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This paper investigated facilitators and barriers to implementing the European Football Fans in Training program (EuroFIT) in professional sports clubs in England, the Netherlands, Norway, and Portugal. We analyzed qualitative data collected at clubs that delivered EuroFIT, based on semi-structured interviews with coordinating staff (n = 15), coaches (n = 16), and focus group interviews with participants (n = 108), as well as data from clubs that considered delivering EuroFIT in the future, based on interviews with staff (n = 7) and stakeholders (n = 8). Facilitators for implementation related to the content and structure of the program, its evidence-base, and the context for delivery in the football stadia. Financial and human resources were both facilitators and barriers. Further barriers were mostly practical, relating to human resources and infrastructure. Major differences between countries related to experience and commitment to running community projects, and differences in infrastructure, financing, and human resources. Professional football clubs’ ability to support health promotion efforts depended on their ethos and the financial and human resources available to them. Overall, the EuroFIT program was well received by clubs, coaches, participants, and stakeholders, which was reflected by the many facilitators supporting sustained implementation. For sustainable implementation, it is crucial that clubs and their stakeholders engage fully with the EuroFIT program and understand that for an adequate program delivery their views (ethos) and ways of working influence the implementation and thereby the effectiveness of EuroFIT. An important prerequisite for future roll out of EuroFIT would be a strong EuroFIT delivery partner organization to ensure financial and human resources while overseeing and guiding the quality of delivery in clubs. Factors influencing the implementation of the EuroFIT lifestyle change program in professional football clubs in Europe: a qualitative study in four European countries

Aim. To explore the effect of an Early Intensive-Upper Limb intervention (EI-UL) compared to EI-UL with integrated Multisensory Stimulation And Priming (MuSSAP) training on improving manual ability in infants with a unilateral brain lesion. Method. A pilot randomised clinical trial with pre- and postintervention and follow-up measurements (T0, T1, and T2) was conducted. Sixteen infants with a unilateral brain lesion (corrected age is 4-10 months) received home-based intervention with video coaching. Eight infants received EI-UL and eight infants received EI-UL with integrated MuSSAP training. Primary outcome was the Hand Assessment for Infants (HAI) score. Additionally, effects were explored on initiation of goal-directed movements in both groups and on attention in the EI-UL with integrated MuSSAP training group. Results. No significant group differences in HAI scores were found. Overall, HAI ‘Affected hand score’ increased between T0 and T1 ( p = 0.001 , Cohen ’ s d = 1.04 ) and between T0 and T2 ( p < 0.001 , Cohen ’ s d = 1.28 ); and the HAI ‘Both Hands Measure’ increased between T0 and T1 ( p < 0.001 , Cohen ’ s d = 1.72 ) and between T0 and T2 ( p < 0.001 , Cohen ’ s d = 1.81 ). At the start of the intervention, six infants (three in both groups) did not demonstrate initiation of goal-directed contralesional upper limb movements. During the intervention one infant receiving EI-UL and all three infants receiving EI-UL with integrated MuSSAP training started to initiate goal-directed movements. Conclusion. The results suggest manual ability of infants with unilateral brain lesion improved with both interventions. We hypothesize that the integrated MuSSAP training may facilitate attention and initiation of contralesional upper limb goal-directed movements. This trial is registered with NCT05533476).

Contains fulltext : 291778.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Uncovering the perspective of children with multiple disabilities is important in health care to enable person-centred health care. For occupational therapists, uncovering the child perspective on meaningful activities is necessary to set appropriate goals for treatment. It is not always evident that children with multiple disabilities can express themselves in an interview. The interviewer should adapt his communication to the child. In literature, alternative communication is widely studied, but a clear algorithm for deciding what to use to successfully gain insight into the child perspective is missing. This study aims to identify helpful interview techniques and interviewer skills and how they can be used to effectively uncover the perspective of children. METHODS: Videos of nine interviews with children with a mitochondrial disorder, conducted by an occupational therapist, were analysed by five researchers. The interviews were analysed to see how well the interviewee had obtained the child's perspectives followed by observation of communicative abilities of the child and the types of questions the interviewer asked. A qualitative directed content analysis of the semi-structured interviews followed. FINDINGS: An interview pattern was observed in the children's communication leading to six successful interviews. Children communicated verbally on four different levels and also used non-verbal communication. The interviewer used five types of questions, which varied between and within the children. The content analysis resulted in two themes: parental influences and interviewer skills. CONCLUSION: Results show the importance of matching the type of questions to the verbal communication level of the child and revealed several interviewer skills and techniques. An overview to guide tailor-made interviewing is presented. The interviewer has a major role in successful interviewing and thus in enabling the inclusion of the child perspective in research and care. 01 april 2023

Copper, lead and tin – an extraordinary Late Bronze Age string of beads from Borger. Around 2017, an amateur metal detectorist searching at Borger in the immediate vicinity of the base of a Middle Bronze Age barrow, which had been excavated in 1987, came across 245 metal beads: four large beads and 241 small ones. One of the four large beads is made of lead, two are of a lead/tin alloy and one is of copper; the 241 biconical and cylindrical small beads are all made of copper. XRF analysis showed that the copper is of a type known as Fahlerz or Fahlore (which includes Singen and Ösenring types of copper). Fahlerz was used mostly in the Early Bronze Age, but also into the Late Bronze Age. The known intensification in the use of lead in Western Europe between 1000 and 500 BC makes it likely that the string of beads was buried – possibly as an isolated deposit – in the Late Bronze Age, no later than the 8th century BC. Further research is planned in the near future, viz. lead-isotope analysis and a small-scale field investigation.

