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Additional file 1: Table S1. Results of one-way ANOVA and post-hoc Tukey’s HSD testing among-elevation variation in environmental and biotic variables. For the Tukey HSD column, elevation not sharing a letter are significantly different. Table S2. Environmental fitness of environmental parameters correlated with DCA ordinations of Generalists, Common taxa, and Specialists. Table S3. Module hubs and connectors in Total network and their topological characteristics and taxonomical features. Figure S1. The distribution of the niche breadthvalues of the ASVs. A B-value of >78 was chosen as a criterion for generalists as this value lies within the outlier area of the B-value distribution, while ASVs with B-values of

The binary ruthenate, RuO$_2$, has been the subject of intense interest due to its itinerant antiferromagnetism and strain-induced superconductivity. The strain mechanism and its effect on the microscopic electronic states leading to the normal and superconducting state, however, remain undisclosed. Here, we investigate highly-strained epitaxial (110) RuO$_2$ films using polarization-dependent oxygen K-edge X-ray absorption spectroscopy (XAS). Through the detection of pre-edge peaks, arising from O:$2p$ - Ru:$4d$ hybridization, we uncover the effects of epitaxial strain on the orbital/electronic structure near the Fermi level. Our data show robust strain-induced shifts of orbital levels and a reduction of hybridization strength. Furthermore, we reveal a pronounced in-plane anisotropy of the electronic structure along the $[110]/[1\bar{1}0]$ directions naturally stemming from the symmetry-breaking epitaxial strain of the substrate. The $B_{2g}$ symmetry component of the epitaxially-enforced strain breaks a sublattice degeneracy, resulting in an increase of the density of states at the Fermi level ($E_F$), possibly paving the way to superconductivity. These results underscore the importance of the effective reduction from tetragonal to orthorhombic lattice symmetry in (110) RuO$_2$ films and its relevance towards the superconducting and magnetic properties.

We have studied fundamental properties of weak-link Sr2RuO4/Sr2RuO4 Josephson junctions fabricated by making a narrow constriction on superconducting Sr2RuO4 films through laser micro-patterning. The junctions show a typical overdamped behavior with much higher critical current density, compared with those previously reported for bulk Sr2RuO4/s-wave superconductor junctions. Observed magnetic field and temperature dependences of the Josephson critical current suggest that the chiral p-wave is unlikely for the superconducting symmetry, encouraging further theoretical calculations of the Sr2RuO4/Sr2RuO4 type junctions., 14 pages, 4 figures

Purpose To evaluate Arg‐Gly‐Asp (RGD)‐conjugated human ferritin (HFn) iron oxide nanoparticles for in vivo magnetic resonance imaging (MRI) of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm (AAA). Materials and Methods HFn was genetically engineered to express the RGD peptide and Fe3O4 nanoparticles were chemically synthesized inside the engineered HFn (RGD‐HFn). Macrophage‐rich left carotid lesions were induced by ligation in FVB mice made hyperlipidemic and diabetic (n = 14), with the contralateral right carotid serving as control. Murine AAAs were created by continuous angiotensin II infusion in ApoE‐deficient mice (n = 12), while control mice underwent saline infusion (n = 8). All mice were imaged before and after intravenous injection with either RGD‐HFn‐Fe3O4 or HFn‐Fe3O4 using a gradient‐echo sequence on a whole‐body 3T clinical scanner, followed by histological analysis. The nanoparticle accumulation was assessed by the extent of T2*‐induced carotid lumen reduction (% lumen loss) or aortic T2*‐weighted signal intensity reduction (% SI [signal intensity] loss). Results RGD‐HFn‐Fe3O4 was taken up more than HFn‐Fe3O4 in both the ligated left carotid arteries (% lumen loss; 69 ± 9% vs. 36 ± 7%, P = 0.01) and AAAs (% SI loss; 47 ± 6% vs. 20 ± 5%, P = 0.01). The AAA % SI loss correlated positively with AAA size (r = 0.89, P < 0.001). Histology confirmed the greater accumulation and colocalization of RGD‐HFn‐Fe3O4 to both vascular macrophages and endothelial cells. Conclusion RGD‐HFn‐Fe3O4 enhances in vivo MRI by targeting both vascular inflammation and angiogenesis, and provides a promising translatable MRI approach to detect high‐risk atherosclerotic and aneurysmal vascular diseases. Level of Evidence: 1 J. Magn. Reson. Imaging 2017;45:1144–1153