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WOS:000882514900017 Diabetes is a serious and chronic public health problem worldwide. Hyper-glycemia leads to the production of free radicals thus impairing oxidant/anti-oxidant balance and causing various complications in diabetes. Herbs can pro-vide natural remedies against various diseases in traditional medicine. Phyto-chemicals especially phenolic compounds have some biological properties such as antioxidant and antidiabetic effects. Plant parts of Prunus spinosa are used in traditional medicine against various disorders. This study evaluated the mixture of Prunus spinosa leaves and flowers extract (PSE) on the antioxidant capacity in diabetes. The phenolic profile of PSE was determined by HPLC method. Antioxidant capacity was evaluated with radical scavenging activities as well as total phenolic and flavonoid content. Seven random groups (n = 8) of rats were constituted to evaluate the antioxidant capacity - control, dia-betic, PSE25, PSE50, insulin, metformin, and acarbose. Total oxidant status (TOS) and total antioxidant status (TAS) were analyzed in the liver tissues. Chlorogenic acid and ellagic acid were found to be the main compound in the mixture of P. spinosa leaves and flowers extract. Antioxidant capacity of PSE exhibited effective radical scavenging activity. Although oxidative stress seri-ously increased in diabetes, PSE25 and PSE50 supplementation significantly recuperated liver antioxidant status. In conclusion, PSE markedly has antioxi-dant capacity through its high phenolic compounds, thus PSE treatment may have potential antioxidant effects for health benefits in diabetes.

Günümüzde işletmeler, finansal bilgilerinin yanı sıra finansal olmayan bilgilerini de paydaşlarına (kamuoyuna) sunarak piyasalardaki etkinliklerini artırmayı hedeflemektedirler. İşletmelerin paydaşlarına sunabileceği ve finansal olmayan başlıca bilgiler çevresel, sosyal ve kurumsal yönetim (ESG) olmak üzere 3 bileşenden oluşmaktadır. Çalışmanın amacı gelişmekte olan ülkeler özelinde işletmelerin yönetim kurulu yapılarının (yönetim kurulu büyüklüğü, yönetim kurulundaki kadın üye oranı, yönetim kurulundaki bağımsız üye oranı ve CEO’ların aynı zamanda yönetim kurulu üyesi olup olmadığı) ESG ve bileşenleri (çevresel, sosyal ve kurumsal yönetim) bakımından kamuyu aydınlatma skorlarına olan etkilerini Morgan Stanley Capital International (MSCI)’ın gelişmekte olan ülkeler sınıflandırmasından hareket ederek irdelemektir. Bu amaçla 21 ülkeden 842 işletmenin 2010-2019 yılları arasındaki toplam 4.973 firma-yıllık veri seti kullanılmış ve panel regresyon analizi yapılmıştır. Buna göre; işletmelerin yönetim kurulu büyüklüğünün, yönetim kurulunda yer alan kadın üye sayısının toplam üye sayısına oranının, yönetim kurulunda yer alan bağımsız üye sayısının toplam üye sayısına oranının ve CEO ve yönetim kurulu başkanı görevlerinin aynı kişi tarafından üstlenilmesinin işletmelerin finansal olmayan bilgiler kapsamında kamuyu aydınlatma düzeyi üzerinde anlamlı etkisi olduğunu göstermektedir. Bu da işletmelerin yönetim kurulu yapısının, finansal olmayan bilgi raporlama davranışını açıklanmasında anlamlı bir faktör olduğunu doğrulamaktadır.

Introduction: Myocardial ischemia due to coronary obstruction and reperfusion due to the opening of the coronary vessel occurring in the acute stage of myocardial infarction leads to lethal arrhythmia and sudden death in humans. That is why pharmacological drug research to decrease these arrhythmias have been researched intensively. In this study, the effect of acute administration of pinacidil and glimepride, on ischemia or reperfusion-induced arrhythmia was aimed to be researched. Methods: Two groups were produced; In the first group, only ischemia was produced by the ligation of the left coronary artery in 20 minutes, and in the second group 6 minutes of ischemia by the ligation of the artery and the subsequent 15 minutes of reperfusion were produced by the opening of the occluded artery. Drugs were administered intravenously at 2 minutes of ischemia in the first group and just following the reperfusion in the second group. The ECG and blood pressure were recorded during ischemia and reperfusion. The type, duration, incidence of arrhythmia, heart rate, blood pressure, and the death rate from the recording were determined. All data were first compared by one-way ANOVA. Then, the drug groups with their control, and control and drug groups with each other were compared by a one-tailed student t-test. The incidence of arrhythmia and the death rate between groups was compared by the Ki square test. Results: Pinacidil significantly decreased the arrhythmia score both in the ischemia and reperfusion period but glimepiride was not effective when they were given intravenously in the acute stage of ischemia or reperfusion. Discussion and Conclusion: This study suggests that pinacidil might be a candidate for drugs that can be used to decrease arrhythmia in the acute stage of myocardial infarction but more study is needed to reveal the antiarrhythmic or proarrhythmic effect of glimepride in the acute stage of myocardial infarction.