This study estimated the comparative efficacy of ciltacabtagene autoleucel (cilta-cel; CARTITUDE-1), a chimeric antigen receptor (CAR)-T-cell therapy, versus 3 non-CAR-T therapies (belantamab mafodotin [DREAMM-2], selinexor plus dexamethasone [STORM Part 2], and melphalan flufenamide plus dexamethasone [HORIZON]), each with distinct mechanisms of action, for the treatment of patients with relapsed or refractory multiple myeloma (RRMM) who were triple-class exposed to an immunomodulatory drug, proteasome inhibitor, and an anti-CD38 monoclonal antibody.Pairwise matching-adjusted indirect treatment comparisons (MAICs) were conducted using patient-level data for cilta-cel from CARTITUDE-1 and summary level data for each comparator (2.5 mg/kg cohort in DREAMM-2, modified intention-to-treat population in STORM Part 2, and triple-class refractory patients in HORIZON). Treated patients from CARTITUDE-1 who satisfied the eligibility of the comparator trial were included. MAICs adjusted for imbalances in important prognostic factors between CARTITUDE-1 and the comparator populations. Comparative efficacy of cilta-cel versus each therapy was estimated for overall response rate, complete response or better rate, progression-free survival, and overall survival.After adjustment, patients treated with cilta-cel demonstrated at least a 3.1-fold and at least a 10.3-fold increase in the likelihood of achieving an overall response or complete response or better, respectively, at least a 74% reduction in the risk of disease progression or death, and at least a 47% reduction in the risk of death. These results were statistically significant.Cilta-cel showed improved efficacy over each comparator for all outcomes, demonstrating its potential as an efficacious treatment for patients with triple-class exposed RRMM.

Open Science calls for researchers to publish as soon as possible any type of research product in such a way their research activity can be transparently assessed, reviewed, reproduced, and rewarded in all its aspects. However, the publishing process has become more and more a burden for scientists, who must, most of the time, spend time to publish their articles, data, software, and other products in the many institutional or thematic repositories of reference. Scenarios include first-time publishing of new resource products or double-publishing of research products, to satisfy institutional mandates and community practices. Such tedious work is often incomplete, with some products ending up unpublished and others showing incomplete or imprecise metadata. Some communities investigated and realised the integration of their research performing services, from research infrastructures and clusters, with repositories for research product deposition. The integration ensures that outcomes of such services are deposited automatically, prior authorization of the users, into a given repository, giving life to an end-to-end scientific workflow, from experimentation to publishing. The limit of existing approaches is to be bound to a specific repository API and format; introducing multiple repositories as potential targets of deposition for the service, multiplies the problem, as bilateral interactions with the respective repository API must be established. For example, the Zenodo deposition API and the B2SHARE API are similar but different in many ways; a service willing to automate publishing into either repositories would require implementing and maintaining two different workflows. For the EOSC to act as enabler for Open Science practices, its Interoperability Framework should guide services of research infrastructures and clusters of the EOSC on how to implement (semi-)automated workflows for the deposition and consumption of research products. To support different integration options, two modalities are supported by these guidelines: SWORD protocol v3 for push mode and a combination of COAR Notify and Signposting for pull mode. The EOSC guidelines for research product onboarding are suggested as metadata exchange format., The guidelines are proposed by the EOSC Future Working Group on Research Product Publishing

The fourthFAIRCORE4EOSC Briefing provides an overview ofthe latest technical updates, the progress on case studiesandthe major project's achievements. Additionally, the Briefing gives insights on the project's external collaborations and envisaged technical meetings.

Protonic ceramic solid oxide cells (P-SOCs) have gained widespread attention due to their potential for operation in the temperature range of 300−500 °C, which is not only beneficial in terms of material stability but also offers unique possibilities from a thermodynamic point of view to realize a series of reactions.For instance, they are ideal for the production of synthetic fuels by hydrogenation of carbon dioxide and nitrogen, upgradation of hydrocarbons, or dehydrogenation reactions. However, the development of P-SOC is quite challenging because it requires a multifront optimization in terms of material synthesis and fabrication procedures. Herein, we report in detail a method to overcome various fabrication challenges for the development of efficient and robust electrode-supported P-SOCs (Ni-BCZY/BCZY/Ni-BCZY) based on a BaCe0.2Zr0.7Y0.1O3−δ (BCZY271) electrolyte. We examined the effect of pore formers on the porosity of the Ni-BCZY support electrode, various electrolyte deposition techniques (spray, spin, and vacuum-assisted), and thermal treatments for developing robust and flat half-cells. Half-cells containing a thin (10−12 μm) pinhole-free electrolyte layer were completed by a screen-printed Ni-BCZY electrode and evaluated as an electrochemical hydrogen pump to access the functionality. The P-SOCs are found to show a current density ranging from 150 to 525 mA cm−2 at 1 V over an operating temperature range of 350−450 °C. The faradaic efficiency of the P-SOCs as well as their stability were also evaluated.

Purpose: To assess the experience and perceived added value of an e-Health application during the physical therapy treatment of patients with temporomandibular disorders (TMD). Materials and methods: A mixed-methods study including semi-structured interviews was performed with orofacial physical therapists (OPTs) and with TMD patients regarding their experience using an e-Health application, Physitrack. The modified telemedicine satisfaction and usefulness questionnaire and pain intensity score before and after treatment were collected from the patients. Results: Ten OPTs, of which nine actively used Physitrack, described that the e-Health application can help to provide personalised care to patients with TMD, due to the satisfying content, user-friendliness, accessibility, efficiency, and ability to motivate patients. Ten patients, of which nine ended up using Physitrack, felt that shared decision-making was very important. These patients were positive towards the application as it was clear, convenient, and efficient, it helped with reassurance and adherence to the exercises and overall increased self-efficacy. This was mostly built on their experience with exercise videos, as this feature was most used. None of the OPTs or patients used all features of Physitrack. The overall satisfaction of Physitrack based on the telemedicine satisfaction and usefulness questionnaire (TSUQ) was 20.5 ± 4.0 and all patients (100%) showed a clinically relevant reduction of TMD pain (more than 2 points and minimally 30% difference). Conclusion: OPTs and patients with TMD shared the idea that exercise videos are of added value on top of usual physical therapy care for TMD complaints, which could be delivered through e-Health.Implications for Rehabilitation Physical therapists and patients with temporomandibular disorders do not use all features of the e-Health application Physitrack in a clinical setting. Exercise videos were the most often used feature and seen as most valuable by physical therapists and patients. Based on a small number of participants, e-Health applications such as Physitrack may be perceived as a valuable addition to the usual care, though this would need verification by a study designed to evaluate the therapeutic effect (e.g., a randomised clinical trial).

