17 results on '"Stéphanie Douchin"'
Search Results
2. Patent foramen ovale closure in children without cardiopathy: Child-PFO study
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Sébastien Hascoët, Ali Houeijeh, Stéphanie Douchin, Claire Dauphin, Alban-Elouen Baruteau, Clément Karsenty, Hugues Lucron, François Godart, Zakaria Jalal, Jérôme Petit, Céline Gronier, Guiti Milani, Aurélie Chalard, Noelie Miton, Philippe Aldebert, and J.B. Thambo
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Male ,Cardiac Catheterization ,medicine.medical_specialty ,Time Factors ,Adolescent ,Septal Occluder Device ,medicine.drug_class ,Foramen Ovale, Patent ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Risk Factors ,medicine ,Humans ,Fluoroscopy ,General anaesthesia ,030212 general & internal medicine ,Retrospective Studies ,Aspirin ,medicine.diagnostic_test ,business.industry ,Anticoagulant ,Age Factors ,Retrospective cohort study ,General Medicine ,medicine.disease ,Surgery ,Stroke ,Shunting ,Treatment Outcome ,Ischemic Attack, Transient ,Patent foramen ovale ,Female ,France ,Cardiology and Cardiovascular Medicine ,business ,Complication ,medicine.drug - Abstract
Summary Background Closure of patent foramen ovale is well-managed in adults, but is performed less frequently in children. Aim To analyse all patent foramen ovale closures performed in the past 20 years in French paediatric centres. Methods Retrospective study of patent foramen ovale closures in children without cardiopathy in nine centres between 2000 and 2019. Results Forty-one procedures were carried out in children (median age: 14.9 years). Thirty-one patent foramen ovales were closed after a transient ischaemic attack or stroke, six for a left-to-right shunt and four for other reasons. Transthoracic echocardiography was used for 72.2% of the diagnoses and transoesophageal echocardiography for 27.8%. A substantial degree of shunting was found in 42.9% of patients and an atrial septal aneurysm in 56.2%. General anaesthesia with transoesophageal echocardiography guidance was performed in 68.3% of the procedures; local anaesthesia and transthoracic echocardiography or intracardiac echocardiography was performed in 31.7%. The success rate was 100%. The median fluoroscopy time was 4.14 minutes: 3.55 minutes with transoesophageal echocardiography; and 4.38 minutes with transthoracic echocardiography (P = 0.67). There was only one periprocedural complication (2.4%). Postoperatively, 80,5% of patients were treated with aspirin and 12,2% with an anticoagulant. The rate of complete occlusion was 56.8% immediately after the procedure, 68.6% at 1 year and 92.3% at the last follow-up. There were no delayed complications or cases of recurrent stroke during follow-up (median follow-up: 568 days). Conclusion Closure of patent foramen ovale in children appears to be safe and effective, as we noted a low rate of immediate complications, no delayed complications and no stroke recurrence in this indication.
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- 2020
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3. Diagnostic Value of (18)F-Fluorodeoxyglucose Positron Emission Tomography Computed Tomography in Prosthetic Pulmonary Valve Infective Endocarditis
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Zakaria Jalal, Hélène Bouvaist, Maëlys Venet, Anne Claire Casalta, Emmanuelle Fournier, Laurianne Le Gloan, Ghoufrane Tlili, Reaksmei Ly, Fabrice Camou, Caroline Ovaert, Clément Karsenty, Yaniss Belaroussi, Maëlle Selegny, J.B. Thambo, Alban-Elouen Baruteau, Sébastien Hascoët, Stéphanie Douchin, Sophie Malekzadeh-Milani, Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de rythmologie et modélisation cardiaque [Pessac] (IHU Liryc), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Chirurgical Marie Lannelongue (CCML), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), CHU Amiens-Picardie, Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Universitaire [Grenoble] (CHU), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Saint-André, Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Agence Nationale de la Recherche, ANR-10-IAHU-0004,LIRYC,L'Institut de Rythmologie et modélisation Cardiaque(2010), Admin, Oskar, and Instituts Hospitalo-Universitaires - L'Institut de Rythmologie et modélisation Cardiaque - - LIRYC2010 - ANR-10-IAHU-0004 - IAHU - VALID
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medicine.diagnostic_test ,business.industry ,Pulmonary valve ,18F-FDG PET/CT ,Computed tomography ,medicine.disease ,Fluorodeoxyglucose positron emission tomography ,medicine.anatomical_structure ,Positron emission tomography ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Infective endocarditis ,medicine ,Radiology, Nuclear Medicine and imaging ,Fdg pet ct ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Congenital heart disease - Abstract
