1. Components of Executive Control in Autism Spectrum Disorder: A Functional Magnetic Resonance Imaging Examination of Dual-Mechanism Accounts
- Author
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Cameron S. Carter, Rachel Wulff, Marjorie Solomon, Marie K. Krug, Matthew V. Elliott, Andrew Gordon, Tyler A. Lesh, and Jeremy Hogeveen
- Subjects
medicine.medical_specialty ,Autism Spectrum Disorder ,Intellectual and Developmental Disabilities (IDD) ,Autism ,Cognitive Neuroscience ,Audiology ,behavioral disciplines and activities ,Dual mechanism ,050105 experimental psychology ,Executive control ,Executive functions ,Executive Function ,Functional connectivity ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,Salience (neuroscience) ,Behavioral and Social Science ,medicine ,Humans ,2.1 Biological and endogenous factors ,Task control ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,Aetiology ,Biological Psychiatry ,Default mode network ,Cerebral Cortex ,Pediatric ,Reactive control ,medicine.diagnostic_test ,05 social sciences ,Neurosciences ,medicine.disease ,Magnetic Resonance Imaging ,Brain Disorders ,Functional recruitment ,Mental Health ,Autism spectrum disorder ,Cognitive control ,Neurology (clinical) ,Functional magnetic resonance imaging ,Psychology ,030217 neurology & neurosurgery - Abstract
Background It remains unclear whether executive control (EC) deficits in autism spectrum disorder (ASD) represent a failure in proactive EC (engaged and maintained before a cognitively demanding event) or in reactive EC (engaged transiently as the event occurs). We addressed this question by administering a paradigm investigating components of EC in a sample of individuals with ASD and typically developing individuals during functional magnetic resonance imaging. Methods During functional magnetic resonance imaging, 141 participants (64 ASD, 77 typically developing) completed a rapid preparing to overcome prepotency task that required participants to respond to an arrow probe based on the color of an initially presented cue. We examined functional recruitment and connectivity in the frontoparietal task control, cingulo-opercular task control, salience, and default mode networks during cue and probe phases of the task. Results ASD participants showed evidence of behavioral EC impairment. Analyses of functional recruitment and connectivity revealed that ASD participants showed significantly greater activity during the cue in networks associated with proactive control processes, but on the less cognitively demanding trials. On the more cognitively demanding trials, cue activity was similar across groups. During the probe, connectivity between regions associated with reactive control processes was uniquely enhanced on more-demanding (relative to less-demanding) trials in individuals with ASD but not in typically developing individuals. Conclusions The current data suggest that rather than arising from a specific failure to engage proactive or reactive forms of EC, the deficits in EC commonly observed in ASD may be due to reduced proactive EC and a consequent overreliance on reactive EC on more cognitively demanding tasks.
- Published
- 2021
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