Public recreation facilities are preferred gathering places for families to participate in physical, social, intellectual, and creative pursuits, and the importance of food environments in these facilities is gaining recognition. Evidence from other Canadian jurisdictions describes such food environments as unsupportive of health, which contradicts national recreation priorities to have healthy choices as the easy choices. This study aimed to characterize food environments in a convenient sample of Saskatchewan public recreation facilities. A convergent/parallel mixed methods study design used quantitative methods to determine the healthfulness of concession stands and vending machines and qualitative methods to examine barriers and facilitators to healthy eating in facilities. The results found that 5% of concession main dishes were defined as healthy and packaged foods/beverages in concession stands and vending machines were defined as Offer Most Often 6% and 8% of the time, respectively, according to Saskatchewan Nutrition Standards. Reported barriers to healthy eating were more than twice as prevalent as facilitators. To align with population health recommendations in Saskatchewan, food environments in public recreation facilities require immediate attention. The results and recommendations can be used to build collective action to address the problem and as a benchmark to measure change. Novelty: Only 5% of concession main dishes were defined as healthy. Only 6% of packaged foods and beverages in concessions, and 8% in vending, were defined as Offer Most Often. Reported barriers to healthy eating were more than twice as prevalent as facilitators, resulting in a current state that is difficult to change.

This study investigates the modification of materials by doping with foreign elements to enhance electrocatalytic activity and focuses on the engineering of an inorganic material composed of transition heterometal-rich pentlandite (Fe3Co3Ni3S8, FCNS) doped with silicon (FCNSSi) as a bifunctional catalyst for the overall electrochemical water splitting process. The FCNSSi electrode exhibits remarkable catalytic activity for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). The OER performance of FCNSSi was evaluated in a 1.0 M KOH solution, achieving an overpotential of 313 mV at 10 mA cm-2. The FCNSSi electrode exhibits a current density of -10 mA cm-2 at a remarkably low overpotential of 164 mV with a Tafel slope of 80.7 mV/dec in HER. Density functional theory (DFT) calculation suggests that Si doping adjusts the binding energies of intermediates on the surface, which weakened the *OH, *O, and *OOH adsorption energies, resulting in enhanced activity for both OER and HER. Moreover, Si doping enhances the hydrogen adsorption activity of all sites. Finally, a two-electrode zero-gap cell assembly was used to investigate the durability of FCNSSi catalyst towards efficient and durable alkaline water electrolysis, demonstrating the promising potential of this catalyst for practical applications at 500 mA cm-2.

The substantial urban contribution to global anthropogenic greenhouse gas (GHG) budgets underlines the importance of improved GHG emissions monitoring in cities. Reducing urban emissions of carbon dioxide (CO2) and methane (CH4) will be critical to mitigating climate change; yet, GHG budgets of individual cities as quantified by emission inventories can be very uncertain. This is due to a lack of appropriate activity data and emission factors for compiling city-scale inventories or uncertainties in spatial downscaling of regional/national emissions.The Vienna Urban Carbon Laboratory is currently investigating how monitoring of CO2 and CH4 emissions in Austria’s capital city can be supported by a range of atmospheric measurement methods, including a tall-tower application of eddy covariance flux measurements. Cities can represent non-ideal conditions for eddy covariance due to the aerodynamically rough surface conditions and spatial heterogeneity in GHG sources (and sinks). Nonetheless, if biases/errors caused by these factors are acceptable, the method provides a potentially significant advantage in that net urban emissions can be directly inferred from the measured vertical turbulent fluxes. Since December 2017, CO2 fluxes at 144 m above the surface have been measured using an eddy covariance system deployed at the A1 Arsenal radio tower in Vienna’s city centre. The original rationale for the tall tower approach was to partially mitigate the aforementioned challenges of urban eddy covariance (e.g. to get above the deep urban roughness layer and measure in the surface layer) and to increase the area of the city sampled by the flux footprint. In May 2022, the observations at the tower were expanded to measure CH4 fluxes, as well as atmospheric mixing ratios of CO2 and its stable carbon isotope composition. Furthermore, between May and July 2022, a parallel measurement campaign with four ground-based, sun-viewing FTIR spectrometers (EM27/SUN) was conducted to measure horizontal gradients in total column CO2 and CH4 concentrations.This conference contribution will present an analysis of the tall-tower eddy covariance measurements of CO2 and CH4 fluxes and discuss potential applications within the scope of operational emissions monitoring. In addition to discussing the encouraging agreement between eddy covariance measurements and local CO2 emission inventories for the years 2018 to 2020, the initial eddy flux-inventory comparison for CH4 will be presented. Moreover, planned analyses (and initial results, where available) on several relevant fronts will be briefly discussed: comparison of the eddy fluxes with inverse modelled CO2 and CH4 fluxes using differential column concentration measurements; comparison of partitioned CO2 fluxes with source-sector emission estimates derived from local inventories and measurements of stable carbon isotope composition of atmopsheric CO2. Finally, trends in CO2 fluxes between 2018 and 2022 will be presented to highlight the potential early indicator function and immediate societal benefits that urban eddy covariance can provide.

