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Intelligence analysts face a difficult problem: distinguishing extremist rhetoric from potential extremist violence. Many are content to express abuse against some target group, but only a few indicate a willingness to engage in violence. We address this problem by building a predictive model for intent, bootstrapping from a seed set of intent words, and language templates expressing intent. We design both an n-gram and attention-based deep learner for intent and use them as colearners to improve both the basis for prediction and the predictions themselves. They converge to stable predictions in a few rounds. We merge predictions of intent with predictions of abusive language to detect posts that indicate a desire for violent action. We validate the predictions by comparing them to crowd-sourced labelling. The methodology can be applied to other linguistic properties for which a plausible starting point can be defined.

The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple serine-proline sites. Replacing wild-type protein with a phosphomutant form of Ngn3 increases a cell generation, the earliest endocrine cell type to be formed in the developing pancreas. Moreover, un(der)phosphorylated Ngn3 maintains insulin expression in adult beta cells in the presence of elevated c-Myc and enhances endocrine specification during ductal reprogramming. Mechanistically, preventing multi-site phosphorylation enhances both Ngn3 stability and DNA binding, promoting the increased expression of target genes that drive differentiation. Therefore, multi-site phosphorylation of Ngn3 controls its ability to promote pancreatic endocrine differentiation and to maintain beta cell function in the presence of pro-proliferation cues and could be manipulated to promote and maintain endocrine differentiation in vitro and in vivo.

Contains fulltext : 179096.pdf (Publisher’s version ) (Open Access)

Summary Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discrete niches in juxta-urethral ducts, generate bipotent basal progenitors in directed epithelial migration streams. Basal progenitors are then dispersed throughout the entire glandular network, dividing and differentiating to replenish the loss of apoptotic luminal cells. Rare lineage-restricted luminal stem cells, and their progeny, are confined to proximal ducts and provide only minor contribution to epithelial homeostasis. In situ cell capture from clonal maps identified delta homolog 1 (DLK1) enrichment of basal stem cells, which was validated in functional spheroid assays. This study establishes significant insights into niche organization and function of prostate stem and progenitor cells, with implications for disease., Graphical Abstract, Highlights • Discrete, proximal stem cell niche domains in juxta-urethral ducts • Basal stem cells generate large-scale, directed, and cohesive cell migration streams • Bipotent basal progenitors maintain the luminal compartment • DLK1 marks stem cells in situ that recapitulate gland histology in 3D culture, Moad et al. find that multipotent prostate basal stem cells, marked by delta homolog 1 (DLK1), reside in proximal ducts and generate directed large-scale epithelial flows traversing the entire length of the branching gland network. This work describes mechanisms underlying 3D epithelial homeostasis in a complex branching tissue.

Dit rapport werd ingediend bij het agentschap samen met een aantal afzonderlijke digitale bijlagen. Een aantal van deze bijlagen zijn niet inbegrepen in dit pdf document en zijn niet online beschikbaar. Sommige bijlagen (grondplannen, foto’s, spoorbeschrijvingen, enz.) kunnen van belang zijn voor een betere lezing en interpretatie van dit rapport. Indien u deze bijlagen wenst te raadplegen kan u daarvoor contact opnemen met: bib.oe@vlaanderen.be

Objective: The canonical WNT/β-catenin pathway plays an important role in embryo- and carcinogenesis. Although β-catenin has been abnormally expressed in a variety of human cancers, little is known about its involvement in the biology of glial tumors. In this project the role of WNT/β-catenin[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

The phase diagram of Sr3Ru2O7 contains a metamagnetic transition that bifurcates to enclose an anomalous phase with intriguing properties - a large resistivity with anisotropy that breaks the crystal-lattice symmetry. We propose that this is a magnetic analogue of the spatially inhomogeneous superconducting Fulde-Ferrell-Larkin-Ovchinnikov state. Based on a microscopic theory of Stoner magnetism we derive a Ginzburg-Landau expansion where the magnetisation transverse to the applied field can become spatially inhomogeneous. We show that this reproduces the observed phase diagram of Sr3Ru2O7., 20 pages, 16 figures; revisions to text and figures

