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Background: Suicide is one of the most important causes of deaths in the United Kingdom, and the numbers are currently increasing. Aim: There are numerous identified determinants of suicidality, and physical multimorbidity is potentially important but is currently understudied. Thus, this study aims to investigate the association of physical multimorbidity with suicidality. Methods: Cross-sectional data from the Adult Psychiatric Morbidity Survey 2007, which was conducted in England between October 2006 and December 2007 by the National Center for Social Research and Leicester University were analyzed. Respondents were asked about 20 physical health conditions, and suicidal ideation and suicide attempts were assessed. Results: Out of 7,403 individuals aged 16 years or over, the prevalence of physical multimorbidity, suicidal ideation, and suicide attempts were 35.1%, 4.3%, and 0.7%, respectively. After adjustment for potential confounders, compared to no physical conditions, 1, 2, 3, and ⩾4 conditions were associated with significant 1.79 (95% CI [1.25, 2.57]), 2.39 (95% CI [1.63, 3.51]), 2.88 (95% CI [1.83, 4.55]), and 6.29 (95% CI [4.12, 9.61]) times higher odds for suicidal ideation. Mediation analysis showed that cognitive problems (mediated percentage 39.2%) and disability (37.5%) explained the largest proportion between multimorbidity and suicidal ideation. Pain (38.0%) and cognitive problems (30.7%) explained the largest proportion between multimorbidity and suicide attempts. Conclusion: In this large sample of UK adults, physical multimorbidity was associated with significantly higher odds for suicidal ideation and suicide attempts. Moreover, several potential mediators were identified, and these may serve as future targets for interventions that aim to prevent suicidality among people with physical multimorbidity.

People with depression and subjective cognitive complaints (SCC) may be at particularly high risk for developing dementia. However, to date, studies on depression and SCC are limited mainly to single high-income countries. Thus, the aim of the present study was to investigate the association between depression and SCC in adults from low- and middle-income countries (LMICs). Cross-sectional, community-based data were analyzed from the World Health Survey. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 (No SCC) to 100 (worse SCC). ICD-10 Diagnostic Criteria for Research was used for the diagnosis of subsyndromal depression, brief depressive episode, and depressive episode. Multivariable linear regression was conducted to explore the associations. Data on 237,952 individuals aged >= 18 years [mean (SD) age 38.4 (16.0) years; females 50.8%] were analyzed. After adjustment for potential confounders (age, sex, education, anxiety), compared to no depressive disorder, subsyndromal depression (b-coefficient 7.91; 95%CI = 5.63-10.18), brief depressive episode (b-coefficient 10.37; 95%CI = 8.95 11.78), and depressive episode (b-coefficient 13.57; 95%CI = 12.33 14.81) were significantly associated with higher mean SCC scores. The association was similar in all age groups (i.e., 18 44, 45 64, and >= 65 years), and both males and females. All depression types assessed were associated with worse SCC among adults in 47 LMICs. Future longitudinal studies are needed to investigate whether older people with depression and SCC are at higher risk for dementia onset in LMICs.

Background Sarcopenia has been associated with a lower quality of life (QoL). However, studies on this association from low- and middle-income countries (LMICs) are scarce. Aims To examine the association between sarcopenia and QoL, in a large nationally representative sample of older adults from six LMICs. Methods Cross-sectional, community-based data from the WHO study on global ageing and adult health (SAGE) were analysed. Non-severe sarcopenia was defined as having low skeletal muscle mass (SMM) and weak handgrip strength but no slow gait speed, while severe sarcopenia was defined as having low SMM, weak handgrip strength, and slow gait speed. QoL was assessed with the 8-item WHO QoL instrument (range 0-100) with higher scores representing better QoL. Multivariable linear regression analysis was conducted. Results Data on 14,585 people aged >= 65 years were analyzed [mean (SD) age 72.6 (11.5) years; 55.0% female]. After adjustment for potential confounders, compared to no sarcopenia, severe sarcopenia was associated with a significant - 3.37 points [95% CI - 5.56, - 1.18] lower QoL score. Non-severe sarcopenia was not significantly associated with lower QoL. Discussion The association between sarcopenia and QoL observed in our study may be explained by factors such as functional impairment and disability related with sarcopenia. Conclusions In this large representative sample of older adults from multiple LMICs, compared to no sarcopenia, only severe sarcopenia was associated with a significantly lower QoL score. Interventions to prevent or manage sarcopenia among older adults in LMICs may contribute to better QoL in this population.

ÖZET Amaç: Sistemik skleroz, vaskülopati, visseral ve kutanöz fibrozis ile karakterize kronik otoimmün bir hastalıktır. D vitamininin immünolojik sistemde çeşitli işlevleri vardır ve farklı çalışmalar otoimmün hastalıkları tetiklemede potansiyel bir rolü olduğunu göstermiştir. Sistemik sklerozlu hastalar düşük serum D vitamini seviyeleri ile başvurabilirler, ancak vitamin D düşüklüğü ile hastalık ve klinik belirti arasındaki ilişki hala belirsizdir. Amacımız, sklerodermalı hastalarda D vitamini eksikliğinin sıklığını belirlemek ve D vitamini konsantrasyonu ile sistemik sklerozun organ tutulumu ile arasındaki ilişkileri analiz etmektir. Materyal ve Metotlar: Bu çalışmada retrospektif olarak 54 Sistemik skleroz tanılı hastanın dosyası tarandı. Kontrol grubu olarak da metabolik kemik hastalığı ve romatolojik öyküsü bulunmayan 50 sağlıklı gönüllü alındı. D vitamini durumu, 25-hidroksivitamin D serum seviyeleri ölçülerek değerlendirildi. Skleroderma hastaları alt grupları ve organ tutulumu açısından veriler analiz edildi. Bulgular: Elli dört sistemik skleroz hastası (49 kadın, ortalama yaş 53,25±10,77 yıl ve hastalık süresi 8 (1-25) yıl) ve 50 kontrol (45 kadın, ortalama yaş 51,02±9,14 yıl) dahil edildi. Sistemik skleroz grubunda ortalama D vitamini düzeyi 11,35±4,09 ng/dL idi. Yedi hastada (%12,9) ağır D vitamini eksikliği (

