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1. Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3

Author

Chandrasekaran, Jayashree, Petit, Emilien, Faber, Jennifer, Coupé, Pierrick, Onyike, Chiadi U, Barker, Peter B, Schmahmann, Jeremy D, Ratai, Eva-Maria, Subramony, S. H., Mareci, Thomas H, Bushara, Khalaf O, Paulson, Henry, Park, Young Woo, Durr, Alexandra, Klockgether, Thomas, Ashizawa, Tetsuo, Lenglet, Christophe, Öz, Gülin, Consortium, READISCA, du Montcel, Sophie Tezenas, Joers, James M, Deelchand, Dinesh K, Považan, Michal, Banan, Guita, Valabregue, Romain, Ehses, Philipp, Center for Magnetic Resonance Research [Minneapolis] (CMRR), University of Minnesota Medical School, University of Minnesota System-University of Minnesota System, Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Johns Hopkins University School of Medicine [Baltimore], University of Florida [Gainesville] (UF), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Dendrite Differenciation Group [DZNE - Bonn], German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Università degli Studi di Pavia = University of Pavia (UNIPV), University Hospital Bonn, Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Patch-based processing for medical and natural images (PICTURA), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Massachusetts General Hospital [Boston, MA, USA], Harvard Medical School [Boston] (HMS), Massachusetts General Hospital [Boston], University of Minnesota System, University of Michigan [Ann Arbor], University of Michigan System, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Texas A&M University [College Station], and Houston Methodist Hospital [Houston, TX, USA]

Subjects
Neurology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), ddc:610
Abstract

This study was undertaken to identify magnetic resonance (MR) metrics that are most sensitive to early changes in the brain in spinocerebellar ataxia type 1 (SCA1) and type 3 (SCA3) using an advanced multimodal MR imaging (MRI) protocol in the multisite trial setting.SCA1 or SCA3 mutation carriers and controls (n = 107) underwent MR scanning in the US-European READISCA study to obtain structural, diffusion MRI, and MR spectroscopy data using an advanced protocol at 3T. Morphometric, microstructural, and neurochemical metrics were analyzed blinded to diagnosis and compared between preataxic SCA (n = 11 SCA1, n = 28 SCA3), ataxic SCA (n = 14 SCA1, n = 37 SCA3), and control (n = 17) groups using nonparametric testing accounting for multiple comparisons. MR metrics that were most sensitive to preataxic abnormalities were identified using receiver operating characteristic (ROC) analyses.Atrophy and microstructural damage in the brainstem and cerebellar peduncles and neurochemical abnormalities in the pons were prominent in both preataxic groups, when patients did not differ from controls clinically. MR metrics were strongly associated with ataxia symptoms, activities of daily living, and estimated ataxia duration. A neurochemical measure was the most sensitive metric to preataxic changes in SCA1 (ROC area under the curve [AUC] = 0.95), and a microstructural metric was the most sensitive metric to preataxic changes in SCA3 (AUC = 0.92).Changes in cerebellar afferent and efferent pathways underlie the earliest symptoms of both SCAs. MR metrics collected with a harmonized advanced protocol in the multisite trial setting allow detection of disease effects in individuals before ataxia onset with potential clinical trial utility for subject stratification. ANN NEUROL 2022.

Published
2023

2. Sensory and corticospinal signs before ataxia onset in SCA1 and SCA3: the READISCA study

Author

Montcel, Sophie Tezenas Du, Petit, Emilien, Olubajo, Titi, Faber, Jennifer, Lallemant-Dudek, Pauline, Bushara, Khalaf, Perlman, Susan, Subramony, S. H., Morgan, David, Jackman, Brianna, Paulson, Henry, Öz, Gülin, Klockgether, Thomas, Durr, Alexandra, Ashizawa, Tetsuo, Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Methodist Hospital Research Institute, University Hospital Bonn, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Minnesota System, University of California (UC), The University of Florida College of Medicine, Michigan State University System, University of Michigan [Ann Arbor], University of Michigan System, University of Minnesota Medical School, Universität Bonn = University of Bonn, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), and Texas A&M University [College Station]

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2022

3. Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias

Author

Gan, Shi-Rui, Wang, Jie, Figueroa, Karla P., Pulst, Stefan M., Tomishon, Darya, Lee, Danielle, Perlman, Susan, Wilmot, George, Gomez, Christopher M., Schmahmann, Jeremy, Paulson, Henry, Shakkottai, Vikram G., Ying, Sarah H., Zesiewicz, Theresa, Bushara, Khalaf, Geschwind, Michael, Xia, Guangbin, Subramony, S. H., Ashizawa, Tetsuo, and Kuo, Sheng-Han

