17 results on '"Tania Jabbar"'
Search Results
2. Toxicity measurement and toxicity studies of drug delivery
- Author
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Muhammad Imran, Syed Ali Raza Naqvi, Tauqir A. Sherazi, Sadaf Ul Hassan, and Tania Jabbar
- Published
- 2023
3. List of contributors
- Author
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Mehwish Abid, Charles Oluwaseun Adetunji, Juliana Bunmi Adetunji, Olulope Olufemi Ajayi, Modupe Doris Ajiboye, Semra Akgönüllü, Devaka Dharmapriya Ariyasena, Muhammad Ashfaq, Muhammad Asif, Monireh Bakhshpour, Anastasia Balafouti, Chamila S. Bandara, Iqra Bano, Maria Batool, Saira Batool, Nilay Bereli, Usman Dawood Butt, Sayandev Chatterjee, Kenneth R. Czerwinski, Sangita Das, Wadazani Dauda, Roberta Anjos de Jesus, Adil Denizli, Zhijin Fan, Luiz Fernando Romanholo Ferreira, Renan Tavares Figueiredo, Hilary A. Fitzgerald, Navin Gamage, Shakira Ghazanfar, Jayamini C. Gunaratne, Sumaira Hanif, Sadaf Ul Hassan, Tanzeel Huma, Tbassum Huma, Oluwatosin Ademola Ijabadeniyi, Muhammad Imran, Abel Inobeme, Amna Iqbal, Tania Jabbar, Cheng Jiang, Kashaf Khaliq, Muniba Khaliq, Saadullah Khattak, Andrew L. Lakes, Zuolei Liao, Russell C. Ludwig, Marryam Mahmood, John Tsado Mathew, Katie M. McBride, Syed Agha Hassnain Mohsan, Pir Muhammad, Sumaira Mumtaz, Ghulam Mustafa, Syed Ali Raza Naqvi, Victor Ruan Silva Nascimento, Muhammad Faizan Nazar, Rumesh M. Nelumdeniya, Frank Abimbola Ogundolie, Olugbemi Tope Olaniyan, Ícaro Mota Oliveira, DhanaLakshmi Padi, Ishanie Rangeeka Perera, Natassa Pippa, Stergios Pispas, Sudhakar Pola, Partha Pratim Das, Harith Ranatunga, Fawad Ur Rehman, Klaus P. Saalbach, Muhammad Atif Saleem, Pavani Sanapala, Dimitrios Selianitis, Theodore Sentoukas, Sohail Anjum Shahzad, Tauqir A. Sherazi, Muhammad Yasir Siddique, Athanasios Skandalis, Sajjad Hussain Sumrra, Nosheen Tawakkul, Sabu Thomas, Savani Weerahewa Thrikawala, Olotu Titilayo, Aykut Arif Topçu, Ranatunga Udayana, Vladislav P. Vlasenko, Keshiya Waruni, Muhammad Nadeem Zafar, and Muhammad Zubair
- Published
- 2023
4. Radiosynthesis, quality control, biodistribution, and infection-imaging study of a new 99mTc-labeled ertapenem radiopharmaceutical
- Author
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Syed Ali Raza Naqvi, Tania Jabbar, Maha A. Alharbi, Asma Noureen, Nada K. Alharbi, Tauqir A. Sherazi, Anum Shahzadi, Ahmed Ezzat Ahmed, M. Shahzad Afzal, and M. Babar Imran
- Subjects
General Chemistry - Abstract
Ertapenem is a member of carbapenem antibiotics used for the treatment of moderate-to-severe intra-abdominal, urinary tract, acute pelvic, and post-surgical gynecologic infections. The antibacterial activity of ertapenem is mediated through binding to penicillin-binding proteins which results in inhibiting the cross-linking of the peptidoglycan layer of the bacterial cell wall. Therefore, ertapenem can be labeled with technetium-99m (99mTc), a gamma emitter radionuclide, for the diagnosis of deep-seated bacterial infections, such as urinary tract, intra-abdominal, osteomyelitis, and post-surgical gynecologic infections. The labeling procedure was carried out by varying the reaction conditions, such as the amount of the ligand and reducing agent, pH, reaction time and temperature, and radioactivity. At optimized reaction conditions more than 93% 99mTc–ertapenem radioconjugate was obtained. 99mTc–ertapenem was found 90% intact in saline medium up to 6 h, while 88% intact in human blood serum up to 3 h. Biodistribution study showed target-to-non-target ratios of 2.91 ± 0.19, 2.39 ± 0.31, and 1.23 ± 0.22 in S. aureus, E. coli, and turpentine oil-infected rat models, respectively. The SPECT scintigraphy showed high uptake of 99mTc–ertapenem in bacterial-infected abscesses, and low counts were recorded in normal and turpentine oil-inflamed tissues. In conclusion, 99mTc–ertapenem can be a potent infection-imaging agent, which can diagnosis deep-seated bacterial infections at early stage but need further pre-clinical evaluation in variety of infection models.
