Search

Your search keyword '"Ronsisvalle, Simone"' showing total 62 results
Start Over Author "Ronsisvalle, Simone" Database OpenAIRE
62 results on '"Ronsisvalle, Simone"'

1. Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes

Author

O'Leary, Renée, Polosa, Riccardo, Li Volti, Giovanni, Bertino, Gaetano, Ferlito, Salvatore, Tomaselli, Venera, Nocera, Francesco, Zanoli, Luca, Alaimo, Salvatore, Anfuso, CARMELINA DANIELA, Barbagallo, IGNAZIO ALBERTO, Basile, Francesco, Battiato, Sebastiano, Bianchi, Alberto, Antonio, G Biondi, Maria Luisa Brandi, Cacciola, Emma, Cacciola, Rossella Rosaria, Cacopardo, Bruno Santi, Calogero, Aldo Eugenio, Cambria, Maria Teresa, Campagna, Davide, Caraci, Filippo, Cariola, Agatino, Caruso, Massimo, Caponnetto, Pasquale, Fabio, Cibella, DI MAURO, Maurizio, DI NUOVO, Santo, Adriana Di Stefano, Drago, Filippo, Failla, Salvatore, Rosario, Faraci, Salvatore, Ferlito, Ferrante, Margherita, Alfredo, Ferro, Giancarlo, A Ferro, Frasca, Francesco, Frittitta, Lucia, Furneri, Pio Maria, Giovanni, Gallo, Galvano, Fabio, Gagliano, Antonio, Grasso, Giuseppe, Francesca, Guarino, Gulino, Antonino, Emmanuele, A Jannini, LA VIGNERA, SANDRO SALVUCCIO MARIA, Lazzarino, Giuseppe, Antonio, Longo, Lupo, Gabriella, Mario, Malerba, Marletta, Luigi, Nicolosi, Guido, OLIVERI CONTI, GEA MARZIA, Parenti, Rosalba, Pulvirenti, Alfredo, Purrello, Francesco, Rapisarda, Francesco, Rapisarda, Venerando, Michele, Reibaldi, Rizzo, Renata, Ronsisvalle, Simone, Ruggieri, Martino, Santagati, Maria Carmela, Satriano, Cristina, Sciacca, Laura, Signorelli, MARIA SALVINA, Marco, Tatullo, Daniele, Tibullo, Venera, Tomaselli, Zanoli, LUCA MARIA, and Zappala', Agata

Subjects
Opinion, Adolescent, Medicine (miscellaneous), SCHEER, Population health, Electronic Nicotine Delivery Systems, 030204 cardiovascular system & hematology, Scientific evidence, European Union Tobacco Products Directive, 03 medical and health sciences, 0302 clinical medicine, Political science, e-cigarettes, ENDS, Gateway, Risk assessment, Tobacco harm reduction, Humans, media_common.cataloged_instance, European Union, 030212 general & internal medicine, European union, media_common, Social work, business.industry, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Tobacco Products, Public relations, Psychiatry and Mental health, Health psychology, Critical appraisal, Smoking Cessation, business, Citation, Environmental Health
Abstract

Background In preparation for the 2021 revision of the European Union Tobacco Products Directive, the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) has posted its Preliminary Opinion on Electronic Cigarettes. They concluded that e-cigarettes only achieve a sub-optimal level of protection of human health. In this paper, we provide evidence that the Opinion’s conclusions are not adequately backed up by scientific evidence and did not discuss the potential health benefits of using alternative combustion-free nicotine-containing products as substitute for tobacco cigarettes. Methods Searches for articles were conducted in PubMed and by citation chasing in Google Scholar. Articles were also retrieved with a review of references in major publications. Primary data from World Health Organization surveys, the conclusions of reviews, and peer-reviewed non-industry studies were cited to address errors and omissions identified in the Opinion. Results The Opinion omitted reporting on the individual and population health benefits of the substitution of e-cigarettes (ENDS) for cigarette smoking. Alternative hypotheses to the gateway theory were not evaluated. Its assessment of cardiovascular risk is contradicted by numerous reviews. It cites ever-use data that do not represent current patterns of use. It did not report non-nicotine use. It presented erroneous statements on trends in ENDS prevalence. It over-emphasized the role of flavours in youth ENDS initiation. It did not discuss cessation in sufficient length. Conclusions For the delivery of a robust and comprehensive final report, the members of the Working Group of the Scientific Committee on Health, Environmental and Emerging Risks will need to consider (1) the potential health benefits of ENDS substitution for cigarette smoking, (2) alternative hypotheses and contradictory studies on the gateway effect, (3) its assessment of cardiovascular risk, (4) the measurements of frequency of use, (5) non-nicotine use, (6) the role of flavours, and (7) a fulsome discussion of cessation.