Milli güvenlik genel olarak devletin güvenliğini ilgilendiren her şeydir. Milli güvenlik faaliyetleri devletin yürütme organı ve idare tarafından yerine getirilmektedir. Dolayısıyla milli güvenlik idare hukuku açısından idarenin bir faaliyet alanı olarak kabul edilmektedir. Anayasa m. 8’de yürütme yetkisi ve görevinin Anayasa ve kanunlara uygun olarak kullanılıp yerine getirileceği ifade edildiği için milli güvenlik faaliyetleri de Anayasa hükümleri çerçevesinde yerine getirilecektir. Ayrıca idarenin her faaliyetinin Anayasal dayanağı olması gerektiği için milli güvenlik faaliyetlerinin de bir takım Anayasal dayanakları vardır. Bunlara Devletin ülkesi ve milletiyle bölünmez bütünlüğünü düzenleyen Ay m. 3, Devletin temel amaç ve görevlerinin ifade edilmiş olduğu Ay m. 5, egemenliği düzenleyen Ay m. 6 hükümleri örnek olarak verilebilecektir. Ayrıca idarenin her faaliyeti bir teşkilat tarafından yerine getirilmektedir. Cumhurbaşkanı, Millî Savunma Bakanlığı (MSB), Milli Güvenlik Kurulu (MGK), Türk Silahlı Kuvvetleri (TSK)/Genelkurmay Başkanlığı, Yüksek Askerî Şûra (YAŞ) ve Cumhurbaşkanlığı Güvenlik ve Dış Politikalar Kurulu milli güvenlik alanında görev ve yetkileri olan idareler ve idari birimlerdir.

Yoksulluk, dünya ülkelerini olumsuz olarak etkileyen ve etki alanının genişlemesi nedeniyle mücadele edilmesi gereken büyük bir sorundur. Yoksulluk sorununa müdahalede bulunulmaz ise kronik bir hal alıp toplumun büyük bir çoğunluğu üzerinde etkisini hissettirecektir. Yoksulluk sorunu ile mücadele şekilleri zamanla değişiklik göstermiş olsa da amaç hiç değişmemiştir. Günümüzde yoksullukla mücadelede etkin rol üstlenen devlet aktörleri bulunmaktadır. Bu çalışmada bu aktörler içerisinden sosyal yardım kurumlarına ve bu kurumların yapmış olduğu sosyal yardımlara değinilmiştir. Sosyal yardım harcamalarının yoksulluk oranı üzerindeki etkisini ölçebilmek amacıyla zaman serisi analizi yapılmıştır. Bu analizlerde Gauss 21 ve Eviews 12 paket programları kullanılmıştır. Çalışmada uygulanan zaman serisi analizi ile yoksulluk oranı ve sosyal yardım harcaması, sosyal yardımdan yararlanan hane sayısı, sosyal yardım harcamasının milli gelir içerisindeki payı arasında uzun dönemli tek yönlü bir nedensellik ilişkisi olduğu ortaya konmuştur

Objective: Yeast causes hospital-acquired infections at increasing rates, which can cause serious mortality, especially in patients with a suppressed immune system. This study aimed to determine the species distribution and antifungal resistance rates of yeast isolated in a hospital. Material and Methods: Isolated yeasts from clinical specimens of patients who received inpatient treatment in different clinics in our hospital between 1 December 2019 and 30 September 2020 were examined. In all of these isolates, species identification was made with an automated system in addition to classical methods. Additionally, the antifungal susceptibility of yeast against amphotericin B, flucytosine, Fluconazole, micafungin, caspofungin, and Voriconazole was investigated using an automated system. Results: In the study, yeasts isolated from 183 clinical samples, including 64 vagen, 62 blood, 28 urine, 12 wounds, eight tracheal aspirates, five peritoneal fluids, three catheters and one cerebrospinal fluid (CSF) samples were included. Of these isolates, 93 were Candida albicans (50,82%), 40 were Candida parapsilosis (21,86%), 17 were Candida tropicalis (9,29%), eight were Candida glabrata (4,37%), eight were Stephanoascus ciferrii (4,37%), five were Candida lusitaniae (2,19%), four were Candida famata (2,19%), four were Cryptococcus laurentii (2,19%) and four were Candida krusei ( 2,19%). Antifungal susceptibility testing was performed in 103 of the isolates. The highest resistance was found against Fluconazole, with 16.8%, and the lowest resistance was against flucytosine, with 2.2%. Antifungal resistance rates of Fluconazole, Voriconazole, amphotericin B, flucytosine, caspofungin and micafungin were found as 16.8%, 8.2%, 6.1%, 2.2%, 2.9% and 6.8% respectively. Conclusion: Due to the increasing frequency of fungal infections due to long-term hospitalization, it has been concluded that identifying the causative species and reporting the antifungal susceptibility status is important in monitoring the change in resistance rates and guiding the treatment.

Objective: Vascular disorders severely impair the psycho-social status of individuals. Various laser and light systems, which have advantages and disadvantages, including the pro-yellow laser are used for the therapy of these disorders.Aim: The goal of the present study was to investigate the effectiveness and feasibility of the 577 nm pro-yellow laser for a broad range of indications including erythematelangiectatic rosacea, facial erythema, post-acne erythema, facial telangiectasis, hemangioma, genital angiokeratoma, and port wine stain nevus.Methods: A total of 98 patients (25 male, 73 female) older than 15 years who were treated with the pro-yellow laser for vascular disorders at the cosmetology unit between 2017 and 2019 were retrospectively included in the study.Results: The mean rate of recovery was 100% in genital angiokeratoma, 94.4% in spider angioma, 83.3% in facial telangiectasis, 74.8% in erythematotelangiectatic rosacea, 72% in facial erythema + facial telangiectasis, and 68.3% in facial erythema. Over 60% of improvement was observed in most patients with vascular disorders. There was no significant link between the Fitzpatrick skin type and treatment success. Treatment success was significantly low in cases with nasal involvement.Conclusion: The current study concluded that pro-yellow laser is an efficient and safe laser modality that may yield satisfactory outcomes regardless of the different skin types.

