Search

Experiments on disordered alloys suggest that spin glasses can be brought into low-energy states faster by annealing quantum fluctuations than by conventional thermal annealing. Due to the importance of spin glasses as a paradigmatic computational testbed, reproducing this phenomenon in a programmable system has remained a central challenge in quantum optimization. Here we achieve this goal by realizing quantum critical spin-glass dynamics on thousands of qubits with a superconducting quantum annealer. We first demonstrate quantitative agreement between quantum annealing and time-evolution of the Schr\"odinger equation in small spin glasses. We then measure dynamics in 3D spin glasses on thousands of qubits, where simulation of many-body quantum dynamics is intractable. We extract critical exponents that clearly distinguish quantum annealing from the slower stochastic dynamics of analogous Monte Carlo algorithms, providing both theoretical and experimental support for a scaling advantage in reducing energy as a function of annealing time.

Dans un monde en pleine mutation, les collectivités locales ont un rôle majeur à jouer pour amplifier la transition écologique et sociale. Pour cela, les communes et intercommunalités doivent consacrer des moyens budgétaires importants et ciblés dans un contexte tendu, marqué par la raréfaction des deniers publics. Pour façonner efficacement l’avenir, l’approche pluriannuelle s’impose. La construction de PPI « pro-climat » sécurise les moyens publics alloués à la transition écologique. Elle permet de changer en profondeur la construction de l’ensemble des politiques publiques et d’entraîner les habitants et le secteur économique dans cette voie. Le succès des plans pluriannuels dépend de la capacité à garantir des ressources durables aux collectivités et d’asseoir un partenariat pluriannuel de confiance entre l’État et les collectivités. Cela pourrait par exemple prendre la forme d’une loi de programmation spécifique pour le climat qui comprendrait un volet territorial, mais, pour aller plus loin, il est aussi nécessaire de repenser les critères de bonne gestion des budgets locaux.

RationaleNontuberculous mycobacterial (NTM) diseases are difficult-to-treat infections, especially in lung transplant (LTx) candidates. Currently, there is a paucity of recommendations on the management of NTM infections in LTx, focusing onMycobacterium aviumcomplex (MAC),M. abscessusandM. kansasii.MethodsPulmonologists, infectious disease specialists, LTx surgeons and Delphi experts with expertise in NTM were recruited. A patient representative was also invited. Three questionnaires comprising questions with multiple response statements were distributed to panellists. Delphi methodology with a Likert scale of 11 points (5 to −5) was applied to define the agreement between experts. Responses from the first two questionnaires were collated to develop a final questionnaire. The consensus was described as a median rating >4 or ResultsPanellists recommend performing sputum cultures and a chest computed tomography scan for NTM screening in LTx candidates. Panellists recommend against absolute contraindication to LTx even with multiple positive sputum cultures for MAC,M. abscessusorM. kansasii.Panellists recommend MAC patients on antimicrobial treatment and culture negative can be listed for LTx without further delay. Panellists recommend 6 months of culture-negative forM. kansasii, but 12 months of further treatment from the time of culture-negative forM. abscessusbefore listing for LTx.ConclusionThis NTM LTx study consensus statement provides essential recommendations for NTM management in LTx and can be utilised as an expert opinion while awaiting evidence-based contributions.

Preventive maintenance practices have been proven to reduce maintenance costs in many industries. In the mining industry, preventive maintenance is the main form of maintenance, especially for mobile equipment. With the increase of sensor data and the installation of wireless infrastructure within underground mines, predictive maintenance practices are beginning to be applied to the mining equipment maintenance process. However, for the transition from preventive to predictive maintenance to succeed, researchers must first understand the maintenance process implemented in mines. In this paper, we conducted interviews with 15 maintenance experts from 7 mining sites (6 gold, 1 diamond) across East-Canada to investigate the maintenance planning process currently implemented in Canadian mines. We documented experts’ feedback on the process, their expectations regarding the introduction of predictive maintenance in mining, and the usability of existing computerized maintenance management software (CMMS). From our results, we compiled a summary of actual maintenance practices and showed how they differ from theoretical practices. Finally, we list the Key Performance Indicators (KPIs) relevant for maintenance planning and user requirements to improve the usability of CMMS.

