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Non-Abelian topological phases (NATPs) are highly sought-after candidate states for quantum computing and communication while lacking straightforward configuration and manipulation, especially for classical waves. In this work, we exploit novel braid-type couplings among a pair of triple-component acoustic dipoles, which act as functional elements with effective imaginary couplings. Sequencing them in one dimension allows us to generate acoustic NATPs in a compact yet reciprocal Hermitian system. We further provide the whole phase diagram that encompasses all i, j, and k non-Abelian phases, and directly demonstrate their unique quotient relations via different endpoint states. Our NATPs based on real-space braiding may inspire the exploration of acoustic devices with non-commutative characters.

Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe COVID-19 patients, and the macrophage is recognized as the direct host cell of SARS-CoV-2 and potential drivers of CSS. In the present study, peramivir was identified to reduce TNF-α by partly intervention of NF-κB activity in LPS-induced macrophage model. In vivo, peramivir reduced the multi-cytokines in serum and bronchoalveolar lavage fluid (BALF), alleviated the acute lung injury and prolonged the survival time in mice. In human peripheral blood mononuclear cells (hPBMCs), peramivir could also inhibit the release of TNF-α. Collectively, we proposed that peramivir might be a candidate for the treatment of COVID-19 and other infections related CSS.

We present a comment on "Spin-Momentum-Locked Edge Mode for Topological Vortex Lasing, Phys. Rev. Lett. vol. 125, 013903 (2020)"(hereafter the Letter).In the Letter, Yang et al. reported on an elegant topological vortex laser and proposed that the near-field spin and OAM of the topological edge mode lasing have a one-to-one far-field radiation correspondence. The near-field information is based on frequency dispersions of the topological edge modes, without supporting measurements and/or computer simulations. Unfortunately, their frequency dispersions shown in Fig. 1(c) (see also Fig. S6 and Eqs. (5.3) and (5.4) in Supplemental Material) are wrong. As the result, the mode assignment of the main mode |-2,+> investigated in the Letter is mistaken, which should be |2,+>. This spoils the one-to-one correspondence claimed in the Letter.

Precise control of elastic waves in modes and coherences is of great use in reinforcing nowadays elastic energy harvesting/storage, nondestructive testing, wave-mater interaction, high sensitivity sensing and information processing, etc. All these implementations are expected to have elastic transmission with lower transmission losses and higher degree of freedom in transmission path. Inspired by topological states of quantum matters, especially quantum spin Hall effects (QSHEs) providing passive solutions of unique disorder-immune surface states protected by underlying nontrivial topological invariants of the bulk, thus solving severe performance trade-offs in experimentally realizable topologically ordered states. Here, we demonstrate experimentally the first elastic analogue of QSHE, by a concise phononic crystal plate with only perforated holes. Strong elastic spin-orbit coupling is realized accompanied by the first topologically-protected phononic circuits with both robustness and negligible propagation loss overcoming many circuit- and system-level performance limits induced by scattering. This elegant approach in a monolithic substrate opens up the possibility of realizing topological materials for phonons in both static and time-dependent regimes, can be immediately applied to multifarious chip-scale devices with both topological protection and massive integration, such as on-chip elastic wave-guiding, elastic splitter, elastic resonator with high quality factor, and even (pseudo-)spin filter.

Discovery of novel topological orders of condensed matters is of a significant interest in both fundamental and applied physics due to the associated quantum conductance behaviors and unique symmetry-protected backscattering-immune propagation against defects, which inspired similar fantastic effects in classical waves system, leading to the revolution of the manipulation of wave propagation. To date, however, only few theoretical models were proposed to realize acoustic topological states. Here, we theoretically and experimentally demonstrate a two dimensional acoustic topological insulators with acoustic analogue of quantum spin Hall Effect. Due to the band inversion mechanism near the double Dirac cones, acoustic one-way pseudospin dependent propagating edge states, corresponding to spin-plus and spin-minus, can be observed at the interface between two graphene-like acoustic crystals. We have also experimentally verified the associated topological immunity of such one-way edge states against the different lattice defects and disorders, which can always lead to inherent propagation loss and noise. We show that this unique acoustic topological phenomenon can offer a new promising application platform for the design of novel acoustic devices, such as one-way sound isolators, acoustic mode switchers, splitters, filters etc., 13 pages, 3 figures