Background Long-read sequencing (LRS) techniques have been very successful in identifying structural variants (SVs). However, the high error rate of LRS made the detection of small variants (substitutions and short indels Methods We sequenced the genomes of eight parent–child trios using high coverage PacBio HiFi LRS (~ 30-fold coverage) and Illumina short-read sequencing (SRS) (~ 50-fold coverage). De novo substitutions, small indels, short tandem repeats (STRs) and SVs were called in both datasets and compared to each other to assess the accuracy of HiFi LRS. In addition, we determined the parent-of-origin of the small DNMs using phasing. Results We identified a total of 672 and 859 de novo substitutions/indels, 28 and 126 de novo STRs, and 24 and 1 de novo SVs in LRS and SRS respectively. For the small variants, there was a 92 and 85% concordance between the platforms. For the STRs and SVs, the concordance was 3.6 and 0.8%, and 4 and 100% respectively. We successfully validated 27/54 LRS-unique small variants, of which 11 (41%) were confirmed as true de novo events. For the SRS-unique small variants, we validated 42/133 DNMs and 8 (19%) were confirmed as true de novo event. Validation of 18 LRS-unique de novo STR calls confirmed none of the repeat expansions as true DNM. Confirmation of the 23 LRS-unique SVs was possible for 19 candidate SVs of which 10 (52.6%) were true de novo events. Furthermore, we were able to assign 96% of DNMs to their parental allele with LRS data, as opposed to just 20% with SRS data. Conclusions HiFi LRS can now produce the most comprehensive variant dataset obtainable by a single technology in a single laboratory, allowing accurate calling of substitutions, indels, STRs and SVs. The accuracy even allows sensitive calling of DNMs on all variant levels, and also allows for phasing, which helps to distinguish true positive from false positive DNMs.

A global investigation across 58 countries highlighting key findings and messages related to the contributions of small-scale fisheries to food security and nutrition.

The third FAIRCORE4EOSC Briefing provides an overview ofthe latest technical updates, the progress on case studies and related requirements, andthe major project's achievements. Additionally, the Briefing summarises the next meetings and external events envisaged by FAIRCORE4EOSC.

Introduction Early evaluation of writing readiness is essential to predict and prevent handwriting difficulties and its negative influences on school occupations. An occupation-based measurement for kindergarten children has been previously developed: Writing Readiness Inventory Tool In Context (WRITIC). In addition, to assess fine motor coordination two tests are frequently used in children with handwriting difficulties: the modified Timed Test of In-Hand Manipulation (Timed TIHM) and the Nine-Hole Peg Test (9-HPT). However, no Dutch reference data are available. Aim To provide reference data for (1) WRITIC, (2) Timed-TIHM and (3) 9-HPT for handwriting readiness assessment in kindergarten children. Methods Three hundred and seventy-four children from Dutch kindergartens in the age of 5 to 6.5 years (5.6±0.4 years, 190 boys/184 girls) participated in the study. Children were recruited at Dutch kindergartens. Full classes of the last year were tested, children were excluded if there was a medical diagnosis such as a visual, auditory, motor or intellectual impairment that hinder handwriting performance. Descriptive statistics and percentiles scores were calculated. The score of the WRITIC (possible score 0–48 points) and the performance time on the Timed-TIHM and 9-HPT are classified as percentile scores lower than the 15th percentile to distinguish low performance from adequate performance. The percentile scores can be used to identify children that are possibly at risk developing handwriting difficulties in first grade. Results WRITIC scores ranged from 23 to 48 (41±4.4), Timed-TIHM ranged from 17.9 to 64.5 seconds (31.4± 7.4 seconds) and 9-HPT ranged from 18.2 to 48.3 seconds (28.4± 5.4). A WRITIC score between 0–36, a performance time of more than 39.6 seconds on the Timed-TIHM and more than 33.8 seconds on the 9-HPT were classified as low performance. Conclusion The reference data of the WRITIC allow to assess which children are possibly at risk developing handwriting difficulties.

The focus of current research on social media drug markets is the use of mainstream platforms such as Facebook, Snapchat and Instagram. No research currently exists examining how lesser-known social media platforms may facilitate online drug supply. This paper presents the first analysis of the use of the social media platform Discord to buy and sell illegal drugs. The study utilizes observational data and qualitative interviews with Discord drug market participants in New Zealand, including sellers and a drug server administrator ( n = 12). Our findings demonstrate that the Discord platform, which was initially established for gaming, is also being used to facilitate drug transactions. Discord is used to establish local drug selling groups called “servers,” which can be joined by accessing an “invite-link.” The advantages of Discord drug servers cited by interviewees included competitive prices and the ability to greatly expand local seller and customer bases beyond pre-existing personal networks. However, accessibility, server size and management varied considerably between drug servers, giving rise to a range of issues and concerns. We use drug market typologies based on theory of “open” and “closed” markets to understand how “lower tier” and “higher tier” Discord drug servers provided different buying and selling environments. “Lower tier” drug servers were generally characterized by greater ease of entry, larger size, higher rates of opportunism among participants and variable server management. Conversely, “higher tier” drug servers typically involved tighter market entry controls, more active server management and were generally smaller in size. The emergence of Discord drug servers illustrates how the evolution of social media platforms presents their users with new spaces that can be adapted to function as drug markets and the tensions that may emerge during the process of learning to buy and sell in a new social media space.