Human breast cancer (BRCA) shows tremendous genomic, gene expression, clinical, and phenotypic heterogeneity. Known driver gene alterations can only explain a portion of this heterogeneity, some of which likely arise from variation in the target cell for transformation, in addition to incompletely understood gene copy number and epigenetic alterations. These factors are difficult to identify with certainty using human patient samples due to widely varying germline genetic backgrounds, thousands of gene copy and epigenetic changes per sample, and, unknown target cell transformation. Activating mutations in the p110α catalytic subunit of PI3K are one of the most common genetic alterations in human BRCA. Here, we report results from two Sleeping Beauty (SB) transposon-accelerated mouse models of Pik3ca-mutant mammary cancer showing how genotype-phenotype correlations can be drawn providing strong candidates for mediating tumor phenotypes, including estrogen-receptor (ER)-dependent gene expression, high cell cycle activity, and immune cell exclusion. We used SB transposon mutagenesis in mice on a Pik3caH1047R activated mutant background to model mammary cancer development in two different mammary epithelial compartments. Both the target cell for mutagenesis and the specific transposon-induced mutations correlated with specific tumor phenotypes, including whether the tumors were ER positive or negative. RNA sequencing of tumors revealed novel genotype-phenotype correlations implicating specific transposon-altered gene drivers of high cell cycle activity, ER-dependent gene expression, and white blood cell exclusion from the tumor. Many transposon-implicated genes are altered at the gene copy number or epigenetic/methylation level in human BRCA, and several were functionally validated. These models provide a source of genetically heterogenous mouse mammary tumors with a uniform initiating mutation, Pik3caH1047R, useful for identifying cooperating pathways and drivers of specific tumor phenotypes. Citation Format: Morito Kurata, Emiily Pope, Jingmin Shu, Wenlin Yuan, Wendy Hudson, Mark Sokolowski, Setareh Bagherzadeh, Zora Modrusan, Eric Stawiski, Steffen Durinck, Sekar Seshigiri, Aaron Sarver, Nuri Temiz, David Largaespada. Discovery of cancer genes and pathways operative in PI3K-activated mammary cancer reveals clinically relevant genotype-phenotype correlations. [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P3-08-04.

Zaman Yönetimi planlama ve organize etme süreci olarak tanımlanmaktadır. Hemşirelerin zaman yönetimini kullanması, hasta bakım ve tedavi sürecinin aksamadan devamlılığını sağladığı gibi bakıma ayrılan sürenin her anının verimli bir şekilde planlamasına olanak vermektedir. Hemşirelerin klinik alanlanda zaman yönetimi ile ilgili bilgi birikiminin ve farkındalıklarının arttırılmasıyla hasta bakım kalitesinin en üst düzeyde olması hedeflenmektedir. Amaç: Bu araştırma hemşirelerin zaman yönetimi konusundaki başarı düzeylerinin değerlendirilmesi amacıyla planlandı. Gereç ve Yöntem: Araştırma hastanede çalışan ve araştırmaya katılmayı kabul eden 151 hemşire ile yürütüldü. Veriler kurum izni ve etik kurul onayı alınarak anket formu ile toplandı. Anketler SPSS 22.0 programı kullanılarak değerlendirildi. Bulgular: Zaman Yönetimi Ölçeği puanlarının hemşirelerin cinsiyetlerine, eğitim durumuna, meslekte toplam çalışma süresine, zaman yönetimi ile ilgili daha önce bilgi alma durumuna, iş tanımlarının mevcut olma durumuna, hemşirelerin kendisi için tanımladığı en uygun davranış tipine, görevini yerine getirirken kullandığı zamanın yeterli olma durumuna göre karşılaştırılmaları yapıldığında istatistiksel olarak anlamlı bir fark bulundu (p

The application of the Quality by Design (QbD) principles in developing a novel high performance liquid chromatography (HPLC) method for the analysis of liothyronine sodium related substances for finished product using Fusion QbD® software is explored. The effect of various chromatographic parameters including, column stationary phase, initial hold time and gradient time on separations were systematically investigated. Results show that optimal separations of these compounds in a standard solution can be achieved using a X Bridge C18 column (150 mm × 4.6 μm, 5m), maintained at sample temperature 15°C by using pH 2.0 buffer solution as mobile phase-A and methanol as mobile phase-B with a flow rate of 1.0 ml/min at 225 nm of detection and a gradient time of 38 minutes. The injection volume is 200 μl. Pre-validation studies of the method were performed and all the parameters met the acceptance criteria. The results are demonstrated that optimized method is selective, linear, precise, repeatable and accurate.

This study aimed to investigate the predictive role of serum C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) on renal mass biopsy outcomes. A total of 71 patients with suspected kidney masses who underwent renal mass biopsy procedure between January 2017 and January 2021 were retrospectively evaluated. Pathological results after the procedure were obtained and pre-procedural serum CRP and NLR levels were extracted from the patients’ data. The patients were grouped into benign and malignant pathology groups according to the histopathology results. The parameters were compared between the groups. Diagnostic role of the parameters in terms of sensitivity, specificity, and positive and negative predictive values was also determined. Additionally, Pearson correlation analysis, and univariate and multivariate cox proportional hazard regression analyses were also performed to investigate the above association with tumor diameter and pathology results, respectively. At the end of the analyses, a total of 60 patients had malignant pathology on histopathological investigations of the mass biopsy specimens, whereas the remaining 11 patients had a benign pathological diagnosis. Significantly higher CRP and NLR levels were detected in the malignant pathology group. The parameters positively correlated with the malignant mass diameter, as well. Serum CRP and NLR determined the malignant masses before the biopsy with sensitivity and specificity of 76.6 and 81.8%, and 88.3 and 45.4%, respectively. Moreover, univariate and multivariate analyses showed that serum CRP level had a significant predictive value for malignant pathology (HR: 0.998, 95% CI: 0.940–0.967, P < 0.001 and HR: 0.951, 95% CI: 0.936–0.966, P < 0.001, respectively). In conclusion, serum CRP and NLR levels were significantly different in patients with malignant pathology after renal mass biopsy compared to the patients with benign pathology. Serum CRP level, in particular, diagnosed malignant pathologies with acceptable sensitivity and specificity values. Additionally, it had a substantial predictive role in determining the malign masses prior the biopsy. Therefore, pre-biopsy serum CRP and NLR levels may be used to predict the diagnostic outcomes of renal mass biopsy in clinical practice. Further studies with larger cohorts can prove our findings in the future.