Methylmercury formed in anoxic reservoirs associates with organic-rich particles and is exported downstream.

Zoos and botanical gardens (ZBGs) play a variety of roles in regional conservation partnerships, including their most common role as the ex situ managers of rare plant and animal populations. Using case studies from a 70-year history of conservation work at the Arizona-Sonora Desert Museum in Tucson, Arizona, USA, this paper illustrates these roles and the characteristics of ZBGs that make them versatile and effective regional conservation partners. ZBGs commonly play the role of conservation advocates, as discussed in the context of the establishment of protected islands in the Gulf of California. ZBGs also conduct field research, including the collection of long-term datasets, as exemplified by the establishment of the Ironwood Forest National Monument and a 40-year Sonoran Desert phenology database. ZBGs can be effective conveners of communities and conservation partners in regional-scale efforts, such as the Sonoran Desert Conservation Plan and Cooperative Weed Management Areas. The paper also explores the challenges faced by ZBGs in sustaining their conservation work.

Chronic pain (CP) is a debilitating disease that reduces quality of life, decreases productivity, and has become a primary cause of health care resource consumption. Despite this, many Canadian family physicians have received little formal education in managing CP, making it one of the most challenging areas of practice in primary care. Project Extension for Community Healthcare Outcomes Chronic PainOpioid Stewardship St. Joseph's Care Group (Project ECHO-SJCG) is an evidence-based educational program connecting community-based health care providers (HCPs) with an interprofessional team by videoconference to learn about management of CP in rural, remote, and underserved areas.To explore key learning points from cases presented at Project ECHO-SJCG, identify and analyze themes and improve future sessions of continuing professional development for HCPs.We completed a thematic analysis of forty cases and key learning points using the constant comparison method. We also summarized descriptive statistics for patient and provider characteristics.Forty cases were presented by 31 HCPs, who received suggestions focused on assessment and diagnosis, pharmacological and non-pharmacological pain symptom management, interventional management, attention to biopsychosocial factors, and appropriate referral to other HCPs.Project ECHO-SJCG cases allow HCPs to gain a broad knowledge base to evaluate and manage CP in their practice. Identified themes highlight common gaps in HCPs' knowledge and will guide future sessions.

Vector-borne diseases are among the greatest causes of human suffering globally. Several studies have linked climate change and increasing temperature with rises in vector abundance, and in the incidence and geographical distribution of diseases. The microbiome of vectors can have profound effects on how efficiently a vector sustains pathogen development and transmission. Growing evidence indicates that the composition of vectors' gut microbiome might change with shifts in temperature. Nonetheless, due to a lack of studies on vector microbiome turnover under a changing climate, the consequences for vector-borne disease incidence are still unknown. Here, we argue that climate change effects on vector competence are still poorly understood and the expected increase in vector-borne disease transmission might not follow a relationship as simple and straightforward as past research has suggested. Furthermore, we pose questions that are yet to be answered to enhance our current understanding of the effect of climate change on vector microbiomes, competence, and, ultimately, vector-borne diseases transmission.

This study evaluates the uncertainty of four components of the hydroclimatic modelling chain on flood projections over 96 basins covering contrasting hydrometeorological regimes located in Canada and Mexico. Two ensembles of climate simulations are considered, a large ensemble of 22 global climate model simulations and a smaller ensemble of three high-resolution regional climate model simulations. The other components are two post-processing techniques, three lumped hydrological models and six probability distributions. These four sources are assessed through a method of variance decomposition applied to six flood indicators over a reference period and two future periods: 1976–2005, 2041–2070 and 2070–2099. Systematic differences are observed between basins with contrasting flood-generating processes. Snow-dominated basins consistently show larger variance contributions from hydrological models, while rain-dominated basins show climate simulations as their dominant source. These results underline the need to consider the variability of each component’s uncertainty contribution and its link to hydroclimatic conditions and dominant processes.