Information on the epidemiology of uncommon EGFR mutations including exon 20 insertions amongst non-small-cell lung cancer (NSCLC) is lacking.The objective of this pragmatic literature review (PLR) and meta-analysis was to generate robust prevalence and incidence estimates based on ranges of exon 20 insertion mutations reported in the literature.Searches of MEDLINE, Embase, congresses and reference lists for articles published from 2013 in key European countries of interest (Belgium, France, Germany, Italy, The Netherlands, Spain, Sweden, Switzerland, United Kingdom) were performed. Articles were reviewed against pre-specified criteria and their quality was appraised using a published checklist. Prevalence estimates were synthesised by random-effects meta-analyses.Eighty unique studies of moderate-to-high quality were included in the PLR. The meta-analysed prevalence for EGFR mutations was 12.5% (95% confidence interval [CI]: 11.0, 14.1) in any stage NSCLC and 14.8% (12.8, 17.1) in advanced/metastatic NSCLC. The prevalence of exon 20 insertions was 0.7% (0.4, 1.1) in any stage NSCLC and 6.1% (4.0, 9.4) in any stage EGFR-positive NSCLC. Mutation status was primarily measured using direct sequencing or a combination of methods. One study reporting exon 20 insertions in advanced/metastatic disease was identified, which reported a prevalence of 0.5% in overall NSCLC and 4.0% in EGFR-positive NSCLC.EGFR exon 20 insertion mutations are rare in NSCLC. There is a high unmet need in patients with exon 20 insertions, including effective therapies. Prospective cohort studies are needed to better clinically characterise these patients.

Thermalization of electron and gas temperature in CO2 microwave plasma is unveiled with the first Thomson scattering measurements. The results contradict the prevalent picture of an increasing electron temperature that causes discharge contraction. It is known that as pressure increases, the radial extension of the plasma reduces from similar to 7 mm diameter at 100 mbar to similar to 2 mm at 400 mbar. We find that, simultaneously, the initial nonequilibrium between similar to 2 eV electron and similar to 0.5 eV gas temperature reduces until thermalization occurs at 0.6 eV. 1D fluid modeling, with excellent agreement with measurements, demonstrates that associative ionization of radicals, a mechanism previously proposed for air plasma, causes the thermalization. In effect, heavy particle and heat transport and thermal chemistry govern electron dynamics, a conclusion that provides a basis for ab initio prediction of power concentration in plasma reactors.

A key challenge in the synthesis and subsequent analysis of supervisory controllers is the impact of state-space explosion caused by concurrency. The main bottleneck is often the memory needed to store the composition of plant and requirement automata and the resulting supervisor. Partial-order reduction (POR) is a well-established technique that alleviates this issue in the field of model checking. It does so by exploiting redundancy in the model with respect to the properties of interest. For controller synthesis, the functional properties of interest are nonblockingness, controllability, and least-restrictiveness, but also performance properties, such as throughput and latency are of interest. We propose an on-the-fly POR on the input model that preserves both functional and performance properties in the synthesized supervisory controller. This improves the scalability of the synthesis (and any subsequent performance analysis). Synthesis experiments show the effectiveness of the POR on a set of realistic manufacturing system models.

Item does not contain fulltext The purposes of this prospective cohort study were (1) to assess if second anterior cruciate ligament (ACL) injury rate 2 years after ACL reconstruction (ACLR) in those who returned to pivoting sport was associated with meeting (a) quantitative return to sport (RTS) criteria, (b) qualitative RTS criteria, and (c) combined quantitative and qualitative RTS criteria, and (2) to determine why athletes did not return to their preinjury (level of) sport. Athletes after ACLR performed RTS tests immediately before RTS: seven movement quantity (strength and hop test battery) and two movement quality (countermovement jump with LESS score and hop-and-hold test) tests. A 2-year postoperative questionnaire asked for RTS, reasons for not returning to the same (level of) sport and second ACL injuries. One hundred and forty-four athletes (82%) completed the questionnaire and 97 of them returned to a pivoting sport. Seven of these athletes had a second ACL injury. Meeting the hop test battery RTS criterion (absolute risk reduction 11%; p = .047) and hop-and-hold test RTS criterion (absolute risk reduction 15%; p = .031) were both significantly associated with a reduced second ACL injury rate. Meeting combined RTS criteria were not significantly associated with second ACL injury rate. Therefore, RTS tests after ACLR should at least comprise a hop test battery or the hop-and-hold test to reduce second ACL injury risk after return to pivoting sport. Also, one-third of all athletes mentioned fear of reinjury as the main reason for not returning to their preinjury (level of) sport. This psychological component should be taken seriously and discussed during rehabilitation.

Contains fulltext : 249012.pdf (Publisher’s version ) (Open Access) Background: The optimal treatment for a distal radius fracture (DRF) remains an ongoing discussion. This study observed whether early activity postinjury can lead to the prevention of type 1 complex regional pain syndrome (CRPS-1). Method: Patients who underwent nonoperative treatment for a DRF were invited to participate in this study. Patients followed an exercise program with progressive loading exercises at home immediately after cast removal. After a minimum of 3 months, patients were interviewed by telephone to determine the presence of disproportionate pain. If present, the patients were seen during a clinical consultation to determine whether they had CRPS-1, using the Budapest Diagnostic Criteria. Results: Of the 129 patients included in this study, 12 reported disproportionate pain, and none were diagnosed with CRPS-1. The incidence of CRPS-1 was zero in this study. Conclusion: A more active treatment approach seems to lower the incidence of CRPS-1. A larger randomized study is necessary to strengthen the evidence.