International audience; OBJECTIVES: The aim of this study was to assess the diagnostic performances of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) in congenital heart disease (CHD) patients with pulmonary prosthetic valve or conduit endocarditis (PPVE) suspicion. BACKGROUND: PPVE is a major issue in the growing CHD population. Diagnosis is challenging, and usual imaging tools are not always efficient or validated in this specific population. Particularly, the diagnostic yield of (18)F-FDG PET/CT remains poorly studied in PPVE. METHODS: A retrospective multicenter study was conducted in 8 French tertiary centers. Children and adult CHD patients who underwent (18)F-FDG PET/CT in the setting of PPVE suspicion between January 2010 and May 2020 were included. The cases were initially classified as definite, possible, or rejected PPVE regarding the modified Duke criteria and finally by the Endocarditis Team consensus. The result of (18)F-FDG PET/CT had been compared with final diagnosis consensus used as gold-standard in our study. RESULTS: A total of 66 cases of PPVE suspicion involving 59 patients (median age 23 years, 73% men) were included. Sensitivity, specificity, positive predictive value, and negative predictive value of (18)F-FDG PET/CT in PPVE suspicion were respectively: 79.1% (95% CI: 68.4%-91.4%), 72.7% (95% CI: 60.4%-85.0%), 91.9% (95% CI: 79.6%-100.0%), and 47.1% (95% CI: 34.8%-59.4%). (18)F-FDG PET/CT findings would help to correctly reclassify 57% (4 of 7) of possible PPVE to definite PPVE. CONCLUSIONS: Using (18)F-FDG PET/CT improves the diagnostic accuracy of the Duke criteria in CHD patients with suspected PPVE. Its high positive predictive value could be helpful in routine to shorten diagnosis and treatment delays and improve clinical outcomes.
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- 2022
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4. Longitudinal Study by Two-Dimensional Speckle-Tracking Echocardiography of the Left Ventricle Rotational Mechanics during Postnatal Adaptation in Healthy Newborns
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Johanne Auriau, Stéphanie Douchin, Yves Usson, Gabrielle Michalowicz, Ba Luu Truong, Hélène Bouvaist, Pierre-Simon Jouk, Centre Hospitalier Universitaire [Grenoble] (CHU), Dynamiques Cellulaire et Tissulaire - Interdisciplinarité, Modèles & Microscopies (TIMC-IMAG-DyCTiM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)
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Male ,Longitudinal study ,medicine.medical_specialty ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Heart Ventricles ,Echocardiography, Three-Dimensional ,Adaptation (eye) ,Speckle tracking echocardiography ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,ComputingMilieux_MISCELLANEOUS ,Retrospective Studies ,0303 health sciences ,business.industry ,Infant, Newborn ,Infant ,Stroke Volume ,Adaptation, Physiological ,3. Good health ,medicine.anatomical_structure ,030301 anatomy & morphology ,Ventricle ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
International audience
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- 2020
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5. Percutaneous closure of patent ductus arteriosus in premature infants: A French national survey
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Damien Bonnet, Claire Dauphin, Younes Boudjemline, Hélène Bouvaist, Sophie Malekzadeh-Milani, Pierre Mauran, Stéphanie Douchin, Aurélie Chalard, Ahmad Akhavi, Paediatric Department, CHU Grenoble, Service de Médecine Interne [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Service de médecine interne, hôpital Gabriel-Montpied, and CHU Clermont-Ferrand
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Cardiac Catheterization ,medicine.medical_specialty ,Time Factors ,Percutaneous ,[SDV]Life Sciences [q-bio] ,Gestational Age ,030204 cardiovascular system & hematology ,Radiography, Interventional ,Balloon dilatation ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Ductus arteriosus ,medicine ,Birth Weight ,Humans ,Infant, Very Low Birth Weight ,Radiology, Nuclear Medicine and imaging ,Complication rate ,030212 general & internal medicine ,Ductus Arteriosus, Patent ,ComputingMilieux_MISCELLANEOUS ,Retrospective Studies ,business.industry ,Hemodynamics ,Infant, Newborn ,Infant ,Large series ,General Medicine ,3. Good health ,Surgery ,Low birth weight ,Treatment Outcome ,medicine.anatomical_structure ,Fluoroscopy ,Health Care Surveys ,Infant, Extremely Premature ,France ,Tricuspid Valve Regurgitation ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Transcatheter closure of patent