We report on the measurements of the kinetics of expanding and collapsing rings in the exciton emission pattern. The rings are found to preserve their integrity during expansion and collapse, indicating that the observed kinetics is controlled by charge carrier transport rather than by a much faster process of exciton production and decay. The relation between ring kinetics and carrier transport, revealed by our experiment and confirmed by comparison with a theoretical model, is used to determine electron and hole transport characteristics in a contactless fashion., 6 pages, 4 figures

We have studied the competition and coexistence of staggered triplet SC with d-wave singlet SC and SDW in the mean-field approximation. Detailed numerical studies demonstrate that particle-hole asymmetry mixes these states and therefore they are simultaneously present. Even more interesting were the results of our study of the influence of a uniform magnetic field. We observe novel transitions that show the characteristics of Fulde-Ferrel phases, yet they concern transitions to different combinations of the above orders. For example, above a given field, in a particle-hole symmetric system we observe a transition from d-wave singlet SC to a state in which d-wave singlet SC coexists with staggered triplet SC and SDW. We believe our results may provide, among others, a direct explanation to recent puzzles about the Fulde Ferrel like states that are apparently observed in CeCoIn5., Comment: To be published in J. Phys. Cond. Mat

We have studied the competition and coexistence of staggered triplet SC with d-wave singlet SC and SDW in the mean-field approximation. Detailed numerical studies demonstrate that particle-hole asymmetry mixes these states and therefore they are simultaneously present. Even more interesting were the results of our study of the influence of a uniform magnetic field. We observe novel transitions that show the characteristics of Fulde-Ferrel phases, yet they concern transitions to different combinations of the above orders. For example, above a given field, in a particle-hole symmetric system we observe a transition from d-wave singlet SC to a state in which d-wave singlet SC coexists with staggered triplet SC and SDW. We believe our results may provide, among others, a direct explanation to recent puzzles about the Fulde Ferrel like states that are apparently observed in CeCoIn5., To be published in J. Phys. Cond. Mat

The phase diagram of Sr3Ru2O7 contains a metamagnetic transition that bifurcates to enclose an anomalous phase with intriguing properties - a large resistivity with anisotropy that breaks the crystal-lattice symmetry. We propose that this is a magnetic analogue of the spatially inhomogeneous superconducting Fulde-Ferrel-Larkin-Ovchinnikov state. We show - through a Ginzburg-Landau expansion where the magnetisation transverse to the applied field can become spatially inhomogeneous - that a Stoner model with electronic band dispersion can reproduce this phase diagram and transport behaviour., Comment: 5 pages, 4 figures; revisions to text

Motivated by recent experimental work, we use first-principles density functional theory methods to conduct an extensive search for low enthalpy structures of C$_6$Ca under pressure. As well as a range of buckled structures, which are energetically competitive over an intermediate range of pressures, we show that the high pressure system ($\gtrsim 18$ GPa) is unstable towards the formation of a novel class of layered structures, with the most stable compound involving carbon sheets containing five- and eight-membered rings. As well as discussing the energetics of the different classes of low enthalpy structures, we comment on the electronic structure of the high pressure compound and its implications for superconductivity., 4 pages 4 figures

Although not an intrinsic superconductor, it has been long--known that, when intercalated with certain dopants, graphite is capable of exhibiting superconductivity. Of the family of graphite--based materials which are known to superconduct, perhaps the most well--studied are the alkali metal--graphite intercalation compounds (GIC) and, of these, the most easily fabricated is the C${}_8$K system which exhibits a transition temperature $\bm{T_c\simeq 0.14} $K. By increasing the alkali metal concentration (through high pressure fabrication techniques), the transition temperature has been shown to increase to as much as $\bm 5 $K in C${}_2$Na. Lately, in an important recent development, Weller \emph{et al.} have shown that, at ambient conditions, the intercalated compounds \cyb and \cca exhibit superconductivity with transition temperatures $\bm{T_c\simeq 6.5} $K and $\bm{11.5} $K respectively, in excess of that presently reported for other graphite--based compounds. We explore the architecture of the states near the Fermi level and identify characteristics of the electronic band structure generic to GICs. As expected, we find that charge transfer from the intercalant atoms to the graphene sheets results in the occupation of the $\bm\pi$--bands. Yet, remarkably, in all those -- and only those -- compounds that superconduct, we find that an interlayer state, which is well separated from the carbon sheets, also becomes occupied. We show that the energy of the interlayer band is controlled by a combination of its occupancy and the separation between the carbon layers., Comment: 4 Figures. Please see accompanying experimental manuscript "Superconductivity in the Intercalated Graphite Compounds C6Yb and C6Ca" by Weller et al