Despite the ubiquitous nature of parasitism, how parasitism alters the outcome of host-species interactions such as competition, mutualism and predation remains unknown. Using a phylogenetically informed meta-analysis of 154 studies, we examined how the mean and variance in the outcomes of species interactions differed between parasitized and non-parasitized hosts. Overall, parasitism did not significantly affect the mean or variance of host-species interaction outcomes, nor did the shared evolutionary histories of hosts and parasites have an effect. Instead, there was considerable variation in outcomes, ranging from strongly detrimental to strongly beneficial for infected hosts. Trophically-transmitted parasites increased the negative effects of predation, parasites increased and decreased the negative effects of interspecific competition for parasitized and non-parasitized heterospecifics, respectively, and parasites had particularly strong negative effects on host species interactions in freshwater and marine habitats, yet were beneficial in terrestrial environments. Our results illuminate the diverse ways in which parasites modify critical linkages in ecological networks, implying that whether the cumulative effects of parasitism are considered detrimental depends not only on the interactions between hosts and their parasites but also on the many other interactions that hosts experience.

Littorinid snails are present in most coastal areas globally, playing a significant role in the ecology of intertidal communities. Laevilitorina is a marine gastropod genus distributed exclusively in the Southern Hemisphere, with 21 species reported from South America, the sub-Antarctic islands, Antarctica, New Zealand, Australia and Tasmania. Here, an updated database of 21 species generated from a combination of sources is presented: 1) new field sampling data; 2) published records; 3) the Global Biodiversity Information Facility (GBIF) and The Atlas of Living Australia (ALA), to provide a comprehensive description of the known geographic distribution of the genus and detailed occurrences for each of the 21 species. The database includes 813 records (occurrences), 53 from field sampling, 174 from the literature, 128 from GBIF, and 458 from ALA. West Antarctica had the highest species richness (8 species), followed by sub-Antarctic islands of New Zealand (4 species) and the south-east shelf of Australia (4 species). The provinces of Magellan, New Zealand South Island, and sub-Antarctic Islands of the Indian Ocean include two species each. This study specifically highlights reports of L. pygmaea and L. venusta, species that have been almost unrecorded since their description. Recent advances in molecular studies of L. caliginosa showed that this species does not correspond to a widely distributed taxon, but to multiple divergent lineages distributed throughout the Southern Ocean. Ongoing molecular and taxonomic studies are necessary for a better understanding of the diversity and biogeography of this genus.

Peripartum cardiomyopathy (PPCM) is associated with severe morbidity and mortality, and the significance of right ventricular (RV) involvement is unclear. We sought to determine whether RV systolic dysfunction or dilatation is associated with adverse clinical outcomes in women with PPCM.We conducted a multicentre retrospective cohort study examining the association between echocardiographic RV systolic dysfunction or dilatation at the time of PPCM diagnosis and clinical outcomes. Clinical endpoints of interest were the need for mechanical support, recovery of left ventricular ejection fraction at follow-up, and a combined endpoint of hospitalization for heart failure, cardiac transplant, or death.A total of 67 women, median age 30 years (interquartile range: 7), were diagnosed with PPCM between 1994 and 2015 in 17 participating centres. Twin pregnancies occurred in 11%; 62% of women were multiparous; and 24% had preeclampsia. RV systolic function was impaired in 18 (27%) and dilated in 8 (12%). Seven women required ventricular assistance, and 8 experienced the composite outcome during follow-up (25 [interquartile range 61] months). RV dysfunction was associated with the need for mechanical support (odds ratio 10.10 (95% confidence interval: 1.86-54.81),RV dysfunction is associated with the need for mechanical support in women with PPCM. These findings may improve risk stratification of complications and clinical management.La cardiomyopathie du péripartum (CMP-PP) est associée à la morbidité grave et à la mortalité, mais on ignore l’importance de l’atteinte ventriculaire droite (VD). Nous avons cherché à déterminer si la dysfonction systolique ou la dilatation VD sont associées aux résultats cliniques défavorables chez les femmes atteintes de CMP-PP.Nous avons mené une étude de cohorte rétrospective multicentrique sur l’association entre la dysfonction systolique ou la dilatation VD à l’échographie au moment du diagnostic de CMP-PP et les résultats cliniques. Les critères cliniques d’intérêt étaient la nécessité d’une assistance mécanique, la récupération de la fraction d’éjection ventriculaire gauche (FEVG) au suivi et un critère combiné d’hospitalisation liée à l’insuffisance cardiaque (IC), la transplantation cardiaque ou la mort.Un total de 67 femmes, dont l’âge médian était de 30 ans (écart interquartile [EI] : 7), ont reçu un diagnostic de CMP-PP entre 1994 et 2015 dans 17 centres participants. Les grossesses gémellaires sont survenues chez 11 % ; 62 % de femmes étaient multipares ; et 24 % souffraient de prééclampsie. La fonction systolique VD était compromise chez 18 (27 %) femmes et le VD, dilaté, chez huit (12 %) femmes. Sept femmes ont eu besoin d’une assistance ventriculaire, et huit ont subi le critère composite durant le suivi (25 [EI : 61] mois). La dysfonction VD a été associée à la nécessité d’une assistance mécanique (rapport de cotes 10,10 [intervalle de confiance à 95 % : 1,86-54,81],La dysfonction VD est associée à la nécessité d’une assistance mécanique chez les femmes atteintes de CMP-PP. Ces conclusions peuvent permettre d’améliorer la stratification des risques de complications et la prise en charge clinique.