Contains fulltext : 249010.pdf (Publisher’s version ) (Open Access) BACKGROUND: After discharge, stroke survivors and their informal caregivers need support from their social networks to resume their most valued activities. Rehabilitation professionals could help them establish a strong support system. OBJECTIVE: Explore how older stroke survivors and their primary informal caregivers expect to resume their valued activities after discharge, and discover their ideas about involving, informing and educating their family members, friends and important others during inpatient rehabilitation so that, once home, they will have adequate support. METHODS: We conducted semi-structured interviews with stroke survivors from three geriatric rehabilitation centres and their primary informal caregivers, used the pictures of daily activities to elicit their perspectives, and applied a descriptive and interpretive design to data analysis. RESULTS: Many participants had no concrete idea about how to resume their activities after discharge but nevertheless were optimistic they would. They expected help to be available and saw no need for professionals to involve their network during inpatient rehabilitation. However, once they had insight into the challenges to expect after discharge, they often appreciated the idea of professionals contacting their network. To better understand the challenges after discharge, it was helpful if professionals provided concrete, honest information about the stroke's consequences for daily life. Actually doing daily activities also helped gain better insights. CONCLUSIONS: To enhance insight in the need of social support after discharge, we suggest that rehabilitation professionals are honest about what to expect and let stroke survivors explore their valued activities in a realistic context more often.

SamenvattingRecreatief ketaminegebruik neemt toe in Nederland. Ketaminemisbruik kan leiden tot schade aan de urinewegen, waardoor urogenitale klachten ontstaan met forse impact op de kwaliteit van leven. Dit artikel gaat over de eerste Nederlandse themapoli met diagnose- en behandelprotocol voor patiënten met ketamine-geïnduceerde urogenitale klachten. Tot op heden zagen we 30 patiënten, van wie 10% betrokkenheid had van de hoge urinewegen. Aanvullende diagnostiek en behandeling waren gefocust op preservatie van nierfunctie. De overige 90% werd gecounseld met als doel te stoppen met ketaminegebruik. Urogenitale klachten werden medicamenteus behandeld. 71% van deze patiënten slaagde erin binnen drie maanden te stoppen met ketaminegebruik en had significant (p

The European Open Science Cloud (EOSC) and the Higher Education Sector Architecture (“Hoger Onderwijs Sector Architectuur”, HOSA) are both initiatives focusing on strengthening the collaboration across stakeholders and sectors at European and national levels. This report discusses the alignment of HOSA with EOSC on the level of principles, stakeholders, governance, platform architecture, platform core components and services offered through the platform. It has been developed through a series of workshops between, the Enterprise Architects of SURF, CITO of GEANT, and the author. It also provides an overview of international architecture and platform initiatives which are of interest to SURF and its members. Finally, it makes recommendations and proposes the next steps. From the discussions during the workshops with the enterprise architects, and in developing this report, it can be concluded that HOSA and EOSC are very similar at the level of aim, principles, stakeholders, and architecture design. While the main objective of HOSA is to support higher education and research in the Netherlands, including access to international platforms, the primary objective of EOSC is to support researchers and research communities from a European perspective. The main differences between HOSA and EOSC are in the targeted audiences and the current state of practice.

The FAIRCORE4EOSC project started in June 2022 and will deliver nine new EOSC-Core components in support of a FAIR research life cycle, bridging the gaps identified in the EOSC SRIA. More specifically, the components will enable an EOSC PID infrastructure, an EOSC research software infrastructure, support for sharing and access to metadata schemas and crosswalks and offer advanced research-intent driven discovery services over all EOSC repositories. This deliverable summarises the overall technical specifications for the FAIRCORE4EOSC components. The deliverable is a snapshot of the input received from WP2, WP3, WP4, WP5, WP6 and WP7 via the milestones at M7. This deliverable will be further updated during the project duration on the project wiki to take into account new requirements and feedback received. The Wiki page that this deliverable is derived from automatically mirrors updates to the content provided by the work packages. Disclaimer: This deliverable has been submitted but not yet officially approved by the European Commission. It is shared here as a reference for the community.

Decreasing the catalytic loading and complexity of electrocatalysts for the reduction of CO2 is a critical necessity towards globally generating carbon-negative synthons. This effort therefore calls for the development of not only more active catalysts per employed g but also for more financially sound ones. Notably, molecular electrocatalysts allow for tuning the electronic and geometric environment around single-atom catalytic centers. Nevertheless, synthetic complexity, cost and electrochemical instability still hamper their large-scale implementation. With industrial application in mind, we herein present a holistic design approach starting from different Ag(I) N,N´-bis(arylimino)acenaphtene complexes to sophisticated architectures of electrolyzer components. Performed in industrially applicable cells at 60°C, this approach allows us to reach catalytic activity for CO formation close to 1 A cm-2, while achieving the highest mass activity reported for CO at 100.000 A gAg-1, accompanied by cost decreases up to a factor of 80 against the current heterogeneous standards. This study thus represents an unprecedented example to show the applicability of homogenous catalysts under industrially relevant conditions.

BackgroundThe concept of ‘complexity’ is widely used by healthcare professionals in patient care. However, it is not completely understood. The inappropriate use and incorrect understanding of complexity lead to ambiguity for hospital-based physiotherapists in dealing with complex patients and work situations.ObjectivesTo develop an understanding of complexity for hospital-based physiotherapy from the perspective of physiotherapists themselves.DesignA grounded theory study was conducted using data from face-to-face, semi-structured interviews with purposive sampled hospital-based physiotherapists. The sampling was used to incorporate variety in hospital work experience, field of expertise and gender. The interviews were conducted in three different types of Dutch hospitals. A conceptual model and grounded theory were constructed after open, axial and selective coding.ResultsTwenty-four hospital-based physiotherapists were interviewed. Two core themes emerged from the data: ‘puzzle-solving’ and ‘reflecting on decisions’. The third theme—‘relationship between learning, adapting and complexity’—describes how hospital-based physiotherapists’ perceptions of complexity change over time. Complexity as a construct was interpreted as the balance between context and patient-related factors on the one hand and therapist-related factors on the other.ConclusionsHospital-based physiotherapists encounter complexity during performing job-related activities and decision-making. Complexity depends on balancing context and patient-related factors and therapist-related factors. In hospital-based physiotherapy, it was perceived as challenging yet meaningful. Complexity contributes to becoming more competent and, as such, a balance between complex and non-complex activities should be sought for hospital-based physiotherapists.