Subjects
Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, lcsh:Diseases of the musculoskeletal system, cerebellum, lcsh:RC346-429, 03 medical and health sciences, postural tremor, 0302 clinical medicine, Tremor, Humans, genetics, Longitudinal Studies, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, 0303 health sciences, FOS: Clinical medicine, Neurosciences, neurodegeneration, Middle Aged, nervous system diseases, Spinocerebellar ataxias, Logistic Models, Neurology, FOS: Biological sciences, Disease Progression, Ataxia, Brief Reports, Female, lcsh:RC925-935, Trinucleotide Repeat Expansion, 030217 neurology & neurosurgery
Abstract

Background: Postural tremor can sometimes occur in spinocerebellar ataxias (SCAs). However, the prevalence and clinical characteristics of postural tremor in SCAs are poorly understood, and whether SCA patients with postural tremor have different ataxia progression is not known. Methods: We studied postural tremor in 315 patients with SCA1, 2, 3, and 6 recruited from the Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA), which consists of 12 participating centers in the United States, and we evaluated ataxia progression in these patients from January 2010 to August 2012. Results: Among 315 SCA patients, postural tremor was most common in SCA2 patients (SCA1, 5.8%; SCA2, 27.5%; SCA3, 12.4%; SCA6, 16.9%; p = 0.007). SCA3 patients with postural tremor had longer CAG repeat expansions than SCA3 patients without postural tremor (73.67 ± 3.12 vs. 70.42 ± 3.96, p = 0.003). Interestingly, SCA1 and SCA6 patients with postural tremor had a slower rate of ataxia progression (SCA1, β = –0.91, p < 0.001; SCA6, β = –1.28, p = 0.025), while SCA2 patients with postural tremor had a faster rate of ataxia progression (β = 1.54, p = 0.034). We also found that the presence of postural tremor in SCA2 patients could be influenced by repeat expansions of ATXN1 (β = –1.53, p = 0.037) and ATXN3 (β = 0.57, p = 0.018), whereas postural tremor in SCA3 was associated with repeat lengths in TBP (β = 0.63, p = 0.041) and PPP2R2B (β = –0.40, p = 0.032). Discussion: Postural tremor could be a clinical feature of SCAs, and the presence of postural tremor could be associated with different rates of ataxia progression. Genetic interactions between ataxia genes might influence the brain circuitry and thus affect the clinical presentation of postural tremor., Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements

Published
2017
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4. Modulation of the age at onset in spinocerebellar ataxia by CAG tracts in various genes

Author

Tezenas du Montcel, Sophie, Durr, Alexandra, Orsi, Laura, Giunti, Paola, Filla, Alessandro, Szymanski, Sandra, Schöls, Ludger, Klockgether, Thomas, Berciano, José, Pandolfo, Massimo, Boesch, Sylvia, Melegh, Bela, Bauer, Peter, Timmann, Dagmar, Mandich, Paola, Camuzat, Agnès, Ataxia, Clinical Research Consortium for Spinocerebellar, network, EUROSCA, Goto, Jun, Ashizawa, Tetsuo, Cazeneuve, Cécile, Tsuji, Shoji, Pulst, Stefan-M, Figueroa, Karla P, Brusco, Alfredo, Riess, Olaf, Brice, Alexis, Stevanin, Giovanni, Figueroa, Karla, Perlman, Susan, Gomez, Christopher, Wilmot, George, Schmahmann, Jeremy, Ichikawa, Yaeko, Ying, Sarah H, Zesiewicz, Theresa, Paulson, Henry, Shakkottai, Vikram, Bushara, Khalaf, Kuo, Sheng-Han, Geschwind, Michael, Xia, Guangbin, Mazzoni, Pietro, Pulst, Stefan, Brussino, Alessandro, Subramony, S. H., du Montcel, Sophie Tezenas, Forlani, Sylvie, Rakowicz, Maria, Sulek, Anna, Mariotti, Caterina, van de Warrenburg, Bart P C, Bela, Melegh, Baliko, Laszlo, Hadzsiev, Kinga, Tezenas du Montcel, S, Durr, A, Bauer, P, Figueroa, Kp, Ichikawa, Y, Brussino, A, Forlani, S, Rakowicz, M, Sch?ls, L, Mariotti, C, van de Warrenburg, Bp, Orsi, L, Giunti, P, Filla, Alessandro, Szymanski, S, Klockgether, T, Berciano, J, Pandolfo, M, Boesch, S, Melegh, B, Timmann, D, Mandich, P, Camuzat, A, Goto, J, Ashizawa, T, Cazeneuve, C, Tsuji, S, Pulst, Sm, Brusco, A, Riess, O, Brice, A, Stevanin, G, Clinical Research Consortium for Spinocerebellar, Ataxia, and the EUROSCA, Network