- Published
- 2022
5. Radiosynthesis, quality control, biodistribution, and infection-imaging study of a new
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Syed Ali Raza, Naqvi, Tania, Jabbar, Maha A, Alharbi, Asma, Noureen, Nada K, Alharbi, Tauqir A, Sherazi, Anum, Shahzadi, Ahmed Ezzat, Ahmed, M Shahzad, Afzal, and M Babar, Imran
- Abstract
Ertapenem is a member of carbapenem antibiotics used for the treatment of moderate-to-severe intra-abdominal, urinary tract, acute pelvic, and post-surgical gynecologic infections. The antibacterial activity of ertapenem is mediated through binding to penicillin-binding proteins which results in inhibiting the cross-linking of the peptidoglycan layer of the bacterial cell wall. Therefore, ertapenem can be labeled with technetium-99m (
- Published
- 2022
6. Facile One-Pot Strategy for Radiosynthesis of
- Author
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Syed Faheem Askari, Rizvi, Tania, Jabbar, Wajeehah, Shahid, M H, Sanad, and Haixia, Zhang
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Mice ,Staphylococcus aureus ,Doxycycline ,Models, Animal ,Animals ,Technetium ,Tissue Distribution ,Radiopharmaceuticals ,Staphylococcal Infections ,Anti-Bacterial Agents - Abstract
The accurate and early diagnosis of infection is an important feature in the biomedical sciences for better treatment and to decrease the rate of morbidity associated with diseases. Doxycycline (DC) is a semisynthetic antibiotic that belongs to tetracycline family and usually prescribed to treat a variety of infections. The objective of the present research work was to develop a new radiopharmaceutical
- Published
- 2021
7. Radiolabeling, quality control, and biological characterization of 177 Lu-labeled kanamycin
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M. Khalid, Muhammad Usman Akbar, Muhammad Sohaib, Saira Hina, Muhammad Razeen Ahmad, Tania Jabbar, Tanveer Hussain Bokhari, Sajid Mehmood, and Samina Roohi
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Pharmacology ,Biodistribution ,Chromatography ,biology ,Chemistry ,Organic Chemistry ,Kanamycin ,010403 inorganic & nuclear chemistry ,Ligand (biochemistry) ,biology.organism_classification ,01 natural sciences ,Biochemistry ,High-performance liquid chromatography ,030218 nuclear medicine & medical imaging ,0104 chemical sciences ,03 medical and health sciences ,Paper chromatography ,0302 clinical medicine ,In vivo ,Drug Discovery ,Radioligand ,medicine ,Molecular Medicine ,medicine.drug ,Streptomyces kanamyceticus - Abstract
Kanamycin is an antibiotic, isolated from Streptomyces kanamyceticus, which is used to treat serious bacterial infections. The fact that the present radioligand 99m Tc-kanamycin used for diagnosis is short-lived, raised a need to label and study kanamycin with one of the most important beta (β) radiation emitting isotope 177 Lu. Labeling yield of 177 Lu-kanamycin was confirmed by different chromatography techniques such as paper chromatography, TLC, HPLC. Several experiments were performed to optimize labeling with changing reaction conditions such as pH, temperature, amount of ligand, and reaction time. In vitro stability analysis was performed incubation with human serum. Electrophoresis analysis was also conducted to determine the charge on 177 Lu-kanamycin. The biodistribution and scintigraphy were performed in normal mice and rabbit, respectively, at different time intervals of postinjection. 177 Lu-kanamycin was prepared with very high yield (~100%), with excellent stability in vivo and in vitro (>99% 6 hr postprep.), at pH 7. Maximum labeling was achieved at less reaction time (15 min), with maximum conjugation of the ligand (12.5 mg) with 177 Lu. Electrophoresis analysis showed net neutral charge. The radioligand showed rapid clearance from body in biodistribution and scintigraphy studies. The preparation 177 Lu-kanamycin could be used as a radio-pharmaceutical for infection imaging purpose, especially when transporting the radioligand to long-range distances.