The dynamically adaptive WAVETRISK-OCEAN global model is used to solve one- and two-layer shallow water ocean models of wind-driven western boundary current (WBC) turbulence. When the submesoscale is resolved, both the one-layer simulation and the barotropic mode of the two-layer simulations have an energy spectrum with a power law of −3, while the baroclinic mode has a power law of −5/3 to −2 for a Munk boundary layer. This is consistent with the theoretical prediction for the power laws of the barotropic and baroclinic (buoyancy variance) cascades in surface quasigeostrophic turbulence. The baroclinic mode has about 20% of the energy of the barotropic mode in this case. When a Munk–Stommel boundary layer dominates, both the baroclinic and barotropic modes have a power law of −3. Local energy spectrum analysis reveals that the midlatitude and equatorial jets have different energy spectra and contribute differently to the global energy spectrum. We have therefore shown that adding a single baroclinic mode qualitatively changes WBC turbulence, introducing an energy spectrum component typical of what occurs in stratified three-dimensional ocean flows. This suggests that the first baroclinic mode may be primarily responsible for the submesoscale turbulence energy spectrum of the oceans. Adding more vertical layers, and therefore more baroclinic modes, could strengthen the first baroclinic mode, producing a dual cascade spectrum (−5/3, −3) or (−3, −5/3) similar to that predicted by quasigeostrophic and surface quasigeostrophic models, respectively. Significance Statement This research investigates how wind energy is transferred from the largest ocean scales (thousands of kilometers) to the small turbulence scales (a few kilometers or less). We do this by using an idealized model that includes the simplest representation of density stratification. Our main finding is that this simple model captures an essential feature of the energy transfer process. Future work will compare our results to those obtained using ocean models with more realistic stratifications.

In this viewpoint, we briefly review the status of antiretroviral therapy (ART), its unmet needs, and the role that broadly neutralizing antibodies (bNAbs) might have in the near future for the treatment of human immunodeficiency virus (HIV). We summarize advances in the development of bNAbs as antiretroviral therapy, the results of main clinical trials of bNAbs for HIV treatment and prevention, and its role in cure trials. The limitations of broadly neutralizing antibodies are the current need for primary resistance testing, the still unclear number of antibodies that must be combined, the lack of penetration in anatomical reservoirs, and the role they might play in cure studies. We compare the advantages and disadvantages of “classical ART” and therapy based on broadly neutralizing antibodies. We conclude that broadly neutralizing antibodies still need considerable improvements before they can be considered an alternative to classical ART.