Subjects
Male, Spinocerebellar Ataxia Type 1, Medizin, ethnology [Asian People], Cohort Studies, Spinocerebellar ataxia type 6, diagnosis [Spinocerebellar Ataxias], genetics [Spinocerebellar Ataxias], Age of Onset, Child, Genetics, ethnology [Spinocerebellar Ataxias], Age at onset, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Phenotype, modifier, Spinocerebellar ataxia, trinucleotide repeats, genetics [European Continental Ancestry Group], Female, Psychology, Machado–Joseph disease, genetics [Trinucleotide Repeat Expansion], Adult, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, genetics [White People], White People, Young Adult, Asian People, ethnology [European Continental Ancestry Group], mental disorders, medicine, Humans, Spinocerebellar Ataxias, ddc:610, Allele, Aged, genetics [Asian Continental Ancestry Group], ethnology [Asian Continental Ancestry Group], genetics [Asian People], medicine.disease, nervous system diseases, nervous system, Neurology (clinical), ethnology [White People], Age of onset, Trinucleotide repeat expansion, Trinucleotide Repeat Expansion
Abstract

Item does not contain fulltext Polyglutamine-coding (CAG)n repeat expansions in seven different genes cause spinocerebellar ataxias. Although the size of the expansion is negatively correlated with age at onset, it accounts for only 50-70% of its variability. To find other factors involved in this variability, we performed a regression analysis in 1255 affected individuals with identified expansions (spinocerebellar ataxia types 1, 2, 3, 6 and 7), recruited through the European Consortium on Spinocerebellar Ataxias, to determine whether age at onset is influenced by the size of the normal allele in eight causal (CAG)n-containing genes (ATXN1-3, 6-7, 17, ATN1 and HTT). We confirmed the negative effect of the expanded allele and detected threshold effects reflected by a quadratic association between age at onset and CAG size in spinocerebellar ataxia types 1, 3 and 6. We also evidenced an interaction between the expanded and normal alleles in trans in individuals with spinocerebellar ataxia types 1, 6 and 7. Except for individuals with spinocerebellar ataxia type 1, age at onset was also influenced by other (CAG)n-containing genes: ATXN7 in spinocerebellar ataxia type 2; ATXN2, ATN1 and HTT in spinocerebellar ataxia type 3; ATXN1 and ATXN3 in spinocerebellar ataxia type 6; and ATXN3 and TBP in spinocerebellar ataxia type 7. This suggests that there are biological relationships among these genes. The results were partially replicated in four independent populations representing 460 Caucasians and 216 Asian samples; the differences are possibly explained by ethnic or geographical differences. As the variability in age at onset is not completely explained by the effects of the causative and modifier sister genes, other genetic or environmental factors must also play a role in these diseases.

Published
2014

5. Perspectives from twenty-two countries on the legal environment for selection

Author

Sackett P. R., Shen W., Myors B., Lievens F., Schollaert E., Van Hoye G., Cronshaw S., Onyura B., Mladinic A., Rodríguez V., Steiner D., Rolland F., Schuler H., Frintrup A., Nikolaou L., Tomprou M., Subramony S, Raj S. B., Tzafrir S., Bamberger P., Bertolino M., Fraccaroli F., Sekiguchi T., Yang H., Anderson N., Evers A., Chernyshenko O., Englert P., Kriek H., Joubert T., Salgado J., König C., Thommen L., Chuang A., Sinangil H., Bayazit M., Cook M., Aguinis H., MARIANI, MARCO GIOVANNI, FARR, JAMES L. (ED.), TIPPINS, NANCY T. (ED.), Sackett P.R., Shen W., Myors B., Lievens F., Schollaert E., Van Hoye G., Cronshaw S., Onyura B., Mladinic A., Rodríguez V., Steiner D., Rolland F., Schuler H., Frintrup A., Nikolaou L., Tomprou M., Subramony S, Raj S.B., Tzafrir S., Bamberger P., Bertolino M., Mariani M.G., Fraccaroli F., Sekiguchi T., Yang H., Anderson N., Evers A., Chernyshenko O., Englert P., Kriek H., Joubert T., Salgado J., König C., Thommen L., Chuang A., Sinangil H., Bayazit M., Cook M., and Aguinis H.