Background Dementia friendly communities (DFCs) are seen as key to participation of people with dementia and carers. Dementia-friendly initiatives (DFI) are important building blocks for the growth of DFCs. Therefore, it is essential to understand how DFIs are developed and sustained to secure the growth of DFCs. This study identifies contextual factors and mechanisms that influence the development and sustainment of Dutch DFIs. It also explains how these contextual factors and mechanisms are interrelated and the outcomes to which they lead. Methods Mixed methods, namely interviews, observations, documentation and focus groups, were used for this realist multiple case study. Participants were professionals (n = 46), volunteers (n = 20), people with dementia (n = 1) and carers (n = 2) who were involved in development and sustainment of DFIs in four Dutch DFCs. Results This study revealed three middle-range program theories as final outcomes: development of a support base, collaboration, and participation in DFIs by people with dementia and carers. These theories address institutional, organisational, interpersonal and individual levels in the community that are essential in development and sustainment of DFIs. Conclusions The development and sustainment of DFIs requires the development of a support base, collaboration, and participation in DFIs by people with dementia and their carers.

Den tyske ubåten U-864 hadde store mengder kvikksølv om bord, da den ble topedert og senket vest av Fedje i 1945. Vraket ligger på omlag 150 m dyp og sjøbunnen rundt er sterkt forurenset av metallisk kvikksølv. På vegne av Kystverket overvåker Havforskningsinstituttet årlig innholdet av kvikksølv i sjømat fisket rundt vraket samt ved referanselokaliteter fire nautiske mil nord og sør for vraket. I 2021 analyserte vi filet av 66 brosmer (Brosme brosme) og klokjøtt og innmat av 69 taskekrabber (Cancer pagurus) for totalkvikksølv. Filet av én brosme prøvetatt ved vraket og fire prøvetatt fire nautiske mil sør for vraket hadde kvikksølvkonsentrasjoner over grenseverdien satt for mattrygghet i EU og Norge. I løpet av perioden overvåkningen har foregått til nå (2005-2021) har til sammen 75 av 1259 brosmer, 6,0 %, hatt kvikksølvnivå over grenseverdien som gjelder mattrygghet. Disse har vært nokså jevnt fordelt mellom vrakområdet og referanselokalitetene lenger nord og sør. Filet av brosme prøvetatt i 2021 nær vraket av U-864 hadde relativt lavt kvikksølvnivå sammenlignet med flere tidligere år, også når kvikksølvnivået var justert for fiskens størrelse. Klokjøtt av krabber hadde et kvikksølvnivå godt under grenseverdien for mattrygghet, og nivået var lavere fire mil sør for vraket sammenlignet med ved vraket og fire mil nord for vraket. I innmat av krabbe var det høyest konsentrasjoner av kvikksølv ved vraket, lavere fire nautiske mil nord og aller lavest fire nautiske mil sør for vraket. Dette har også blitt observert tidligere hos krabbe. Det finnes ikke mattrygghetsgrenseverdier som gjelder for innmat av krabbe. Gjennomsnittlig kvikksølvnivå i krabber fanget ved vraket av U-864 var på nivå med flere tidligere år, som 2017 og 2019. Det er ikke grunnlag for å fastslå at det har vært en økning i perioden overvåkingen har pågått, det vil si fra 2006 for kokte krabber og fra 2017 for rå krabber. Resultater av bestemmelse av andre metaller i krabbe er for første gang tatt med i denne rapporten. Arsen, kadmium og selen viste relativt høye nivåer sammenlignet med det som tidligere er målt i krabbe fisket andre steder ved kysten, og det er mulig at dette skyldes forurensning fra ubåtvraket. Men det er ikke mulig å fastslå det sikkert basert på disse resultatene. Det var imidlertid ingen prøver av klokjøtt som hadde konsentrasjoner av kadmium eller bly over grenseverdiene som gjelder for disse tungmetallene i klokjøtt. Heller ikke for disse stoffene er det grenseverdier som gjelder brunmat, men kadmiumnivået i brunmat av taskekrabbe er generelt høyt også ellers langs kysten, og Mattilsynet advarer folk flest mot å spise for mye brunmat av krabber, mens gravide, ammende og barn anbefales å unngå brunmaten helt. Kvikksølv i sjømat ved U-864 - Resultater fra overvåkning i 2021

Masteroppgave i engelsk, Høgskulen på Vestlandet, campus Bergen MGUEN550

Additional file 1. Topic guide.

Additional file 3. Ten outlines cross case synthesis.

