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Purpose Faecal sludge (FS) and organic market waste (MW) have resources that could be recovered by co-composting though not fully explored under changing climatic conditions in Nigeria. This study explored the characteristics and nutrient quality of co-composts produced from pre-treated FS and MW feedstocks in Nigeria. Methods The study was exploratory and analytical in design and co-composting was purposively selected for resource-recovery. The raw faecal sludge (FS) was harvested from septic tanks of households (50%) and institutions (50%) through mechanical evacuation service trucks and dewatered using 0.1% gradient sand filter. The biodegradable MW was sorted and used for further studies. The dewatered FS (DFS) and MW were mixed in ratios 1:3, 1:5 and 1:7, respectively with DFS and MW as controls. Each of the mixes was made into 1m3 heap and co-composted using the windrow method. The experiments were monitored for 88 days with fortnight composite sampling from each mix (13-weeks). The samples were analyzed for temperature, pH, moisture-contents, micronutrients, macronutrients and pollutants using Standard Methods. Results At maturity, N:P:K (%) indicate good composts at 9: 5: 4, 18: 7: 19 and 3: 3: 1 in the 1: 3, 1: 5 and 1: 7 mixes, respectively, while those of controls were: 19:12:12 (DFS) and 17:14:11(MW) with no significant differences between experimental and control mixes. Also, four factors extracted (pollutants, agronomic, macronutrients and micronutrients), explained 78.2% variability. Conclusion The matured co-compost satisfied nutrients and pollutants quality for agricultural use, recovered organic fertiliser from raw domestic and institutional faecal sludge and market waste.

μ-opioid receptors (MOPr) play a critical role in social play, reward and pain, in a sex- and age-dependent manner. There is evidence to suggest that sex and age differences in brain MOPr density may be responsible for this variability; however, little is known about the factors driving these differences in cerebral MOPr density. Emerging evidence highlights gut microbiota's critical influence and its bidirectional interaction with the brain on neurodevelopment. Therefore, we aimed to determine the impact of gut microbiota on MOPr density in male and female brains at different developmental stages. Quantitative [3 H]DAMGO autoradiographic binding was carried out in the forebrain of male and female conventional (CON) and germ-free (GF) rats at postnatal days (PND) 8, 22 and 116-150. Significant 'microbiota status X sex', 'age X brain region' interactions and microbiota status- and age-dependent effects on MOPr binding were uncovered. Microbiota status influenced MOPr levels in males but not females, with higher MOPr levels observed in GF versus CON rats overall regions and age groups. In contrast, no overall sex differences were observed in GF or CON rats. Interestingly, within-age planned comparison analysis conducted in frontal cortical and brain regions associated with reward revealed that this microbiota effect was restricted only to PND22 rats. Thus, this pilot study uncovers the critical sex-dependent role of gut microbiota in regulating cerebral MOPr density, which is restricted to the sensitive developmental period of weaning. This may have implications in understanding the importance of microbiota during early development on opioid signalling and associated behaviours.

Studies have shown that organic fertilizer, a product of biodegradable organic matter, is not popular among Nigerian farmers because of its low quality. To alleviate this problem, this study was designed to explore the effect of nutrient-rich materials on quality of fertilizer made from market organic wastes. It adopted an experimental study design, comprising organic fertilizer preparation, fortification with natural fortifiers, farm plot experiments and laboratory analyses. The experiment was laid out in a randomized complete block design with factorial arrangement and three replications. The main plots comprised three crops - maize (cereal), soybean (legume) and yam (tuber) while five different fortified organic fertilizers at three rates of applications -2.0, 2.5, and 3.0 ton/ha and control (organic fertilizers without fortification) - formed subplots. Nutrient-rich materials sourced from animal, plant and rock changed the chemical composition of organic fertilizer made from market wastes and yielded better agronomic performances than the synthetic fertilizer. Hence, fortification of organic fertilizer with natural materials which are readily available and environmentally friendly should be promoted among the farmers.