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- 2017
8. Extraction of HCV-RNA from Plasma Samples: Development towards Semiautomation
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Tania Jabbar, Fawad Niazi, Imran Amin, and Muhammad Saeed Akhtar
- Subjects
Detection limit ,lcsh:QD71-142 ,Chromatography ,Article Subject ,Plasma samples ,Serial dilution ,Chemistry ,Extraction (chemistry) ,lcsh:Analytical chemistry ,computer.software_genre ,Analytical Chemistry ,TaqMan ,Extraction methods ,RNA extraction ,Data mining ,computer ,Research Article - Abstract
A semiautomated extraction protocol of HCV-RNA using Favorgen RNA extraction kit has been developed. The kit provided protocol was modified by replacing manual spin steps with vacuum filtration. The assay performance was evaluated by real-time qPCR based on Taqman technology. Assay linearity was confirmed with the serial dilutions of RTA (Turkey) containing 1×(106, 105, 104, and 103) IU mL−1. Comparison of test results obtained by two extraction methods showed a good correlation (r=0.95,n=30) with detection limit of 102 IU mL−1. The semiautomated vacuum filtration based protocol demonstrated high throughput: 35 minutes for the extraction of a batch of 30 samples (150 µL each) with reduced labor, time, waste, and cost. Performance characteristics of semiautomated system make it suitable for use in diagnostic purpose and viral load determinations.
- Published
- 2015
9. Radiolabeling, quality control, and biological characterization of
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Muhammad Usman, Akbar, Tanveer Hussain, Bokhari, Muhammad, Khalid, Muhammad Razeen, Ahmad, Samina, Roohi, Saira, Hina, Sajid, Mehmood, Muhammad, Sohaib, and Tania, Jabbar
- Subjects
Electrophoresis ,Male ,Quality Control ,Radioisotopes ,Temperature ,Hydrogen-Ion Concentration ,Lutetium ,Mice ,Drug Stability ,Kanamycin ,Isotope Labeling ,Animals ,Humans ,Tissue Distribution ,Whole Body Imaging ,Chromatography, Thin Layer ,Rabbits ,Radiopharmaceuticals ,Radionuclide Imaging ,Chromatography, High Pressure Liquid - Abstract
Kanamycin is an antibiotic, isolated from Streptomyces kanamyceticus, which is used to treat serious bacterial infections. The fact that the present radioligand
- Published
- 2016
10. Investigation of the isotopic ratio 129I/I in petrified wood
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Otto Cichocki, Tania Jabbar, Gabriele Wallner, Johannes H. Sterba, and Peter Steier
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Isotopes of uranium ,Isotope ,Fossils ,Stable isotope ratio ,Health, Toxicology and Mutagenesis ,Mineralogy ,chemistry.chemical_element ,General Medicine ,Uranium ,Wood ,Pollution ,Petrified wood ,Iodine Radioisotopes ,chemistry ,Austria ,visual_art ,visual_art.visual_art_medium ,Fossil wood ,Environmental Chemistry ,Neutron activation analysis ,Waste Management and Disposal ,Geology ,Iodine ,Accelerator mass spectrometry - Abstract
In fossil specimens, measurements of the natural isotopic ratio (129)I/I may provide a method to estimate the age of sample. The motivation for measuring the isotopic composition ((129)I/I) of petrified wood samples collected from Austria was to check this feasibility. Alkaline fusion together with anion exchange was used to extract iodine from the sample. Typical sample size for this study was 10-90 g. An atomic ratio as low as 10(-14) was determined using accelerator mass spectrometry (AMS). Uranium concentrations measured by instrumental neutron activation analysis (INAA) and