Transmission mode is a key factor that influences host–parasite coevolution. Vector-borne pathogens are among the most important disease agents for humans and wildlife due to their broad distribution, high diversity, prevalence and lethality. They comprise some of the most important and widespread human pathogens, such as yellow fever, leishmania and malaria. Vector-borne parasites (in this review, those transmitted by blood-feeding Diptera) follow unique transmission routes towards their vertebrate hosts. Consequently, each part of this tri-partite (i.e. parasite, vector and host) interaction can influence co- and counter-evolutionary pressures among antagonists. This mode of transmission may favour the evolution of greater virulence to the vertebrate host; however, pathogen–vector interactions can also have a broad spectrum of fitness costs to the insect vector. To complete their life cycle, vector-borne pathogens must overcome immune responses from 2 unrelated organisms, since they can activate responses in both vertebrate and invertebrate hosts, possibly creating a trade-off between investments against both types of immunity. Here, we assess how dipteran vector-borne transmission shapes the evolution of hosts, vectors and the pathogens themselves. Hosts, vectors and pathogens co-evolve together in a constant antagonistic arms race with each participant's primary goal being to maximize its performance and fitness.

Nematodes constitute one of the most speciose metazoan groups on earth, and a significant proportion of them have parasitic life styles. Zooparasitic nematodes have zoonotic, commercial and ecological significance within natural systems. Due to their generally small size and hidden nature within their hosts, and the fact that species discrimination using traditional morphological characteristics is often challenging, their biodiversity is not well known, especially within marine ecosystems. For instance, the majority of New Zealand's marine animals have never been the subject of nematode studies, and many currently known nematodes in New Zealand await confirmation of their species identity with modern taxonomic techniques. In this study, we present the results of an extensive biodiversity survey and phylogenetic analyses of parasitic nematodes infecting New Zealand's marine animals. We used genetic data to differentiate nematodes to the lowest taxonomic level possible and present phylogenies of the dominant clades to illustrate their genetic diversity in New Zealand. Our findings reveal a high diversity of parasitic nematodes (23 taxa) infecting New Zealand's marine animals (62 of 94 free-living animal species investigated). The novel data collected here provide a solid baseline for future assessments of change in diversity and distribution of parasitic nematodes.

Cet article présente une analyse de la distribution spatiale des investissements en innovation du gouvernement du Canada dans diverses régions et collectivités du pays. La démarche proposée consiste à exploiter les données ouvertes du Programme de divulgation proactive des renseignements du gouvernement du Canada. Au total, 39 419 entrées valides représentant 10,8 milliards de dollars de subventions et de contributions octroyées de 2018 à 2020 sont analysées. À l’aide de statistiques descriptives, nous comparons les montants octroyés dans les provinces, les grandes agglomérations urbaines et leurs zones d’influence. Nous montrons notamment que les plus grandes métropoles du pays attirent la plus grande part des investissements en innovation par habitant. En dehors des métropoles, le soutien public à l’innovation est plus faible et cette différence par rapport aux métropoles est statistiquement significative. Ces observations ont des implications pour la recherche sur l’attraction d’investissements publics en innovation dans les écosystèmes entrepreneuriaux des milieux ruraux., This paper presents an analysis of the spatial distribution of the Government of Canada innovation investment in various regions and communities across the country. The proposed approach uses open data from Canada’s Proactive Information Disclosure Program. A total of 39,419 valid entries representing $10.8 billion in grants and contributions awarded from 2018 to 2020 are analyzed. Using descriptive statistics, we compare the amounts granted in the provinces, large urban agglomerations, and their respective influenced zones. In particular, we show that the country’s largest urban centers attract the largest share of investment in innovation per capita. Outside large urban centers, public support for innovation is relatively weaker and this difference compared to larger urban centers is statistically significant. These observations have implications for research on attracting public investment in innovation to entrepreneurial ecosystems in a rural environment.