Makale, WOS:000959740900001, The significant technological advances observed in the 21st century and resulting sociological changes require social adaptation. These changes created an essential role for the teachers to instruct the changing qualifications. The present study aimed to determine the profile of preschool teachers in Turkey. Thus, this research was designed as a descriptive study. The study group included 652 teachers. Most of the teachers participating in the research were female participants. Most of the teachers are graduates of pre-school education. However, there are also teachers who have graduated from child development and other fields. The "Turkish Preschool Education Student Profile Questionnaire" developed by Erkan et al. (2001) was adapted by the authors to research the teacher profile. When the findings were examined, it was found that 86% of the teachers participated in educational activities, and these educational activities generally participated in in-service trainings, scientific conferences and cultural events belonging to the ministry; they usually participate in these activities whenever they have the opportunity; the reasons for participating in educational activities are usually due to the lack of time and family situations; It has been determined that the hobbies of teachers are reading books, music, movies, theater and social media. In addition, it was determined that most of the teachers willingly chose pre-school education, as the reason for this, they generally showed that they love children and love to teach. Teachers stated that they volunteered to be a preschool teacher and that they love and care about children. The findings are discussed in the light of the relevant literature. Then recommendations are given., 21. yüzyıl ile ortaya çıkan muazzam teknolojik değişim ve buna bağlı olarak gelişen sosyolojik değişim, toplumların bu süreci yaratmasını ve buna uyum sağlamasını zorunlu kılmıştır. Bu süreçte yaşanan değişimin bir sonucu olarak öğretmenler, değişen niteliklerin topluma aktarılmasında önemli bir role sahiptir. Bu araştırma, Türkiye'de çalışmakta olan okul öncesi öğretmenlerinin profilini belirlemeyi amaçlamıştır. Bu amaçla bu araştırma, betimsel araştırma ile desenlendirilmiştir. Çalışma grubu 652 öğretmenden oluşmaktadır. Araştırmaya katılan öğretmenlerin çoğunu kadın katılımcılar oluşturmuştur. Öğretmenlerin çoğu okul öncesi eğitimi mezunudur. Bununla birlikte çocuk gelişimi ve diğer alanlardan mezun olan öğretmenler de mevcuttur. Erkan ve diğerleri tarafından 2001 yılında geliştirilen “Türkiye'de Okul Öncesi Eğitim Öğrenci Profiline Ait Anket” araştırmacılar tarafından uyarlanarak öğretmen profili için uygun hale getirilmiştir. Bulgular incelendiğinde öğretmenlerin %86’sının eğitsel aktivitelere katıldığı, bu eğitsel aktivitelerin genellikle bakanlığa ait hizmet içi eğitimler, bilimsel konferanslar ve kültürel etkinlikler olduğu; bu etkinliklere genellikle fırsat bulduklarında katıldıkları; eğitsel etkinliklere katılma nedenlerinin genellikle zaman bulma sıkıntısı ve ailesel durumlardan kaynaklı olduğu; öğretmenlerin hobilerinin kitap okuma, müzik, film, tiyatro ve sosyal medya şeklinde sıralandığı belirlenmiştir. Ayrıca öğretmenlerin birçoğu isteyerek okul öncesi eğitimi seçtiğini, bunun nedeni olarak da genellikle çocukları ve öğretmeyi sevmelerini belirtmiştir. Öğretmenler, okul öncesi öğretmenliğini isteyerek yaptıklarını, çocukları sevdiklerini ve önemsediklerini belirtmişlerdir. Bulgular ilgili alanyazın ışığında tartışılmıştır. Ardından önerilere yer verilmiştir.

(1) Objective: We performed a systematic review to explore the prevalence of intravenous (IV) rehydration therapy in hospital settings, and we assessed it by patient groups and populations. (2) Methods: A systematic review of major databases and grey literature was undertaken from inception to 28 March 2022. Studies reporting prevalence of IV rehydration therapy in a hospital setting were identified. The data were synthesised in a narrative approach. (3) Results: Overall, 29 papers met the inclusion criteria. The prevalence of IV rehydration therapy in paediatric patients ranged from 4.5% (hospitalised with diarrhoea and dehydration) to 100% (admitted to the emergency department with mild to moderate dehydration caused by viral gastroenteritis), and in adults this ranged from 1.5% (had single substance ingestion of modafinil) to 100% (hospitalised with hypercalcemia). The most common indication for IV rehydration therapy in paediatric patients was dehydration due to fluid loss from the gastrointestinal tract. Other causes included malnutrition, neuromuscular disease, bronchiolitis, and influenza. In adults, indications for IV rehydration therapy were much more diverse: fever, diarrhoea, drug intoxication, hypercalcemia, cancer, and postural tachycardia syndrome; (4) Conclusions: This systematic review showed that IV rehydration therapy in paediatric patients is often used to treat dehydration and diarrhoea, while in adults it has a broader spectrum of use. While IV rehydration therapy is important in correcting fluid problems and electrolyte status, the maintenance fluid prescribing practices vary considerably, and guidelines are scarce.

Purpose Multimorbidity (i.e., ≥ 2 chronic conditions) poses a challenge for health systems and governments, globally. Several studies have found inverse associations between multimorbidity and quality of life (QoL). However, there is a paucity of studies from low- and middle-income countries (LMICs), especially among the older population, as well as studies examining mediating factors in this association. Thus, the present study aimed to explore the associations, and mediating factors, between multimorbidity and QoL among older adults in LMICs. Methods Cross-sectional nationally representative data from the Study on Global Ageing and Adult Health were analyzed. A total of 11 chronic conditions were assessed. QoL was assessed with the 8-item WHO QoL instrument (range 0–100) with higher scores representing better QoL. Multivariable linear regression and mediation analyses were conducted to assess associations. Results The final sample consisted of 34,129 adults aged ≥ 50 years [mean (SD) age 62.4 (16.0) years; age range 50–114 years; 52.0% females]. Compared to no chronic conditions, 2 (b-coefficient − 5.89; 95% CI − 6.83, − 4.95), 3 (− 8.35; − 9.63, − 7.06), 4 (− 10.87; − 12.37, − 9.36), and ≥ 5 (− 13.48; − 15.91, − 11.06) chronic conditions were significantly associated with lower QoL, dose-dependently. The mediation analysis showed that mobility (47.9%) explained the largest proportion of the association between multimorbidity and QoL, followed by pain/discomfort (43.5%), sleep/energy (35.0%), negative affect (31.9%), cognition (20.2%), self-care (17.0%), and interpersonal activities (12.0%). Conclusion A greater number of chronic conditions was associated with lower QoL dose-dependently among older adults in LMICs. Public health and medical practitioners should aim to address the identified mediators to improve QoL in patients with multimorbidity.

Aims the literature regarding the association between multimorbidity and dementia is still unclear. Therefore, we aimed to explore the potential association between multimorbidity at the baseline and the risk of future dementia in the SHARE (Survey of Health, Ageing and Retirement in Europe) study, a large European research survey, with a follow-up of 15 years. Methods in this longitudinal study, multimorbidity was defined as the presence of two or more chronic medical conditions, among 14 self-reported at the baseline evaluation. Incident dementia was ascertained using self-reported information. Cox regression analysis, adjusted for potential confounders, was run and hazard ratios (HRs), with their 95% confidence intervals (CIs), that were estimated in the whole sample and by 5 year groups. Results among 30,419 participants initially considered in wave 1, the 23,196 included participants had a mean age of 64.3 years. The prevalence of multimorbidity at baseline was 36.1%. Multimorbidity at baseline significantly increased the risk of dementia in the overall sample (HR = 1.14; 95% CI: 1.03–1.27) and in participants younger than 55 years (HR = 2.06; 95% CI: 1.12–3.79), in those between 60 and 65 years (HR = 1.66; 95% CI: 1.16–2.37) and in those between 65 and 70 years (HR = 1.54; 95% CI: 1.19–2.00). In the overall sample, high cholesterol levels, stroke, diabetes and osteoporosis increased the risk of dementia, particularly if present among participants between 60 and 70 years of age. Conclusions multimorbidity significantly increases the risk of dementia, particularly in younger people, indicating the need for early detection of multimorbidity for preventing cognitive worsening.