ductus arteriosus (PDA) in premature infants has been shown to be feasible in small series. Outcomes in larger series are currently lacking.All premature infants ( 36 weeks GA) who underwent transcatheter PDA closure were included in a multicenter French national survey. Demographic data (gestational age [GA], birth weight [BW]) and procedural data (weight [PW], age at procedure [AP], procedural success, fluoroscopy time, and type of device) were collected. Outcomes and procedural complications were reviewed.Between September 2013 and June 2017, 102 patients were included. In 71 cases, PDA pharmacological closure had been attempted. Mean GA was 27 ± 2.9 weeks. Mean BW and PW were 1,040 ± 715 g and 1,543 ± 698 g, respectively. Mean AP was 39 ± 26 days. Number of premature infants1 kg, between 1 and 2 kg, and 2 kg was 21, 59, and 22, respectively. Mean fluoroscopic time was 6.5 min. Success rate was 99%. Device- or procedure-related complications were reported in nine patients (8.9%) including three LPA stenoses (requiring surgery in two and balloon dilatation in one), two neo-coarctations (one requiring subsequent surgery), and three instances of tricuspid valve regurgitation at follow-up. Seven deaths were reported, none being related to the procedure. Mean follow-up was 39.75 ± 13.1 months.In this large series of premature infants undergoing transcatheter PDA closure, it was demonstrated that this procedure can be performed successfully in the vast majority of patients with an acceptable complication rate. Future efforts should focus on minimizing complications, particularly device-related vascular stenoses.
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- 2019
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6. Diagnostic Value of
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Maëlys, Venet, Zakaria, Jalal, Reaksmei, Ly, Sophie, Malekzadeh-Milani, Sebastien, Hascoët, Emmanuelle, Fournier, Caroline, Ovaert, Anne Claire, Casalta, Clément, Karsenty, Alban Elouen, Baruteau, Laurianne, Le Gloan, Maëlle, Selegny, Stéphanie, Douchin, Hélène, Bouvaist, Yaniss, Belaroussi, Fabrice, Camou, Ghoufrane, Tlili, and Jean-Benoît, Thambo
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Adult ,Male ,Pulmonary Valve ,Endocarditis ,Young Adult ,Fluorodeoxyglucose F18 ,Predictive Value of Tests ,Heart Valve Prosthesis ,Positron Emission Tomography Computed Tomography ,Humans ,Female ,Radiopharmaceuticals ,Child ,Retrospective Studies - Abstract
The aim of this study was to assess the diagnostic performances ofPPVE is a major issue in the growing CHD population. Diagnosis is challenging, and usual imaging tools are not always efficient or validated in this specific population. Particularly, the diagnostic yield ofA retrospective multicenter study was conducted in 8 French tertiary centers. Children and adult CHD patients who underwentA total of 66 cases of PPVE suspicion involving 59 patients (median age 23 years, 73% men) were included. Sensitivity, specificity, positive predictive value, and negative predictive value ofUsing
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- 2021
7. Cardiovascular events in perimembranous ventricular septal defect with left ventricular volume overload: a French prospective cohort study (FRANCISCO)
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Damien Bonnet, Ali Houeijeh, Gilles Bosser, Clément Karsenty, Pamela Moceri, Pauline Helms, Lisa Guirgis, Elise Barre, Quentin Hauet, Sébastien Hascoët, Khaled Hadeed, Virginie Lambert, Xavier Iriart, Nicolas Pangaud, Bérangère Urbina-Hiel, Meriem Mostefa-Kara, Charlotte Denis, Eric Hery, Zakaria Jalal, Nadir Benbrik, Pierre Mauran, Pascale Maragnes, Hugues Lucron, Pascal Amedro, Céline Gronier, Francisco investigators, Magalie Ladouceur, Stéphanie Douchin, François Godart, Bruno Lefort, Karine Warin Fresse, Jean Benoit Thambo, Maurice Guirgis, Diala Khraiche, Adeline Basquin, Daniela Laux, Ronan Bonefoy, Estibaliz Valdeolmillos, Ivan Bouzguenda, Caroline Ovaert, Antoine Legendre, Laurence Iserin, Samir Harchaoui, Laurence Cohen, Jean Marc Lupoglazoff, Bertrand Leobon, Anne-Sophie Leborgne, Carine Vastel, Aurélie Chalard, Nicolas Combes, Alban-Elouen Baruteau, Hélène Ansquer, Guy Vaksmann, Lucile Houyel, Claire Bertail, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
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Heart Septal Defects, Ventricular ,Cardiac Catheterization ,medicine.medical_specialty ,Septal Occluder Device ,Heart Ventricles ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Volume overload ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Ventricular outflow tract ,Prospective Studies ,030212 general & internal medicine ,Child ,Prospective cohort study ,Stroke ,Heart Failure ,business.industry ,General Medicine ,medicine.disease ,Haemolysis ,3. Good health ,Observational Studies as Topic ,Treatment Outcome ,Child, Preschool ,Heart failure ,Pediatrics, Perinatology and Child Health ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Watchful waiting ,Cohort study - Abstract
