Study related to the production process of collagen extracts lately grown rapidly. Scientists are working to find a production process that efficient and effective, but the impact is very low in human. The production process of collagen extract performed by developed countries more applying chemical processes in order to increase production. However, the use of chemicals in the production process of course feared to affect humans as consumers. Collagen extracts usually produced from cattle bones and skin. Bone has potential as a raw material source of collagen as a health food anti-osteoporosis and premature aging [1]. Osteoporosis is one of the health problems that experienced by many people, especially the elderly. Osteoporosis cases were more experienced by women than men. The reason related to hormonal problems. Bone is one by-product of cattle that have not been widely used. Bone of broiler is one that has potential as a source of protein collagen. Bone is structurally rich in bioactive compounds, especially proteins collagen. It is bonded firmly with the minerals calcium and phosphorus. In producing the extract collagen from the bones, it takes demineralization. This process can use HCl 1M for 48 or 96 hours [2]. The use of solvent extractant has affected the quantity and quality of the product. One of them has affected the value of the yield, moisture content, protein content and calcium levels. The application of a solution of 0.5 M CH3COOH extractant has produced a better yield value [3]. In addition, the curing process needed to produce collagen extract optimum. The applications of the curing process for 4 days with a concentration of 9% (v/v) were to produce collagen extract better [4]. The Collagen is compound found in the bones of cattle. In principle, have similarities in terms of chemical composition, morphology, distribution, function and pathology with collagen compound owned by the human body [5]. Collagen is the main structural protein in the extracellular tissues of animal bodies. Collagen is a structural protein by the body tissues of cattle [6]. Recently, it has been widely used as a food supplement to prevent bone disease (osteoporosis), joint pain (osteoarthritis) and premature aging [7-8]. Collagen extract generally produced using chemical processes [9-10]. Structurally, bone is rich in bioactive compounds particularly collagen protein [11-12]. The production process is involving a chemical compound that needs special attention. Exposure to chemical compounds in the human body will certainly affect the body's metabolism. It is most important that chemical compounds have the potential to damage a particular organ in the human body. One of the organ in the human body that can be damaged due to exposure to the chemical compound is a kidney. To study the extent of organ damage in humans caused by the consumption of collagen extract is not possible to use human beings as objects of experimentation. Therefore, considered for the use of experimental animals, such as mice (Mus musculus). The researchers have carried out the use of mice (Mus musculus) as experimental material. Mice have many advantages such as short life cycle; mice can live up to the age of 1-3 years [13]. Kidneys are vital organs that function in homeostasis by regulating the volume and composition of the plasma, particularly electrolytes and water. Kidneys regulate electrolytes and non-electrolytes of the body, as well as urine excrete excess [14]. The use of experimental animals in assessing the effect of chemical compounds of Aluminum chloride (AlCl3) on the tissue structure of testicular has been done by previous researchers. Use of Aluminum chloride was combined with turmeric (Curcuma longa) indicates a change in the structure of the testes form tubular dilation and hypoplasia [15]. The objective of this study was to evaluate the effect of the consumption of collagen extracts processed chemically to the macroscopic and microscopic appearance of the kidneys in mice (Mus musculus). Needs collagen in the food and pharmaceutical industry has increased along with the development of human civilization. Extract collagen was produced through a chemical process that required special attention. The use of chemicals in the production process of collagen extract are potentially damage the organs, especially the kidneys. Therefore, prior to extract collagen administered to humans, it first has required testing. Impact consuming of collagen extracts were not tested on the humans, but it should be tested in animal experiments, for example mice (Mus musculus). Tests using experimental animals are very important to know the effects on the kidney when humans consume collagen extract. The aim of this study was to analyze the effect of consumption of collagen extract of broiler's bone on the tissue structure of kidney. This study was conducted 30 individuals on male Balb/C mice (Mus musculus) (average body weight, 20-25 grams, age, 2-3 months as experimental animals. Treatment divided into 5 groups administered dose of the extract collagen, the groups A, B, C, D and E. Each group consisted of 6 mice were divided randomly. Dose of group A is 0 mg/kg of bw, dose of group B is 5 mg/kg of bw, dose of group C is 50 mg/kg of bw, dose of group D is 500 mg/kg of bw, and dose of group E is 5000 mg/kg of bw. Collagen extract given to the mice every week for 30 days. The results showed that based on macroscopic analysis, no significant differences related to the texture and consistency of the surface of the kidney of mice (Mus musculus) that consume collagen extract for 30 days unless a different color. Based on microscopic analysis showed that, the dosage 5-50 mg/kg of bw did not show significant differences related to changes in the structure of the kidney tissue of mice (Mus musculus) during consumption (30 days) extract collagen compared to controls (0 mg/kg of bw). However, the extract collagen doses of 500-5000 mg/kg of bw in mice (Mus musculus) for 30 days showed highly significant differences in kidney tissue structures, especially compared to the control (0 mg/kg of bw). The use of the extract collagen that consumed does not exceed the recommended dose of 50 mg/kg of bw per week