α-spectrometry were found to be less than 3 mg kg(-1), therefore the contribution from fissiogenic (129)I was small and an estimation of ages was based on the decrease of the initial ratio (due to decay of the cosmogenic (129)I in a closed system) after subtraction of the fissiogenic (129)I. The value of the prenuclear ratio is crucial for the use of the (129)I system for dating purposes in the terrestrial environment. From the preanthropogenic (initial) ratio of 1.5 × 10(-12) of the hydrosphere and the results of the present study for the samples from Altenburg (1.05 × 10(-12)) and Fuerwald (6.16 × 10(-13)), respective ages of 8 ± 2.2 and 20.2 ± 2.2 million years were derived. Since samples were collected from a stratum deposited in the Upper Oligocene/Ergerien period (~25-30 million years ago), it can be concluded that these isotopic ratios do not show ages but an elapsed time since fossil wood was isolated from mineral rich water. Paleontological investigation shows that samples from Altenburg had mixed characteristics of old and modern Tertiary plants, thus an origin from a younger stratum re-sedimented with Oligocene cannot be excluded. However, the sample from Drasenhofen reflects that the (129)I/I system might not always be suitable for the dating of petrified wood sample due to fixation of anthropogenic (129)I into surface fractures.
- Published
- 2013
11. Retrospective measurements of airborne 129Iodine in Austria
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Norbert Kandler, Peter Steier, Tania Jabbar, Gabriele Wallner, and Christian Katzlberger
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Health, Toxicology and Mutagenesis ,Radiation Dosage ,Mass Spectrometry ,Iodine Radioisotopes ,Dose limit ,Radiation Monitoring ,Risk Factors ,Humans ,Environmental Chemistry ,Thyroid Neoplasms ,Waste Management and Disposal ,Historical record ,Retrospective Studies ,Radionuclide ,Inhalation ,Equivalent dose ,Environmental Exposure ,General Medicine ,Environmental exposure ,Pollution ,Isotopic ratio ,Air Pollutants, Radioactive ,Austria ,Environmental chemistry ,Environmental science ,Radiation monitoring ,Seasons ,Iodine - Abstract
The knowledge about the distribution of anthropogenic (129)I is crucial for a successful establishment of transport mechanisms, fate and behaviour in the environment. In present study, the historical record of dry deposition of (129)I in Austria over four decades back to the 1960s is reconstructed. The (129)I/(127)I isotopic ratio of the order of 10(-9)-10(-7) in airborne particles revealed a prominent anthropogenic (129)I signature. The time profile of airborne (129)I follows directly the pattern of the gaseous emissions from European reprocessing plants. Furthermore, temporal variations of (129)I were traced monthly over two years. The potential risks of internal exposure to (129)I are associated with both inhalation and ingestion. Since dose via inhalation was found insignificant, the thyroid equivalent dose from the internal exposure of (129)I using a value of 10(-8) for the isotopic ratio (129)I/(127)I in the thyroid and ICRP reference man was calculated. The corresponding thyroid cancer risk factor of 10(-11) for an adult from life-time exposure is one order of magnitude higher than for a 1-year old child. Due to low radiation toxicity of (129)I the annual dose is 8 × 10(4) times lower than the dose limit of the National Research Council, USA which is 0.04 mSv y(-1) to whole body or any organ for a combined beta and photon emitting radionuclide.
