surgery, Carcinoma, Endometrioid, Switzerland, ddc:613, Adenocarcinoma, Clear Cell, Aged, Retrospective Studies
Abstract

OBJECTIVES: Our aim was to compare the survival between patients with clear cell carcinoma (CC) and patients with endometrioid carcinoma (EC). METHODS: Through the population-based Geneva Cancer Registry, we identified 1,380 resident women diagnosed with uterine cancer between 1970 and 2000. We excluded those with papillary serous endometrial carcinoma and uterine sarcomas. We categorized patients as CC (n = 32, 2.8%) or EC (n = 1,145, 97.2%). Uterine cancer-specific survival rates were calculated by Kaplan-Meier analysis. We used Cox proportional hazards analysis to compare uterine cancer mortality risks between groups, and adjusted these risks for other prognostic factors. RESULTS: CC patients presented with a more advanced stage at diagnosis than EC patients (p = 0.002). Compared to women with EC, women with CC had a significantly greater risk of dying from their disease (hazard ratio [HR] 2.9, 95% confidence interval (95% CI) 1.7-4.9). After adjustment for age, stage and adjuvant chemotherapy, the risk of dying from uterine cancer was still significantly higher for CC patients (HR 2.0, 95% CI 1.2-3.4). By univariate analysis, the risk of dying of endometrial cancer was not significantly higher in CC patients than in patients with poorly-differentiated EC (HR 1.3, 95% CI 0.7-2.3). CONCLUSION: This population-based investigation shows that patients with CC have a poorer outcome than those with EC. Studies to determine the role of adjuvant treatment in CC patients are needed.

Published
2008

2. RD39 Status Report 2004

Author

Borer, K, Janos, S, Pretzl, K, Chen, W, Li, Z, Da Vià, C, Casagrande, L, Grohmann, S, Heijne, Erik H M, Lourenço, C, Niinikoski, T O, Nüssle, G, Perea-Solano, B, Hempel, O, Herzog, R, Wobst, E, Borchi, E, Bruzzi, M, Menichelli, D, Pirollo, S, Popowski, Y, Bates, R, Buttar, C, O'Shea, V, Parkes, C, Hrknen, J, Luukka, P, Tuovinen, E, Tuominen, E, de Boer, Wim, Bol, H, Dierlamm, A, Furgeri, A, Grigoriev, E, Hauler, F, Jungermann, L, Abreu, M, Rato-Mendes, P, Sonderegger, P, Sousa, P, García, E, Lisbon, Cindro, V, Mandic, I, Mikuz, M, Zavrtanik, M, Militaru, O, Piotrzkowski, K, Rouby, X, De Masi, Rita, Paul, S, Buontempo, S, D'Ambrosio, N, Pagano, S, Eremin, V, Ilyashenko, I, Verbitskaya, E, Laiho, R, Vlasenko, L, Vlasenko, M, Anbinderis, P, Anbinderis, T, Gaubas, E, Gorbatenko, V, Kalesinskas, V, Kapturauskas, J, and Vaitkus, J

Subjects
Detectors and Experimental Techniques
Published
2004

3. RD39 Status Report 2003

Author

Borer, K, Janos, S, Pretzl, K, Britvitch, I, Kuznetsov, A A, Musienko, Y, Reucroft, S, Swain, J, Chen, W, Li, Z, Da Vià, C, Casagrande, L, Grohmann, S, Heijne, Erik H M, Lourenço, C, Niinikoski, T O, Nüssle, G, Palmieri, V G, Perea-Solano, B, Hempel, O, Herzog, R, Wobst, E, Borchi, E, Bruzzi, M, Menichelli, D, Pirollo, S, Popowski, Y, O'Shea, V, Rahman, M, Ruggiero, G, Härkönen, J, Luukka, Panja, Tuominen, E, Tuovinen, E, de Boer, Wim, Bol, H, Dierlamm, A, Furgeri, A, Grigoriev, E, Hauler, F, Jungermann, L, Abreu, M, Rato-Mendes, P, Sonderegger, P, Sousa, P, Cindro, V, Mandic, I, Mikuz, M, Zavrtanik, M, Militaru, O, Piotrzkowski, K, Rouby, X, De Masi, R, Paul, S, Buontempo, S, D'Ambrosio, N, Pagano, S, Eremin, V, Ilyashenko, Yu S, Verbitskaya, E, Laiho, R, Vlasenko, L, Vlasenko, M, Anbinderis, P, Anbinderis, T, Gaubas, E, Gorbatenko, V, Kalesinskas, V, Kapturauskas, J, and Vaitkus, J