Rapid nutrient depletion in soils is one of the major problems that affect food production and food security in Sub-Saharan Africa. Studies have linked the growth of food crops with seasonal variation and differences in weather conditions. This study was conducted to assess the effects of various organic fertilizer formulations (OFFs) on the growth and yield of selected crops (Zea mays L.; Glycine max, TX 114 and Dioscorea rotundata Poir) during rainy and dry seasons to ensuring climate-smart agriculture. The OFFs used were plant-based (PB), animal-based (AB), rock-based (RB), organic mixture (OM-mixture of PB, AB and RB), synthetic/chemical (SC) while ordinary compost without fortification served as control. Effects of OFFs on growth parameters (number of leaves, plant height, stem girth, leaf area, and crop yield) of maize, yam and soybeans were assessed in plot experiments across the two seasons. The RB gave highest growth performances in maize and soybean plots at both seasons when applied at 2.5 t ha−1. It also improved yam growth when applied at 2.5 t ha−1 (rainy season) and 3.0 t ha−1 (dry season) more than any other fertilizer. The largest yield of maize in the dry season was obtained from plots with PB at 2.0 t ha−1. The AB at 2.0 t ha−1 gave the largest soybean yield in the rainy season. Organic fertilizers enriched especially with rock-based and plant-based materials have the potential to ameliorate the threat of climate change and seasonal variation to food security.

Summary: The African Giant Rat, AGR is an indigenous nocturnal rodent noted for its unique olfactory and cognitive abilities. They have been deployed more recently in the detection of landmines and diagnosis of tuberculosis – two scourges that have had a tremendous negative impact on the African landscape. This olfactory-aided cognition has been linked to the hippocampus. While the anatomical infrastructure of the olfactory bulb of the AGR has been elucidated, little is known about the adaptive cytoarchitecture of the AGR hippocampal formation. This study describes the histological features, including subfields and stratifications of the AGR hippocampus using Nissl and Golgi stains. The basic cytoarchitecture of the AGR hippocampus observed in this study, with respect to stratification, subfields and cell types, is similar to those reported in the laboratory rats. Cell types identified in the AGR hippocampus include pyramidal cells, granule cells and mossy cells with mossy fibers and Schaffer collaterals also delineated. Hippocampal proper subfields CA1 to CA4 were identified. CA3 pyramidal neurons formed a well-defined cell layer starting in between the upper and lower ends of the dentate gyrus and had larger, more distinct pyramidal cells and higher cell layer thickness (240.0±6.0 μm) relative to subfields CA1 (87.0±2.0 μm) and CA2 (109.0±4.20 μm) with significant statistical differences at p

This chapter summarizes the sources of greenhouse gas (GHG) emissions from different economic sectors in Nigeria and emphasizes those arising from agriculture and forestry. The impacts of climate change on agricultural systems in Nigeria are likely to be large, motivating the need for additional knowledge to assess current practices and formulate appropriate modifications for both mitigation and adaptation. Some current farming practices are believed to be adaptive, but further study would provide better assessments. We also analyzed the trade-offs between household income and GHG emissions at two contrasting sites in northern Nigeria. A farm optimization model maximizing the value of crop, livestock, and tree production activities in a single representative year assessed the potential impacts for GHG reductions of 10% and 25% and the maximum allowable reductions of 26% and 30% on farm activities and income. Emissions reductions of 10% reduced annual household incomes by less than 5% but required substantive changes, especially in livestock owned. Maximum possible GHG emissions reductions (while still meeting minimum household consumption needs) would require marked changes in production pattern and would lower household incomes by 22–44%. We did not assess effects over longer periods, where the role of livestock as a key asset may imply additional negative impacts. Productivity-enhancing technologies that would simultaneously reduce GHG emissions and increase incomes are needed for smallholder farms to play a larger role in climate change mitigation without the burden of reduced incomes and greater risk. This suggests the need for programmatic and policy actions both by national agricultural research systems and the Consultative Group for International Agricultural Research (CGIAR).

The purpose of this study was to assess the knowledge of prostate cancer and screening and its associated factors in young Black men aged 18 to 40 years. This was a cross-sectional study conducted in a convenience sample of 267 young Black men in Austin, Texas. Knowledge about prostate cancer and screening was operationalized through 14 items, including 12 items from the Knowledge about Prostate Cancer Screening Questionnaire (PC knowledge), and two items assessing dietary knowledge and prostate cancer screening controversy. PC knowledge scores were regressed on age, cues to action, health screening experience, and demographic/personal factors. Most participants were African American men of American origin (65.3%) and were college freshmen (18.9%). PC knowledge scores were low, with mean correct responses of 28.5%, mean knowledge score of 5.25 ± 3.81 (possible score range of 0 to 14, with higher scores indicating higher PC knowledge) and a median score of 5.00. On average, 47% of the respondents replied “Don’t Know” to the questions. Overall, PC knowledge scores were low among these young Black men, especially in domains related to risk factors, screening age guidelines, limitations, and diet. It is thus important that these men be educated more on these important domains of prostate cancer and screening so that the decision to screen or not will be an informed one. Health screening experience, residence area, major field of study, and academic classification were significant predictors of knowledge.