Subjects
COUNTRIES, PSYCHOLOGISTS, LEGAL ENVIRONMENT, PERSONNEL SELECTION
Abstract

(from the chapter) To compare and contrast the legal environment for personnel selection in various countries, the senior author prepared a set of questions about the legal environment for selection, prepared model answers describing the legal environment in the United States, and contacted psychologists in various countries, asking them to prepare a document responding to each question and describing the legal environment in their country. They were also invited to suggest additional project participants in other countries. Some invitees declined; some initially agreed, but subsequently did not participate. The goal was to obtain a range of perspectives by sampling about 20 countries, thus, this is by no means a complete catalog of the legal environment around the world. Researchers and practitioners who are experts on the topic of selection participated from 22 countries.

Published
2010

6. Consensus clinical management guidelines for Friedreich ataxia

Author

Corben, Louise A., Lynch, David, Pandolfo, Massimo, Schulz, Jörg B., Delatycki, Martin B., Clinical Management Guidelines Writing Group, Balcer, Laura, Bartek, Ron, Bates, Claire, Campagna, Emma, Cnop, Miriam, Dürr, Alexandra, Emmanuel, Anton, Farmer, Jennifer, Flynn, John, Friedman, Lisa S., Giunti, Paola, Hadjivassiliou, Marios, Ho, Michael, Isaya, Grazia, Kearney, Mary, Loucas, Melissa, Mariotti, Caterina, Milne, Sarah, Morlet, Thierry, McGarry, Andrew, Panicker, Jalesh, Parkinson, Michael, Payne, R. Mark, Peverill, Roger, Rance, Gary, Rodriguez, Lucy, Schadt, Kimberly A., Seyer, Lauren, Subramony, S. H., Sullivan, Kelly L., Vogel, Adam, Yiu, Eppie, Yoon, Grace, and Zesiewicz, Theresa A.

Subjects
Weakness, medicine.medical_specialty, Ataxia, Génétique clinique, Consensus, Scoliosis, Disease, Review, Pharmacologie, Guidelines, Recommendations, Dysarthria, Clinical, Physical medicine and rehabilitation, Intervention (counseling), medicine, Humans, Genetics(clinical), Pharmacology (medical), Disease management (health), Genetics (clinical), Evidence, Medicine(all), Cerebellar ataxia, business.industry, Médecine pathologie humaine, Disease Management, General Medicine, Neuropathologie, Sciences bio-médicales et agricoles, medicine.disease, Friedreich ataxia, Practice Guidelines as Topic, medicine.symptom, business
Abstract

Friedreich ataxia (FRDA), a multisystem autosomal recessive condition, is the most common inherited ataxia in Caucasians, affecting approximately 1 in 29,000 individuals. The hallmark clinical features of FRDA include progressive afferent and cerebellar ataxia, dysarthria, impaired vibration sense and proprioception, absent tendon reflexes in lower limbs, pyramidal weakness, scoliosis, foot deformity and cardiomyopathy. Despite significant progress in the search for disease modifying agents, the chronic progressive nature of FRDA continues to have a profound impact on the health and well-being of people with FRDA. At present there is no proven treatment that can slow the progression or eventual outcome of this life-shortening condition. Thirty-nine expert clinicians located in Europe, Australia, Canada and USA critically appraised the published evidence related to FRDA clinical care and provided this evidence in a concise manner. Where no published data specific to FRDA existed, recommendations were based on data related to similar conditions and/or expert consensus. There were 146 recommendations developed to ensure best practice in the delivery of health services to people with FRDA. Sixty-two percent of recommendations are based on expert opinion or good practice indicating the paucity of high-level quality clinical studies in this area. Whilst the development of these guidelines provides a critical first step in the provision of appropriate clinical care for people with FRDA, it also highlights the urgency of undertaking high-quality clinical studies that will ensure the delivery of optimum clinical management and intervention for people with FRDA., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2014

7. Mutation in the Kv3.3 Voltage-Gated Potassium Channel Causing Spinocerebellar Ataxia 13 Disrupts Sound-Localization Mechanisms

Author

Middlebrooks, John C, Nick, Harry S, Subramony, S. H, Advincula, Joel, Rosales, Raymond L, Lee, Lillian V, Ashizawa, Tetsuo, Waters, Michael F, and Dryer, Stuart E

Subjects
Superior Olive, System, Medial Nucleus, Subunits, Medicine and Health Sciences, Life Sciences, Neuronal Excitability, Mouse-Brain, Expression, Interaural Phase, Cues, Trapezoid Body
Published
2013