Review of: Adventure Games: Playing the Outsider, Aaron A. Reed, John T. Murray and Anastasia Salter (2020) New York: Bloomsbury Academic, 230 pp., ISBN 978-1-50138-582-7, p/bk, USD 52.50

OBJECTIVE Prism adaptation was shown to modify auditory perception. Using a dichotic listening task, which assesses auditory divided attention, benefits of a rightward prism adaptation were demonstrated in neglect patients (i.e., a syndrome following right hemisphere brain damage) by reducing their left auditory extinction. It is currently unknown whether prism adaptation affects auditory divided attention in healthy subjects. In the present study, we investigated the aftereffects of prism adaptation on dichotic listening. METHOD A sample of 47 young adults performed a dichotic listening task, in which pairs of words were presented with two words sounded simultaneously, one in each ear. Three parameters were measured: The percentage of recalled words, the percentage of correctly recalled words, and the laterality index (LI). RESULTS Prism adaptation to a leftward optical deviation (L-PA) significantly increased the overall percentage of recalled words (p = .044) and that from the right ear (p = .002), and the overall LI (p = .049). CONCLUSIONS For the first time, these findings demonstrate that L-PA produced an orientation of the auditory divided attention in favor of the right ear in healthy participants. This asymmetrical aftereffect provides a new argument in favor of the cross-modal dimension of prism adaptation, although an acclimatization effect of the dichotic listening task is also discussed. Our study opens up a new avenue for using prism adaptation in the field of auditory rehabilitation requiring a modulation of auditory attention. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Ectinogonia is a genus of jewel beetles from the western slope of the Andes Cordillera, inhabiting arid and semiarid ecosystems in different biogeographical provinces. Most of the species in this genus have undergone several rearrangements and misassignments over time, making the taxonomic history of Ectinogonia particularly complex. Recent studies based on molecular phylogenies suggest that the taxonomy of the genus should be revised using genetic tools. Because some species are polymorphic and others cryptic and monomorphic, species diversity may be over- or underestimated. We performed here the first comprehensive molecular phylogeny for Ectinogonia s.s. using nuclear and mitochondrial genes. We also performed species delimitation analyses to estimate diversity within Ectinogonia. Results show that Ectinogonia is divided into two main groups: the artificial ‘southern group’ and the natural ‘northern clade’. The southern group matched with the current morphology-based taxonomy, whereas the northern clade contained the largest number of species, several of which do not fit with the current taxonomy. There was both genetic-morphological uncoupling and crypsis by convergence, suggesting a complex evolutionary history. We also provide a new taxonomic arrangement based on our results.

International audience; In this study, we propose to use classical molecular dynamics (MD) coupled with $^1$H NMR spectroscopy to study the conformations of different actinyl An$^{VI}$ (An = U, Np, and Pu) and An$^{V}$ (An = Np) complexes with tetra-ethyl dyglicolamide (TEDGA) ligands in order to have a better representation of such complexes in solution. Molecular dynamics simulations showed its effectiveness in interpreting the experiments by the calculation of geometric factors needed for the determination of magnetic properties of these complexes. We demonstrated that different conformations of the An$^{V}$ and An$^{VI}$ complexes with TEDGA exist in solution with different coordination modes, which is experimentally confirmed by $^1$H NMR and EXAFS spectroscopies. Furthermore, MD simulations provide additional insights into the structures of complexes in solution since conformations with fast exchanges, which are not accessible from NMR experiments, have been observed by MD simulations.

Bacterial biofilms consist of bacterial cells embedded within a self-produced extracellular polymeric substance (EPS) composed of exopolysaccharides, extra cellular DNA, proteins and lipids. The enzyme Dispersin B (DspB) is a CAZy type 20 β-hexosaminidase enzyme that catalyses the hydrolysis of poly-N-acetylglucosamine (PNAG), a major biofilm polysaccharide produced by a wide variety of biofilm-forming bacteria. Native PNAG is partially de-N-acetylated, and the degree of deacetylation varies between species and dependent on the environment. We have previously shown that DspB is able to perform both endo- and exo-glycosidic bond cleavage of PNAG depending on the de-N-acetylation patterns present in the PNAG substrate. Here, we used a combination of synthetic PNAG substrate analogues, site-directed mutagenesis and in vitro biofilm dispersal assay to investigate the molecular basis for the endo-glycosidic cleavage activity of DspB and the importance of this activity for dispersal of PNAG-dependent Staphylococcus epidermidis biofilms. We found that D242 contributes to the endoglycosidase activity of DspB through electrostatic interactions with cationic substrates in the -2 binding site. A DspB

