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6 results on '"Stefani, Piero Maria"'

1. Punctual and kinetic MRD analysis from the Fondazione Italiana Linfomi MCL0208 phase III trial in mantle cell lymphoma

Author

Ferrero, Simone, Grimaldi, Daniele, Genuardi, Elisa, Drandi, Daniela, Zaccaria, Gian Maria, Alessandria, Beatrice, Ghislieri, Marco, Ferrante, Martina, Evangelista, Andrea, Mantoan, Barbara, De Luca, Gabriele, Stefani, Piero Maria, Benedetti, Fabio, Casaroli, Ivana Rita, Zanni, Manuela, Castellino, Claudia, Pavone, Vincenzo, Petrini, Mario, Francesca, Re, Hohaus, Stefan, Musuraca, Gerardo, Cascavilla, Nicola, Ghiggi, Chiara, Liberati, Anna Marina Marina, Cortelazzo, Sergio, and Ladetto, Marco

Subjects
Lymphoid Neoplasia
Published
2022

2. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, Giuseppe, Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Milone, G., Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, Placanica, Paola, Girmenia, C, Bertaina, A, Piciocchi, A, Perruccio, K, Algarotti, A, Busca, A, Cattaneo, C, Raiola, Am, Guidi, S, Iori, Ap, Candoni, A, Irrera, G, Milone, G, Marcacci, G, Scimè, R, Musso, M, Cudillo, L, Sica, S, Castagna, L, Corradini, P, Marchesi, F, Pastore, D, Alessandrino, Ep, Annaloro, C, Ciceri, F, Santarone, S, Nassi, L, Farina, C, Viscoli, C, Rossolini, Gm, Bonifazi, F, Rambaldi, A, for the Gruppo Italiano Trapianto di Midollo Osseo, (GITMO), Associazione Microbiologi Clinici Italiani, (AMCLI), Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, G., Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, and Placanica, Paola

Subjects
0301 basic medicine, Male, Transplantation Conditioning, Drug Resistance, Bacteremia, 0302 clinical medicine, epidemiology, Gram negative bacteremia, multidrug resistance, stem cell transplant, survival, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Age Factor, Prospective Studies, Prospective cohort study, Child, Transplantation, Homologou, education.field_of_study, Incidence (epidemiology), Incidence, Bacterial, Age Factors, Hematopoietic Stem Cell Transplantation, Middle Aged, Transplantation, Autologou, surgical procedures, operative, Infectious Diseases, Italy, Child, Preschool, Female, medicine.symptom, Multiple, Autologous, Human, Homologous, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Transplantation, Autologous, 03 medical and health sciences, Young Adult, Internal medicine, Gram-Negative Bacteria, Gram-Negative Bacterial Infection, Escherichia coli, Humans, Transplantation, Homologous, Preschool, education, Aged, Gram-Negative Bacterial Infections, Infant, Transplantation, business.industry, Risk Factor, medicine.disease, Prospective Studie, Carriage, Otitis, business, Settore MED/15 - Malattie del Sangue, 030215 immunology
Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

3. MYC Rearranged Aggressive B-Cell Lymphomas

Author

Tisi, Maria Chiara, Ferrero, Simone, Dogliotti, Irene, Tecchio, Cristina, Carli, Giuseppe, Novo, Mattia, Stefani, Piero Maria, Rattotti, Sara, Balzarotti, Monica, Marino, Dario, Pelosini, Matteo, Romano, Alessandra, Flenghi, Leonardo, Zilioli, Vittorio Ruggero, Calimeri, Teresa, Di Napoli, Arianna, Zanni, Manuela, Finolezzi, Erica, Mosna, Federico, Gini, Guido, Mansueto, Giovanna, Di Rocco, Alice, Tomei, Gabriella, Sgherza, Nicola, Olivieri, Jacopo, Nassi, Luca, Piazza, Francesco, Fama, Angelo, Greco, Antonio, Giannoccaro, Margherita, Mazzone, Anna Maria, Visco, Carlo, Loseto, Giacomo, and Zaja, Francesco

Subjects
aggressive B lymphoma, C-myc rearrangement, C-myc rearrangement, aggressive B lymphoma
Published
2019

