1. Polycaprolactone / bioactive glass hybrid scaffolds with controlled porosity
- Author
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Bossard, C, Granel, Henri, Jallot, Edouard, Fayon, F, Montouillout, Valerie, Drouet, Christophe, Soulié, Jérémy, Wittrant, Y., Lao, J, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)
- Subjects
[PHYS]Physics [physics] ,[SDV]Life Sciences [q-bio] ,[CHIM]Chemical Sciences - Abstract
International audience; Inorganic-organic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of bioactive glasses (BG) with the toughness of polymers. In such hybrids, the main challenge concerns the incorporation of calcium into the BG silicate network, which plays a major role in biomineralisation. Hybrids comprised of polycaprolactone (PCL, M n = 80,000 g/mol) and SiO 2-CaO BG were produced by a sol-gel process and built into porous scaffolds with controlled pore and interconnection sizes. PCL was chosen as the polymer because its slow degradation in vivo makes it a suitable candidate for bone filling. The calcium incorporation, apatite-forming ability, mechanical properties and degradation rate of the hybrid scaffolds were evaluated.
- Published
- 2018