8. Measuring the rate of progression in Friedreich ataxia: Implications for clinical trial design

Author

Friedman, Lisa S, Farmer, Jennifer M, Perlman, Susan, Wilmot, George, Gomez, Christopher, Bushara, Khalaf O, Mathews, Katherine D, Subramony, S. H, Ashizawa, Tetsuo, Balcer, Laura J, Wilson, Robert B, and Lynch, David R

Subjects
Adult, Male, Neurologic Examination, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Trials as Topic, Walking, Middle Aged, DNA, Mitochondrial, Severity of Illness Index, Article, Speech Disorders, Young Adult, Double-Blind Method, Trinucleotide Repeats, Friedreich Ataxia, Iron-Binding Proteins, Activities of Daily Living, Disease Progression, Humans, Point Mutation, Female, Aged
Abstract

Friedreich ataxia is an autosomal recessive neurodegenerative disorder characterized by ataxia of all four limbs, dysarthria and arreflexia. A variety of measures are currently used to quantify disease progression, including the Friedreich Ataxia Rating Scale, examiner-rated functional disability scales, self-reported activities of daily living and performance measures such as the timed 25-foot walk, 9-hole pegboard test, PATA speech test, and low-contrast letter acuity vision charts. The present study examines the rate of disease progression over one and two years in a cohort of 236 Friedreich ataxia patients using these scales and performance measure composites. The Friedreich Ataxia Rating Scale and performance-measure composites captured disease progression, with a greater sensitivity to change over two years than over one year. The measures differed in their sensitivity to change and in possible bias. These results help to establish norms for progression in FRDA that can be useful in measuring the long-term success of therapeutic agents and defining sample-size calculations for double-blind clinical trials.

