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5 results on '"Tabudravu, Jioji"'

1. MS Dereplication for Rapid Discovery of Structurally New or Novel Natural Products

Author

Tabudravu, Jioji, Pellissier, Leonie, Smith, Alan James, Kid, Richard, Milton, Edward J., Deng, Hai, Ebel, Rainer, Gissi, Carmela, Milne, Bruce F., Cimpan, Gabriela, and Jaspars, Marcel

Subjects
F410
Abstract

In order to accelerate the isolation and characterisation of structurally new or novel natural products, it is crucial to develop efficient strategies that prioritise samples with greatest promise early in the workflow so that resources can be utilised in a more efficient and cost-effective manner. Two complementary approaches have been developed: One is based on targeted identification of known compounds held in a database based on high resolution MS and predicted LC retention time data [1]. The second is an MS metrics-based approach where the software algorithm calculates metrics for sample novelty, complexity, and diversity after interrogating databases of known compounds, and contaminants. These metrics are then used to prioritise samples for isolation and structure elucidation work [2]. Both dereplication approaches have been validated using natural product extracts resulting in the isolation and characterization of new or novel natural products.

Published
2020

3. Clionasterol, a Triterpenoid from the Kenyan Marine Green Macroalga Halimeda macroloba

Author

Jaspars, Marcel, Dzeha, Thomas, and Tabudravu, Jioji

Subjects
F163, Algae, clionasterol, macroalga, Halimeda macroloba, spectroscopy, bioprospecting, Kenya
Abstract

Keywords: clionasterol, macroalga, Halimeda macroloba, spectroscopy, bioprospecting, Kenya The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result. Western Indian Ocean Journal of Marine Sciences Vol.2(2) 2003: 157-161

Published
2003

4. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp

Author

David Clarke, Marcel Jaspars, Klaus D. Feussner, Marc Stierhof, Karolina Subko, Johan Isaksson, Espen Hansen, Kine Østnes Hansen, Jioji N. Tabudravu, Mukesh Sharma, Fernando Fernandez Diaz-Rullo, Ignacio Pérez-Victoria, [Stierhof, Marc] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Subko, Karolina] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Jaspars, Marcel] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Tabudravu, Jioji N.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Hansen, Kine Ostnes] UiT Arctic Univ Norway, Marbio, N-9037 Tromso, Norway, [Hansen, Espen] UiT Arctic Univ Norway, Marbio, N-9037 Tromso, Norway, [Sharma, Mukesh] Univ South Pacific, Fac Sci Technol & Environm, Inst Appl Sci, POB 1168, Suva, Fiji, [Feussner, Klaus] Univ South Pacific, Fac Sci Technol & Environm, Inst Appl Sci, POB 1168, Suva, Fiji, [Diaz-Rullo, Fernando Fernandez] Univ Aberdeen, Inst Med Sci, Aberdeen AB24 3UE, Scotland, [Isaksson, Johan] UiT Arctic Univ Norway, Dept Chem, N-9037 Tromso, Norway, [Perez-Victoria, Ignacio] Fdn MEDINA, Parque Tecnol Salud,Ave Conocimiento 34, Granada 18016, Spain, [Clarke, David] Univ Edinburgh, Sch Chem, Joseph Black Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland, EU, and NCDDG

Subjects
Asteropus, Stereochemistry, Antiproliferative activity, Latrunculia sp, 010402 general chemistry, 01 natural sciences, Biochemistry, Antifungal peptides, Cyclic depsipeptide, LCMS, Papua-new-guinea, Drug Discovery, medicine, Cytotoxic T cell, Bioorganic chemistry, Cytotoxicity, Fibroblast, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, NMR, 0104 chemical sciences, Sponge, medicine.anatomical_structure, Theonella-swinhoei, Cell culture, Callipeltin, Acid hydrolysis, Derivatisation
Abstract