The long-term prospective multi-centre nationwide (French) observational study FRANCISCO will provide new information on perimembranous ventricular septal defect with left ventricular overload but no pulmonary hypertension in children older than 1 year. Outcomes will be compared according to treatment strategy (watchful waiting, surgical closure, or percutaneous closure) and anatomic features of the defect. The results are expected to provide additional guidance about the optimal treatment of this specific population, which is unclear at present. Background The management of paediatric isolated perimembranous ventricular septal defect (pmVSD) with left ventricle (LV) volume overload but no pulmonary arterial hypertension (PAH) remains controversial. Three therapeutic approaches are considered: watchful waiting, surgical closure, and percutaneous closure. We aim to investigate the long-term outcomes of these patients according to anatomic pmVSD characteristics and treatment strategy. Methods The Filiale de Cardiologie Pediatrique et Congenitale (FCPC) designed the FRANCISCO registry, a long-term prospective nationwide multi-centre observational cohort study sponsored by the French Society of Cardiology, which enrolled, over 2 years (2018–2020), patients older than 1 year who had isolated pmVSD with LV volume overload. Prevalent complications related to pmVSD at baseline were exclusion criteria. Clinical, echocardiographic, and functional data will be collected at inclusion then after 1, 5, and 10 years. A core lab will analyse all baseline echocardiographic data to depict anatomical pmVSD features. The primary outcome is the 5-year incidence of cardiovascular events (infective endocarditis, sub-aortic stenosis, aortic regurgitation, right ventricular outflow tract stenosis, tricuspid regurgitation, PAH, arrhythmia, stroke, haemolysis, heart failure, or death from a cardiovascular event). We plan to enrol 200 patients, given the 10% estimated 5-year incidence of cardiovascular events with a 95% confidence interval of ±5%. Associations linking anatomical pmVSD features and treatment strategy to the incidence of complications will be assessed. Conclusions The FRANSCICO study will provide the long-term incidence of complications in patients older than 1 year with pmVSD and LV volume overload. The results are expected to improve guidance for treatment decisions.
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- 2021
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8. Exposure to low-dose ionizing radiation from cardiac catheterization and risk of cancer: the COCCINELLE study
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Sophie Malekzadeh-Milani, Jean-Benoit Thambo, Marie-Odile Bernier, S. Dreuil, Clément Karsenty, François Godart, Estelle Rage, Caroline Ovaert, Sylvie Di Filippo, Kossi Abalo, Claire Dauphin, Jean-François Piéchaud, Klervi Leuraud, Patrice Guerin, Sébastien Hascoët, Stéphanie Douchin, Sarah S. Cohen, Tiphaine Feuillet, Damien Bonnet, Pauline Helms, Pierre Mauran, Bruno Lefort, PSE-SANTE/SESANE/LEPID, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), 2.M3C-Necker, Hôpital universitaire Necker-Enfants malades, Université de Paris, Paris, France, 3.Cardiology department, Hôpital Marie Lannelongue, Le Plessis Robinson, France, PSE-SANTE/SER/UEM, Cardiology department, Hôpital Marie Lannelongue, Le Plessis Robinson, France, Service de Cardiologie Maladies Vasculaires [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Paediatric and Congential Cardiology Department, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Cardiopédiatrie, hôpital couple enfant, CHU Grenoble Alpes, 38043 Grenoble cedex 9, France, Service de Cardiologie Infantile et Congénitale, Institut Cœur Poumon, 59037 Lille Cedex France, CHU Nantes, INSERM, Nantes Université, Clinique Cardiologique et des Maladies Vasculaires, CIC 1413, Institut du Thorax, Nantes, France., Unit of Cardiopediatrics, University Hospital of Strasbourg, Strasbourg, France, Institut des Cardiopathies Congénitales, CHRU Tours, 49 boulevard Béranger, 37000 Tours, France, Unité de cardiologie pédiatrique et congénitale, American Memorial Hospital, CHU de Reims, 47 rue Cognacq-Jay, 51092 Reims Cedex, France, Cardiologie pédiatrique et congénitale, Timone enfants, AP-HM et INSERM 1251, Aix-Marseille Université, Marseille France, Institut Hospitalier Jacques-Cartier, 91300 Massy, France, Department of Pediatric and Adult Congenital Cardiology, Bordeaux University Hospital (CHU), 33600 Pessac, France, M3C-Necker, Hôpital universitaire Necker-Enfants malades, Université de Paris, Paris, France, Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Unité d'expertise en radioprotection médicale (IRSN/PSE-SANTE/SER/UEM), Service d'études et d'expertise en radioprotection (IRSN/PSE-SANTE/SER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), and Hospices Civils de Lyon (HCL)