An experiment was conducted at the Agronomy Field Laboratory, Bangladesh Agricultural University, Mymensingh from July to November 2015 to find out the effect of planting and nutrient management on the growth, yield and protein content of aromatic fine rice (cv. Binadhan-13). The experimental treatments comprised six planting arrangement viz. 25 cm × 20 cm, 25 cm × 15 cm, 25 cm × 10 cm, 20 cm × 20 cm, 20 cm × 15 cm, 20 cm × 10 cm and four nutrient management viz. recommended dose of inorganic fertilizer (RDF) N-P2O5-K2O-S-Zn at the rate of 75-42-75-17-2 kg ha-1 respectively; Cow dung @ 10 t ha-1, 25% less than RDF + Cow dung @ 5 t ha-1, 50% less than RDF + Cow dung @ 5 t ha-1. The experiment was laid out in a randomized complete block design (RCBD) with three replications. Different crop characters, yield contributing characters, yield and grain quality were significantly influenced by planting arrangement and nutrient management. In the crop growth stage, the maximum number of tillers hill-1 (19.03) was recorded from the 25 cm × 15 cm spacing fertilized with 25% less than RDF + cow dung @ 5 t ha-1 and the highest total dry matter production (62.70), crop growth rate (19.37) and chlorophyll content (35.77) of leaf were recorded from the 20 cm × 15 cm spacing fertilized with 25% less than RDF + cow dung @ 5 t ha-1. At harvest, the highest grain yield (3.66 t ha-1) and protein content (9.63%) were recorded from the 20 cm × 15 cm spacing fertilized with 25% less than RDF + cow dung @ 5 t ha-1. So, transplantation at 20 cm × 15 cm spacing and fertilization with 25% less than the recommended dose of inorganic fertilizer + cow dung @ 5 t ha-1 was found to be promising practice for the cultivation of aromatic fine rice (cv. Binadhan-13).

Objective: We aimed to assess cardiac autonomic balance with heart rate variability by using 24-hour Holter electrocardiography and also to assess susceptibility to ventricular arrhythmias by using microvolt T wave alternance in children with attention deficit hyperactivity disorder. Method: This study was conducted with age- and gender-matched groups of 40 patients taking long-acting methylphenidate for more than a year and 55 healthy controls. Heart rate variability analysis for cardiac autonomic functions and microvolt T wave alternance measurements for susceptibility to ventricular arrhythmias were evaluated by 24-hour Holter electrocardiography. Results: The mean age 10.9 ± 2.7 years, mean duration of therapy 22.76 months, and mean methylphenidate doses were 37.64 mg/day. The study group had considerably higher rMSSD, higher HF, and a lower LF/HF ratio (respectively, p : 0.02, p : 0.001 and p : 0.01). While parasympathetic activity parameters were elevated, sympathetic activity parameters were low during the sleep period. Increase in the microvolt T wave alternance values of the study group was not found to be statistically significant (p > 0.05). Conclusion: In children taking long-acting methylphenidate, the autonomic balance was shown to be in favour of the parasympathetic system. Determination of the vulnerability to life-threatening ventricular arrhythmias has been evaluated for the first time in children with attention deficit hyperactivity disorder. Accordingly, microvolt T-wave alternance values give the notion that drug use is safe.

İnsan hayatında önemli bir geçiş dönemi olan Evlilik, insanoğlunun çocukluk ve ergenlik döneminden sonra gerçekleştirdiği bir aşamadır. Toplum neslinin devamı ve aile çatısının oluşumu için gerekli bir aşamadır. Bu aşamayı şekillendiren toplumsal, dini ve ekonomik birçok etkeninde şekillendirdiği evlilik kurumu birçok ülkeye göre değişiklik göstermektedir. Bu çalışmada yüzyıllardır sınır komşusu olarak bu coğrafyada ortak tarihe ve kültüre sahip olan Türkiye İran Azerbaycan kültürüne ait evlilik ve düğün ritüelleri ele alınmıştır. İki ülkenin insan hayatında bir geçiş dönemi olan evlilik sürecinde ne tür aşamalar olduğu belirtilmiştir. Çalışmada belirtilen “eş seçimi”, “kız isteme”, “söz kesme”, “nişan”, “çeyiz”, “kına gecesi”, “düğün günü” ve “nikâh ve gerdek” gibi başlıklar altında her iki kültüre ait ritüeller elde edilerek hangi noktalarda benzerlik gösterdikleri, hangi noktada ayrıştıkları somut verilerle ortaya konulmuştur. Toplum içerisinde sosyal ve ekonomik konum, yaşam biçimleri evlilik sürecinde birtakım değişiklikleri de beraberinde getirmektedir; Bu çalışmada her iki ülkenin ritüelleri ana hatlarıyla ele alınmıştır. Çalışmada Türkiye kısmı yapılan çalışmalar üzerinden değerlendirilirken, İran Azerbaycan bölgesi için coğrafyanın genel durumu göz önünde bulundurularak 20 soruluk mülakat soruları kullanılmıştır. Bireylerle yüz yüze görüşülmüştür. Yapılan görüşmelerden elde edilen bilgilerin içerik yorumlamaları yapılmış, evlenme ve düğün ritüeli ile ilgili somut veriler toplanmıştır. Her iki bölgenin evlenme öncesi, düğün süreci ve düğün sonrası yapılan etkinliklere ilişkin bilgiler tespit edilerek ritüeller ortaya çıkarılmıştır. Çalışma sonucunda elde edilen bulgularla, her iki bölgede evlilik sürecine dair okuyucuyu bilgilendirmesi ve başka çalışmalara katkı sağlaması amaçlanmıştır.

ÖZ Amaç: Maksilla ve mandibulanın trabeküler mikromimarisini mikrobilgisayarlı tomografi (mikro-BT) kullanarak değerlendirmek. Materyal ve metod: Yirmi adet maksiller ve mandibula kadavra örneği, mikro BT kullanılarak tarandı. Numuneler Skyscan 1275® micro-CT sistemi (SkyScan, Kontich, Belçika) kullanılarak aşağıdaki parametrelerle tarandı. Tarama verileri CTan yazılımına aktarıldı ve analiz edildi. Morfometrik parametreler; doku hacmi (DH), Kemik hacmi (KH), kemik hacmi yüzdesi (KH/DH), doku yüzeyi (DY), kemik yüzeyi (KY), kesişme yüzeyi (KY), kemik yüzeyi/hacim oranı (KY/KH), kemik yüzey yoğunluğu (BS/TV), trabeküler patern faktörü (Tb.Pf), yapı modeli indeksi (YMI), trabeküler kalınlık (Tb. Th), trabeküler ayrılma (Tb. Sp), trabeküler sayı (Tb.N) ve anizotropi derecesi (DA), CTAnalyzer yazılımı kullanılarak değerlendirildi. İstatistiksel anlamlılık p

A modified applied element model to simulate the behaviour of plain concrete continuum structures including discrete cracking is proposed in this study. In the classical applied element model, Poisson effects are fully ignored. To remediate this issue, diagonal elements are introduced to include the Poisson effect, and the constitutive parameters are rigorously determined using the Cauchy–Born rule and the hyper-elastic theory. The formulation is validated for linear elastic problems and the consistency and convergence behaviour of the numerical approach is shown. Tensile softening formulation using the concept of fracture energy is utilised for the nonlinear range. In this range, the approach is validated using the classical benchmark tests with pure tensile, split-tensile, combined shear-tensile and bending dominated push-over loading. The load–displacement behaviour and crack response were captured successfully, showing the proposed methodology can be used to quantify discrete cracks on large systems, such as dam monoliths, from initiation to significant damage levels.