Background/Aim: Several blood and serum-based parameters have been described as prognostic markers of clear cell renal cell carcinoma (ccRCC). But most of these markers have inconsistent results and are not used in routine clinical practice. Therefore, novel potential predictor biomarkers are needed for the management of ccRCC patients in clinical practice. Here, we investigate the predictive value of a novel marker, serum C-NLR score, for pathological characteristics and oncological outcomes of ccRCC. Methods: A total of 162 RCC patients who underwent radical or partial nephrectomy between January 2015 and January 2021 were evaluated in a retrospective cohort study setting. The serum C-NLR score was compared according to the tumor histopathology-associated parameters. The predictive role of those parameters and C-NLR score on the oncological outcomes of ccRCC was also investigated. Results: The median serum C-NLR scores exhibited statistically significant increases in ccRCC patients with pathological necrosis, lymphovascular invasion, and variant differentiation. Among histopathological characteristics, only tumor necrosis and variant differentiation were associated with overall survival (OS) and tumor grade with metastasis-free survival (MFS) (no metastasis detected in grade 1–2 tumors) in Kaplan Meier analyses. Serum C-NLR score was also associated with OS but not MFS. In the univariate analyses, tumor necrosis, variant differentiation, and C-NLR score were associated with OS of localized RCC patients who underwent nephrectomy (HR: 0.29; 95% CI: 0.08–1.01; P=0.04, HR: 6.01; 95% CI: 1.66–21.82; P=0.006 and, HR: 1.21; 95% CI: 0.20–5.16; P=0.04). However, in the multivariate analysis, only variant differentiation and C-NLR score were associated with OS (HR: 1.43; 95% CI: 0.82–2.98; P=0.03 and HR: 1.21; 95% CI: 0.20–5.16; P=0.04). Tumor grade was directly associated with MFS because grade 1–2 tumors did not exhibit any metastasis. Conclusion: Serum C-NLR score was higher in worse histopathological entities. Moreover, it predicts the OS for patients with ccRCC as an independent factor.

Musculoskeletal infections, including septic arthritis, osteomyelitis, and soft tissue infections, are critical morbidity factors for children and adolescents. This study investigated the role of D-dimer levels for diagnosing childhood musculoskeletal infections. This single-center prospective study was initiated in April 2020 following approval from the local ethics committee. The study included 54 children, divided into the infection group ( n = 21), comprising patients who underwent surgical treatment for childhood musculoskeletal infections and had macroscopically visible purulent discharge during surgery, and the control group ( n = 33), comprising healthy children. In the infection group, the mean values of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), plasma D-dimer, and white blood cell (WBC) were 39.42 ± 27.00 mm/h, 101.50 ± 76.90 mg/l, 2.34 ± 2.59 mg/l, and 15.55 ± 6.86 × 10 9 /l, respectively. On comparison, the infection group showed higher levels of WBC, CRP, ESR, D-dimer, and neutrophil-to-lymphocyte ratio than the control group. When the D-dimer cutoff value of 0.43 mg/l was taken, it was observed that it had 95.2% sensitivity and 81.8% specificity. The area under curve (AUC) of the above-mentioned parameters calculated via receiver operating characteristic curves showed CRP levels as the optimum predictor of childhood musculoskeletal infections, followed by the ESR, plasma D-dimer, and WBC levels in descending order (AUC: 0.999, 0.997, 0.986, and 0.935, respectively). D-dimer is another test, which in combination with other conventional established tests (CRP and ESR) can be helpful in diagnosis of pediatric infection. We recommend the addition of D-Dimer to ESR, CRP, and WBC as a first-line investigation in cases with suspected pediatric musculoskeletal infections.

Introduction: The aim of this study was to define the difference between lateral nasal wall anatomy and variations as linear and angular in patients with class II and class III dentofacial deformities and to determine a surgical margin for safe entry by establishing an ideal osteotomy line for lateral nasal wall osteotomy during Le Fort I surgery. Materials and Methods: Eighty-five patients with dentofacial deformities, who were admitted to Medipol Mega University Hospital between September 2018 and February 2021, and 170 regions, including the right and left, were evaluated. In the axial image taken from coronal sections 5 mm above the deepest point of the nasal floor, lateral nasal wall angulations and linear and angular distances to the descending palatine canal were measured. Class II and class III patients were evaluated according to the right and left regions and gender. Results: The angled right distance values to the descending palatine artery of class III patients are higher than the values of the angled left distance to the descending palatine canal (p = 0.034). The right second angulation levels of class II female patients are higher than those of class II male patients (p = 0.037). Class III male patients have a significantly higher right linear distance to the descending palatine canal and right second angulation levels compared to class III female patients (p1 = 0.009; p2 = 0.003). The right second angulation levels of class II male patients are significantly lower than those of class III male patients (p = 0.003). Conclusion: This study described the mean angulations and linear distances between anatomic structures of the lateral nasal wall in patients with class II and class III dentofacial deformities for the purpose of a safe osteotomy. The location of the descending palatine canal and the morphology of the lateral nasal wall are not significantly associated with dentofacial deformity.