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medicine.medical_specialty ,education.field_of_study ,Childhood Cancer Registry ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,[SDV]Life Sciences [q-bio] ,Population ,Cancer ,Immunosuppression ,medicine.disease ,Confidence interval ,030218 nuclear medicine & medical imaging ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Cohort ,medicine ,Cardiology and Cardiovascular Medicine ,business ,education ,Cardiac catheterization - Abstract
International audience; Background The COCCINELLE study is a nationwide retrospective French cohort set up to evaluate the risk of radiation associated cancer in patients who undergone cardiac catheterization (CC) procedures for diagnosis or treatment of congenital heart disease during childhood [1].Material and methods Children who undergone CC procedures from 01/01/2000 to 31/12/2013 before the age of 16 in one of the 15 pediatric cardiology departments which perform pediatric CC in mainland France were included. The follow-up started at the date of the first recorded CC procedure until the exit date, i.e. the date of death, the date of first cancer diagnosis, the date of the 18th birthday, or the 31/12/2015, whichever occurred first. The cohort was linked to the National Childhood Cancer Registry to identify patients diagnosed with cancer and with the French National Directory for the Identification of Natural Persons to retrieve the patients’ vital status. An external comparison was conducted using standardized incidence ratios (SIR). Breslow and Day’s approximation was used to estimate 95% confidence intervals (CI) for the SIRs [2]. Results A total of 17,104 children were included in the cohort and followed for 110,335 person-years, with 22,227 CC procedures collected. Among the patients, 81.6 % received only one procedure. Fifty-nine cancer cases were observed in the cohort. SIRs were increased for all-cancer (SIR = 3.8, 95% CI 2.9, 4.9), leukemia (SIR = 3.3, 95% CI 2.0, 5.4), lymphoma (SIR = 14.9, 95% CI 9.9, 22.5) and solid cancers excluding central nervous system tumors (SIR = 3.3, 95% CI 2.0, 5.5) compared with the general population. Conclusion Increased risks of cancer were observed. Potential explanations include shared genetic or environmental factors, immunosuppression drugs, and exposure to medical ionizing radiation procedures. The dose-response analysis between ionizing radiation doses received during CCs and cancer occurrence will allow to address this question.Keywords: Ionizing radiation, cardiac catheterization, congenital heart disease, cancerCompeting interestsThe authors declare that they have no competing of interest.References1.Baysson H, Nkoumazok B, Barnaoui S, Réhel J, Girodon B, Milani G, Boudjemline Y, Bonnet D, Laurier D, Bernier M (2015) Follow-up of children exposed to ionising radiation from cardiac catheterisation: the Coccinelle study. Radiation protection dosimetry 165:13–162.Breslow NE, Day NE (1987) Statistical Methods in Cancer Research Volume II: The Design and Analysis of Cohort Studies, IARC Scientific Publication. IARC Scientific Publication No. 82, Lyon, France: International Agency for Research on Cancer.NotesCOCCINELLE: French acronym for COhorte sur le risque de Cancer après Cardiologie INterventionnELLECC: Cardiac CatheterizationSIR: Standardized Incidence Ratios CI: Confidence IntervalsCNS: Central Nervous System
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- 2021
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9. Endovascular treatment for native coarctation in children in France. A multicentric, retrospective long-term analysis
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Sophie Malekzadeh-Milani, Hélène Bouvaist, Damien Bonnet, Fedoua El Louali, Sébastien Hascoët, Ali Houjejeh, Jean-Benoit Thambo, Stéphanie Douchin, Philippe Aldebert, Zakaria Jalal, Mélanie Bard, François Godart, Clément Karsenty, Claire Dauphin, Alban Baruteau, Caroline Ovaert, and Hugues Lucron
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education.field_of_study ,medicine.medical_specialty ,Percutaneous ,business.industry ,medicine.medical_treatment ,Gold standard ,Population ,Stent ,medicine.disease ,Balloon ,Surgery ,Aortic valvuloplasty ,Stenosis ,Occlusion ,medicine ,Cardiology and Cardiovascular Medicine ,education ,business - Abstract