4. The prognostic value of positron emission tomography performed after two courses (INTERIM-PET) of standard therapy on treatment outcome in early stage Hodgkin lymphoma: A multicentric study by the fondazione italiana linfomi (FIL)

Author

Michele Spina, Pier Luigi Zinzani, Francesco Merli, Stefani Piero Maria, Andrea Gallamini, Vittorio Stefoni, Alberto Biggi, Alessandro Levis, Sancetta Rosaria, Luigi Rigacci, Umberto Vitolo, Benedetta Puccini, Alberto Bosi, Antonio Castagnoli, Manuel Gotti, Monica Balzarotti, Caterina Stelitano, L. Rigacci, B. Puccini, P. L. Zinzani, A. Biggi, A. Castagnoli, F. Merli, M. Balzarotti, C. Stelitano, M. Spina, U. Vitolo, V. Stefoni, A. Levi, M. Gotti, S. Rosaria, S. P. Maria, A. Bosi, and A. Gallamini

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, HL, Disease-Free Survival, Predictive Value of Tests, Internal medicine, Humans, Medicine, Stage (cooking), Survival rate, Aged, Neoplasm Staging, Univariate analysis, medicine.diagnostic_test, business.industry, ABVD, Retrospective cohort study, Hematology, Middle Aged, Hodgkin Disease, Radiography, Survival Rate, Radiation therapy, Positron emission tomography, Positron-Emission Tomography, Predictive value of tests, Female, business, Nuclear medicine, Follow-Up Studies, medicine.drug
Abstract

This retrospective study included 246 patients with a new diagnosis of Hodgkin Lymphoma (HL) with a localized-stage (IA-IIA), consecutively admitted from January 2002 to December 2008, by twelve Italian hematological centers on behalf of Fondazione Italiana Linfomi (FIL). Patients were staged at baseline and after two cycles of chemotherapy with PET. All patients were treated with four cycles of ABVD followed by involved-field radiotherapy. No treatment change, based on PET-2 results was allowed. Endpoint of the study was the predictive role of PET-2 on 2-y failure-free survival (FFS). PET-2 was positive in 36 patients (15%) and negative in 210. After a mean follow-up of 46 (3–105) months 19/36 PET-2 positive patients progressed or relapsed and 17 achieved and maintained a CCR. The positive and negative predictive value of a PET2 was 53% and 95%, respectively. The sensibility, specificity and accuracy of PET2 were 65.5%, 92% and 89%, respectively. PET-2 positive scans were centrally reviewed according to the recently defined Deauville Criteria. Upon review the PPV and NPV was 73% and 96% overall. Factors with prognostic significance for progression in univariate analysis were a positive PET-2 (P = 0.000) and the presence of bulky disease (P

Published
2015
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5. MYC Rearranged Aggressive B-Cell Lymphomas: A Report on 100 Patients of the Fondazione Italiana Linfomi (FIL)

Author

Maria Chiara Tisi, Simone Ferrero, Irene Dogliotti, Cristina Tecchio, Giuseppe Carli, Mattia Novo, Piero Maria Stefani, Sara Rattotti, Monica Balzarotti, Dario Marino, Matteo Pelosini, Alessandra Romano, Leonardo Flenghi, Vittorio Ruggero Zilioli, Teresa Calimeri, Arianna Di Napoli, Manuela Zanni, Erica Finolezzi, Federico Mosna, Guido Gini, Giovanna Mansueto, Alice Di Rocco, Gabriella Tomei, Nicola Sgherza, Jacopo Olivieri, Luca Nassi, Francesco Piazza, Angelo Fama, Antonio Greco, Margherita Giannoccaro, Anna Maria Mazzone, Carlo Visco, Giacomo Loseto, Francesco Zaja, on behalf of the Fondazione Italiana Linfomi Postgraduate Master course, Tisi, Maria Chiara, Ferrero, Simone, Dogliotti, Irene, Tecchio, Cristina, Carli, Giuseppe, Novo, Mattia, Stefani, Piero Maria, Rattotti, Sara, Balzarotti, Monica, Marino, Dario, Pelosini, Matteo, Romano, Alessandra, Flenghi, Leonardo, Zilioli, Vittorio Ruggero, Calimeri, Teresa, Di Napoli, Arianna, Zanni, Manuela, Finolezzi, Erica, Mosna, Federico, Gini, Guido, Mansueto, Giovanna, Di Rocco, Alice, Tomei, Gabriella, Sgherza, Nicola, Olivieri, Jacopo, Nassi, Luca, Piazza, Francesco, Fama, Angelo, Greco, Antonio, Giannoccaro, Margherita, Mazzone, Anna Maria, Visco, Carlo, Loseto, Giacomo, and Zaja, Francesco