Published
2021

2. Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research

Author

Hajat, C., Stein, E., Selya, A., Polosa, Riccardo, Bertino, Gaetano, Tomaselli, Venera, Ronsisvalle, Simone, Galvano, Fabio, OLIVERI CONTI, GEA MARZIA, Santagati, Maria Carmela, The CoEHAR study group, and Zanoli, LUCA MARIA

Subjects
Epidemiology, Vaping, Smoking, e-cigarettes, Electronic Nicotine Delivery Systems, Epidemiologic Studies, Electronic nicotine delivery systems (ENDS), Emergency Medicine, Internal Medicine, Critical Analysis, Humans, Smoking Cessation, Vape pens, Vapes
Abstract

The prevalence of vaping, also known as using e-cigarettes, vapes and vape pens, has prompted a demand for reliable, evidence-based research. However, published literature on the topic of vaping often raises concerns, characterized by serious flaws and a failure to adhere to accepted scientific methodologies. In this narrative review, we analyze popular vaping studies published in medical journals that purport to evaluate the association of vaping and smoking cessation, smoking initiation or health outcomes. We analyzed 24 included studies to identify the questions they claimed to address, stated methods, manner of implementation, discussions, and stated conclusions. After critical appraisal, we noted a multiplicity of flaws in these studies, and identified patterns as to the nature of such flaws. Many studies lacked a clear hypothesis statement: to the extent that a hypothesis could be inferred, the methods were not tailored to address the question of interest. Moreover, main outcome measures were poorly identified, and data analysis was further complicated by failure to control for confounding factors. The body of literature on “gateway” theory for the initiation of smoking was particularly unreliable. Overall, the results and discussion contained numerous unreliable assertions due to poor methods, including data collection that lacked relevance, and assertions that were unfounded. Many researchers claimed to find a causal association while not supporting such findings with meaningful data: the discussions and conclusions of such studies were, therefore, misleading. Herein, we identify the common flaws in the study design, methodology, and implementation found in published vaping studies. We present our summary recommendations for future vaping research. Our aim is to prompt future researchers to adhere to scientific methods to produce more reliable findings and conclusions in the field of vaping research.

Published
2022

3. Evaluation of educational seminar on the analysis of pesticides in cannabis

Author

Vella Szijj, Janis, Ronsisvalle, Simone, Attard Pizzuto, Maresca, Sammut Bartolo, Nicolette, Wirth, Francesca, Serracino-Inglott, Anthony, Azzopardi, Lilian M., and EAFP Conference : ‘Towards Pharmacy 5.0 Education'

Subjects
Drugs, Medicine, Pesticides, Cannabis
Abstract

There is a need for sensitive, accurate and efficient methods of analysis to determine amounts of pesticides in herbal products intended for medicinal use, such as cannabis. An educational seminar on the analysis of pesticides in cannabis was organised for scientists and healthcare professionals involved in pharmaceutical analysis, evaluation of herbal medicinal products and patient care. During the seminar, reflections on standardised methods of analysis of pesticides that could be adopted by the industry were discussed to support services development that ensure quality, efficacy and safety of herbal medicinal products., peer-reviewed

Published
2022

5. Pharmacological properties and biochemical mechanisms of MOR ligands might be due to different binding poses. MD Studies

Author

Ronsisvalle, Simone, Federica, Panarello, Spadaro, Angelo, Franchini, SILVIA GIUSEPPINA, Pappalardo, Matteo, Guccione, Salvatore, and Basile, Livia

Subjects
opioid receptor, MOR, allosteric site, orthosteric site, molecular dynamics, molecular modeling, benzo-morphans, MOR, molecular modeling, benzo-morphans, allosteric site, opioid receptor, orthosteric site, molecular dynamics
Published
2020

14. In Silico Modeling of the Immune System: Cellular and Molecular Scale Approaches

Author

Belfiore, Mariagrazia, Pennisi, Marzio, Aricò, Giuseppina, Ronsisvalle, Simone, and Pappalardo, Francesco

Subjects
Article Subject
Abstract

The revolutions in biotechnology and information technology have produced clinical data, which complement biological data. These data enable detailed descriptions of various healthy and diseased states and responses to therapies. For the investigation of the physiology and pathology of the immune responses, computer and mathematical models have been used in the last decades, enabling the representation of biological processes. In this modeling effort, a major issue is represented by the communication between models that work at cellular and molecular level, that is, multiscale representation. Here we sketch some attempts to model immune system dynamics at both levels.

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results