A field experiment was conducted at National Horticultural Research Institute Idi-ishin, Ibadan to investigate the influence of mulching materials on population of plant parasitic nematodes, weed density, soil moisture, temperature content, growth and yields of okra (Abelmoschus esculentus L. Moench). The mulch materials were dried leaves of Azadirachta indica , Terminalia catappa , Eugenia uniflora, Pannicum maximum (grass straw) and plastic mulch with hoeing and no weeding as control. The experiment was conducted between June to September 2010. The experimental design was randomized complete block design in three replications. Data were collected on Vegetative Growth (VG), Gall Indices (GI), nematode reproduction. All data were analysed using ANOVA (p=0.05). GI was reduced by 76.91% in black plastic mulch, 69.28% in Azadirachta indica, 61.43% in no weeding control, 46% in Eugenia uniflora, 23.09% in Terminalia catappa and 15.24% in Pannicum maximum as compared to Hoeing weeding control. The root-knot nematode in the soil were also reduced by 96.63%, 89.28%, 76.81%, 53.63%, 50.72% and 24.63% in black plastic, no weeding control, Eugenia uniflora, Terminalia catappa, Azadirachta indica and Pannicum maximum mulching materials respectively as compared to hoe weeding control. The mulching materials significantly affected the growth and yield of okra (P≤0.05) with black plastic mulch resulting in the highest number of pods (30.0), fresh weight (378.0g) and dry weight (58.3g) per plant. Highest soil moisture retention was observed from hoe weeding plot (6%) while the highest soil temperature was recorded from black plastic mulch (25 o C) and the least weed density (6.0 plant/m 2 ) weed fresh weight (100.0g) and weed dry weight (34.0g) was also recorded on plastic mulch plot. These were significantly lower P≤0.05 compared with other mulched materials and no weeding control. Therefore mulch materials reduced the root-knot nematodes in the soil, weed interference in okra production while, enhancing moisture retention promotes faster plant growth and yield of okra. Keywords: Gall indices, Mulch materials, Nematode population, soil moisture and weed density

Black men are more likely to be diagnosed with prostate cancer, with higher stage and higher grade at presentation. Evidence suggests that for education in health promotion behaviors (such as screenings) in early adult years, young Black men can be better equipped to make informed decisions in later years. Using the theory of reasoned action (TRA), we assessed the intention of young Black men to screen for prostate cancer when it is recommended and determined its correlates. This was a cross-sectional study of 267 Black men aged 18 to 40 years. A 47-item questionnaire collected information on demographics/personal factors, attitudes toward prostate cancer screening, social influence, comfortability with prostate examinations, cues to action, health screening experiences, knowledge of prostate cancer and screening, and intention. Descriptive statistics were calculated for all variables and hierarchical logistic regression was employed to determine significant predictors of prostate cancer screening intentions. The regression model accounted for 46% of the variance in intention (p

This study was conducted to identify the salient behavioral beliefs of young Black men toward prostate cancer screening, and to identify the issues surrounding their comfortability with prostate examinations. A total of 20 Black men, aged between 18 and 40 years, participated in three focus group sessions between June 2013 and July 2013 in Austin, Texas. Participants were asked open-ended questions about: (a) the advantages and disadvantages of screening to identify salient behavioral beliefs about screening and (b) issues that would make prostate examinations comfortable or uncomfortable to identify comfortability factors. Focus group discussions were tape-recorded, transcribed, and content analyzed to identify emerging themes of salient beliefs and comfortability. Also, nine salient behavioral beliefs toward prostate cancer screening were identified, and eight factors were linked to comfortability with prostate examinations. Given the increase of prostate cancer disparity as a public health issue, understanding the beliefs of Black men of prescreening age (18-40 years) may be crucial to the effectiveness of future interventions to improve screening when recommended at later ages.