- Published
- 2012
12. Iodine Isotopes (127I and 129I) in Aerosols at High Altitude Alp Stations
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Gabriele Wallner, Alfred Priller, Tania Jabbar, August Kaiser, Peter Steier, and Norbert Kandler
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Aerosols ,Hydrology ,Air Pollutants ,Isotope ,Altitude ,chemistry.chemical_element ,General Chemistry ,Effects of high altitude on humans ,Particulates ,Iodine ,Atmospheric sciences ,Mass Spectrometry ,Iodine Radioisotopes ,Atmosphere ,Isotopic ratio ,chemistry ,Austria ,Germany ,Iodine Isotopes ,Environmental Chemistry ,Environmental science ,Anion Exchange Resins ,Sea level - Abstract
Concentrations of gases and particulate matter have been proven to be affected by meteorological and geographical variables from urban locations to high mountain clean air sites. Following our previous research in Vienna, we summarize here new findings about concentration levels of iodine isotopes in aerosols collected at two Alpine meteorological stations, Sonnblick (Austria) and Zugspitze (Germany) during 2001. The present study mainly focuses on the effect of altitude on the anthropogenic concentration of (129)I and on the isotopic ratio (129)I/(127)I. Iodine was separated from matrix elements by using either an anion exchange method or solvent extraction, and was analyzed by ICP-MS and AMS. Over the altitude change from Vienna to Zugspitze and Sonnblick (202 m to 2962 m and 3106 m above sea level), stable iodine level decreased from an average of 0.94 ng m(-3) to 0.52 ng m(-3) and 0.62 ng m(-3), respectively. Similarly, (129)I concentrations at both Alpine stations were about 1 order of magnitude lower (10(4) atoms m(-3)) than values obtained for Vienna (10(5) atoms m(-3)) and reveal a strong vertical concentration gradient of (129)I. A high degree of variability is observed, which is due to wide variation in the origin of air masses. Furthermore, air trajectory analysis demonstrates the importance of large scale air transport mostly from southeast Europe for influencing Sonnblick whereas influence from northwest Europe is strong at Zugspitze. In contrast to (129)I, a higher concentration of (7)Be was found at higher altitude stations compared to Vienna which probably results from its production in the upper atmosphere.
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- 2012
13. AMS analysis of iodine-129 in aerosols from Austria
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Christian Katzlberger, Peter Steier, Gabriele Wallner, Tania Jabbar, and Norbert Kandler
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Matrix (chemical analysis) ,Nuclear and High Energy Physics ,Radionuclide ,Ion exchange ,Chemistry ,Distribution pattern ,Aquatic ecosystem ,Environmental chemistry ,chemistry.chemical_element ,Iodine ,Instrumentation ,Spent nuclear fuel ,Aerosol - Abstract
Atmospheric concentrations of many elements have been significantly increased by human activities. The quantification of these changes and their effect on the terrestrial and aquatic ecosystems is important because of their potentially adverse effects. The human nuclear activities, especially releases from the spent nuclear fuel reprocessing plants, are presently the main source of 129I in the environment. In this work, the concentration of 129I and the ratios of 129I/127I in aerosols weekly collected in Vienna, Austria (202 m a.s.l) during the year 2001 are presented. Iodine was extracted from the aerosol filters using a strong basic solution and separated from the matrix elements by anion exchange. The chemical yield of the procedure, determined by ICP-MS, ranges from 70% to 95%. The AMS results indicated that the 129I/127I isotopic ratios were of the order 10−8 to 10−7. The 129I originated from gaseous emissions from the Sellafield reprocessing plant. The measured 129I concentrations were compared with those of 7Be, a cosmogenic radionuclide. Although, both radionuclides exhibit nearly the same distribution pattern (higher levels in summer and lower in winter) their different origins can clearly be deduced from short term variations.
- Published
- 2011
14. Natural radionuclides in Austrian bottled mineral waters
- Author
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Tania Jabbar and Gabriele Wallner
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Radionuclide ,Isotope ,Chemistry ,Health, Toxicology and Mutagenesis ,Liquid scintillation counting ,Radiochemistry ,Public Health, Environmental and Occupational Health ,chemistry.chemical_element ,Uranium ,Pollution ,Analytical Chemistry ,Radium ,Mineral water ,Nuclear Energy and Engineering ,Radiology, Nuclear Medicine and imaging ,Nuclide ,Spectroscopy ,Polonium - Abstract
All commercially available mineral waters of Austrian origin were investigated with regard to the natural radionuclides 228Ra, 226Ra, 210Pb, 210Po, 238U and 234U. From 1 to 1.5 L of sample the nuclides were extracted and measured sequentially: the radium isotopes as well as 210Pb were measured by liquid scintillation counting after separation on a membrane loaded with element-selective particles (Empore Radium Disks), 210Po was determined by α-particle spectroscopy after spontaneous deposition onto a copper planchette and uranium was determined also by α-particle spectroscopy after anion separation and microprecipitation with NdF3. The calculated committed effective doses for adults, teens and babies were compared to the total indicative dose of 0.1 mSv/year given in the EC Drinking Water Directive. The dominant portion of the committed effective dose was due to 228Ra. Highly mineralised waters showed also higher 226Ra and 228Ra levels.