Studies of Feshbach resonance phenomena in fermionic alkali gases have drawn heavily on the intuition afforded by a Fermi-Bose theory which presents the Feshbach molecule as a featureless Bose particle. While this model may provide a suitable platform to explore the lithium-6 system, we argue that its application to potassium-40, where the hyperfine structure is inverted, is inappropriate. Introducing a three-state Fermi model, where a spin state is shared by the open and closed channel states, we show that effects of ``Pauli blocking'' are recorded in the internal structure of the condensate wave function., References added, Fig.1 revised, and Fig.3 removed

The bilayer ruthenate Sr_3Ru_2O_7 has been cited as a textbook example of itinerant metamagnetic quantum criticality. However, recent studies of the ultra-pure system have revealed striking anomalies in magnetism and transport in the vicinity of the quantum critical point. Drawing on new experimental data, we propose that the anomalous phase behavior can be accommodated by a mechanism which relies on the effects of strong magnetoelastic coupling. We argue that the phenomenological theory identified here is more generic and raises the possibility of quantum tricritical behaviour., Comment: 5pages, 4 figures. Text revised for clarity and some more experimental data included

We use a novel method based on the semi-classical analysis of sigma-models to describe the phenomenon of strong localization in quasi one-dimensional conductors, obtaining the full distribution of transmission eigenvalues. For several symmetry classes, describing random superconducting and chiral Hamiltonians, the target space of the appropriate sigma-model is a (super)group manifold. In these cases our approach turns out to be exact. The results offer a novel perspective on localization., Comment: Published version

The macroscopic exciton rings observed in the photoluminescence (PL) patterns of excitons in coupled quantum wells (CQWs) are explained by a series of experiments and a theory based on the idea of carrier imbalance, transport and recombination. The rings are found to be a source of cold excitons with temperature close to that of the lattice. We explored states of excitons in the ring over a range of temperatures down to 380 mK. These studies reveal a sharp, albeit continuous, second order phase transition to a low-temperature ordered exciton state, characterized by ring fragmentation into a periodic array of aggregates. An instability at the onset of degeneracy in the cold exciton system, due to stimulated exciton formation, is proposed as the transition mechanism., 8 pages including 4 figures

The random flux model (defined here as a model of lattice fermions hopping under the influence of maximally random link disorder) is analysed field theoretically. It is shown that the long range physics of the model is described by the supersymmetric version of a field theory that has been derived earlier in connection with lattice fermions subject to weak random hopping. More precisely, the field theory relevant for the behaviour of n-point correlation functions is of non-linear sigma model type, where the group GL(n|n) is the global invariant manifold. It is argued that the model universally describes the long range physics of random phase fermions and provides further evidence in favour of the existence of delocalised states in the middle of the band in two dimensions. The same formalism is applied to the study of non-Abelian generalisations of the random flux model, i.e. N-component fermions whose hopping is mediated by random U(N) matrices. We discuss some physical applications of these models and argue that, for sufficiently large N, the existence of long range correlations in the band center (equivalent to metallic behaviour in the Abelian case) can be safely deduced from the RG analysis of the model., 33 pages, 5 eps-figures; Nucl. Physics B, to appear

We present exact results for the dynamical structure function, i.e.~the density-density correlations for the 1/r^2 system of interacting particles at three special values of the coupling constant. The results are interpreted in terms of exact excitations of the model which are available from Bethe's Ansatz, thereby throwing light on the quasi-particle content of the elementary excitations. We also obtain the first moment of the discrete version of the model, which provides a non-trivial check on its structure function. We show that the property of spectrum saturation is a common feature of both versions., Comment: 29 pages + 11 figures available upon request, REVTeX 3.0, CMT-ERM/93-1