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Los asuntos que más interesaron a Erwin Schrödinger los fue exponiendo en conferencias y en los textos publicados por Cambridge University Press en los años de estancia en Dublín. Sus principales inquietudes científicas se dirigieron no solo a la búsqueda de la formulación matemática de los fenómenos cuánticos, esfuerzo que culminó con su función de onda, una ecuación fundamental en mecánica cuántica, sino también a la cuestión de la codificación de los caracteres biológicos hereditarios, un asunto aún no resuelto en vida de Schrödinger. En filosofía mostró interés sobre todo por el monismo, la consciencia y el tema de la determinación versus indeterminación. La lectura de Schopenhauer le descubrió el monismo Vedanta, una visión que influyó poderosamente en su pensamiento. The issues of most interest to Erwin Schrödinger were shared in lectures and texts published by Cambridge University Press during the years he spent in Dublin. His main scientific concerns were directed not only at the quest for the mathematical formulation of quantum phenomena, effort that culminated in his wave function, a fundamental equation in quantum mechanics, but also at the question of the coding of hereditary biological characters, a matter not yet resolved in Schrödinger's lifetime. In philosophy he was interested, above all, in monism, consciousness and the theme of determination versus indeterminacy. Reading Schopenhauer introduced him to Vedanta monism, a view that powerfully influenced his thinking. Universidad de Sevilla. Grado en Filosofía more...

The maintenance of genome integrity is a critical process for cell life. To face DNA lesions, living beings have developed a complex network called DNA damage response (DDR), which encompasses an intricate phosphorylation signalling cascade, enabling a quick DNA damage repair. To control this signalling cascade and to avoid an illegitimate activation, this network is tightly regulated by protein phosphatases, such as Protein Phosphatase 2A (PP2A). Moreover, histone chaperones assist the DNA repair mechanisms altering chromatin dynamics through their nucleosome assembly activity. Recent studies have reported that the mitochondrial respiratory protein cytochrome c is promptly translocated into the cell nucleus upon DNA damage, where it interacts with several histone chaperones. Within this context, the role of nuclear cytochrome c has been partially disclosed. Here, we have delved into the functional consequences of the novel DNA damage-induced complex formed by cytochrome c with the histone chaperones ANP32A and ANP32B. Strikingly, the heme protein impairs the PP2A inhibitory effect exerted by the histone chaperones ANP32A, ANP32B and SET/TAF-I. Furthermore, biophysical and structural approaches have been used to characterize the cytochrome c complex with ANP32A and ANP32B and to unveil the molecular mechanism underlying the cytoplasmic accumulation of ANP32B upon its phosphorylation. In addition, we have extended our knowledge on the histone chaperone regulation in the DDR by studying the Arabidopsis thaliana complex between cytochrome c and NRP1, a SET/TAF-I analogous. Herein we propose a novel standpoint about DDR regulation, in which cytochrome c exerts a modulating role on such signalling cascade through its interaction with histone chaperones, both by tuning their nucleosome assembly and PP2A inhibitory activity. more...