With the air leakage test methods, the leakage tests of the products that are required to be leakproof are carried out. This leakage test starts with placing the product on a fixture. The in-ternal pressure is increased by filling compressed air into the product placed in the Fixture. The product is filled with compressed air up to a previously calculated test pressure value. After the test pressure value is reached for the desired product, the air filling process is completed, and the stabilization period begins. At the end of this period, information about the leakage of the product is obtained, depending on whether there is a change in the internal pressure of the product. In order to fill the product with compressed air, there must be an air hole on the product. Products without this air hole cannot be tested with these methods. With the new method we will develop, it will be possible to test the leakage of closed products without atmosphere-air connection.

Hotel bathrooms are one of the most important places in terms of customer satisfaction, and where the most complaints are reported. To share their experiences, guests rate hotels, comment, and share images of their positive or negative ratings. An important part of the room images shared by guests is related to bathrooms. Guests tend to prove their satisfaction or dissatisfaction with the bathrooms with images in their comments. These Positive or negative comments and visuals potentially affect the prospective guests. In this study, two different versions of a deep learning algorithm were designed to classify hotel bathrooms as satisfactory (good) or unsatisfactory (bad, when any defects such as dirtiness, deficiencies, malfunctions were present) by analyzing images. The best-performer between the two models was determined as a result of a series of extensive experimental studies. The models were trained for each of 144 combinations of 5 hyper-parameter sets with a data set containing more than 11 thousand bathroom images, specially created for this study. The “HotelBath” data set was shared also with the community with this study. Four different image sizes were taken into consideration: 128, 256, 512 and 1024 pixels in both directions. The classification performances of the models were measured with several metrics. Both algorithms showed very attractive performances even with many combinations of hyper-parameters. They can classify bathroom images with very high accuracy. Suh that the top algorithm achieved an accuracy of 92.4% and an AUC (area under the curve) score of 0.967. In addition, other metrics also proved the success of the algorithm. The proposed method can allow the rapid, accurate and automatic detection of such undesired circumstances in hotel bathrooms from images. Such a detection system can allow hotel management to take necessary actions quickly to remedy such unsatisfactory cases.

Araştırmanın amacı core kuvvet antrenman (CKA) modelinin işitme engelli bireylerin denge ve fiziksel performansları üzerine etkilerini incelemektir. Araştırmaya 30 işitme engelli öğrenci katıldı. Katılımcılar, egzersiz grubu (EG: 15; 4 kadın 11 erkek; yaş: 19,60±1,96) ve kontrol grubu (KG: 15, 4 kadın 11 erkek; yaş: 19,73±1,03) olarak rastgele iki gruba ayrıldı. EG’ye dört haftalık (haftada 5 gün) CKA programı uygulandı. KG’deki katılımcılar sadece günlük yaşamlarına devam ettiler. Tüm katılımcılara antrenman uygulaması başında ve sonunda boy uzunluğu, vücut ağırlığı, denge, esneklik, sağ-sol el kavrama kuvveti, dikey sıçrama, durarak uzun atlama, şınav ve mekik testleri uygulandı. Grup içi ve gruplar arası farkları karşılaştırmak için 2x2 mixed faktör ANOVA kullanıldı. Dört haftalık CKA programı sonrası EG’de esneklik, sağ-sol el kavrama kuvveti, durarak uzun atlama, dikey sıçrama, şınav ve mekik testi değişkenlerinde anlamlı gelişim görüldü (p, The purpose of the study was to investigate the effects of core strength training (CST) on the balance and physical performance parameters in deaf individuals. Thirty deaf students participated. The subjects were randomly separated into two groups as experimental (EG: 15; 4 female 11 male; age: 19.60±1.96) and control group (CG: 15; 4 female 11 male; age: 19.73±1.03). A four-week CST program was implemented in the EG. The CG subjects only participated in their daily life. Height, body weight, balance, flexibility, right-left hand grip strength, vertical jump, standing long jump, push-up and curl-up tests were applied to all subjects baseline and after four-week program. 2x2 mixed factor ANOVA test was performed. Flexibility, right-left hand grip strength, standing long jump, vertical jump, push-up and curl-up variables significantly improved after a 4-week period in the EG (p

Public open spaces provide many services that will improve the physical and mental health of the society and increase the quality of life. These services are an important indicator for measuring spatial quality. In this study, it is aimed to evaluate the reinforcement elements used in the Özgürlük Park in the city of Çanakkale according to the spatial quality criteria in the Space Quality Diagram. Situation analysis, which is a component of the qualitative research design, was used in line with the target and the reinforcement elements were evaluated as successful or unsuccessful. As a result, it was determined that the park is an area with high quality value, but the "maintenance" criterion was found to be insufficient in the area. It is suggested that the maintenance and repair works of the reinforcement elements and plant elements in the area should be carried out regularly.

Verticillium wilt disease in cotton is a soil-borne disease that causes significant yield losses, and it is therefore important to identify disease-resistant genotypes. Current study was carried out in the experimental field of the Faculty of Agriculture, Dicle University (Diyarbakir) in the year 2020 to determine the tolerance levels of some cotton genotypes which contain different characteristics to wilt disease (Verticillium dahliae Kleb.). The experiment area has been naturally infected with Verticillium wilt pathogens. A total of 124 cotton genotypes, including four controls (DP-499, Edessa, ST-468, ES-1), were arranged in five blocks according to the Augmented Design. The indices of stem cross-section and the leaf-disease severity were found significant. The leaf-disease severity varied between 0.12-3.09 at 50-60 % at boll opening period, whilst stem cross-section values ranged between 0.36-2.30. Moreover, a positive correlation was found between the indices. In conclusion, G7, G12, G21, G22, G23, G41, G51, G55, and G101 were determined as tolerant genotypes to Verticillium wilt in terms of examining two parameters.