Contains fulltext : 290609.pdf (Publisher’s version ) (Open Access) Genome sequencing (GS) can identify novel diagnoses for patients who remain undiagnosed after routine diagnostic procedures. We tested whether GS is a better first-tier genetic diagnostic test than current standard of care (SOC) by assessing the technical and clinical validity of GS for patients with neurodevelopmental disorders (NDD). We performed both GS and exome sequencing in 150 consecutive NDD patient-parent trios. The primary outcome was diagnostic yield, calculated from disease-causing variants affecting exonic sequence of known NDD genes. GS (30%, n = 45) and SOC (28.7%, n = 43) had similar diagnostic yield. All 43 conclusive diagnoses obtained with SOC testing were also identified by GS. SOC, however, required integration of multiple test results to obtain these diagnoses. GS yielded two more conclusive diagnoses, and four more possible diagnoses than ES-based SOC (35 vs. 31). Interestingly, these six variants detected only by GS were copy number variants (CNVs). Our data demonstrate the technical and clinical validity of GS to serve as routine first-tier genetic test for patients with NDD. Although the additional diagnostic yield from GS is limited, GS comprehensively identified all variants in a single experiment, suggesting that GS constitutes a more efficient genetic diagnostic workflow. 01 januari 2023

Vår forståelse av jordens atmosfære har utviklet seg betydelig, mens vår kunnskap om havet forblir begrenset på grunn av utfordringer knyttet til utilgjengelighet og teknologiske begrensninger. I denne sammenhengen framstår den frittstående undervannsovervåkingsstasjonen (SUMS) som et viktig verktøy for havforskning. Utviklet for å måle og kommunisere vitale parametere i havet, overvinner SUMS-riggen logistiske utfordringer og gir enestående innsikt i det marine miljøet. Dens allsidighet tillater integrering med fjernstyrte undervannsfarkoster (ROV-er) for utforskning av utilgjengelige områder. Avansert akustisk modemteknologi gjør det mulig å danne et nettverk av sammenkoblede observasjonsposter, som letter datainnsamling og analyse for å forbedre vår forståelse av havets dynamiske natur. Utviklingen av SUMS-riggen har nådd betydelige milepæler, med vellykkede sensoravlesninger og datahåndteringsevner. Imidlertid kreves ytterligere undersøkelser for å fastslå funksjonaliteten og nøyaktigheten til sensorene, spesielt med hensyn til inkonsekvenser observert med Atlas Scientific-sensorene. Maskinvareforbedringer og optimalisering av programvaren har bidratt til et pålitelig og effektivt sluttprodukt. Prosjektets aspekter knyttet til masseproduksjon har gitt betydelige resultater, med to fullt operative rigger klare for utplassering på havets dyp. Detaljert dokumentasjon sikrer reproduksjonsevne og skalerbarhet av designet. Samlet sett viser fremgangen som er oppnådd, teamets dedikasjon til å utvikle et pålitelig og effektivt undervannsovervåkingssystem, og legger et solid grunnlag for fremtidige forbedringer og utvidelser innen feltet undervannsteknologi. Our understanding of the Earth's atmosphere has made significant strides, while our knowledge of the ocean remains limited due to challenges such as inaccessibility and technological limitations. In this context, the standalone underwater monitoring station (SUMS) emerges as a crucial tool for oceanographic research. Designed to measure and communicate vital parameters in the ocean, the SUMS rig overcomes logistical challenges and provides unprecedented insights into the marine environment. Its versatility allows integration with Remotely Operated Vehicles (ROVs) for exploration in inaccessible areas. Advanced acoustic modem technology enables the formation of an interconnected network of observation posts, facilitating data collection and analysis to enhance our understanding of the ocean's dynamic nature. The development of the SUMS rig has reached significant milestones, demonstrating successful sensor readings and data processing capabilities. However, further examination is required to ascertain the functionality and accuracy of the sensors, particularly in the case of inconsistencies observed with Atlas Scientific sensors. Hardware improvements and software optimization have contributed to a reliable and efficient final product. The project's mass production aspects have yielded notable outcomes, with two fully operational rigs ready for deployment. Detailed documentation ensures reproducibility and scalability of the design. Overall, the progress made showcases the team's dedication to developing a reliable and efficient underwater monitoring system, laying a strong foundation for future refinement and expansion in the field of underwater technology.

Transforming CO2 into value-added chemicals is crucial to realizing a carbon-neutral economy, and plasmabased conversion, a Power-2-X technology, offers a promising route to realizing an efficient and scalable process. This paper investigates the effects of post-plasma placement of a converging-diverging nozzle in a vortexstabilized 2.45 GHz CO2 microwave plasma reactor to increase energy efficiency and conversion. The CDN leads to a 21 % relative increase in energy efficiency (31 %) and CO2 conversion (13 %) at high flow rates and nearatmospheric conditions. The most significant performance improvement was seen at low flow rates and subatmospheric pressure (300 mbar), where energy efficiency was 23 % and conversion was 28 %, a 71 % relative increase over conditions without the CDN. Using CFD simulations, we found that the CDN produces a change in the flow geometry, leading to a confined temperature profile at the height of the plasma, and forced extraction of CO to the post-CDN region.

Item does not contain fulltext INTRODUCTION: The curriculum of the three dental schools in the Netherlands consists of a three-year bachelor's and three-year master's course. The education programmes focus inter alia on clinical dental reasoning, thinking and acting scientifically, general oral healthcare activities, and communication and (inter)professional cooperation. This study examined how recently graduated dentists, in the light of their work experience, evaluate their education in retrospect. MATERIALS AND METHODS: All 1074 dentists who graduated between 2012 and mid-2017 were invited by e-mail to answer a web survey. Of those, 314 (29%) took part in the study. RESULTS: The majority of dentists were positive about their knowledge of general and clinical oral healthcare fields when they graduated (70% and 68%, respectively). Fewer dentists were satisfied with their skills in terms of some specific procedures (50%) and clinical professional areas (33%). By far, the majority (85%) were satisfied with the educational skills of their teachers. The majority (70%) felt that their education fitted in well with their professional practice. Nevertheless, 60% thought a year's trainee work experience would be a good idea. The overall evaluation of dentists who have their own practices was less positive than those who do not. CONCLUSION: Knowledge and skills relating to managing a practice were not sufficiently addressed in the programme. The introduction of a practical internship would be desirable, preferably during the education. But when they look back, the majority of recently graduated dentists in the Netherlands are generally positive about the education they received.