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Soft body cutting simulation is the core module of virtual surgical training systems. By making full use of the powerful computing resources of modern computers, the existing methods have already met the needs of real-time interaction. However, there is still a lack of high realism. The main reason is that most current methods follows the "Intersection-IS-Fracture" mode, namely cutting fracture occurs as long as the cutting blade intersects with the object. To model real-life cutting phenomenon considering deformable objects' fracture resistance, this paper presents a highly realistic virtual cutting simulation algorithm by introducing an energy-based cutting fracture evolution model.We design the framework based on the co-rotational linear FEM model to support large deformations of soft objects and also adopt the composite finite element method (CFEM) to balance between simulation accuracy and efficiency. Then, a cutting plane constrained Griffth's energy minimization scheme is proposed to determine when and how to generate a new cut. Moreover, to provide the contact effect before the fracture occurs, we design a material-aware adaptation scheme that can guarantee indentation consistent with the cutting tool blade and visually plausible indentation-induced deformation to avoiding large computational effort.The experimental results demonstrate that the proposed algorithm is feasible for generating highly realistic cutting simulation results of different objects with various materials and geometrical characteristics while introducing a negligible computational cost. Besides, for different blade shapes, the proposed algorithm can produce highly consistent indentation and fracture. Qualitative evaluation and performance analysis indicate the versatility of the proposed algorithm.

According to WADA guidelines, the presence of Higenamine (HG) in urine should not be ≥10 ng/mL. HG is widely found in materials used in Chinese herbal medicines as well as food and additives. This paper is the first method wherein a rat model has been used to evaluate the pharmacokinetics of orally administered HG by LC-MS/MS and would be helpful in doping control analysis. The method was found to be linear over a concentration range of 0.5(lower limit of quantification, LLOQ)-500 ng/mL for plasma and 0.5(LLOQ)-1000 ng/mL for urine. The values for intra- and inter-day accuracy and precision did not deviate by >12.25% for HG in plasma and 5.87% in urine. Extraction recoveries of HG were 70.30-86.71% from plasma and 74.93%-79.29% from urine. HG was stable in plasma and urine after the extraction process and when exposed to different storage conditions. The findings of this study could provide some reference value for the assessment of HG misuse and for the control of intake and external application of HG-related materials (foods and medicinal herbs). Our key findings are that high levels of external application or oral administration of HG-rich materials may lead to a positive urine test for HG in athletes.

In the perspective of present monetary system, the author proposes that we should analyze the comprehensive effectiveness with the combination of the former gold standard system and diversified monetary systems, such as the credit currency and the digital currency, which are highlighted in this new era, and confirm the more complete digital currency policy according to present development status so as to promote the healthier and more reasonable and effective development of the monetary funds. In this paper, the author launches research and exploration with the combination of gold standard, credit currency and digital currency.

To evaluate the ovarian response and pregnancy outcomes in patients with excessive ovarian response receiving long-protocol pituitary down-regulation during repeated in vitro fertilization and embryo transfer (IVF-ET).Sixty IVF-ET cycles from January 2008 to December 2011 were analyzed retrospectively. The clinical characteristics were compared between the various treatment cycles.Compared with those with the first treatment cycle, the patients receiving repeated cycles had a significantly older age (P0.001), reduced initial doses of Gn (P=0.049), and moderately lowered estrogen level on the day of hCG administration (E₂) (P=0.027) and the number of oocytes retrieved (P=0.030). The high-quality embryo formation rate (P0.001) and clinical pregnancy rate (P=0.009) were both significantly higher in patients with repeated cycles. The dose for down-regulation, total Gn dose, duration of Gn stimulation, number of two pronuclei (PN), number of fertilized oocyte, and the cancellation rate for a high risk of ovarian hyperstimulation syndrome (OHSS) were all comparable between the two groups (P0.05). The recurrence rate of ovarian excessive respond was 40% (12/30).For patients receiving repeated IVF treatment cycle with a high ovarian response, a smaller initial dose of Gn should be used to minimize the risk of hyper-response and improve the outcome of assisted reproductive treatment.

To improve production efficiency, reduce production costs, and realize automation management under the virtual instrument software LabVIEW graphical programming language environment in industrial production processes, this paper uses weighing machines and a temperature acquisition module to collect data, send the data to a principal computer by multichannel serial port communication, analyze and process the data on the principal computer, and finally realize real-time data display and storage functions. The system effectively implements quality control and management in the production process, and its us in production showed that it works stably and has excellent reliability and scalability.