Background Percutaneous treatment of native coarctation (coA), gold standard in adult patients, is still debated in children. We aim to report the French multicentre experience. Methods All patients aged 1 to 18 yrs with native coA, treated percutaneously between 01/2000 and 12/2018, were included in this multcentric (9 centres) retrospective survey. Results One hundred and thirty three children (34 female) were included. Indication for treatment was hypertension in 109, exercise hypertension in 8 and other reasons in 16 patients. Mean age at intervention was 11.5 ± 3.9 years, mean weight 41 ± 18 kg. Procedure consisted of isolated balloon dilatation in 5 (mean age 2,63 yrs, mean weight 12 kg), balloon dilatation followed by stent implantation in 8 (mean age 11 yrs, mean weight 37 kg), and immediate stent implantation in 120 (mean age 12 yrs, mean weight 43 kg). Stents used (n = 124/128) were covered in 43, non-covered in 77, including 38 open cell stents. Invasive gradient across coA dropped from 28 mmHg (range 5 to 64) at baseline (n = 124) to 3 mmHg (range -5 to 20) after intervention (n = 105). Three associated lesions were treated: 1 PDA closure, 1 aortic valvuloplasty and 1 left SVC occlusion. Serious vascular complications occurred in 8 patients (6%) (3 pseudo-aneurysms, 2 dissections, 2 stenosis and 1 occlusion) requiring surgery in 2. Reintervention was performed in 22%: 2 patients had surgery, 28 were treated percutaneously (14 balloon dilatations, 14 stent implantations). Mean follow-up reached 4.9 ± 4.7 years. At latest follow-up, 25% remained hypertensive with 15 patients (11%) on anti-hypertensive medication. MRI, CTscan or fluoroscopy imaging, are available in 52 patients during follow-up (39%). Rate of aneurysm formation, stent fracture and risks factors for reintervention or residual hypertension will be presented. Conclusions Percutaneous treatment of native coarctation was safe and efficient in our french population. Close follow-up is required for longer-term results.
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- 2021
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10. Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in prosthetic pulmonary valve infective endocarditis
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Maëlys Venet, Zakaria Jalal, Laurianne Le Gloan, Sébastien Hascoët, Yaniss Belaroussi, Stéphanie Douchin, Sophie Malekzadeh-Milani, Hélène Bouvaist, Ghoufrane Tlili, J.B. Thambo, Caroline Ovaert, Fabrice Camou, Emmanuelle Fournier, Alban-Elouen Baruteau, Maëlle Selegny, Reaksmei Ly, Clément Karsenty, and Anne Claire Casalta
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education.field_of_study ,medicine.medical_specialty ,medicine.diagnostic_test ,Heart disease ,business.industry ,Population ,Computed tomography ,medicine.disease ,Fluorodeoxyglucose positron emission tomography ,medicine.anatomical_structure ,Positron emission tomography ,Infective endocarditis ,Pulmonary valve ,medicine ,Endocarditis ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,education - Abstract
Background Pulmonary prosthetic valve and conduit infective endocarditis (PPVE) is a major issue in the growing congenital heart disease (CHD) population. Diagnosis is challenging and usual imaging tools are not always efficient nor validated in this specific population. Particularly, the diagnostic yield of 18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) remains poorly studied in PPVE. Aims The Aim of this study was to assess the diagnostic performances of 18F-FDG PET/CT in CHD patients with PPVE suspicion. Methods A retrospective multicenter study was conducted in 8 French tertiary centers. Children and adult CHD patients who underwent a 18F-FDG PET/CT in the setting of PPVE suspicion between January 2010 and May 2020 were included. The cases are initially classified as definite, possible or rejected PPVE regarding the modified Duke criteria (DC) and finally by the Endocarditis Team consensus. The result of 18F-FDG PET/CT had been compared to final diagnosis consensus used as gold-standard in our study. Results Sixty-six cases of PPVE suspicion involving 59 patients (median age 23, 73% male) were included. Sensitivity, specificity, positive predictive value and negative predictive value of 18F-FDG PET/CT in PPVE suspicion were respectively: 79.1% (68.4–91.4), 72.7% (60.4–85.0), 91.9% (79.6–100) and 47.1% (34.8–59.4). 18F-FDG PET/CT findings would help to rightly reclassify 43% of possible PPVE to definite PPVE. Conclusion Using 18F-FDG PET/CT improves the diagnostic accuracy of the Duke Criteria in CHD patients with suspected PPVE. Its high positive predictive value could be helpful in routine to shorten diagnosis and treatment delays and improve clinical outcomes.