In this paper, I develop an algorithmic impossible-worlds model of belief and knowledge that provides a middle ground between models that entail that everyone is logically omniscient and those that are compatible with even the most egregious kinds of logical incompetence. In outline, the model entails that an agent believes (knows) $\phi $ just in case she can easily (and correctly) compute that $\phi $ is true and thus has the capacity to make her actions depend on whether $\phi $ . The model thereby captures the standard view that belief and knowledge ground are constitutively connected to dispositions to act. As I explain, the model improves upon standard algorithmic models developed by Parikh, Halpern, Moses, Vardi, and Duc, among other ways, by integrating them into an impossible-worlds framework. The model also avoids some important disadvantages of recent candidate middle-ground models based on dynamic epistemic logic or step logic, and it can subsume their most important advantages.

Microorganisms are crucial for human survival in view of both mutualistic and pathogen interactions. The control of the balance could be achieved by use of the antibiotics. There is a continuous arms race that exists between the pathogen and the antibiotics. The emergence of multidrug-resistant (MDR) bacteria threatens health even for insignificant injuries. However, the discovery of new antibiotics is not a fast process, and the healthcare system will suffer if the evolution of MDR lingers in its current frequency. The cationic photosensitizers (PSs) provide a unique approach to develop novel, light-inducible antimicrobial drugs. Here, we examine the antimicrobial activity of innovative selenophene-modified boron dipyrromethene (BODIPY)-based PSs on a variety of Gram (+) and Gram (-) bacteria. The candidates demonstrate a level of confidence in both light-dependent and independent inhibition of bacterial growth. Among them, selenophene conjugated PS candidates (BOD-Se and BOD-Se-I) are promising agents to induce photodynamic inhibition (PDI) on all experimented bacteria: E. coli, S. aureus, B. cereus, and P. aeruginosa. Further characterizations revealed that photocleavage ability on DNA molecules could be potentially advantageous over extracellular DNA possessing biofilm-forming bacteria such as B. cereus and P. aeruginosa. Microscopy analysis with fluorescent BOD-H confirmed the colocalization on GFP expressing E. coli., NA

Background: Sleep duration may influence risk for sarcopenia but studies on this topic are scarce, especially from low and- middle-income countries (LMICs). Thus, the aim of the present study was to investigate the association between sleep duration and sarcopenia among adults aged ≥ 65years from five LMICs (China, Ghana, India, Russia, South Africa). Methods: Cross-sectional, community-based data from the WHO study on global ageing and adult health (SAGE) were analysed. Sarcopenia was defined as having low skeletal muscle mass (SMM) and weak handgrip strength, while severe sarcopenia was defined as having low SMM, weak handgrip strength, and slow gait speed. Self-reported sleep duration in the past two nights were averaged and classified as ≤ 6, > 6 to ≤ 9, and ≥ 9h/day. Multivariable logistic regression analysis was conducted. Results: Data on 13,210 adults aged ≥ 65years [mean (SD) age 72.6 (11.3) years; 55.0% females] were analyzed. In the overall sample, compared to > 6 to ≤ 9h/day of sleep duration, > 9h/day was associated with 1.70 (95% CI 1.15–2.51) and 1.75 (95% CI 1.08–2.84) times higher odds for sarcopenia and severe sarcopenia, respectively. No significant associations were observed among males, but associations were particularly pronounced among females [i.e., OR = 2.19 (95% CI 1.26–3.81) for sarcopenia, and OR = 2.26 (95% CI 1.20–4.23) for severe sarcopenia]. Conclusions: Long sleep duration was associated with an increased odds of sarcopenia and severe sarcopenia in LMICs, particularly in females. Future studies should investigate whether addressing long sleep duration among females can lead to lower risk for sarcopenia onset in LMICs. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

BackgroundPain and sarcopenia are common in older people. Cross-sectional studies have reported a significant association between these two conditions, but cohort studies exploring pain as a potential risk factor for sarcopenia are scarce. Given this background, the aim of the present work was to investigate the association between pain (and its severity) at baseline, and the incidence of sarcopenia over 10 years of follow-up in a large representative sample of the English older adult population.MethodsPain was diagnosed using self-reported information and categorized as mild to severe pain at four sites (low back, hip, knee, and feet). Incident sarcopenia was defined as having low handgrip strength and low skeletal muscle mass during the follow-up period. The association between pain at baseline and incident sarcopenia was assessed using an adjusted logistic regression analysis, and reported as odds ratios (ORs) with their 95% confidence intervals (CIs).ResultsThe 4 102 participants without sarcopenia at baseline had a mean ± standard deviation age of 69.7 ± 7.2 years, and they were mainly male (55.6%). Pain was present in 35.3% of the sample. Over 10 years of follow-up, 13.9% of the participants developed sarcopenia. After adjusting for 12 potential confounders, people with pain reported a significantly higher risk of sarcopenia (OR = 1.46: 95% CI: 1.18–1.82). However, only severe pain was significantly associated with incident sarcopenia, without significant differences across the four sites assessed.ConclusionsThe presence of pain, particularly severe pain, was associated with a significantly higher risk of incident sarcopenia.