Published
2010

9. ENDARTERECTOMY FOR ASYMPTOMATIC CAROTID-ARTERY STENOSIS

Author

WALKER, M, MARLER, J, GOLDSTEIN, M, GRADY, P, TOOLE, J, BAKER, W, CASTALDO, J, CHAMBLESS, L, MOORE, W, ROBERTSON, J, YOUNG, B, HOWARD, V, PURVIS, S, VERNON, D, NEEDHAM, K, BECK, P, DOZIER, M, LEFKOWITZ, D, HOWARD, G, CROUSE, J, HERRINGTON, D, FURBERG, C, ESSICK, K, HICKS, R, NELSON, J, BALL, W, BLAND, E, CONDON, S, ELLIOTT, T, GRIZZLE, J, HAYES, D, HENLEY, S, JOHNSON, J, LOCKLEAR, J, MISCH, M, PATON, C, SCHWARTZ, S, WALKER, C, WILLIAMS, O, EASTON, J, GOLDSTONE, J, HALLENBECK, J, HOFF, J, KARP, H, KRONMAL, R, BROTT, T, TOMSICK, T, BRODERICK, J, SAUERBECK, L, BLUM, C, DYKEN, M, BRUST, J, DICK, A, GOTSHALL, R, HEYMAN, A, SWANSON, P, ADAMS, H, DEMPSEY, R, ERNST, C, ROTHROCK, J, COHEN, S, NICHOLAS, G, LONGENECKER, J, BARBOUR, P, BERGER, A, CELANI, V, ECKERT, N, GOODREAU, J, HUTCHINSON, J, JENNY, D, LIN, Z, MCDONALD, K, PISTONE, W, RAEGRANT, A, REDENBAUGH, J, REX, J, WOHLBERG, C, KARANJIA, P, SWANSON, M, LOBNER, S, KOLTS, R, KUEHNER, M, HINER, B, MADDEN, K, CARLSON, R, DAVIS, J, GALLANT, T, WARNER, J, FAUST, A, FRYZA, N, HASENAUER, J, REGNER, M, RONKIN, L, SCHAEFER, S, STRACK, D, TURNER, L, WALGENBACH, A, GRAVES, J, MICHALSKI, S, SCHUETTE, L, MOHR, J, TATEMICHI, T, MARSHALL, R, MAST, H, RAMOS, O, CORRELL, J, LIBMAN, R, PETTY, G, CABRERE, A, OROPEZA, L, GONZALEZ, T, PETTIGREW, C, SADLER, R, ENDEAN, E, SHERROW, J, HAUER, M, LEE, C, NORTON, J, MCQUILLEN, M, MATTINGLY, S, DEKOSKY, S, MASSEY, A, SIMARD, D, TURCOTTE, J, BENGUIGUI, C, COTE, J, BOUCHARD, J, ROBERGE, C, BRUNET, D, BEDARD, F, LANGELIER, R, LAJEUNESSE, M, BIGAOUETTE, J, PARENT, J, LYDEN, P, HYE, R, LEWIS, S, CALI, G, BABCOCK, T, TAFTALVAREZ, B, BRODY, M, ZWEIFLER, R, SEDWITZ, M, STABILE, B, FREISCHLAG, J, WOLF, Y, SIVO, J, FORSYTHE, J, ADAME, M, GUPTA, S, BURKE, K, GREISLER, H, LITTOOY, F, KELLY, M, PULSINELLI, W, CAMPBELL, J, CROCKARELL, J, WATRIDGE, C, ACKER, J, ERKULWATER, S, JACEWICZ, M, WALKER, G, OSULLIVAN, P, SAUER, C, VASU, K, GAINES, K, BAKHITIAN, B, BERTORINI, T, BENNETT, S, THOMAS, T, STAHL, N, TAYLOR, C, GIAMPAPA, M, CONNELL, J, RILEY, J, BRADLEY, A, NEWMAN, K, MANNING, R, MCCREA, M, HACHINSKI, V, FERGUSON, G, MAYER, C, BARNETT, J, PEERLESS, S, BUCHAN, A, REICHMAN, H, KERTESZ, A, LOWNIE, S, WHITE, C, FOX, A, RANKIN, R, SPENCE, J, BARR, H, PADDOCKELIASZIW, L, ASSIS, L, PEXMAN, J, DICICCO, M, TATE, B, JAMES, C, RAKER, E, COATSWORTH, J, HARRIS, S, BEEBE, H, BIRCHFIELD, R, BUTLERLEVY, K, CRANE, R, FRYER, D, MACLEAN, J, PATTERSON, L, QUIGLEY, T, RAVITS, J, TAYLOR, L, PULLEN, S, BOSWELL, S, KENNY, K, ROEDERSHEIMER, L, FOWL, R, TEW, J, KEMPCZINSKI, R, REED, R, WELLING, R, SCHOMAKER, B, MCWHORTER, J, BRANCH, C, SATTERFIELD, J, CORDELL, R, DEAN, R, PLONK, G, HARPOLD, G, WALKER, F, NUNN, C, MYERS, L, TEGELER, C, HARDIN, S, MEADS, D, LOFTUS, C, VINING, L, BENDIXEN, B, BILLER, J, CORSON, J, DAVIS, P, GODERSKY, J, GORDON, D, JACOBY, M, KAPPELLE, L, KRESOWIK, T, MARSH, E, LOVE, B, SHAMMA, A, GRIMSMAN, K, KARBOSKI, D, MILLER, E, JOHNSON, C, JONES, C, STONE, B, MAGUIRE, M, EARLEY, C, KAPLAN, P, CAVALUZZI, J, WATERS, G, CHACHICH, B, AUER, A, LOGAN, W, WILCOX, M, GREEN, B, HURLEY, J, PENNELL, R, WOODS, J, LEVINE, R, NEPUTE, J, THOMASSON, J, BLACKBURN, C, FOLDES, M, KLEMP, K, NAPPIER, B, RUTHERFORD, K, SCHROER, S, HOGAN, J, THORPE, L, FEINBERG, W, HUNTER, G, BRUCK, D, BERNHARD, V, MCINTYRE, K, CARTER, L, LABADIE, E, JOHNSON, D, MOSCHONAS, C, HAMILTON, R, FORRER, S, SEEGER, J, CARMODY, R, VOLD, B, LAGUNA, J, KRIKAWA, J, DEVINE, J, CASTRILLO, A, KISTLER, S, LEDBETTER, B, DORR, K, SMITH, R, HAERER, A, BROWN, R, RUSSELL, W, RIGDON, E, RHODES, R, SMITH, E, GRAEBER, M, DOORENBOS, D, SUBRAMONY, S, ATNIP, R, BRENNAN, R, FRIEDMAN, D, NEUMYER, M, THIELE, B, SMITH, F, BARR, J, DUCKROW, R, JANESKY, C, MEILSTRUP, J, MCNAMARA, K, RODICHOK, L, STEWART, L, SULLIVAN, M, WENGROVITZ, M, CLAGETT, G, UNWIN, H, BRYAN, W, MATKINS, C, PATTERSON, C, ALWAY, C, BOYD, P, INMAN, M, ALBISTON, C, SCOGGINS, E, SWILLING, J, WALDEN, K, AHN, S, AMOS, E, BAKER, J, DOBKIN, B, DONAYRE, C, GELABERT, H, JORDAN, S, MACHLEDER, H, QUINONESBALDRICH, W, SAVER, J, ELSADEN, S, HOLGATE, R, JABOUR, B, JACOBS, J, ABRAHAM, T, VESCERA, C, VONRAJCS, J, CARTER, V, CARTER, D, DIXGOSS, D, HERNANDEZ, E, COULL, B, LOBOA, L, MONETA, G, PORTER, J, YEAGER, R, WHITTAKER, L, BRASS, L, GUSBERG, R, LOVEJOY, A, FAYAD, P, SUMPIO, B, MEIER, G, CHANG, V, MARZITELLI, K, CHYATTE, D, HAMMERS, L, LEPORE, F, PAVALKIS, F, MELE, J, KISIEL, D, BARNES, R, CHESSER, M, ARCHER, R, THOMPSON, B, MACDONALD, C, BARONE, G, EIDT, J, HARSHFIELD, D, MCFARLAND, D, NICKOLS, J, HOWARD, C, NIX, M, OVERSTREET, J, TROILLETT, R, TAYLOR, J, LEE, H, AKINS, P, HARBISON, J, PRIDGEON, R, FELTON, W, POSNER, M, SOBEL, M, CLIFTON, G, CONWAY, C, COCKRELL, A, STRINGER, W, WINGO, J, NICHOLS, B, SMOKER, W, FISHER, R, SPETZLER, R, FREY, J, ZABRAMSKI, J, HUNSLEY, S, JAHNKE, H, PLENGE, K, HOLLAND, R, TURNER, R, STRAVA, D, STUMPFF, S, HODAK, J, FLOM, R, DEAN, B, THOMPSON, R, HUGHES, R, LEPLER, B, BOWEN, J, BENOIT, C, HOLLIER, L, OCHSNER, J, STRUB, R, LANG, V, 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D, ATKINSON, K, PETERS, M, COHEN, B, YAO, J, ROSTON, S, BLACKBURN, D, CHADWICK, L, MCCARTHY, W, PEARCE, W, FRANK, J, FERNANDEZBEER, E, PATRICK, J, GREEN, R, SATRAN, R, RICOTTA, J, DEWEESE, J, HOLLANDER, J, OBRIEN, M, MCNAMARA, J, ROSE, S, COHEN, D, FURLAN, A, LITTLE, J, BRYERTON, B, SILA, C, AWAD, I, CHIMOWITZ, M, ROBERTSON, S, BECKER, C, PAUSHTER, D, OLEARY, D, JONES, A, GEE, W, SHEBEL, N, FISHER, M, SCHENK, E, FUTRELL, N, MILLIKAN, C, DIENER, H, FIELDS, W, FOLSTEIN, M, GAUTIER, J, HARRISON, M, HASS, W, HENNERICI, M, SPENCER, M, and VONREUTERN, G