Öz Bu çalışmanın amacı Borsa İstanbul’da, BIST TÜM Endeksinde işlem gören işletmeler özelinde, işletmelerin sürdürülebilirlik raporu yayımlama ve bu raporlara bağımsız güvence hizmeti alma kararlarında etkili olan faktörleri incelemektir. 2010-2020 dönemine ait veri seti üzerinden, fark testleri ve lojistik regresyon analizleri ile işletme büyüklüğü, borçluluk oranı, kârlılık, yönetim kurulu büyüklüğü, yönetim kurulu kadın üye oranı ve sürdürülebilirlik performansının sürdürülebilirlik raporu yayımlama olasılıklarını anlamlı bir şekilde artırdığı; benzer şekilde işletme büyüklüğü ve borçluluk oranı, yönetim kurulu kadın üye oranı ve sürdürülebilirlik performansının işletmelerin sürdürülebilirlik raporlarına bağımsız güvence hizmeti alma olasılıklarını pozitif yönde etkilediği sonucuna ulaşılmıştır.

This study focuses on the manufacturing of hybrid functionally graded metal matrix composite (HFGMMC) using Al7039 alloy matrix phase which is used as armor material in today’s world. In this context, manufacturing stages of matrix material were analyzed, and necessary parameters were determined for remanufacturing using casting method. With the determined parameters, the matrix material was reinforced by SiC, Al2O3, and B4C particles in different volume rates at an average size of 3–10 µm using stir casting method. Three metal matrix composite (MMC) plates which were manufactured using different reinforcement particles in different volume rates were joined as semi-solid with the effect of temperature and pressure in a specially designed mold. In order to complete the manufacturing process, hot forging, and heat treatment were applied to the manufactured composite plate in accordance with the parameters determined in the manufacturing of the matrix. The manufactured MMC and HFGMMC plates were compared in terms of their micro structure, micro hardness, tensile strength, and wear behavior. Finally, HFGMMC plates were joined together by friction stir welding (FSW) in order to analyze their micro structures and mechanical properties after welding.

This study aimed to assess the preliminary outcomes of kinematically aligned robot-assisted total knee arthroplasty (TKA) with patient-specific cartilage thickness measurement. Patients who underwent kinematically aligned robot-assisted TKA were included in this study. Robot-assisted total knee arthroplasties were performed by NAVIO Surgical System (SmithNephew, Memphis, USA), an image-free handheld robotic system. The kinematic alignment technique was performed according to our intraoperative cartilage thickness measurement technique. Hip-knee-ankle angle (HKA), mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA), joint-line orientation angle (JLOA), and joint-line convergence angle (JLCA) were measured through standing full-length anteroposterior radiographs. Knee Injury and Osteoarthritis Outcome Score, Oxford score, VAS pain and satisfaction score, and Forgotten Joint Score were used to assess clinical outcomes. A total of 142 knees of 109 patients (92 females and 17 males) were evaluated in this study. There was a significant correction in HKA, JLCA, and mMPTA postoperatively (p ≤0.001, 0.001, and 0.029, respectively). We observed no significant change in mLDFA and JLOA measurements. All clinical scores significantly increased at the latest follow-up. Our results demonstrated that kinematically aligned robot-assisted TKA with patient-specific cartilage thickness measurement demonstrated no significant change in mLDFA and JLOA, as expected; however, significantly corrected the deformity in HKA, mMPTA, and JLCA measurements.

Introduction Patients with phantosmia, often thought to be an olfactory hallucination, can smell an odor that nobody else can smell. We describe the first case of phantosmia secondary to an intranasal bacterial infection. Case summary An 82-year old male presented to clinic with a multi-year history of phantosmia that had a severe impact on the patient’s quality of life. Prior diagnostic and treatments were unsuccessful and consisted of nasal endoscopy, brain computed tomography (CT) scan, and tooth extraction. A nasal culture returned as light growth of Pseudomonas Stutzeri. Empiric treatment with mupirocin had begun, and worsened the smell, but was stopped and switched to topical gentamicin and oral trimethoprimsulfamethoxazole.By 1 week, the smell had improved subjectively. At 5 year follow-up,with regular application of topical gentamicin the patient stated the smell was cured,rating the symptoms as a 0 out of 10. Discussion As individuals age, olfactory changes are common, however, some will experience severe, unpleasant smell sensations. After neurologic etiologies are ruled out, treatment often relies on destroying a component of the olfaction system. Future research should investigate bacterial etiologies for phantosmia. Our case had a unique intranasal culture result and was responsive to antibiotic treatment.

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics, which is often associated with psychiatric comorbidities. Dysfunction of basal ganglia pathways might account for the wide spectrum of symptoms in TS patients. Although psychiatric symptoms may be related to limbic networks, the specific contribution of different limbic structures remains unclear. We used tractography to investigate cortical connectivity with the striatal area (caudate, putamen, core and shell of the nucleus accumbens), the subthalamic nucleus (STN), and the adjacent medial subthalamic region (MSR) in 58 TS patients and 35 healthy volunteers. 82% of TS patients showed psychiatric comorbidities, with significantly higher levels of anxiety and impulsivity compared to controls. Tractography analysis revealed significantly increased limbic cortical connectivity of the left MSR with the entorhinal (BA34), insular (BA48), and temporal (BA38) cortices in TS patients compared to controls. Furthermore, we found that left insular-STN connectivity was positively correlated with impulsivity scores for all subjects and with anxiety scores for all subjects, particularly for TS. Our study highlights a heterogenous modification of limbic structure connectivity in TS, with specific abnormalities found for the subthalamic area. Abnormal connectivity with the insular cortex might underpin the higher level of impulsivity and anxiety observed in TS.

