1. Transfusion-Associated Hepatitis G Virus Infection Following Surgery
- Author
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Hirosi Sunagawa, Hisao Iizuka, Naomi Kato, Takanori Murayama, Masamitu Sanui, Norimasa Seo, Yosihisa Taniguchi, Akiko Iwata, Hirosi Otuka, Takesi Tanaka, Nobuo Futagami, and Toshifumi Fujiwara
- Subjects
medicine.medical_specialty ,business.industry ,Transmission (medicine) ,virus diseases ,Viremia ,medicine.disease ,digestive system diseases ,Virus ,Hepatitis G ,Surgery ,Posttransfusion hepatitis ,Epidemiology ,medicine ,Blood units ,business - Abstract
A new hepatitis-associated virus, hepatitis G virus (HGV), has been reported. Although its epidemiology, mode of transmission, and infectiousness are not yet well understood, it may be transmitted by transfusion. We investigated the transmission of HGV in 146 patients who underwent surgery, during which an average of 6.0±6.0 (range 1 to 35) units of blood was transfused. Transmission was determined through postoperative detection of HGV-RNA. Ten patients (6.8%) demonstrated HGV-RNA in the serum within 1 to 4 weeks after operation. Among these, HGV-RNA was detected in at least one of the blood units received by seven patients, all of whose units were available for testing. HGV-RNA was detected transiently for 2 to 3 weeks after surgery in two, and persisted after transfusion in the other eight. HGV viremia did not resolve in most of these patients and persisted longer than 16 months. None of them developed posttransfusion hepatitis. These results indicate that HGV can be transmitted by transfusion and that infection is permanent, but does not induce posttransfusion hepatitis.
- Published
- 1998