Published
1995

10. The gene for autosomal dominant spinocerebellar ataxia (SCA1) maps centromeric to D6S89 and shows no recombination, in nine large kindreds, with a dinucleotide repeat at the AM10 locus

Author

Kwiatkowski Jr, T. J., Orr, H. T., Banfi, S., Mccall, A. E., Jodice, C., Francesca Persichetti, Novelletto, A., Leborgne-Demarquoy, F., Duvick, L. A., Frontali, M., Subramony, S. H., Beaudet, A. L., Terrenato, L., Zoghbi, H. Y., and Ranum, L. P. W.

Subjects
Settore BIO/18 - Genetica, Settore MED/03 - Genetica Medica
Published
1993

12. International perspectives on the legal environment for selection

Author

Oleksandr S. Chernyshenko, Mark Cook, Heinz Schuler, Maria Tomprou, Dirk D. Steiner, Florence Rolland, Ioannis Nikolaou, Peter Bamberger, Hennie J. Kriek, Franco Fraccaroli, Larissa A. Thommen, Steven F. Cronshaw, S. Subramony, Shabu B. Raj, Tina Joubert, Arne Evers, Neil Anderson, Mahmut Bayazit, Cornelius J. König, Filip Lievens, Brett Myors, Aichia Chuang, Paul R. Sackett, Hyuckseung Yang, Andreas Frintrup, Marilena Bertolino, Tomoki Sekiguchi, Jesús F. Salgado, Betty Onyura, Herman Aguinis, Antonio Mladinic, Eveline Schollaert, Marco Giovanni Mariani, Shay S. Tzafrir, Greet Van Hoye, Handan Kepir Sinangil, Viviana Rodríguez, Paul Englert, Winny Shen, Myors B., Lievens F., Schollaert E., Van Hoye G., Cronshaw S.F., Mladinic A., Rodríguez V., Aguinis H., Steiner D.D., Rolland F., Schuler H., Frintrup A., Nikolaou I., Tomprou M., Subramony S., Raj S.B., Tzafrir S., Bamberger P., Bertolino M., Mariani M.G., Fraccaroli F., Sekiguchi T., Onyura B., Yang H., Anderson N., Evers A., Chernyshenko O., Englert P., Kriek H.J., Joubert T., Salgado J.F., König C.J., Thommen L.A., Chuang A., Sinangil H.K., Bayazit M., Cook M., Shen W., Sackett P.R., University of Zurich, Leadership and Management (ABS, FEB), and Arbeids- en Organisatie Psychologie (Psychologie, FMG)