Purpose Food insecurity and multimoribidity (i.e., ≥ 2 chronic conditions) may be linked bidirectionally, but there are no studies on this topic from LMICs. Therefore, the aim of the present study was to examine the association between food insecurity and physical multimorbidity in a large representative sample of older adults from six LMICs. Methods Cross-sectional, community-based data on adults aged ≥ 50 years from the World Health Organization’s Study on Global AGEing and Adult Health (SAGE) conducted in China, Ghana, India, Mexico, Russia, and South Africa were analyzed. A total of 11 chronic physical conditions were assessed. Past 12 month food insecurity was assessed with two questions on frequency of eating less and hunger due to lack of food. Multivariable logistic regression analysis was conducted to assess the associations. Results Data on 34,129 adults aged ≥ 50 years [mean (SD) age 62.4 (16.0) years; age range 50–114 years; 47.9% males] were analyzed. After adjustment for potential confounders, in the overall sample, compared to being food secure, moderate and severe food insecurity were associated with 1.29 (95% CI 1.06–1.56) and 1.56 (95% CI 1.13–2.16) times higher odds for multimorbidity, respectively Conclusion Food insecurity was associated with greater odds for multimorbidity in older adults from LMICs. Addressing food insecurity in the general population may reduce risk for multimorbidity, while screening for food insecurity and addressing it among those with multimorbidity may lead to better clinical outcomes, pending future longitudinal research

Background/Aim: Oxidative stress is known to increase in patients receiving anesthesia before undergoing surgery. Since newborns are more sensitive to oxygen-free radicals, the effects and characteristics of anesthesia methods that are used for pregnant women require analysis. This study aimed to evaluate the effects of spinal and general anesthesia on oxidative stress by investigating thiol disulfide and ischemia modified albumin (IMA) concentrations in the cord blood of patients undergoing cesarean section (C-section) via spinal or general anesthesia. Methods: This cross-sectional prospective study included 60 patients who were indicated for elective cesarean section. Patients with chronic disease, pregnancy complications and/or required emergency cesareans were not included. Group 1 (n = 30) underwent general anesthesia, and Group 2 (n = 30) underwent spinal anesthesia during their C-sections. Thiol–disulfide levels were evaluated concurrently in all blood samples taken from the umbilical artery remaining on the placental side. Results: The mean age (SD) of the mothers was 30.6 (4.4) years and the mean gestational age (SD) was 39.0 (0.9) weeks. Gestational age, birth weight, and first and fifth min Apgar scores of the two groups were similar. The mean (SD) native thiol (362.4 [63.8]; 323.2 [45.8]), total thiol (409.6 [70.2]; 363.5 [46.1]), and disulfide values (23.6 (5.4); 20.2 (4.3)) were significantly higher in group 1 than group 2, while the median (interquartile range [IQR]) values of IMA (0.89 (0.85-max 0.92); 0.85 (min 0.82-max 0.879) were significantly higher in group 2 than group 1 (P < 0.05). Conclusions: As general anesthesia may cause a higher degree of oxidative stress, selecting the appropriate anesthetic technique may be especially important for risky pregnancies in which increased oxidative stress in the mother and baby may be critical for the outcome.

Purpose This study explores the relationships between the cognitive demands of the questions asked by a teacher educator (TE) and prospective teachers’ (PT) capacity for critical thinking (CT). Design/Approach/Methods Participants comprised a TE and 32 PTs. The cognitive demands of the TE's questions and PTs’ CT were analyzed using a systematic observation approach. Findings Results indicate that there are tangible connections between the increasing mental demand of TE questions and PTs’ higher-order cognitive processing. The PTs achieved higher-order CT when the TE asked more cognitively demanding questions. For instance, when the TE's questions were pitched at the cognitive demand levels—namely, the analyze, evaluate, and/or create levels—the PT answers were longer and reflected higher CT, such as inductive reasoning, suggesting new ways of thinking, or legitimating the arguments of others. Accordingly, results suggest that intentionally subjecting PTs to sustained higher cognitive demands via questions may help them reach their optimal CT capacity. Originality/Value Although proposed teaching strategies have been invaluable in proposing content-specific interventions for fostering the CT of university students, how lecturers should use their questions to conduct such interventions has been overlooked. This study addresses this gap.

Background: In the absence of evidence from randomised controlled trials, observational data can be used to emulate clinical trials and guide clinical decisions. Observational studies are, however, susceptible to confounding and bias. Among the used techniques to reduce indication bias are propensity score matching and marginal structural models. Objective: To use the comparative effectiveness of fingolimod vs natalizumab to compare the results obtained with propensity score matching and marginal structural models. Methods: Patients with clinically isolated syndrome or relapsing remitting MS who were treated with either fingolimod or natalizumab were identified in the MSBase registry. Patients were propensity score matched, and inverse probability of treatment weighted at six monthly intervals, using the following variables: age, sex, disability, MS duration, MS course, prior relapses, and prior therapies. Studied outcomes were cumulative hazard of relapse, disability accumulation, and disability improvement. Results: 4608 patients (1659 natalizumab, 2949 fingolimod) fulfilled inclusion criteria, and were propensity score matched or repeatedly reweighed with marginal structural models. Natalizumab treatment was associated with a lower probability of relapse (PS matching: HR 0.67 [95% CI 0.62-0.80]; marginal structural model: 0.71 [0.62-0.80]), and higher probability of disability improvement (PS matching: 1.21 [1.02 -1.43]; marginal structural model 1.43 1.19 -1.72]). There was no evidence of a difference in the magnitude of effect between the two methods. Conclusions: The relative effectiveness of two therapies can be efficiently compared by either marginal structural models or propensity score matching when applied in clearly defined clinical contexts and in sufficiently powered cohorts.

BACKGROUND: The COVID-19 pandemic has brought many restrictions that affected Turkey as well as other countries around the world. Restrictions on education, sports activities and social activities affected students physically and psychologically. OBJECTIVE: The aim of this study is to investigate the impact of the COVID-19 pandemic on weight gain, physical activity, and mental health among university students. METHODS: The study included students of Pamukkale University aged between 18–25 years. Participants answered the online survey about changes in body composition and physical activity habits during the pandemic. International Physical Activity Questionnaire (IPAQ) was used to assess physical activity levels. Beck Depression Scale (BDS) was used to assess the mental health. RESULTS: 848 (546 females, 302 males) students average aged 20,72±1,63 years were included in the study. When the physical activity times before and during the pandemic were compared, a statistically significant difference was found (p

Objective: Acute ischemic stroke (AIS) is a major cause of mortality and morbidity throughout the world. Intravenous thrombolysis (IVT) and endovasculary treatments (EVT) are recomended currently in eligible patients admitted within the therapeutic window. In this study, the data of AIS patients who were treated with intravenous and EVT methods in Istanbul Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital between 2017-2020 were evaluated retrospectively. Materials and Methods: Five hundred and ninety patients who received IVT and/or EVT were included in the study. Demographic, clinical, radiological characteristics, risk factors and post-treatment clinical characteristics of these patients were analyzed. Results: Of the 590 patients, 324 (54.9\%) underwent IVT, 164 (27.8\%) EVT and 102 (17.3\%) combined IVT+EVT. The median National Institutes of Health Stroke Scale (NIHSS) scores were 9 (1-21) in the iv tPA group, 13 (3-27) in the EVT group, 12 (4-23) in the combined treatment group at admission In the IVT group, 220 patients had no artery occlusion (67.9\%), M2 segment of the middle cerebral artery (MCA) was found to be the most frequently occluded artery with 32 patients (9.9\%). In the EVT and combined IVT+EVT groups, the M1 segment of the MCA had the highest occlusion rate {[}76 (44.2\%), 49 (45\%), respectively]. Asymptomatic hemorrhage rate was higher in the EVT group than the other groups. Symptomatic hemorrhage rate was lower in the IVT group compared to the other groups. A total of 182 (56.2\%), 67 (39\%) and 53 (48.6\%) patients in the IVT, EVT and combined IVT+EVT groups had good outcome, respectively. Conclusion: Acute stroke treatment has been proven to significantly reduce the serious burden of stroke on patients, caregivers and society. For this reason, the societal awareness of the importance of urgent admission to emergency departmentsand the number and capacity of centers that provide AIS treatments should be increased.