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- 2021
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11. Transcatheter occlusion of the patent ductus arteriosus in premature infants weighing less than 1200 g
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Stéphanie Douchin, Claire Dauphin, Patrice Morville, and Hélène Bouvaist
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Cardiac Catheterization ,medicine.medical_specialty ,Septal Occluder Device ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Ductus arteriosus ,medicine ,Humans ,Neonatology ,Ductus Arteriosus, Patent ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Infant ,Obstetrics and Gynecology ,General Medicine ,Left pulmonary artery ,Infant, Low Birth Weight ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Transcatheter occlusion ,Angiography ,Gestation ,business ,Ligation ,Infant, Premature ,Venous cannulation - Abstract
ObjectivesOver the last few decades different strategies have been proposed to treat persistent ductal patency in premature infants. The advent of the Amplatzer Duct Occluder II Additional Size (ADOIIAS) provided the potential to close the patent ductus arteriosus (PDA). Opinions differ on the significance and treatment of PDA in premature neonates. Because surgical ligation and medical therapy both have their drawbacks, interventional catheterisation can be considered as an alternative means of closing the ductus arteriosus. Our aim was to analyse the feasibility, safety and efficacy of this device in premature infants weighing MethodsEighteen premature infants underwent transcatheter closure. The procedure was performed in the catheterisation laboratory by venous cannulation without angiography. The position of the occluder was directed by X-ray and ultrasound. We looked at procedural details, device size selection, complications and short-term and mid-term outcomes.ResultsEighteen infants born at gestational ages ranging between 23.6 and 29+6 weeks (mean±SD 25+6±3 weeks) underwent transcatheter PDA closure. Their mean age and weight at the time of the procedure was 20 days (range 8–44 days) and 980 g (range 680–1200 g), respectively. The mean PDA and device waist diameters were 3.2±0.6 mm (range 2.2–4 mm) and 4.5±0.6 mm, respectively, and the mean PDA and device lengths were 4.3±1.2 mm (range 2–10 mm) and 2.5±0.9 mm, respectively. Complete closure was achieved in all but one patient. There was no device migration. One patient developed a left pulmonary artery obstruction. Three infants died. Two deaths were related to complications of prematurity and one to the procedure.ConclusionsTranscatheter closure of a PDA is feasible in very low weight infants with ADOIIAS and is an alternative to surgery. Success requires perfect selection and placement of the occluder.
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- 2017
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12. Cardiogenic shock and tako-tsubo cardiomyopathy in a 9-year-old girl with retroperitoneal paraganglioma
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Ludovic Mansuy, Johanne Auriau, and Stéphanie Douchin
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Abdominal pain ,medicine.medical_specialty ,biology ,business.industry ,Cardiogenic shock ,Infarction ,medicine.disease ,Troponin ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,030225 pediatrics ,Intensive care ,Internal medicine ,Heart failure ,Pediatrics, Perinatology and Child Health ,Circulatory system ,cardiovascular system ,medicine ,biology.protein ,Cardiology ,cardiovascular diseases ,medicine.symptom ,business - Abstract
A 9-year-old girl was admitted to the paediatric intensive care unit for acute heart failure associated with high blood pressure. She had a history of asthenia, abdominal pain and profuse sweating. The ECG showed elements compatible with an anterolateral infarction associated with an elevated troponin I, but the coronary angiogram was normal (figure 1A). On echocardiogram and left ventriculography, there was a severe left ventricular systolic dysfunction (30%) with …
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- 2018
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13. Etiology and management of pericardial effusion in children: retrospective review in a non-surgical center
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Gérard Blaysat, Hélène Bouvaist, Stéphanie Douchin, Charlotte Couturier, and Claire Massardier
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Retrospective review ,medicine.medical_specialty ,business.industry ,General surgery ,medicine ,Etiology ,Center (algebra and category theory) ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Pericardial effusion - Published
- 2017
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14. Editorial