The Coronavirus disease 2019 (COVID-19) has been affecting our lives since December 19. Naturally, during the COVID-19 outbreak, it has become a point of interest whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection might affect oocyte, and sperm and influence the implantation during the assisted reproductive technology cycles. In the current narrative review, we aimed to scrutinize articles about SARS-CoV-2 infection and infertility concerning the safety of gametes and the endometrium. Whereas the available data suggest that SARS-CoV-2 interferes with various types of molecular pathways in the oocyte, spermatozoa, and endometrium, the lack of co-expression in angiotensin-converting enzyme 2 and transmembrane protease serine 2 in those cell lines theoretically avoid concerns by patients and reproductive endocrinologists. However, one should consider that those observations were based on a few case series and should be confirmed with further observational studies including a larger sample size with various clinic spectrums. Alternative pathways that can be utilized by the virus to invade gametes and individual differences in molecular expression are other potential limitations that should be considered.

Objective: This study aimed to determine the incidence and risk factors of perioperative pressure injury (PI) in surgical patients. Material and Methods: This descriptive, prospective, and comparative study was conducted with 101 patients who underwent general surgery in a training and research hospital in İstanbul between September 2018 and June 2019. Data were collected using the “Patient Data Form,” the “Braden Scale,” and the “International Pressure Injury Classification System.” Data were analyzed with parametric and nonparametric tests using the SPSS package program. The statistical significance level was taken as p

Tarhana is one of the traditional Turkish fermented food and it is served as a soup. In this study, bacterial microbiota and chemical properties (acidity, salt, and moisture content) of tarhana samples (n=96) were examined. The metagenomic analysis revealed that Firmicutes were the dominant phylum and Bacillaceae, Enterococcaceae, Paenibacillaceae, Enterobacteriaceae, and Clostridiaceae were the dominant bacterial families. In the samples, Bacillus, Enterococcus, and Paenibacillus were mostly identified at the genus level. Alpha diversity and evenness showed that sample 30 had the highest diversity collected from İzmir. Principal Coordinate Analysis was used to identify relationships of samples at different taxonomic levels and it was found that most of the samples were closely related at the phylum level. Chemical analysis indicated that the acidity of tarhana samples varied between 5.00% and 42.5%, moisture contents were 4.39–18.66% and salt values were from 0.32% to 6.64%. The results of this study extensively demonstrated the chemical properties and the dominant bacterial communities present in tarhana samples collected from different parts of Türkiye.

Background: Tularemia is a zoonotic disease endemic in the northern hemisphere. The causative agent of the disease is Francisella tularensis. F.tularensis is endemic in Turkey, predominantly in the Marmara and Black Sea regions, and causes small outbreaks. This study aimed to investigate the seroprevalence of F.tularensis in patients admitted to the Otorhinolaryngology outpatient clinic with the complaint of neck mass by using two different methods. Methods: Serum samples were collected from patients who were admitted to the Otorhinolaryngology outpatient clinic of Dicle University Faculty of Medicine Hospitals between January 2021 and December 2021 with the complaint of neck mass. A commercially available immunochromatographic lateral flow test (ICT) and a single-assay chemiluminescence test (CHT) were used to detect F.tularensis antibodies. Rose-Bengal test was performed on all sera to determine cross-reactions with antibodies produced in brucellosis. Brucella immunocapture agglutination tests (BCT) were performed on the sera of patients with positive screening tests. Results: The ages of patients diagnosed with neck mass ranged between 14–70 years, with a mean age of 44.5±12.1 years. Sixty two (62%) of the patients were male, and 38 (38%) were female. When the test results were evaluated, two sera were positive for F.tularensis by both ICT and CHT methods. The first serum tests were negative for Brucella. The titer of the second serum in the chemiluminescence test was low positive. Conclusion: Tularemia should be considered in the differential diagnosis of patients presenting with neck mass complaints, especially in patients living in rural areas, and specific diagnostic tests should be performed. In addition, a more comprehensive seroprevalence study supported by molecular testing techniques to be conducted in Diyarbakır will provide clearer data on the extent to which tularemia affects our region and which subspecies is the causative agent. Giriş: Tularemi, kuzey yarımkürede endemik olarak görülen zoonotik bir hastalıktır. Hastalığın etkeni Francisella tularensis’tir. Francisella tularensis, Türkiye’de, Marmara ve Karadeniz bölgelerinde endemiktir ve küçük salgınlara neden olmaktadır. Bu çalışmada, Kulak Burun Boğaz polikliniğine boyunda kitle şikayeti ile başvuran hastalarda Francisella tularensis seroprevalansının iki farklı yöntem kullanılarak araştırılması amaçlandı. Yöntem: Dicle Üniversitesi Tıp Fakültesi Hastaneleri Kulak Burun Boğaz polikliniğine Ocak 2021-Aralık 2021 tarihleri arasında boyunda kitle şikayeti ile başvuran hastalardan serum örnekleri toplandı. F. tularemia karşı oluşan antikorlar ticari olarak temin edilebilen immunokromatografik (ICT) ve kemilüminesans (CHT) yöntemle çalışılan testlerle tespit edildi. Brusellozda oluşan antikorlarla çapraz reaksiyonları belirlemek için tüm serumlara Rose-Bengal tarama testi yapıldı. Tarama testleri pozitif olan hastaların serumlarına Brucella immunocapture aglütinasyon testleri (BCT) yapıldı. Bulgular: Boyun kitlesi tanısı alan hastaların yaşları 14-70 arasında değişmekte olup, ortalama yaş 44,5±12,1’di. Hastaların 62’si (%62) erkek, 38’i (%38) kadındı. Test sonuçları değerlendirildiğinde, hem ICT hem de CHT yöntemiyle iki farklı serum F. tularemia için pozitif bulundu. Brucella antikorları için ilk serumun testleri negatifti. Kemilüminesans yöntemle çalışan testte ikinci serumun titresi düşük derecede pozitif saptanmıştır. Sonuç: Boyunda kitle şikayeti ile başvuran ve özellikle kırsal kesimde yaşayan hastalarda ayırıcı tanıda tularemi düşünülmeli ve spesifik tanı testleri yapılmalıdır. Ayrıca Diyarbakır’da yapılacak moleküler test teknikleriyle desteklenmiş daha kapsamlı bir seroprevalans çalışması, tulareminin bölgemizi ne ölçüde etkilediği ve hangi alt türün etken olduğu konusunda daha net veriler sağlayacaktır.