2020 yılı başından itibaren Dünya genelinde yaşanan Kovid-19 pandemisi ile birlikte Ekim 2021’de ünlü sosyal medya şirketi Facebook’un bir sanal gerçeklik/artırılmış gerçeklik teknolojisi olarak “Meta” uygulamasını tanıtması sonrasında VR/AR teknolojilerine ilgi hızlı bir artış seyrine girmiştir. Bilgi teknolojileri, modern dünyayı tamamen değiştirmekte ve sosyal ilişkilerin dijitalleşmesi, insanlar arasındaki etkileşimin manzarasını, sosyal gerçekliğin doğasını ve yönünü büyük ölçüde dönüşüme zorlamaktadır. Bu dönüşüm, ülkelerin ceza politikaları ile ceza hukuku yaklaşımlarını da yakından etkilemektedir. Her geçen gün, VR/AR ortamlarında işlendiği iddia edilen hukuka aykırı eylemlerle daha sık karşılıyoruz. VR/AR teknolojilerinin haptik etkilerinin geliştirilmesi, bu ortamlarda işlenen eylemlerin sanal-ötesi etkiler olarak nitelendirilme olasılığını da güçlendirmektedir. Makaleyle, söz konusu etkileşimlerin ceza hukuku ve felsefesi ile penoloji üzerindeki olası etkilerine ilişkin bir tartışma oluşturulması arzu edilmiştir.

Introduction: New surgical treatment methods are being investigated in sacrococcygeal pilonidal sinus disease. Minimal invasive methods such as endoscopic pilonidal sinus treatment (EPSIT) and sinus laser therapy (SiLaT) have promising results and advantages of laparoscopic surgery. Aim: To compare the efficiency and safety of EPSIT with SiLaT. Material and methods: Seventy-three patients with pilonidal sinus who had undergone EPSIT or SiLaT within 2 years were evaluated retrospectively. Data of patients’ demographics, complications and postoperative course were collected and compared between the two groups. Results: We analyzed seventy-three patients who underwent EPSIT or SiLaT, with a mean age of 23.4 ±8.4 (12–46) years and body mass index (BMI) of 25.5 ±4.5 (18–38) kg/m2. Among them, 36 patients (26 males, ten females) underwent EPSIT and 37 patients (27 males, ten females) underwent SiLaT. Mean operative time was similar for both groups (32.3 ±14.8 vs. 31.0 ±14.8; p = 0.757). Early complications (minimal bleeding) were recorded in 2 patients in the SiLaT group. The duration of analgesic use was significantly lower in the EPSIT group compared to the SiLaT group (1.3 ±0.5 (1–3) vs. 1.9 ±1.1 (1–5); p = 0.005). The mean postoperative time of total wound healing was similar for both groups: 23.6 ±14.7 (12–90) vs. 25.2 ±14.5 (14–90) days (p = 0.385). There was no significant difference in the average time of return to total daily activity (3.4 ±0.9 (2–5) vs. 3.6 ±1.2 (2–7) days, p = 0.679). There were no significant differences between the groups regarding late postoperative complications (recurrence: 7). Conclusions: Both methods have similar early and late complications. The duration of need for analgesic usage was shorter in EPSIT patients. © 2023 Termedia Publishing House Ltd.. All rights reserved.

Background/aim: During multiple sclerosis (MS) treatment different modes of action such as lateral (interferon beta to glatiramer acetate or glatiramer acetate to interferon beta) or vertical (interferon beta/glatiramer acetate to fingolimod) drug switch can be performed. This study aims to investigate the clinical effectiveness of switching from the first-line injectable disease modifying treatments (iDMTs) to fingolimod (FNG) compared to switching between first-line iDMTs. Materials and methods: This is a multicenter, observational and retrospective study of patients with relapsing-remitting MS who had lateral and vertical switch. The observation period included three key assessment time points (before the switch, at switch, and after the switch). Data were collected from the MS patients’ database by neurologists between January 2018 and June 2019. The longest follow-up period of the patients was determined as 24 months after the switch. Results: In 462 MS patients that were included in the study, both treatments significantly decreased the number of relapses during the postswitch 12 months versus preswitch one year while patients in the FNG group experienced significantly fewer relapses compared to iDMT cohort in the postswitch 12 months period. FNG cohort experienced fewer relapses than in the iDMT cohort within the postswitch 2 year. The mean time to first relapse after the switch was significantly longer in the FNG group. Conclusion: The present study revealed superior effectiveness of vertical switch over lateral switch regarding the improvement in relapse outcomes. Patients in the FNG cohort experienced sustainably fewer relapses during the follow-up period after the switch compared the iDMT cohort. Importantly, switching to FNG was more effective in delaying time to first relapse when compared with iDMTs.

Context: More studies are needed to compare the effect of voluntary contraction, electrical stimulation, and electrical stimulation superimposed onto voluntary contraction in improving trained and untrained homolog muscle strength and lower-extremity endurance. Design: Seventy-six healthy young adults (age = 20.41 [3.07] y, 61 females and 15 males) were included in the study. Subjects were randomly divided into 3 groups as voluntary isometric contraction (IC) group, Russian current (RC) group, and superimposed Russian current (SRC) group. Methods: All training regimens were performed under physiotherapist supervision for a total of 18 sessions (3 times per week for 6 wk). In each session, 10 ICs were achieved with voluntary isometric exercise only, RC only, or RC superimposed onto ICs. Main outcome measures were trained and untrained quadriceps strength (maximal voluntary isometric contraction [MVIC]) and lower-extremity endurance (sit-to-stand test). Results: After 6 weeks of training, all outcome measures improved in all groups (P P = .562). The trained quadriceps MVIC score (P η2 = .478), untrained quadriceps MVIC score (P = .011, η2 = .115), and sit-to-stand test score (P η2 = .357) differed significantly among the 3 groups; post hoc analysis revealed that the trained quadriceps MVIC score was higher in SRC and RC groups than in the IC group, untrained quadriceps MVIC score was higher in SRC group than in the RC group, and sit-to-stand test score was higher in SRC group than in the RC group and IC group. Conclusions: RC and RC superimposed onto IC are superior to IC in improving quadriceps muscle strength, and RC superimposed onto IC is superior to RC and IC in improving lower-extremity endurance. RC superimposed onto IC and voluntary IC created cross-education effect on untrained quadriceps.