- Published
- 2010
15. Biotransformation of Radionuclides: Trends and Challenges
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Gabriele Wallner and Tania Jabbar
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Human health ,Radionuclide ,Bioremediation ,Biotransformation ,Microbial ecology ,Waste management ,Environmental remediation ,Radioactive contamination ,Environmental science ,Radionuclide contamination - Abstract
Radioactive contamination poses risks to environment and human health. The microbial-mediated transformation presents opportunity for the remediation of radionuclide contamination of the environment by immobilizing them or accelerating their removal. This chapter aims to interpret the mechanisms by which microbes interact with their surroundings to eliminate radionuclides of concern from the environment and how they influence the behavior and transport of radionuclides. Recent advances in microbial ecology have provided molecular strategies for the modeling of microbial process in order to increase the effectiveness and reliability of bioremediation and natural attenuation of polluted sites.
- Published
- 2015
16. Corrigendum to 'Extraction of HCV-RNA from Plasma Samples: Development towards Semiautomation'
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Muhammad Saeed Akhtar, Tania Jabbar, Fawad Ali, and Imran Amin
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lcsh:QD71-142 ,Chromatography ,Plasma samples ,010405 organic chemistry ,business.industry ,Chemistry ,010401 analytical chemistry ,Extraction (chemistry) ,lcsh:Analytical chemistry ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,Text mining ,Corrigendum ,business - Abstract
A semiautomated extraction protocol of HCV-RNA using Favorgen RNA extraction kit has been developed. The kit provided protocol was modified by replacing manual spin steps with vacuum filtration. The assay performance was evaluated by real-time qPCR based on Taqman technology. Assay linearity was confirmed with the serial dilutions of RTA (Turkey) containing 1 × (10(6), 10(5), 10(4), and 10(3)) IU mL(-1). Comparison of test results obtained by two extraction methods showed a good correlation (r = 0.95, n = 30) with detection limit of 10(2) IU mL(-1). The semiautomated vacuum filtration based protocol demonstrated high throughput: 35 minutes for the extraction of a batch of 30 samples (150 µL each) with reduced labor, time, waste, and cost. Performance characteristics of semiautomated system make it suitable for use in diagnostic purpose and viral load determinations.
- Published
- 2016
17. A review on 129I analysis in air
- Author
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Gabriele Wallner, Tania Jabbar, and Peter Steier
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business.industry ,Health, Toxicology and Mutagenesis ,General Medicine ,Tracing ,Pollution ,Nuclear facilities ,Radiation exposure ,Iodine Radioisotopes ,Air Pollutants, Radioactive ,Environmental chemistry ,Environmental Chemistry ,Radiation monitoring ,Environmental science ,Sample collection ,Sensitivity (control systems) ,Current (fluid) ,Process engineering ,business ,Waste Management and Disposal ,Environmental Monitoring - Abstract
A review of literature focused on (129)I determination in air is provided. (129)I analysis in the environment represents a vital tool for tracing transport mechanisms, distribution pathways, safety assessment and its application as environmental tracer. To achieve that, specific chemical extraction methods and high sensitivity analytical techniques have been developed. This paper is intended to give an overview about the sample collection, extraction and distribution of (129)I in the air. Sensitivity of available measurement techniques for the determination of (129)I is compared. The article also provides the summary of current worldwide distribution of (129)I in air and respective radiation exposure of man.
- Published
- 2012
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