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1. Hemodialysis with Polymethylmethacrylate Restores the Response to Hepatitis B Vaccination in Chronic Dialysis Patients: Hypothesized Mechanism of Action

Author

Sidoti Antonino, Imperiali Patrizio, Lombardi Marco, Tekle Kiros Seble, Ralli Chiara, Capitanini Alessandro, Piluso Adriano, Conti Paolo, Duranti Diletta, Gabbrilelli Claudio, and Duranti Ennio

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Urology, Autosomal dominant polycystic kidney disease, Analgesic nephropathy, medicine.disease, Artificial kidney, Virus, Vaccination, Blood pressure, Automotive Engineering, medicine, Albuminuria, Hemodialysis, medicine.symptom, business
Abstract

Patients undergoing hemodialysis often present with a reduced response to anti-hepatitis B virus (anti-HBV) vaccination. The soluble form of CD40 (sCD40) is elevated in hemodialysis patients and this has been shown to correlate with lack of response to anti-HBV vaccination. Due to its high molecular weight, conventional dialyzers cannot clear sCD40. Previous studies have demonstrated, that dialysis membranes in polymethylmethacrylate (PMMA) can reduce the levels of sCD40.

Published
2016
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