The aim of this study was to investigate the polymorphism of the ? – casein gene (kappa casein, CSN3) in buffaloes and determine its effects on milk yield traits. Data were obtained from 2016 to 2019 from all animals in the ongoing Anatolian Buffalo Breeding Project. Genomic DNA was collected from a total of 209 buffaloes of different ages and sexes, namely 31 Murrah, 46 Anatolian buffaloes, and 132 of their crosses (Murrah × Anatolian). Genotyping of CSN3 gene by polymerase chain reaction–restriction fragment length polymorphism (PCR – RFLP) technique with restriction enzyme (AcuI) revealed three genotypes: AA (0.689), AB (0.282), and BB (0.028), and the frequencies of A and B alleles were 0.83 and 0.17, respectively. A total of 113 milk yield data and 74 milk component analyses of dairy buffaloes were used to compare CSN3 genotypes for milk yield traits. Statistical analysis showed that there was a significant difference in lactation milk yield between CSN3 genotypes: BB, 1560.3 ± 326.7 kg, AB, 1278.1 ± 111.3 kg, and AA, 1060.9 ± 85.6 kg (p < 0.05). However, the mean values of lactation length and milk components were not significant between genotypes (p > 0.05). These results suggest that these variations $(135^{ThrACC} / IleATC /136^{ThrACC} / ThrACT)$ in the buffalo CSN3 gene may be used as genetic markers in dairy buffalo breeding programs.

Çeviri, sadece farklı milletlerden farklı insanların iletişiminde değil, aynı zamanda bir milletin siyasetinin, kültürünün ve toplumunun gelişmesinde de önemli bir rol oynamaktadır. Farsçadan Türkçeye birçok eser tercüme edilmiş, her iki dil ve kültür etkileşim içinde olmuştur. Bu çalışmada, İranlı şair Nizâmi Gencevî’nin hamselerinden biri olan Leyla ile Mecnun adlı mesnevisinin Ali Nihat Tarlan (1965), A. Naci Tokmak (2013) ve Samed Vurgun (2019) tarafından yapılan Türkçe çevirileri, Belçikalı bilim insanı André Lefevere tarafından öne sürülen “yeniden yazma” kavramına göre değerlendirilmektedir. Çalışmada ilk olarak “yeniden yazma” kavramı genel hatlarıyla ele alınarak çalışmanın genel çerçevesi belirlenmektedir. Çalışma üç bölümden oluşmaktadır. Birinci bölümde André Lefevere’nin savunduğu çeviride yeniden yazma kavramı hakkında bilge verilmektedir. İkinci bölümde çalışmanın temellendirilmesi için kaynak metin ve yazarı hakkında kısaca bilgi verilmektedir. Üçüncü bölümde çeviri aracılığıyla yapıtların farklı kültürlere taşındığı savunulan yeniden yazma kavramı doğrultusunda kaynak ve erek metinlerden alınan örneklerle çevirmen yorumları, çeviri stratejileri tespit edilmektedir. Çalışma, kaynak metin aktarımının erek metinlerdeki görünümünü, çevirmenin ekleme ya da çıkarma yapıp yapmadığını ve çevirmenin yeniden yazma eylemini tespit etmeyi amaçlamaktadır., Translation plays an important role, not only in communication between people of different nationalities, but also in the development of politics, culture, and society. Many works have been translated from Persian to Turkish, and the languages have been in interaction for centuries. In this study, Turkish translations of Leila and Majnun, one of the masnavi of the Iranian poet Nizami Ganjavi, by Ali Nihat Tarlan (1965), A. Naci Tokmak (2013) and Samed Vurgun (2019) are evaluated according to the concept of rewriting put forward by the Belgian scientist André Lefevere. The general framework of the study is determined by first considering the concept of rewriting in general terms. This study includes three parts. In the first part, information is provided about the concept of rewriting in translation, as advocated by André Lefevere. In the second part, brief information about the source text and its author are provided to justify the study. In the third chapter, translator comments and translation strategies are determined with the examples taken from source and target texts in line with the concept of rewriting, which claims to transfer works to different cultures through translation. The study aims to determine the appearance of the source text transfer in the target texts, whether the translator adds or removes something, and the translator’s rewriting action.

Bu çalışmada, eksenel yükleme testi yapılan beş farklı projeye ait derin karıştırma kolonlarının taşıma gücünün grafiksel ve analitik yöntemler ile belirlenmesi ve sonuçların birbiri ile kıyaslanması olarak amaçlanmıştır. Yükleme deneylerinin sonuçlarının yorumlanmasında literatürde sıkça kullanılan üç yöntem kullanılmıştır. Bunlar Decourt, De Beer ve Chin-Kondner yöntemleridir. Sahada oluşturulan derin karıştırma kolonlarına eksenel yükleme testleri uygulanmıştır. Her proje için daha önceden belirlenen proje yükü değeri baz alınarak yükleme gerçekleştirilmiştir. Yük artışı ile deformasyonlar arasındaki ilişkiden yola çıkılarak yapılan hesaplamalarda Decourt ve Chin-Kondner yöntemleri ile hesaplanan taşıma gücü değerlerinin beş proje için birbirine yakın sonuçlar verdiği ortaya çıkmıştır. De Beer yöntemi ile hesaplanan taşıma gücü değerleri diğer yöntemlere oranla nispeten daha düşük çıkmıştır.

Background-\ud \ud Both obesity and malnutrition are common health problems in older adults.\ud \ud Aim-\ud \ud The aim of our study is to investigate the prevalence of undernutrition and related factors in older obese patients.\ud \ud Methods-\ud \ud 1911 older outpatients who underwent comprehensive geriatric assessment were included in this cross-sectional study. Body mass index (BMI) was categorized as follows: ‘Underweight’ = BMI 23.5, 17–23.5, or

Aim Cardiovascular morbidity is increased in patients with psoriatic arthritis (PsA) compared to the general population. Several recent studies have indicated that pentraxin 3 (PTX-3) and cell adhesion molecules (CAMs) might be independent biomarkers of subclinical atherosclerosis. In this study, we aimed to determine the relationship of CAMs and PTX-3 with carotid intima media thickness (CIMT) in patients with PsA and to compare CIMT and serum levels of these biomarkers in patients with healthy controls (HCs). Method PsA patients fulfilling the CASPAR (Classification criteria for Psoriatic Arthritis) criteria without traditional cardiovascular (CV) comorbidity and HCs without autoimmune and/or CV disease were included in this cross-sectional study. Carotid artery Doppler ultrasound examinations were conducted by a single radiologist blinded to the participants’ clinical characteristics. Serum vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin, and PTX-3 concentrations were analized. Results 43 PsA patients (27 females, mean age 42.49±11.70 years, and a mean disease duration of 9.37±7.96 years) and 37 HCs (28 females, mean age 42.16±11.38 years) were included. In regression analyses, age and PTX-3 were found to be the best predictors of CIMT in patients with PsA. CIMT was significantly higher in PsA patients compared with HCs (0.63±0.18 vs. 0.49±0.10 mm, p Conclusion In our study, age and serum level of PTX-3 were found to be the predictors of CIMT in patients with PsA without CV comorbidity. This outcome highlights the importance of monitoring CIMT and serum level of PTX-3 as CV risk factors in PsA patients.