This paper introduces a new method for the early detection of gastric cancer using a combination of feature extraction based on discrete wavelet transformation (DWT) for horizontal attenuated total reflectance–Fourier transform infrared spectroscopy (HATR–FT-IR) and classification using probability neural network (PNN). 344 FT-IR spectra were collected from 172 pairs of fresh normal and abnormal stomach tissue᾽s samples. After preprocessing, 5 features were extracted with DWT analysis. Based on the PNN classification, all FT-IR spectra were classified into three categories. The accuracy of identifying normal gastric tissue, early gastric cancer tissue and gastric cancer tissue samples were 100.00, 97.56 and 100.00%, respectively. This result indicated that FT-IR with DWT and PNN could effectively and easily diagnose gastric cancer in its early stages.

Recently, artificial bandgap materials (such as photonic crystals and phononic crystals) have been becoming the research hotspot of the next generation intelligent materials, because of its extremely designable, tunable and controllable capacity of classical waves. On the other hand, topological material phase, originally proposed and first demonstrated in Fermionic electronic systems, has been proposed in more and more Bosonic systems. In this review paper, we first focus on some of the representative photonic/phononic topological models, and four common types of topological photonic system are discussed:1) photonic/phononic quantum Hall effect with broken time-reversal symmetry; 2) photonic topological insulator and the associated pseudo-time-reversal symmetry protected mechanism; 3) time/space periodically modulated photonic Floquet topological insulator; 4) a summary and outlook including a brief introduction of Zak phase in one-dimensional systems and Weyl point in three-dimensional systems. Finally, the underlying Dirac model is analyzed.

Symmetry-protected photonic topological insulator exhibiting robust pseudo-spin-dependent transportation, analogous to quantum spin Hall (QSH) phases and topological insulators, are of great importance in fundamental physics. Such transportation robustness is protected by time-reversal symmetry. Since electrons (fermion) and photons (boson) obey different statistics rules and associate with different time-reversal operators (i.e., Tf and Tb, respectively), whether photonic counterpart of Kramers degeneracy is topologically protected by bosonic Tb remains unidentified. Here, we construct the degenerate gapless edge states of two photonic pseudo-spins (left/right circular polarizations) in the band gap of a two-dimensional photonic crystal with strong magneto-electric coupling. We further demonstrated that the topological edge states are in fact protected by Tf rather than commonly believed Tb and their pseudo-spin dependent transportation is robust against Tf invariant impurities, discovering for the first time the topological nature of photons. Our results will pave a way towards novel photonic topological insulators and revolutionize our understandings in topological physics of fundamental particles., 20 pages, 4 figures

We propose an optical counterpart of the quantum spin Hall (QSH) effect in a two-dimensional photonic crystal composed of a gyrotropic medium exhibiting both gyroelectric and gyromagnetic properties simultaneously. Such QSH effect shows unidirectional polarization-dependent transportation of photonic topological edged states, which is robust against certain disorders and impurities. More importantly, we find that such unique property is not protected by conventional time-reversal symmetry of photons obeying the Bosonic statistics but rather by the same symmetry, as electron's time-reversal symmetry. Based on the tight-binding approximation approach, we construct an effective Hamiltonian for this photonic structure, which is shown to have a similar form to that of an electronic QSH system. Furthermore, the invariant of such model is calculated in order to unify its topological non-trivial character. Our finding provides a viable way to exploit the optical topological property, and also can be leveraged to develop a photonic platform to mimic the spin properties of electrons., Comment: 20 pages, 5 figures