Division of labour through the formation of morphologically and functionally distinct castes is a recurring theme in the evolution of animal sociality. The mechanisms driving the differentiation of individuals into distinct castes remain poorly understood, especially for animals forming clonal colonies. We test the association between microbiomes and caste formation within the social trematode Philophthalmus attenuatus, using a metabarcoding approach targeting the bacterial 16S SSU rRNA gene. Clonal colonies of this trematode within snail hosts comprise large reproductive individuals which produce dispersal stages, and small, non-reproducing soldiers which defend the colony against invaders. In colonies extracted directly from field-collected snails, reproductives harboured more diverse bacterial communities than soldiers, and reproductives and soldiers harboured distinct bacterial communities, at all taxonomic levels considered. No single bacterial taxon showed high enough prevalence in either soldiers or reproductives to be singled out as a key driver, indicating that the whole microbial community contributes to these differences. Other colonies were experimentally exposed to antibiotics to alter their bacterial communities, and sampled shortly after treatment and weeks later after allowing for turnover of colony members. At those time points, bacterial communities of the two castes still differed across all antibiotic treatments; however, the caste ratio within colonies changed: after antibiotic disruption and turnover of individuals, new individuals were more likely to become reproductives than in undisturbed control colonies. Our results reveal that each caste has a distinct microbiome; whether the social context affects the microbiota, or whether microbes contribute to modulating the phenotype of individuals, remains to be determined.

Alarm floods are dangerous because the quantity of alarms triggered is too numerous for operators to reliably implement the right corrective action. Process operators of complex systems, such as chemical plants or nuclear power production, are faced with alarm management systems that can be better built in consideration of human capabilities and limitations. Developing human-machine interfaces (HMIs) that better support operators is critical for ensuring the safe and reliable operation of critical systems and processes. The research team has developed an accessible and adaptable prototyping environment dedicated for research on alarm management and human-machine interactions in the process industry. The method used was to build on the Tennessee Eastman Process (TEP) simulator and incorporate Human-Machine design guidelines. The results are an open-sourced prototyping environment that incorporates data from a real chemical plant and integrates true alarm data and thresholds. At the end of this article, we share the Github link to the entire MATLAB, Simulink and App Designer files of PER4Mance: a prototyping environment for research on human-machine interactions for alarm flood management.

The goal of this study is to determine the effect of type and frequency of exercise on the self-esteem of college-aged males using a two-part online survey distributed amongst Georgetown students. Recent literature has investigated the implications of exercise on individuals’ self-perception, in which partaking in frequent endurance exercise is associated with higher levels of self-esteem. Consequently, my research group postulated that if male college students perform endurance exercise, rather than strength exercise, then they will have a higher level of self-esteem. Additionally, it was hypothesized that if exercise is performed at a high frequency, versus a low frequency, then they would have a higher level of self-esteem. Frequency of exercise was operationalized through hours per week, in which each subject was then categorized into a type of exercise based on which they reported having the highest frequency. Self-esteem was calculated through responses to a modified version of the Rosenberg Self-Esteem Scale (Rosenberg, 1965). The results indicated that the high frequency endurance group had the highest mean self-esteem score, followed by the high frequency strength group, low frequency strength group, and low frequency endurance group. Through a 2x2 ANOVA test with a between-groups design, it was revealed that frequency of exercise, not type of exercise, had the most significant effect on self-esteem. Therefore, the relationship between frequency of exercise and self-esteem was found to be statistically significant, while that between type of exercise and self esteem was not. These conclusions are relevant to building upon related academic literature concerning male self-esteem and the impacts of physical activity, as well as incorporation into university settings in order to improve students’ self-esteem levels.