Composting has proven to be most effective in combating large organic waste generation in urban settings like Ibadan. This study was designed to determine macro-invertebrate population changes as indicator for stages of organic waste composting. Mixture of cow rumen (240 kg) and vegetable (80 kg) waste were shared equally into aerated (A) and non-aerated (B) windrows. Composite samples were taken twice from the each windrow for eight weeks. Macro-invertebrates were separated from compost by spread and Berlese funnel methods and species biodiversity by Simpson's (D) and Shannon-Weiner (H) indices. Data were analysed using descriptive statistics and t-test at 5% level of significance. Dipteran, Coleopteran and Acarina population changes were predominantly observed. Biodiversity scores of D and H were 0.21; 1.89 in A and 0.19; 1.12 in B. Windrow B had more species abundance than A. Successive changes in macro-invertebrate population can be used with physico-chemical parameters during composting process.

arcass and organs characteristics of two breeds and sexes of poultry which include Duck and Guinea fowl (GF) were investigated. A total of twenty four matured birds with twelve from each breed were used for this study in a 2 × 2 (Breed × Sex) factorial arrangement in a completely randomized design. The birds were slaughtered in batches of four properly bled, defeathered and dressed, the carcasses and organs weighed. The birds carcasses were chilled at 4 ºC for 24hrs prior to fabrication into primal cuts. The results showed that duck had higher (P

One of the goals of antiretroviral therapy (ART) is to attenuate HIV-induced systemic immune activation and inflammation. We determined the dynamics of biomarkers of immune activation, microbial translocation and inflammation during initial ART with a nucleos(t)ide-sparing regimen of darunavir/ritonavir plus raltegravir. We also evaluated associations between these biomarkers and the virological response to the regimen.

Background:Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world.Methods and Findings:1,571 HIV-1-infected persons (47% women) from nine countries in four continents were assigned with equal probability to open-label antiretroviral therapy with efavirenz plus lamivudine-zidovudine (EFV+3TC-ZDV), atazanavir plus didanosine-EC plus emtricitabine (ATV+DDI+FTC), or efavirenz plus emtricitabine-tenofovir-disoproxil fumarate (DF) (EFV+FTC-TDF). ATV+DDI+FTC and EFV+FTC-TDF were hypothesized to be non-inferior to EFV+3TC-ZDV if the upper one-sided 95% confidence bound for the hazard ratio (HR) was ≤1.35 when 30% of participants had treatment failure.An independent monitoring board recommended stopping study follow-up prior to accumulation of 472 treatment failures. Comparing EFV+FTC-TDF to EFV+3TC-ZDV, during a median 184 wk of follow-up there were 95 treatment failures (18%) among 526 participants versus 98 failures among 519 participants (19%; HR 0.95, 95% CI 0.72-1.27; p = 0.74). Safety endpoints occurred in 243 (46%) participants assigned to EFV+FTC-TDF versus 313 (60%) assigned to EFV+3TC-ZDV (HR 0.64, CI 0.54-0.76; p

Background The role of viral load level and/or CD4 (Cluster of differentiation 4) cell count in the aetiopathogenesis of hearing loss in HIV infection is unclear. Therefore, we investigated the relationship between CD4 cell counts, viral load and hearing threshold of HIV (Human immunodeficiency virus) infected adults.This cohort audiometric study involved consecutive HIV-infected and HIV-uninfected adults as controls. Clinical data relating to hearing loss, HIV status, and highly -active antiretroviral therapy (HAART) were obtained. Audiornetric evaluation was performed. The most recent CD4 cell counts and RNA viral load-of HIV-infected participants were obtained from clinic records.There were 299(66.7%) HIV-infected adults and 149(33.3%) controls with mean age of 39.64± 12.45 years and 39.60±12.45 years respectively (p=0.98). In both groups, there were more participants with left hearing loss. Mild to profound hearing loss was found in 65.9% HIV- infected participants and 53.7% controls. Majority (86.3%) of the HIV-infected participants were on HAART. The mean CD4 cell count was 654.58±289.15 in 41 HIV-infected participants not on HAART and 523.95±300.17 in 258 participants on HAART (p=0.01). Majority,- 197 (62%) HIV- infected participants with hearing loss had CD4 cell count ≤200 cells/mm3. Higher viral load significantly correlated with low CD4 cell counts (p0.0 1; r=0. 18) and low CD4 cell count significantly correlated with high hearing threshold (pO.01; r=0. 17).There was a trend towards more hearing loss among the HIV-infected adults. The higher hearing threshold in those with low CD4 cell counts of200 cells/mm3 suggests possible relationship between hearing status and severity of HIV disease.