Subjects
Affirmative action, Social Psychology, BF Psychology, 10093 Institute of Psychology, Personnel selection, Ethnic group, LEGAL ENVIRONMENT, Preferential treatment, Disadvantaged, Job performance, Selection (linguistics), INTERNATIONAL PERSPECTIVES, Industrial and organizational psychology, HD0028 Management. Industrial Management, Psychology, 150 Psychology, Social psychology, PERSONNEL SELECTION, Applied Psychology
Abstract

Perspectives from 22 countries on aspects of the legal environment for selection are presented in this article. Issues addressed include (a) whether there are racial/ethnic/religious subgroups viewed as “disadvantaged,” (b) whether research documents mean differences between groups on individual difference measures relevant to job performance, (c) whether there are laws prohibiting discrimination against specific groups, (d) the evidence required to make and refute a claim of discrimination, (e) the consequences of violation of the laws, (f) whether particular selection methods are limited or banned, (g) whether preferential treatment of members of disadvantaged groups is permitted, and (h) whether the practice of industrial and organizational psychology has been affected by the legal environment.

Published
2008

13. Broadening International Perspectives on the Legal Environment for Personnel Selection

Author

Ioannis Nikolaou, Marco Giovanni Mariani, Dirk D. Steiner, Paul R. Sackett, Shabu B. Raj, Tomoki Sekiguchi, Paul Englert, Arne Evers, Greet Van Hoye, Florence Rolland, Franco Fraccaroli, Marilena Bertolino, Hyuckseung Yang, Mahmut Bayazit, Eveline Schollaert, Betty Onyura, Filip Lievens, Cornelius J. König, Shay S. Tzafrir, Handan Kepir Sinangil, Larissa A. Thommen, Brett Myors, Andreas Frintrup, Jesús F. Salgado, S. Subramony, Winny Shen, Oleksandr S. Chernyshenko, Antonio Mladinic, Mark Cook, Hennie J. Kriek, Herman Aguinis, Viviana Rodríguez, Tina Joubert, Neil Anderson, Steven F. Cronshaw, Aichia Chuang, Maria Tomprou, Heinz Schuler, Peter Bamberger, Leadership and Management (ABS, FEB), Myors B., Lievens F., Schollaert E., Van Hoye G., Cronshaw S.F., Mladinic A., Rodríguez V., Aguinis H., Steiner D.D., Rolland F., Schuler H., Frintrup A., Nikolaou I., Tomprou M., Subramony S., Raj S.B., Tzafrir S., Bamberger P., Bertolino M., Mariani M., Fraccaroli F., Sekiguchi T., Onyura B., Yang H., Anderson N., Evers A., Chernyshenko O., Englert P., Kriek H.J., Joubert T., Salgado J.F., König C.J., Thommen L.A., Chuang A., Sinangil H.K., Bayazit M., Cook M., Shen W., and Sackett P.R.

Subjects
Social Psychology, Individual difference, Applied psychology, Personnel selection, Ethnic group, Behavioural sciences, Disadvantaged, Job performance, Selection (linguistics), INTERNATIONAL PERSPECTIVES, LEGAL ENVIROMENT, Industrial and organizational psychology, Psychology, PERSONNEL SELECTION, Social psychology, Applied Psychology
Abstract

Perspectives from 22 countries on aspects of the legal environment for selection are presented in this article. Issues addressed include (a) whether there are racial/ethnic/religious subgroups viewed as "disadvantaged," (b) whether research documents mean differences between groups on individual difference measures relevant to job performance, (c) whether there are laws prohibiting discrimination against specific groups, (d) the evidence required to make and refute a claim of discrimination, (e) the consequences of violation of the laws, (f) whether particular selection methods are limited or banned, (g) whether preferential treatment of members of disadvantaged groups is permitted, and (h) whether the practice of industrial and organizational psychology has been affected by the legal environment.

Published
2008

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