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Philippe Acar, Gérard Blaysat, Hélène Bouvaist, and Stéphanie Douchin
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Cardiology and Cardiovascular Medicine - Published
- 2016
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15. Editorial
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Philippe Acar, Gérard Blaysat, Hélène Bouvaist, and Stéphanie Douchin
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Cardiology and Cardiovascular Medicine - Published
- 2016
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16. Life threatening iatrogenic abnormal venous return following atrial septal defect surgery
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Stéphanie Douchin, Eric Arnaud-Crozat, Geraldine Dessertaine, Benoît Berthoud, Gérald Vanzetto, Pierre-Vladimir Ennezat, and Raphaëlle-Ashley Guerbaai
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medicine.medical_specialty ,business.industry ,Anesthesia ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Venous return curve ,Surgery - Published
- 2014
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17. Fermeture du canal artériel par voie percutanée : analyse de l’expérience grenobloise sur les onze dernières années
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Follenfant, Marion, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Stéphanie Douchin
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Cathétérisme cardiaque ,Traitement ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Canal artériel persistant - Abstract
Objective: Evaluate the results of percutaneous closure of patent ductus arteriosus (PDA) performed in Grenoble. Material and methods: retrospective analysis of catheterization realized between January 2005 and February 2016 with the aim of PDA closure. We studied: Procedure’s results (success rate, type of device, residual shunting, adverse effects) and X-ray doses (fluoroscopy time in minutes and dose area product (DAP) by age groups). Results: 76 procedures were realized, mean age was 5.6 years, mean weight 17.8 kg and the sex ratio was 2.5 female for 1 male. 30% of our patients were preterm, 18% had congenital malformation associated and 29% presented with symptoms of cardiac insufficiency. A device implanted in 70 cases (92%): 17 coils before 2010 and 53 Amplatz® devices. The PDA couldn’t be closed in 6 cases: 1 already closed, 1 wide closed by surgery, 4 thin couldn’t be crossed. After a device was installed, complete occlusion was obtained in 81% at day 1, 90% at a month and 97% at 8 months. Mean fluoroscopy time was 12 min. The medians DAP were 3767, 3180, 6950, 10325 et 28047mGy.cm2 for age groups of respectively < 1 year, 1-4 years, 5-9 years, 10-15 years and >15 years. All these medians are less than or equal to the results of a large American cohort. No death or major adverse effect was to regret. Four patients (5%) presented with early complications. Conclusion: Patent ductus arteriosus percutaneous closure in Grenoble hospital gives good results with a low rate of complication and levels of radiation that are less than or equal to literature data.; Objectif : Evaluer les résultats des fermetures du canal artériel (CA) réalisées par voie percutanée au CHU de Grenoble. Matériel et méthodes : Analyse rétrospective des procédures de cathétérisme réalisée entre janvier 2005 et février 2016, ayant pour objectif la fermeture d’un CA. Ont été étudiés: les résultats (réussite du geste, type de prothèse, shunt résiduel, complications) et la dosimétrie (temps de scopie en minutes et produit dose surface (PDS) par tranche d’âge). Résultats : 76 procédures ont été réalisées. L’âge moyen des patients était de 5.6 ans, le poids moyen de 17.8 kg et le sex ratio de 2.5 filles pour 1 garçon. 30% des patients avaient des antécédents de prématurité, 18% des malformations associées et 29% des symptômes d’insuffisance cardiaque. Une prothèse a été mise en place dans 70 cas (92%) : 17 coils avant 2010 et 53 prothèses Amplatz®. 6 échecs de fermeture : 1 déjà fermé, 1 large opéré secondairement, 4 petits non franchissables. Après mise en place d’une prothèse, l’occlusion complète du CA était obtenue dans 81% des cas à J1, 90% à 1 mois et 97% à 8 mois. Le temps de scopie moyen était de 12 min. Les PDS médians en mGy.cm2 étaient de 3767, 3180, 6950, 10325 et 28047 pour les tranches d’âge < 1 an, 1-4 ans, 5-9 ans, 10-15 ans et >15 ans respectivement. Toutes ces médianes sont inférieures ou égales aux résultats d’une grande cohorte américaine. Aucun décès ou effet indésirable majeur n’est à déplorer. Quatre patients ont présenté des complications précoces (5%). Conclusion : La procédure étudiée donne de bons résultats avec un faible taux de complications et des niveaux d’irradiation inférieurs ou égaux aux données de la littérature.
- Published
- 2016
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