Four new callipeltin A derivatives (N-Q) have been isolated from the Solomon Island marine sponge Asteropus sp. Their structures were established by spectroscopic techniques followed by acid hydrolysis and derivatisation of the free amino acids, and subsequent LCMS analysis of the derivatives. The compounds were evaluated for their activity against cancer cell lines A2058 (melanoma), HT-29 (colorectal adenocarcinoma) and MCF-7 (breast adenocarcinoma) and non-malignant MRC-5 fibroblast cells. While the acyclic callipeltins P and Q were inactive the cyclic callipeltins N and O showed significant cytotoxicity against all exposed cell lines with IC50 values as low as 0.16 mu M confirming the role of cyclic configuration in biological activity. (C) 2016 Elsevier Ltd. All rights reserved.

Published
2016

5. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040

Author

Leonie Pellissier, Hai Deng, Marcel Jaspars, Eva C. Sonnenschein, Bruce F. Milne, Jioji N. Tabudravu, Daniëlle Copmans, Espen Hansen, Jeanette Hammer Andersen, Kine Østnes Hanssen, Mercedes de la Cruz, Lone Gram, Venke Kristoffersen, José R. Tormo, Stephan Goralczyk, Floriane M. Vabre, Rainer Ebel, Marc Stierhof, Peter de Witte, Caridad Díaz, [Sonnenschein, Eva C.] Tech Univ Denmark, Dept Biotechnol & Biomed, Matematiktorvet 301, DK-2800 Lyngby, Denmark, [Gram, Lone] Tech Univ Denmark, Dept Biotechnol & Biomed, Matematiktorvet 301, DK-2800 Lyngby, Denmark, [Stierhof, Marc] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Goralczyk, Stephan] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Vabre, Floriane M.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Pellissier, Leonie] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Ebel, Rainer] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Jaspars, Marcel] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Tabudravu, Jioji N.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [de Witte, Peter] Dept Pharmaceut & Pharmacol Sci, Lab Mol Biodiscovery, KU Leuven Campus,O&N 2 Herestr 49,Box 824, B-3000 Leuven, Belgium, [Copmans, Danielle] Dept Pharmaceut & Pharmacol Sci, Lab Mol Biodiscovery, KU Leuven Campus,O&N 2 Herestr 49,Box 824, B-3000 Leuven, Belgium, [Hanssen, Kine Ostnes] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [Andersen, Jeanette Hammer] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [Hansen, Espen] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [Kristoffersen, Venke] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [de la Cruz, Mercedes] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Ave Conocimiento 34,Parque Tecnol Ciencias Salud, Granada 18016, Spain, [Diaz, Caridad] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Ave Conocimiento 34,Parque Tecnol Ciencias Salud, Granada 18016, Spain, [Tormo, Jose R.] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Ave Conocimiento 34,Parque Tecnol Ciencias Salud, Granada 18016, Spain, [Milne, Bruce F.] Univ Coimbra, Dept Phys, CFisUC, Rua Larga, P-3004516 Coimbra, Portugal, EU seventh Framework Programme Project 'PharmaSea', Portuguese Foundation for Science and Technology, DIPC, CFM (UPV/EHU), and Laboratory for Advanced Computation (University of Coimbra)

Subjects
0301 basic medicine, Mycobacterium-tuberculosis, 030106 microbiology, F100, Microorganisms, Siderocalin, Library science, 010402 general chemistry, 01 natural sciences, Biochemistry, 03 medical and health sciences, LCMS, Siderophore, Drug Discovery, Vibrio-cholerae, Pseudomonas-aeruginosa, Pyochelin, Microbial iron transport, biology, Chemistry, Organic Chemistry, biology.organism_classification, NMR, Coordination chemistry, 0104 chemical sciences, 3. Good health, Recognition, Pseudoalteromonas, Acquisition, Pseudoalteromonas piscicida, Pseudochelin A
Abstract

A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 mu M, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity. (C) 2017 Elsevier Ltd. All rights reserved.

Published
2017

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