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7 results on '"Port, F."'

1. Safeguarding gene drive experiments in the laboratory

Author

Akbari, OS, Bellen, HJ, Bier, E, Bullock, SL, Burt, A, Church, GM, Cook, KR, Duchek, P, Edwards, OR, Esvelt, KM, Gantz, VM, Golic, KG, Gratz, SJ, Harrison, MM, Hayes, KR, James, AA, Kaufman, TC, Knoblich, J, Malik, HS, Matthews, KA, O'Connor-Giles, KM, Parks, AL, Perrimon, N, Port, F, Russell, S, Ueda, R, and Wildonger, J

Published
2015
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6. Mineral metabolism and haemoglobin concentration among haemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Author

Justin M. Albert, Tadao Akizawa, Naoki Kimata, José Manuel Barrueco Cruz, Friedrich K. Port, Sudtida Satayathum, Ronald L. Pisoni, Takashi Akiba, Vittorio E. Andreucci, Eric W. Young, Kimata, N, Akiba, T, Pisoni, Rl, Albert, Jm, Satayathum, S, Cruz, Jm, Akizawa, T, Andreucci, VITTORIO EMANUELE, Young, Ew, and Port, F. K.

Subjects
Adult, Male, medicine.medical_specialty, Anemia, medicine.medical_treatment, Parathyroid hormone, Hemoglobins, Erythroid Cells, Renal Dialysis, Internal medicine, medicine, Vitamin D and neurology, Humans, Erythropoietin, Dialysis, Aged, Cell Proliferation, Transplantation, business.industry, Cell Differentiation, Phosphorus, Odds ratio, Middle Aged, medicine.disease, Recombinant Proteins, Endocrinology, Parathyroid Hormone, Nephrology, Calcium, Female, Hemodialysis, business, Body mass index, Kidney disease
Abstract

Bone and mineral metabolism is abnormal in most chronic haemodialysis patients and is associated with a high mortality risk. Because of possible pathogenic links between anaemia and intact parathyroid hormone (iPTH), the present study evaluated associations of mineral metabolism indicators with haemoglobin (Hb).Data were collected from 317 facilities (12 089 haemodialysis patients) in Australia, Belgium, Canada, France, Germany, Italy, Japan, New Zealand, Spain, Sweden, the United Kingdom and the United States by the Dialysis Outcomes and Practice Patterns Study (DOPPS). The major outcome studied was probability of haemodialysis patients having a target Hb, per guidelines, of/=11 g/dl at baseline. Major predictor variables were patient characteristics and laboratory markers of mineral metabolism: albumin-corrected serum calcium (calcium(Alb)), serum phosphorus (PO(4)) and iPTH. Analyses were adjusted for demographics, 15 comorbidity classes, baseline laboratory values, body mass index, years on dialysis, erythropoietin dose, vitamin D and catheter use, cause of end-stage renal disease and country.The adjusted odds ratio (AOR) of having Hb/=11 g/dl was significantly higher (P0.0001) in patients with higher calcium(Alb) (AOR = 1.32 per 1 mg/dl), higher PO(4) (AOR = 1.08 per 1 mg/dl) and lower iPTH (AOR = 0.96 per 100 pg/ml). Furthermore, 4 month intrapatient changes in Hb concentration were significantly (P0.0001) related to 4 month changes in calcium(Alb) (0.17 g/dl Hb rise per 1 mg/dl higher calcium(Alb)) and PO(4) (0.11 g/dl Hb rise per 1 mg/dl higher PO(4)). Mean weekly recombinant human erythropoietin (rHuEpo) doses were higher for patients with high PO(4) or iPTH levels, but lower for patients with calcium(Alb)9.5 mg/dl, after patient mix and Hb concentration adjustments.The results of this study indicate that higher serum calcium(Alb) and PO(4) levels are each independently associated with better anaemia control. This relationship is independent of vitamin D use, PTH levels and prescribed rHuEpo dose. Despite this benefit of better anaemia control at higher serum calcium(Alb) and PO(4) concentrations, lower calcium and PO(4) levels, as recommended by the K/DOQI guidelines, should still serve as the long-term goal for HD patients in order to minimize tissue calcification and mortality risk.

Published
2005
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7. Sleep quality predicts quality of life and mortality risk in haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Author

Friedrich K. Port, Hugh C. Rayner, Stacey J. Elder, Kiyoshi Kurokawa, Rajiv Saran, Anna L. Furniss, Rachel B. Fissell, Shunichi Fukuhara, Tadao Akizawa, Ronald L. Pisoni, Vittorio E. Andreucci, Elder, S. J., Pisoni, R. L., Akizawa, T., Fissell, R., Andreucci, VITTORIO EMANUELE, Fukuhara, S., Kurokawa, K., Rayner, H. C., Furniss, A. L., Port, F. K., and Saran, R.

Subjects
Male, Sleep Wake Disorders, medicine.medical_specialty, medicine.medical_treatment, Physical exercise, Quality of life, Japan, Predictive Value of Tests, Renal Dialysis, Risk Factors, Internal medicine, Outcome Assessment, Health Care, medicine, Humans, Risk factor, Practice Patterns, Physicians', Dialysis, Aged, Transplantation, Sleep disorder, business.industry, Proportional hazards model, Middle Aged, medicine.disease, Prognosis, Health Surveys, United States, Europe, Nephrology, Predictive value of tests, Physical therapy, Linear Models, Quality of Life, Female, Kidney Diseases, Hemodialysis, business
Abstract

Background. Poor sleep quality (SQ) affects many haemodialysis (HD) patients and could potentially predict their morbidity, mortality, quality of life (QOL) and patterns of medication use. Methods. Data on SQ were collected from 11 351 patients in 308 dialysis units in seven countries in the Dialysis Outcomes and Practice Patterns Study (DOPPS) between 1996 and 2001 through a patient self-reported SQ scale, ranging from 0 (worst) to 10 (best). A score of

Published
2007

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