Introduction: Fuziline is one of the many antioxidants currently being tested to treat cardiac damage. In our study, histopathological and biochemical effects of fuziline were investigated in mice with dobutamine-induced heart damage in vitro. Methods: Thirty-two adult male BALB/c mice, average weight of 18-20 g, were randomly divided into four groups - Group 1 (sham, n=8), Group 2 (control, dobutamine, n=8), Group 3 (treatment 1, dobutamine + fuziline, n=8), and Group 4 (treatment 2, fuziline, n=8). Biochemical parameters and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were measured. Interleukin 1 beta (IL-1β), NLR family, pyrin domain containing protein 3 (NLRP3), 8-hydroxy-deoxyguanosine (8-OHDG), gasdermin D (GSDMD), and galectin 3 (GAL-3) levels were analyzed by enzyme-linked immunosorbent assay method, and histopathological examination of heart tissues was performed. Results: When dobutamine + fuziline and fuziline groups were compared, troponin-I (P

Objective: This study aimed to examine the effects of prenatal stress (PS) induced by dexamethasone exposure on gene expression levels of epigenetic enzymes in hippocampus and cerebral cortex of male rats through relative mRNA levels of histone acetyltransferases (activating transcription factor 2, P300), histone deacetylases (HDAC1, HDAC2), and DNA methyltransferases (DNMT1, DNMT3a, DNMT3b). Methods: Pregnant rats were daily injected subcutaneously with dexamethasone (0.2 mg/kg) or saline during the third week of gestation. After birth, male rats were killed at 90 days of age (n = 5 for control and dexamethasone groups). Hippocampal and cortical tissues were used for gene expression analyses. The effects of dexamethasone on epigenetic mechanisms were investigated by real-time polymerase chain reaction through relative mRNA levels of DNMT1, DNMT3a, DNMT3b, activating transcription factor 2, P300, HDAC1, and HDAC2. Statistical comparisons were performed with Student's t-test. Results: Prenatal dexamethasone exposure (PDE) caused increased DNMT1, DNMT3a, DNMT3b, activating transcription factor 2 and decreased P300 mRNA levels in hippocampus while increased DNMT3a, DNMT3b, activating transcription factor 2, P300, HDAC1, and HDAC2 mRNA levels were achieved in cortex. Furthermore, no significant differences were obtained in cortical DNMT1 and hippocampal HDAC1 and HDAC2 gene expression levels between control and prenatally stressed rats. Conclusion: Our results emphasize the effect of prenatal dexamethasone exposure on gene expression levels of epigenetic enzymes involved in histone acetylation/deacetylation and DNA methylation in male rats and suggest that prenatal stress may lead to epigenetic dysregulation through alterations in hippocampal and cortical gene expression patterns of DNMT1, DNMT3a, DNMT3b, activating transcription factor 2, P300, HDAC1, and HDAC2., Izmir Katip Celebi University [2018-ONAP-ECZF-0001], This study was supported by a grant from Izmir Katip Celebi University (2018-ONAP-ECZF-0001

The present study evaluated the potential effects of biliary drainage before pancreaticoduodenectomy on postoperative outcomes and presented the details of a surgeon's 6 years of experience.All consecutive pancreatoduodenectomies performed from 2015 to 2021 were retrospectively analyzed. The study population was divided into two groups: the stented group (Group I) and the nonstented group (Group II). Patient demographic data and clinical characteristics were compared between the two groups.This study comprised 106 individuals who underwent pancreaticoduodenectomy for periampullary tumors. The median age of the patients was 64.41 ± 11.67 years, and 65 (61.3%) were males. Sixty-seven patients (63.2%) received biliary drains (stented group), and 39 (36.8%) patients did not (nonstented group). Total bilirubin values (6.39 mg/dl) were higher in the nonstented patient group than in the stented group. The rate of total complications was significantly higher in the stented group than in the nonstented group [please check this carefully] (p 0.05). The length of stay, operation time and pancreatic fistula were found to be higher in the stented group than in the nonstented group.Although the total bilirubin value was higher in the nonstented patient group than in the stented group, preoperative biliary drainage increased postoperative complication rates, operation time, and hospital stay. An advanced age and the presence of stents were independent risk factors influencing morbidity development according to the multivariate analysis.