Although parasite community studies are growing in numbers, our understanding of which macro-ecological and evolutionary processes have shaped parasite communities is still based on a narrow range of host–parasite systems. The present study assessed the diversity and endoparasite species composition in New Zealand deep-sea fish (grenadiers, family Macrouridae), and tested the effects of host phylogeny and geography on the structure of endoparasite communities using a distance decay framework. We found that grenadiers from the Chatham Rise harboured a surprisingly high diversity of digeneans, cestodes and nematodes, with different species of grenadiers having different parasite assemblages. Our results demonstrate that community similarity based on the presence/absence of parasites was only affected by the phylogenetic relatedness among grenadier species. In contrast, both phylogenetic distance among grenadiers (measured as the number of base-pair differences of DNA sequences) and geographic distance between sample locations influenced the similarity of parasite communities based on the parasites' prevalence and mean abundance. Our key findings highlight the significant effect of deep-sea host phylogeny in shaping their parasite assemblages, a factor previously neglected in studies of parasite communities in deep-sea systems.

Currently, in high-dose rate (HDR) brachytherapy planning, the catheter's positions are often selected by the planner, which involves the planner's experience. The catheters are then inserted using a template that helps to guide the catheters. For certain applications, it is of interest to choose the optimal location and number of catheters needed for dose coverage and potential decrease of the treatment's toxicity. Hence, it is of great importance to develop patient-specific algorithms for catheters and dose optimization.A modified Centroidal Voronoi tessellation (CVT) algorithm is implemented and merged with a graphics processing unit (GPU)-based multi-criteria optimization algorithm (gMCO). The CVT algorithm optimizes the catheters' positions, and the gMCO algorithm optimizes the dwell times and dwell positions. The CVT algorithm can be used simultaneously for insertion with or without a template. Some improvements to the CVT algorithm are presented such as a new way of considering the area that needs to be covered. One hundred eight previously treated prostates HDR cases using real-time ultrasound are used to evaluate the different optimization procedures. The plan robustness is evaluated using two types of errors: deviations (random) in the insertion and deviation (systematic) in the reconstruction of the catheters.Using gMCO on clinically inserted catheter increases the acceptance rate by 37% for Radiation Therapy Oncology Group (RTOG) criteria. Our results show that all the patients respect RTOG criteria with 11 catheters using CVT+gMCO with a template of 5 mm. The number of catheters needed for all patients to respect RTOG criteria with the freehand technique is 10 catheters using CVT+gMCO. When deviations are introduced, using a template, the acceptance rate goes to 85% with 3 mm deviations using 11 catheters. This decrease is less significant when the number of catheters is higher, decreasing by less than 5% with a 3 mm deviation using 13 catheters or more. In conclusion, it is feasible to decrease the number of catheters needed to treat most patients.Some cases still need a high number of catheters to reach the plan's criteria. Using gMCO allows an increase in the plan quality, while using CVT reduces the number of catheters. A higher number of catheters equates to plans that are more robust to deviations.

In its advice to taxonomists, the International Commission on Zoological Nomenclature (ICZN) recommends that scientific species names should be compact, memorable, and easy to pronounce. Here, using a dataset of over 3000 species of parasitic helminths described in the past two decades, we investigate trends in the length of Latin specific names (=epithets) chosen by taxonomists. Our results reveal no significant temporal change in the length of species epithets as a function of year of description, with annual averages fluctuating around the overall average length of just over 9 letters. We also found that lengths of species epithets did not differ among the various host taxa from which the parasites were recovered, however acanthocephalan species have been given longer species epithets than other helminth taxa. Finally, although species epithets were shorter than genus names for three-quarters of the species in our dataset, we detected no relationship between the length of species epithets and that of genus names across all species included, i.e., there was no evidence that shorter species epithets are chosen to compensate for long genus names. We conclude by encouraging parasite taxonomists to follow the recommendations of the ICZN and choose species epithets that are, as much as possible, compact and easy to remember, pronounce and spell.