Subjects
Detectors and Experimental Techniques
Published
2003

4. Silicon Ultra fast Cameras for electron and gamma sources In Medical Applications

Author

Caccia, Massimo, Airoldi, A, Alemi, M, Amati, M, Badano, L, Bartsch, V, Berst, D, Bianchi, C, Bol, H, Bulgheroni, A, Cannillo, F, Cappellini, C, Czermak, A, Claus, G, Colledani, C, Conte, Leopoldo, Deptuch, G, DE BOER, W, Dierlamm, A, Domanski, K, Dulinski, W, Dulny, B, Ferrando, O, Grigoriev, E, Grabiec, P, Lorusso, R, Jaroszewicz, B, Jungermann, L, Kucewicz, W, Kucharski, K, Kuta, S, Leo, G, Machowski, W, Marczewski, J, Mondry, G, Niemiec, H, Novario, Raffaele, Paolucci, L, Pezzetta, M, Popowski, Y, Riester, Jl, Sampietro, C, Sapor, M, Schweickert, H, and S. P. A. .

Published
2003

5. Bolometric Detectors: state of art

Author

Pedretti, M, Airoldi, A, Alemi, M, Amati, M, Badano, L, Bartsch, V, Berst, D, Bianchi, C, Bol, H, Bulgheroni, A, Cannillo, F, Cappellini, C., Czermak, A, Claus, G, Colledani, C, Conte, Leopoldo, Deptuch, G, DE BOER, W, Dierlamm, A, Domanski, K, Dulinski, W, Dulny, B, Ferrando, O, Grigoriev, E, Grabiec, P, Lorusso, R, Jaroszewicz, B, Jungermann, L, Kucewicz, W, Kucharski, K, Kuta, S, Leo, G, Machowski, W, Marczewski, J, Mondry, G, Niemiec, H, Novario, Raffaele, Paolucci, L, Pezzetta, M, Popowski, Y, Riester, Jl, Sampietro, C, Sapor, M, and Schweickert, H

Published
2003

8. 144Ce as a potential candidate for interstitial and intravascular brachytherapy

Author

Zilio, V. O., Joneja, O. P., Popowski, Y., Bochud, F. O., and Chawla, R.

Subjects
cerium, dosimetry, brachytherapy, phantoms, ionisation chambers, Monte Carlo methods, calibration
Abstract

To investigate the suitability of 144Ce for both interstitial and intravascular brachytherapy applications. Monte Carlo calculations of radial dose rate distributions in water were performed for 144Ce in a spring-shaped source and compared with two commonly used interstitial and intravascular sources, 192Ir and 32P. The numeric simulations were checked experimentally with a calibrated ionization chamber in a water phantom. Other source characteristics, such as half-life and specific activity, were also compared. For interstitial brachytherapy, 144Ce presents dosimetric advantages over 192Ir in terms of higher dose rate at shorter distances and lower irradiation of organs outside the tumor. The source size and shape reduce the anisotropy and the number of dwell positions necessary. The longer half-life of 144Ce might also be advantageous over 192Ir. For intravascular brachytherapy, 144Ce permits the treatment of larger arteries as compared with 32P, compensates centering errors more effectively, and has a more suitable half-life. The experimental validation showed good agreement (within 10%) with the Monte Carlo simulated dose rate distributions. There are certain potential advantages of using 144Ce as a source for both interstitial and intravascular brachytherapy. The basis for this finding is provided by the Monte Carlo radial dose rate comparisons with 192Ir and 32P, as well as by such characteristics as half-life and specific activity. [All rights reserved Elsevier]

9. RD39 status report

Author

Borer, K., Janos, S., Pretzl, K., Britvich, I., Kuznetsov, A., Musienko, Yu, Reucroft, S., Swain, J., Chen, W., Li, Zheng, Da Via, C., Casagrande, L., Grohmann, S., Heijne, E., Lourenco, C., Niinikoski, T. O., Nussle, G., Palmieri, V. G., Perea Solano, B., Hempel, O., Herzog, R., Wobst, E., Borchi, E., Bruzzi, M., Menichelli, D., Pirollo, S., Popowski, Y., O Shea, V., Rahman, M., Ruggiero, G., Harkonen, J., Luukka, P., Tuominen, E., Tuovinen, E., Boer, W., Bol, J., Dierlamm, A., Furgeri, A., Grigorev, E., Hauler, F., Jungermann, L., Abreu, M. C., Rato-Mendes, P., Sonderegger, P., Sousa, P., Cindro, V., Mandic, I., Mikuz, M., Zavrtanik, M., Militaru, O., Piotrzkowski, K., Rouby, X., Masi, R., Stephan Paul, Buontempo, S., D Ambrosio, N., Pagano, S., Eremin, V., Ilyashenko, I., Verbitskaya, E., Laiho, R., Vlasenko, L., Vlasenko, M., Anbinderis, P., Anbinderis, T., Gaubas, E., Gorbatenko, V., Kalesinskas, V., Kapturauskas, J., and Vaitkus, J.