The design and exploration of carbon-based electrode materials have become highly significant for developing supercapacitor technology, which has attracted considerable attention in energy storage systems. Here, nitrogen-doped reduced graphene oxide (N-rGO) – Polyaniline (PANI) nanocomposites were synthesized by a facile two-step method in which in situ polymerization of aniline monomer was performed on hydrothermally synthesized N-rGO nanosheets in DBSA and H2SO4 medium for co-doping of PANI chains. The effects of acid concentrations (DBSA:H2SO4 0.5 − 0.25:1 n/n) and N-rGO:aniline ratio (N-rGO:aniline 1:4–10 m/m) used in the preparation of the electrode material on the capacitive properties were investigated. It is found that the co-doped N-rGO-PANI nanocomposites exhibit a high specific capacitance of 346.3 Fg− 1 at 1 Ag− 1, remarkable rate capacity (99.9%, 1–10 Ag− 1) and excellent cycling stability at 5 Ag− 1 (81.3%, 5000 cycles) in a two-electrode system. As a result, constructing co-doped PANI chains and N-doped rGO provided a viable and simple way to improve the capacitive performances of supercapacitors.

Background: Cytogenetic findings are important prognostic factors in acute myeloid leukemia. Large systematic data about chromosomal characteristics of Turkish AML patients have not been reported to date. Objectives: The karyotypic profiles of 157 adult AML patients were evaluated retrospectively and compared with other reports from different populations. Methods: Cytogenetics analyses were performed on bone marrow samples using G-banding. Patients were categorized according to their cytogenetic results into four groups with the addition of a normal karyotyped group to the favorable, intermediate and adverse groups of European Leukemia Network. Results: Cytogenetic analyses were carried out successfully in 138 patients (88%). Abnormal karyotypes were found in 79 (57.2%) patients of which 13 (9.4%) were in favorable, 37 (26.8%) in intermediate and 29 (21%) in adverse groups. t(8;21) (5%) was the most common favorable abnormality while monosomal karyotypes (15.9%) in adverse group. Conclusion: This single center study is the most comprehensive study about the cytogenetic profile of acute myeloid leukemia in Turkey with comparison of other population-based studies. While there were similarities and differences with different publications, our results did not show a marked tendency to the findings of any specific geographic region. Keywords: Acute myeloid leukemia; cytogenetics; chromosomal abnormalities; adult.

Background: The most frequent cytogenetic aberration is 13q14.3 deletion in Chronic Lymphocytic Leukemia (CLL). HsamiR-15a/hsa-miR-16-1 are tumor suppressor miRNAs encoded from 13q14.3 region. Objectives: The aim of this study was to investigate the 13q14.3 deletion using molecular and cytogenetic techniques and association with miRNA-15a/miRNA-16-1. Materials And Methods: We used peripheral blood samples of 30 CLL patients who were either induced and or non-induced with DSP30+IL-2 to determine 13q14.3 deletion by karyotyping and iFISH. Expression levels of hsa-miR-15a/miR-16-1 were measured using qRT PCR and compared with deletions. Results: 13q14.3 deletion was detected in 8.6% of cases by karyotyping and in 65% by iFISH. Mosaic forms (monoallelic+biallelic) were observed in 50% of cases. Besides determining common chromosome abnormalities such as add(2)(q37), t(2;7) (p11.2;q22), del(6)(q13q21), del(6)(q25), add(9)(q21), del(11)(q23), t(11;14)(q13;q32), del(13)(q11q12), del(13)(q12q14), add(14)(q23), del(14)(q23), t(14;19)(q32;q13.1), del(15)(q23), del(17)(p12), t(18;22)(q21;q11.2), add(21)(p13) and t(17;21)(q11.2;122), we also determined t(1;13)(q32;q34), inv(2)(p25q21), del(13)(q22q32), t(14;19) (q24;q13), dup(17)(q21q23), der(21;21)(p13;p13) which have not been reported previously. Mitotic index data was found statistically significant and DSP30+IL-2 increased mitotic index by 2.5 folds. Association between decreased miR-16-1 expression and deletions was statistically significant. Conclusion: We suggest that cytogenetic and iFISH analyses are complementary and use of DSP30+IL-2 is effective .in CLL. Decreased expression of hsa-miR-16-1 is remarkable. Keywords: CLL; miR-15a/miR-16-1; 13q14.3 deletion.

Introduction: Cardiac arrhythmias and sudden death may occur as a result of ventricular myocardial fibrosis or ischemia in patients with systemic sclerosis (SSc). QT prolongation and QT dispersion, which facilitate the development of ventricular fibrillation, are important cardiac problems associated with increased mortality. In this study, we aimed to investigate the prevalence of corrected QT dispersion (cQTD) and related factors in our patients with systemic sclerosis compared to healthy controls. Material and Method: The 12-lead electrocardiograms with a rate of 25 mm/s of patients with no previous history of cardiovascular disease and controls were analyzed. cQTD was defined as the difference between the maximum QT interval and the minimum QT interval. Nailfold capillaroscopy examination was performed. Disease activity was evaluated using revised European Scleroderma Study Group activity index. Results: Forty-nine SSc patients (45 females, mean age 53.26±10.63 years, and disease duration 8.0 (1-25) years) and 41 controls (37 females, mean age 49.29±8.02 years) were included. While the frequency of smoking was significantly higher in controls (p=0.025), erythrocyte sedimentation rate was higher in patients (p

This study aims to compare patient-reported outcomes (PROs) after different types of oncoplastic surgery (OPS) procedures and correlate the results with previously published normative data from women with no prior history of breast cancer (BC) and breast surgery.Cross-sectional study of patients with stage I-II BC undergoing a specific selection of OPS procedures from 04/2012 to 12/2018 by three breast surgeons at a single tertiary referral hospital in Switzerland. PROs were evaluated using the postoperative BREAST-Q questionnaire.One hundred twenty-seven patients met the inclusion criteria and were surveyed. All OPS techniques achieved comparably elevated scores in satisfaction with breasts, psychosocial, and sexual well-being. Compared to normative data of healthy women, all OPS groups postoperatively achieved significantly better satisfaction with breasts, psychosocial, and sexual well-being.This study shows high PROs across all types of OPS, which were superior to normative data from healthy women. Our findings confirm that OPS is associated with high quality of life and patient satisfaction.

Studies have demonstrated an association between CHD and neurodevelopmental delay. This delay is associated with many factors like reduced blood flow and oxygen, cardiac catheterisations, and genetic factors. Apo E gene polymorphism is one of these genetic factors. This study aims to show the effect of Apo E gene polymorphism on neurodevelopmental process in children having CHD. A total of 188 children having CHD were admitted to the study. Apo E gene polymorphism of these patients was determined, and psychometric evaluation was performed. The relationship between psychometric test results and gene polymorphism was evaluated. This study shows that, similar to the literature, patients having cyanotic CHD have worse scores than acyanotic patients, and the children with CHD are under risk in terms of neuropsychiatric disorders. Other novel and important findings of this study were the lower verbal scores of ε2 allele carriers than ε4 carriers in Wechsler Intelligence Scale for Children-Revised group and the worse test score of patients having VSD than other acyanotic patients. Besides, some special disorders may be seen in this patient group.