1. Xenopus resources: transgenic, inbred and mutant animals, training opportunities, and web-based support
- Author
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Horb, Marko, Wlizia, Marcin, Abu-Daya, Anita, McNamara, Sean, Gajdasik, Dominika, Igawa, Takeshi, Suzuki, Atsushi, Ogino, Hajime, Noble, Anna, Robert, Jacques, James-Zorn, Christina, Guille, Matthew, Nicolas, Morgane, Lafond, Thomas, Boujard, Daniel, Audic, Yann, Guillet, Brigitte, Kashiwagi, Akihiko, Kashiwagi, Keiko, Suzuki, Nanoka, Tazawa, Ichiro, Ochi, Haruki, Furuno, Nobuaki, Takasc, Minoru, Nakajima, Keisuke, Hanada, Hicleki, Miura, Ikuo, Kurabayashi, Atsushi, Kato, Takashi, Sato, Kei, Takcbayashi-Suzuki, Kimiko, Yoshida, Hitoshi, Marine Biological Laboratory (MBL), University of Chicago, University of Rochester [USA], Biosit : biologie, santé, innovation technologique (SFR UMS CNRS 3480 - INSERM 018), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de Ressources Biologiques Xénopes, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Wellcome Trust [212942/Z/18/Z], BBSRC [BB/R014841/1], NIH (ORIP/NICHD) [P40 OD010997], Eunice Kennedy Shriver National Institute of Child Health and Human Development [P41 HD064556], NIH/NIAID [R24-AI-059830, R21AI139718], GIS-IBISA 2014, Fondation Maladies Rares 2016, Japan Agency for Medical Research and Development (AMED), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Rennes (UR)
- Subjects
Resource (biology) ,Physiology ,Transgene ,[SDV]Life Sciences [q-bio] ,Mutant ,Xenopus ,inbred strains ,ORFeome ,Review ,APC-PAID ,Biology ,transgenesis ,lcsh:Physiology ,03 medical and health sciences ,Xenopus laevis ,0302 clinical medicine ,Genome editing ,Physiology (medical) ,Web application ,Xenopus tropicalis ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,BB/R014841/1 ,0303 health sciences ,lcsh:QP1-981 ,business.industry ,gene editing ,RCUK ,biology.organism_classification ,model organism database ,Evolutionary biology ,BBSRC ,business ,Developmental biology ,resource centers ,030217 neurology & neurosurgery - Abstract
Two species of the clawed frog family, Xenopus laevis and X. tropicalis, are widely used as tools to investigate both normal and disease-state biochemistry, genetics, cell biology, and developmental biology. To support both frog specialist and non-specialist scientists needing access to these models for their research, a number of centralized resources exist around the world. These include centers that hold live and frozen stocks of transgenic, inbred and mutant animals and centers that hold molecular resources. This infrastructure is supported by a model organism database. Here, we describe much of this infrastructure and encourage the community to make the best use of it and to guide the resource centers in developing new lines and libraries.
- Published
- 2019
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