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Background: Multiple sclerosis (MS) as chronic neurodegenerative disease significantly impact patients' quality of life (QoL). QoL instruments can be generic (EQ-5D, SF-36) and disease-specific like MSQoL-54. Use of disease-specific instruments is preferred since it captures broader symptoms related to MS than generic instruments. Mental health is impacted by MS and different psychiatric conditions significantly impact QoL. We have conducted prospective non-interventional study among MS patients. Aim was to measure and compare MS patients QoL by generic and disease-specific instrument at baseline and after one year and to identify potential correlation between these two types of measurements and to assess mental health scores among MS patients in Bosnia and Herzegovina (B&H) and other countries. Subjects and methods: Study included 62 patients diagnosed with MS and treated at Neurology clinic in Sarajevo from April 2016 to May 2017. Study was approved by Ethical Committee. QoL has been measured by EQ-5D and MSQoL-54. Measurement has been performed at baseline and after 12 months. Results: Average utility score measured by EQ-5D at the baseline and end of the study were 0.688 and 0.639 respectively with no significant difference (p=0.850). EQ-5D utility and MSQoL-54 score showed high correlation at baseline ; rho=0.873 p=0.0001 for physical health and rho=0.711 p=0.0001 for mental health. At the end of the study no significant correlations have been found (p>0.05). High negative correlation found between EDSS and scores measured by EQ-5D and MSQoL-54 ; at baseline (rho=-0.744 p=0.0001) and at the end of the study (rho=-0.832 p=0.0001). Similar MS impact and loss of QoL found in B&H and other countries. Conclusions: Both instruments can be used in measuring QoL but disease-specific are preferred since they capture broader symptoms impacting MS patient QoL. Using QoL instruments could drive clinician decision and patient-centric care as well as reimbursement and policy decision by recording treatment outcomes.

In numerous studies, asymptomatic hyperglycemia has been shown to be a risk factor for cardiovascular and coronary disease, with a higher risk of dying from coronary disease. Hyperglycemia may develop during severe diseases (e.g., acute myocardial infarction) in people who have not previously suffered from diabetes. The aim of the study was to determine the number of patients with acute myocardial infarction (AMI) in whom hyperglycemia was detected for the first time during AMI. The study included 412 nondiabetic patients treated for AMI at the Department for Medicine, Cantonal Hospital in Zenica, during 1991, 1993 and 1996. The 1993 European standards were used to make the diagnosis of hyperglycemia. Out of 412 nondiabetics with AMI, 113 (27.43%) had hyperglycemia during their hospital stay. According to year of treatment, there were 29 (22.83%), 50 (34.97%) and 34 (23.94%) patients in 1991, 1993 and 1996, respectively. According to year of hospitalization, a statistically significantly higher percentage of nondiabetics with first-ever detected hyperglycemia during AMI were recorded in the war year 1993 as compared with 1991 and 1996 (p

Risk factors for coronary disease, apart from some others, are cigarette smoking, excessive consumption of alcohol, overweight and obesity. The aim of the study was to evaluate the frequency of these three risk factors of coronary disease among diabetics and nondiabetics treated for acute myocardial infarction (AMI) before the war in 1991, during the war in 1993, and after the war in 1996. The aim was also to establish whether there were differences in the frequency of these three factors in diabetics treated for AMI among the three study years. The study included diabetic and nondiabetic patients with AMI hospitalized at the Department of Medicine, Cantonal Hospital in Zenica during the mentioned period. According to study years, there were 163 AMI patients in 1991, 36 (22.09%) of them diabetic and 127 (77.91%) nondiabetic ; 174 AMI patients in 1993, 31 (17.82%) of them diabetic and 143 (82.18%) nondiabetic ; and 169 AMI patients in 1996, 27 (15.98%) of them diabetic and 142 (84.02%) nondiabetic. Patient data were obtained from medical files of the Department of Medicine, Cantonal Hospital in Zenica, and a few missing data directly from the patients or their close relatives through a questionnaire. The study was retrospective in design. Statistical analysis was done by use of chi2-test and t-test. Data are shown in tables and figures. There were significantly fewer smokers and alcohol users among diabetic compared to nodiabetic AMI patients in all three study years. On the other hand, there was a significantly higher percent of overweight and obese patients among diabetic compared to nondiabetic AMI patients. A significantly higher percent of smokers and alcohol abuse patients were recorded among diabetic AMI patients in 1991 and 1993 compared to 1996. However, there was a statistically significantly higher percent of overweight and obese patients among diabetic AMI patients in 1991 and 1996 than in 1993. In conclusion, we found a statistically lower percent of smokers and alcohol abusers but a higher percent of overweight and obese patients among diabetic as compared to nondiabetic AMI patients. Among diabetic AMI patients there was a statistically higher percent of smokers and alcohol abusers in 1991 and 1993 than in 1996, and a statistically lower percent of overweight and obese patients in 1993 compared to 1991 and 1996.