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46 results on '"Raffa, Vittoria"'

1. Effects of Metal Oxide Nanoparticles in Zebrafish

Author

d’Amora, Marta, Schmidt, Tiziana Julia Nadjeschda, Konstantinidou, Soultana, Raffa, Vittoria, De Angelis, Francesco, and Tantussi, Francesco

Subjects
Article Subject
Abstract

Metal oxide nanoparticles (MO NPs) are increasingly employed in many fields with a wide range of applications from industries to drug delivery. Due to their semiconducting properties, metal oxide nanoparticles are commonly used in the manufacturing of several commercial products available in the market, including cosmetics, food additives, textile, paint, and antibacterial ointments. The use of metallic oxide nanoparticles for medical and cosmetic purposes leads to unavoidable human exposure, requiring a proper knowledge of their potentially harmful effects. This review offers a comprehensive overview of the possible toxicity of metallic oxide nanoparticles in zebrafish during both adulthood and growth stages, with an emphasis on the role of oxidative stress.

Published
2022
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15. Nano-Oncology: Clinical Application for Cancer Therapy and Future Perspectives

Author

Riggio, Cristina, Pagni, Eleonora, Raffa, Vittoria, and Cuschieri, Alfred

Subjects
Article Subject
Abstract

Nano-oncology, the application of Nanomedicine to cancer diagnosis and treatment, has the potential to transform clinical oncology by enhancing the efficacy of cancer chemotherapy for a wide spectrum of invasive cancers. It achieves this by enabling novel drug delivery systems which target the tumour site with several functional molecules, including tumour-specific ligands, antibodies, cytotoxic agents, and imaging probes simultaneously thereby improving tumour response rates in addition to significant reduction of the systemic toxicity associated with current chemotherapy regimens. For this reason, nano-oncology is attracting considerable scientific interest and a growing investment by the global pharmaceutical industry. Several therapeutic nano-carriers have been approved for clinical use and others are undergoing phase II and III clinical trials. This paper describes the current approved formulations, such as liposomes and polymeric nanoparticles, and discusses the overall present status of nano-oncology as an emerging branch of nanomedicine and its future perspectives in cancer and therapy.

Published
2011
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20. A carbon nanotube based nanodevice for gene therapy

Author

Raffa, Vittoria, Ciofania, G, Vittorio, Orazio, Pizzorusso, T, Bardi, G, Costa, Mario, Kostarelos, K, Al Jamal, K, Zhiaei, A, Nitodas, S, Burghard, M, Santhosh, P, and Cuschieri, A.

Published
2009

24. Gene transfer mediated by carbon nanotubes

Author

Raffa, Vittoria, Vittorio, Orazio, Costa, Mario, Ziaei, A, Al Jamal, K. D., Pizzorusso, T, Bardi, G, Gherardini, L, Kostarelos, K, Nunes, A, Nitodas, S, Karachalios, T, Burghard, M, Santhosh, P, Amsharov, N, Riggio, Cristina, and Cuschieri, A.

Published
2009

46. Axonal plasticity in response to active forces generated through magnetic nano-pulling

Author

Alessandro Falconieri, Sara De Vincentiis, Valentina Cappello, Domenica Convertino, Ravi Das, Samuele Ghignoli, Sofia Figoli, Stefano Luin, Frederic Català-Castro, Laura Marchetti, Ugo Borello, Michael Krieg, Vittoria Raffa, Falconieri, Alessandro, De Vincentiis, Sara, Cappello, Valentina, Convertino, Domenica, Das, Ravi, Ghignoli, Samuele, Figoli, Sofia, Luin, Stefano, Català-Castro, Frederic, Marchetti, Laura, Borello, Ugo, Krieg, Michael, and Raffa, Vittoria

Subjects
axon, magnetic nanoparticles, Neuroscience [CP], CP: Cell biology, CP: Neuroscience, force, local translation, microtubules, outgrowth, remodeling, synapse, magnetic nanoparticle, Cell biology [CP], Settore BIO/11 - Biologia Molecolare, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), General Biochemistry, Genetics and Molecular Biology, Settore FIS/03 - Fisica della Materia, microtubule
Abstract

Mechanical force is crucial in guiding axon outgrowth before and after synapse formation. This process is referred to as "stretch growth."However, how neurons transduce mechanical input into signaling pathways remains poorly understood. Another open question is how stretch growth is coupled in time with the interca-lated addition of new mass along the entire axon. Here, we demonstrate that active mechanical force gener-ated by magnetic nano-pulling induces remodeling of the axonal cytoskeleton. Specifically, the increase in the axonal density of microtubules induced by nano-pulling leads to an accumulation of organelles and signaling vesicles, which, in turn, promotes local translation by increasing the probability of assembly of the "translation factories."Modulation of axonal transport and local translation sustains enhanced axon outgrowth and synapse maturation.

Published
2023

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