10. Summary, plan and resources of RD39 projects

Author

Borer, K., Janos, S., Pretzl, K., Chen, W., Li, Z., Da Via, C., Granata, V., Casagrande, L., Collins, P., Grohmann, S., Heijne, E., Lourenco, C., Niinikoski, T. O., Perea Solano, B., Palmieri, V. G., Sonderegger, P., Hempel, O., Herzog, R., Wobst, E., Borchi, E., Bruzzi, M., Lagomarsino, S., Menichelli, D., Pini, S., Sciortino, Silvio, Grigorev, E., Popowski, Y., Bell, W., Devine, S. R. H., O Shea, V., Ruggiero, G., Smith, K., Harkonen, J., Tuominen, E., Boer, W., Dierlamm, A., Hauler, F., Jungermann, L., Abreu, M., Rato-Mendes, P., Sousa, P., Piotrzkowski, K., Graulich, J. S., Vladimir Cindro, Mandic, I., Mikuz, M., Zavrtanik, M., Masi, R., Paul, S., Buontempo, S., D Ambrosio, N., Pagano, S., Laiho, R., Vlasenko, L., Vlasenko, M., Eremin, V., and Verbitskaya, E.

Subjects
Detectors and Experimental Techniques

11. Absolute depth-dose-rate measurements for an 192Ir HDR brachytherapy source in water using MOSFET detectors

Author

Zilio, V. O., Joneja, O. P., Popowski, Y., Rosenfeld, A., and Chawla, R.

Subjects
MOSFET, dosimetry, Physics::Medical Physics, brachytherapy, Monte Carlo methods, iridium
Abstract

Reported MOSFET measurements concern mostly external radiotherapy and in vivo dosimetry. In this paper, we apply the technique for absolute dosimetry in the context of HDR brachytherapy using an 192Ir source. Measured radial dose rate distributions in water for different planes perpendicular to the source axis are presented and special attention is paid to the calibration of the R and K type detectors, and to the determination of appropriate correction factors for the sensitivity variation with the increase of the threshold voltage and the energy dependence. The experimental results are compared with Monte Carlo simulated dose rate distributions. The experimental results show a good agreement with the Monte Carlo simulations: the discrepancy between experimental and Monte Carlo results being within 5% for 82% of the points and within 10% for 95% of the points. Moreover, all points except two are found to lie within the experimental uncertainties, confirming thereby the quality of the results obtained

12. RD39 status report 2005

Author

Britvich, I., Kuznetsov, A., Musienko, Yu, Reucroft, S., Swain, J., Chen, W., Li, Z., Grohmann, S., Heijne, E., Lourenco, C., Niinikoski, T. O., Nussle, G., Perea Solano, B., Hempel, O., Herzog, R., Wobst, E., Borchi, E., Bruzzi, M., Menichelli, D., Pirollo, S., Popowski, Y., Bates, R., Craig Buttar, O Shea, V., Parkes, C., Harkonen, J., Luukka, P., Tuominen, E., Tuovinen, E., Boer, W., Bol, J., Dierlamm, A., Furgeri, A., Grigoriev, E., Hauler, F., Jungermann, L., Abreu, M. C., Rato-Mendes, P., Sonderegger, P., Sousa, P., Cindro, V., Mandic, I., Mikuz, M., Zavrtanik, M., Militaru, O., Piotrzkowski, K., Rouby, X., Masi, R., Paul, S., Buontempo, S., D Ambrosio, N., Pagano, S., Eremin, V., Ilyashenko, I., Verbitskaya, E., Laiho, R., Vlasenko, L., Vlasenko, M., Anbinderis, P., Anbinderis, T., Gaubas, E., Gorbatenko, V., Kalesinskas, V., Kapturauskas, J., and Vaitkus, J.

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