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While affective non-verbal communication between pedestrians and drivers has been shown to improve on-road safety and driving experiences, it remains a challenge to design driver assistance systems that can automatically capture these affective cues. In this early work, we identify users' emotional self-report responses towards commonly occurring pedestrian actions while crossing a road. We conducted a crowd-sourced web-based survey (N=91), where respondents with prior driving experience viewed videos of 25 pedestrian interaction scenarios selected from the JAAD (Joint Attention for Autonomous Driving) dataset, and thereafter provided valence and arousal self-reports. We found participants' emotion self-reports (especially valence) are strongly influenced by actions including hand waving, nodding, impolite hand gestures, and inattentive pedestrian(s) crossing while engaged with a phone. Our findings provide a first step towards designing in-vehicle empathic interfaces that can assist in driver emotion regulation during on-road interactions, where the identified pedestrian actions serve as future driver emotion induction stimuli.

A new method of solving the power-flow problem, the holomorphically embedded load-flow method (HELM) is theoretically guaranteed to find the high-voltage solution, if one exists, up to the saddle-node bifurcation point (SNBP), provided sufficient precision is used and the conditions of Stahls theorem are satisfied. Sigma indices, have been proposed as estimators of the distance from the present operating point to the SNBP, and indicators of the weak buses in a system. In this paper, it is shown that the sigma condition proposed in [2] will not produce reliable results and that a modified requirement can be used to produce a tight upper bound on the SNBP. Introduced is an approach to estimate the weak buses in the system using the HEM power series with numerical results compared to traditional modal analysis for a 14-bus system., Comment: 4 pages, 3 figures

Methicillin resistant Staphylococcus aureus (MRSA), a pathogenic bacterium that causes life threatening outbreaks such as community-onset and nosocomial infections has emerged as ‘superbug’. The organism developed resistance to all classes of antibiotics including the best known Vancomycin (VRSA). Hence, there is a need to develop new therapeutic agents. This study mainly evaluates the potential use of botanicals against MRSA infections. Computer aided design is an initial platform to screen novel inhibitors and the data finds applications in drug development. The drug-likeness and efficiency of various herbal compounds were screened by ADMET and docking studies. The virulent factor of most of the MRSA associated infections are Penicillin Binding Protein 2A (PBP2A) and Panton-Valentine Leukocidin (PVL). Hence, native structures of these proteins (PDB: 1VQQ and 1T5R) were used as the drug targets. The docking studies revealed that the active component of Aloe vera, β-sitosterol (3S, 8S, 9S, 10R, 13R, 14S, 17R) ­17­ [(2R, 5R)-5-ethyl-6-methylheptan-2-yl] -10, 13-dimethyl 2, 3, 4, 7, 8, 9, 11, 12, 14, 15, 16, 17- dodecahydro-1H-cyclopenta [a] phenanthren-3-ol) showed best binding energies of -7.40 kcal/mol and ­6.34 kcal/mol for PBP2A and PVL toxin, respectively. Similarly, Meliantriol (1S-1-[ (2R, 3R, 5R)-5-hydroxy-3-[(3S, 5R, 9R, 10R, 13S, 14S, 17S)-3-hydroxy 4, 4, 10, 13, 14-pentamethyl-2, 3, 5, 6, 9, 11, 12, 15, 16, 17-decahydro-1H-cyclopenta[a] phenanthren-17-yl] oxolan-2-yl] -2- methylpropane-1, 2 diol), active compound in Azadirachta indica (Neem) showed the binding energies of ­6.02 kcal/mol for PBP2A and ­8.94 for PVL toxin. Similar studies were conducted with selected herbal compound based on pharmacokinetic properties. All in silico data tested in vitro concluded that herbal extracts of Aloe-vera, Neem, Guava (Psidium guajava), Pomegranate (Punica granatum) and tea (Camellia sinensis) can be used as therapeutics against MRSA infections.

Additional file 1. Supplementary Materials, contains supplemental figures and tables outlining curation SOP guidelines illustrated by workflow figures, tables, and screenshots from the CIViC interface.

Additional file 1. Supplementary Materials, contains supplemental figures and tables outlining curation SOP guidelines illustrated by workflow figures, tables, and screenshots from the CIViC interface.