Subjects
Letter, business.industry, lcsh:RC633-647.5, MYC, NHL, lymphoma, Hematology, lcsh:Diseases of the blood and blood-forming organs, Text mining, medicine.anatomical_structure, Cancer research, medicine, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, business, B cell
Abstract

Supplemental Digital Content is available in the text.

Published
2019

6. A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi

Author

Filippo Gherlinzoni, Maria Chiara Tisi, Irene Federici, Giulia Perali, Nicola Cascavilla, Francesco Saraceni, Gabriella Tomei, Anna Maria Mazzone, Federico Mosna, Jacopo Olivieri, Enrico Orciuolo, Simone Ferrero, Piero Maria Stefani, Giuseppe Carli, Paola Ghione, Francesco Lanza, Matteo Pelosini, Margherita Giannoccaro, Silvia Finotto, Renato Fanin, Katia Codeluppi, T. Calimeri, Atto Billio, Patrizia Chiusolo, Carlo Borghero, Giacomo Loseto, Sara Rattotti, Dario Marino, Riccardo Centurioni, R. Matera, Nicola Sgherza, Simona Sica, Attilio Olivieri, Angelo Fama, Francesco Zaja, Olivieri, Jacopo, Mosna, Federico, Pelosini, Matteo, Fama, Angelo, Rattotti, Sara, Giannoccaro, Margherita, Carli, Giuseppe, Tisi, Maria Chiara, Ferrero, Simone, Sgherza, Nicola, Mazzone, Anna Maria, Marino, Dario, Calimeri, Teresa, Loseto, Giacomo, Saraceni, Francesco, Tomei, Gabriella, Sica, Simona, Perali, Giulia, Codeluppi, Katia, Billio, Atto, Olivieri, Attilio, Orciuolo, Enrico, Matera, Rossella, Stefani, Piero Maria, Borghero, Carlo, Ghione, Paola, Cascavilla, Nicola, Lanza, Francesco, Chiusolo, Patrizia, Finotto, Silvia, Federici, Irene, Gherlinzoni, Filippo, Centurioni, Riccardo, Fanin, Renato, and Zaja, Francesco

Subjects
Male, Oncology, medicine.medical_specialty, Transplantation conditioning, Lymphoma, Transplantation, Autologous, BEAM regimen, Fotemustine, medicine.medical_treatment, Hematopoietic stem cell transplantation, Autologou, Transplantation, Autologous, NO, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, immune system diseases, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Hematology, Melphalan, Etoposide, Retrospective Studies, Chemotherapy, Carmustine, business.industry, Cytarabine, Hematopoietic Stem Cell Transplantation, Retrospective cohort study, Middle Aged, medicine.disease, Italy, 030220 oncology & carcinogenesis, Female, Transplantation Conditioning, business, 030215 immunology, medicine.drug
Abstract

BEAM (carmustine [bis-chloroethylnitrosourea (BCNU)]-etoposide-cytarabine-melphalan) chemotherapy is the standard conditioning regimen for autologous stem cell transplantation (ASCT) in lymphomas. Owing to BCNU shortages, many centers switched to fotemustine-substituted BEAM (FEAM), lacking proof of equivalence. We conducted a retrospective cohort study in 18 Italian centers to compare the safety and efficacy of BEAM and FEAM regimens for ASCT in lymphomas performed from 2008 to 2015. We enrolled 1038 patients (BEAM = 607, FEAM = 431), of which 27% had Hodgkin lymphoma (HL), 14% indolent non-Hodgkin lymphoma (NHL), and 59% aggressive NHL. Baseline characteristics including age, sex, stage, B-symptoms, extranodal involvement, previous treatments, response before ASCT, and overall conditioning intensity were well balanced between BEAM and FEAM; notable exceptions were median ASCT year (BEAM = 2011 versus FEAM = 2013, P

Published
2018

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