To evaluate the expression of microRNA (miR)-let-7b in peripheral blood cells of patients with primary biliary cirrhosis (PBC) and investigate its relationship to clinical disease parameters.Peripheral blood and serum samples were obtained for study from 60 PBC patients and 60 healthy controls. Peripheral blood cells were extracted and subjected to real-time PCR to measure miR-let-7b expression. Serum levels of interleukin (IL)-18, total bilirubin (TBIL), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were measured by standard biochemical assays. The relationship between miR-let-7b expression and disease parameters was assessed by Spearman's rank correlation test.PBC patients showed significantly lower expression of miR-let-7b in peripheral blood cells than healthy controls (P less than 0.001); moreover, the miR-let-7b expression level decreased in parallel to increases in disease severity (stage III / IIIIV). In PBC patients, the miR-let-7b expression was significantly correlated with Mayo risk scores (r = -0.4930, P less than 0.001), IL-18 (r = -0.4643, P less than 0.001) and ALP (r = -4119, P less than 0.001), but not with TBIL or GGT.Decreased expression of miR-let-7b may be associated with development and progression of PBC, and this miRNA may represent a novel target of improved diagnostic and preventive strategies for PBC.

For an emergency event under uncertainty environment, in order to make a better decision, a new definition about emergency event is given, which is a set that the element is event attributes including key attribute, secondary attribute, environment attribute and disserve evaluation attribute, etc. And the response decision for the emergency event also is defined newly by a set including the decision of extracting attributes, determining decision object and choosing action. Then, for a simple barrier lake event, we model the response decision problem into a infinite period stochastic dynamic programming problem when the event is random and dynamic. And a numerical example is given, the results show that the model can solve the problem effectively when the state of emergency event and the action set are finite.

In order to improve the auto-generating test paper's quality at the cost of low time, an intelligent algorithm based on immune genetic algorithm was proposed. In the algorithm immune process was added into the basic framework of genetic algorithm, and the algorithm based on vaccination was put forward and used for test paper auto-generating. The problem that genetic algorithm is precocity and easy to fall into a local optimization was resolved by this algorithm. The feasibility and validity of the algorithm was proved by test data compared with other algorithms. At last the validating system enhances the users' condition constraints for test paper through manual inching, thus the system is more simple and practical.

Background Cancer-testis antigens (CTAs) are suitable targets for cancer-specific immunotherapy. The aim of the study is to investigate the expression of CTAs in intrahepatic cholagiocarcinoma (IHCC) and evaluate their potential therapeutic values. Methods Eighty-nine IHCC patients were retrospectively assessed for their expression of CTAs and HLA Class I by immunohistochemistry using the following antibodies: MA454 recognizing MAGE-A1, 57B recognizing multiple MAGE-A (MAGE-A3/A4), E978 recognizing NY-ESO-1, and EMR8-5 recognizing HLA class I. The clinicopathological and prognostic significance of individual CTA markers and their combination were further evaluated. Results The expression rates of MAGE-A1, MAGE-A3/4 and NY-ESO-1 were 29.2%, 27.0% and 22.5%, respectively. The concomitant expression of CTAs and HLA class I antigen was observed in 33.7% of the IHCC tumors. We found that positive MAGE-3/4 expression correlated with larger tumor size (≥ 5 cm), tumor recurrence and poor prognosis. Moreover, we identified 52 cases (58.4%) of IHCC patients with at least one CTA marker expression, and this subgroup displayed a higher frequency of larger tumor size and a shorter survival than the other cases. Furthermore, expression of at least one CTA marker was also an independent prognostic factor in patients with IHCC. Conclusion Our data suggest that specific immunotherapy targeted CTAs might be a novel treatment option for IHCC patients.

In a productive system with new generation and old generation product, one hand, producer faces the needs for new components, and the other hand, also needs consider the after-sales service needs for components of sold products. The after-sales service needs can be satisfied by ordering the old components, and also by new components. For determining the optimal order quantities for new and old components, a single period stochastic inventory model was formulated. The uniqueness and existence of optimal decisions were proved, and the conditions that should satisfy were given. And moreover, some properties for optimal decisions were obtained.

In a remanufacturing reverse supply chain consisting of a manufacturer with random yield and a recycling business with uncertain supply, a Stackelberg game problem was studied, where recycling business determines the selling price before uncertain supply was realized, and the Manufacturer determines the order quantity. The existence and uniqueness of the Stackelberg equilibrium were proved, and some properties were obtained, including the manufacturer's order quantity does not depend on the recycling business's uncertain supply, and the Manufacturer 's shortage risk are larger than that with no supply uncertainty. At last, a numerical analysis was given.